Mechanical thrombectomy: can it be safely delivered out of hours in the UK? (2020)
Journal Article
Weddell, J., Parr, E., Knight, S., Muddegowda, G., Natarajan, I., Chembala, J., …Roffe, C. (2020). Mechanical thrombectomy: can it be safely delivered out of hours in the UK?. BMC Neurology, 20, Article 326. https://doi.org/10.1186/s12883-020-01909-8

BACKGROUND: Mechanical thrombectomy was approved by NICE as a treatment for stroke in 2016. However, most of the evidence is from studies conducted during working hours. Only few centres in the UK perform thrombectomies out-of-hours. The Royal Stoke... Read More about Mechanical thrombectomy: can it be safely delivered out of hours in the UK?.

Continuous or intermittent? Which regiment of enteral nutrition is better for acute stroke patients? A systematic review and meta-analysis (2019)
Journal Article
Di Paolo, G., Twomlow, E., Hanna, F., Farmer, A., Lancaster, J., Sim, J., & Roffe, C. (2019). Continuous or intermittent? Which regiment of enteral nutrition is better for acute stroke patients? A systematic review and meta-analysis. https://doi.org/10.32474/OJNBD.2019.03.000163

Background and purpose: Enteral nutrition via nasogastric tube in acute stroke patients with dysphagia is an important determinant of patient outcomes. It is unclear whether intermittent or continuous feeding is more efficacious. The aim of this revi... Read More about Continuous or intermittent? Which regiment of enteral nutrition is better for acute stroke patients? A systematic review and meta-analysis.

The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial. (2014)
Journal Article
Roffe, C., Nevatte, T., Crome, P., Gray, R., Sim, J., Pountain, S., …Handy, P. (2014). The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial. Trials, 15, Article 99. https://doi.org/10.1186/1745-6215-15-99

BACKGROUND: Mild hypoxia is common in stroke patients and may have significant adverse effects on the ischemic brain after stroke. The use of oxygen treatment is rapidly increasing in European stroke units but is not without side effects. It impedes... Read More about The Stroke Oxygen Study (SO2S) - a multi-center, study to assess whether routine oxygen treatment in the first 72 hours after a stroke improves long-term outcome: study protocol for a randomized controlled trial..