Compassion fatigue and the effectiveness of support structures for diagnostic radiographers in oncology. (2020)
Journal Article
(2020). Compassion fatigue and the effectiveness of support structures for diagnostic radiographers in oncology. Journal of Medical Imaging and Radiation Sciences, 22-28. https://doi.org/10.1016/j.jmir.2020.11.008

INTRODUCTION: Diagnostic radiographers working in oncology will have frequent contact with the same patients over a prolonged period. This can be mentally exhausting for the radiographer. Compassion fatigue (CF) occurs after repeated exposure to stre... Read More about Compassion fatigue and the effectiveness of support structures for diagnostic radiographers in oncology..

characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons (2020)
Journal Article
Singh, A., Chow, O., Jenkins, S., Zhu, L., Rose, E., Astbury, K., & Chen, R. (2021). characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons. Neuroscience, 453, Article 17-31. https://doi.org/10.1016/j.neuroscience.2020.11.008

Preconditioning tissue with sublethal ischaemia or hypoxia can confer tolerance (protection) against subsequent ischaemic challenge. In vitro ischaemic preconditioning (IPC) is typically achieved through oxygen glucose deprivation (OGD), whereas hypo... Read More about characterizing ischaemic tolerance in rat pheochromocytoma (PC12) cells and primary rat neurons.

Is it time for biocatalysis in fragment-based drug discovery? (2020)
Journal Article
Cosgrove. (2020). Is it time for biocatalysis in fragment-based drug discovery?. Chemical Science, 11104 - 11112. https://doi.org/10.1039/D0SC04103C

The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature... Read More about Is it time for biocatalysis in fragment-based drug discovery?.

Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells. (2020)
Journal Article
(2020). Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells. Journal of Physiology, 3891 - 3910. https://doi.org/10.1113/JP279795

KEY POINTS: Age-related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age-related changes occurrin... Read More about Age-related changes in the biophysical and morphological characteristics of mouse cochlear outer hair cells..

Wearable epilepsy seizure monitor user interface evaluation (2020)
Presentation / Conference Contribution
Rukasha, T., Woolley, S. I., & Collins, T. (2020, September). Wearable epilepsy seizure monitor user interface evaluation. Presented at UbiComp/ISWC '20 Adjunct: Adjunct Proceedings of the 2020 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2020 ACM International Symposium on Wearable Computers, Virtual Event (Mexico Based)

Wearable health devices have the potential to incentivize individuals in health-promoting behaviors and to assist in the monitoring of health conditions. Wearable epilepsy seizure monitoring devices are now evolving that can support individuals and t... Read More about Wearable epilepsy seizure monitor user interface evaluation.

Mechanical thrombectomy: can it be safely delivered out of hours in the UK? (2020)
Journal Article
Weddell, J., Parr, E., Knight, S., Muddegowda, G., Natarajan, I., Chembala, J., Ferdinand, P., Ahmad, N., Pencz, Z., Rana, S., Warusevitane, A., Jadun, C., Nayak, S., Hashim, Z., Augustine, A., Sim, J., & Roffe, C. (2020). Mechanical thrombectomy: can it be safely delivered out of hours in the UK?. BMC Neurology, 20, Article 326. https://doi.org/10.1186/s12883-020-01909-8

BACKGROUND: Mechanical thrombectomy was approved by NICE as a treatment for stroke in 2016. However, most of the evidence is from studies conducted during working hours. Only few centres in the UK perform thrombectomies out-of-hours. The Royal Stoke... Read More about Mechanical thrombectomy: can it be safely delivered out of hours in the UK?.

Dose-Response Tendon-Specific Markers Induction by Growth Differentiation Factor-5 in Human Bone Marrow and Umbilical Cord Mesenchymal Stem Cells. (2020)
Journal Article
(2020). Dose-Response Tendon-Specific Markers Induction by Growth Differentiation Factor-5 in Human Bone Marrow and Umbilical Cord Mesenchymal Stem Cells. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms21165905

Mesenchymal stem cells derived from human bone marrow (hBM-MSCs) are utilized in tendon tissue-engineering protocols while extra-embryonic cord-derived, including from Wharton's Jelly (hWJ-MSCs), are emerging as useful alternatives. To explore the te... Read More about Dose-Response Tendon-Specific Markers Induction by Growth Differentiation Factor-5 in Human Bone Marrow and Umbilical Cord Mesenchymal Stem Cells..

Implementation research: making better use of evidence to improve healthcare. (2020)
Journal Article
Dziedzic, & Swaithes. (2020). Implementation research: making better use of evidence to improve healthcare. Rheumatology, 1799 - 1801. https://doi.org/10.1093/rheumatology/keaa088

'No abstract'

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1. (2020)
Journal Article
Reynisson. (2020). Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1. Molecules, https://doi.org/10.3390/molecules25153496

Two novel structural types of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors with hexahydroisobenzofuran 11 and 3-oxabicyclo [3.3.1]nonane 12 scaffolds were discovered. These monoterpene-derived compounds were synthesized through preliminary isome... Read More about Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1..

Stratified care versus usual care for management of patients presenting with sciatica in primary care (SCOPiC): a randomised controlled trial (2020)
Journal Article
Konstantinou, K., Lewis, M., Dunn, K., Hay, E., Van Der Windt, D., Artus, M., Hill, J., Hughes, G., Robinson, M., Saunders, B., Bartlam, B., Mallen, C., Ogollah, R., Kigozi, J., Jowett, S., & Foster, N. (2020). Stratified care versus usual care for management of patients presenting with sciatica in primary care (SCOPiC): a randomised controlled trial. The Lancet Rheumatology, 2(7), e401-e411. https://doi.org/10.1016/S2665-9913%2820%2930099-0

Background
Sciatica has a substantial impact on individuals and society. Stratified care has been shown to lead to better outcomes among patients with non-specific low back pain, but it has not been tested for sciatica. We aimed to investigate the c... Read More about Stratified care versus usual care for management of patients presenting with sciatica in primary care (SCOPiC): a randomised controlled trial.

Outcomes of Percutaneous Coronary Intervention in Patients with Crohn’s Disease and Ulcerative Colitis (from a nationwide cohort) (2020)
Journal Article
Nolan, & Mamas. (2020). Outcomes of Percutaneous Coronary Intervention in Patients with Crohn’s Disease and Ulcerative Colitis (from a nationwide cohort). American Journal of Cardiology, 30-36. https://doi.org/10.1016/j.amjcard.2020.06.013

Patients with inflammatory bowel disease (IBD) are at an increased risk of ischemic heart disease. However, there is limited evidence on how their outcomes after percutaneous coronary intervention (PCI) compare to those without IBD. All PCI-related h... Read More about Outcomes of Percutaneous Coronary Intervention in Patients with Crohn’s Disease and Ulcerative Colitis (from a nationwide cohort).

3D Direct Printing of Silicone Meniscus Implant Using a Novel Heat-Cured Extrusion-Based Printer (2020)
Journal Article
Luis, E., Pan, H. M., Sing, S. L., Bajpai, R., Song, J., & Yeong, W. Y. (2020). 3D Direct Printing of Silicone Meniscus Implant Using a Novel Heat-Cured Extrusion-Based Printer. Polymers, 12(5), Article ARTN 1031. https://doi.org/10.3390/polym12051031

The first successful direct 3D printing, or additive manufacturing (AM), of heat-cured silicone meniscal implants, using biocompatible and bio-implantable silicone resins is reported. Silicone implants have conventionally been manufactured by indirec... Read More about 3D Direct Printing of Silicone Meniscus Implant Using a Novel Heat-Cured Extrusion-Based Printer.

Molecular crosstalk between non-SMN-related and SMN-related spinal muscular atrophy (2020)
Journal Article
Šoltić, D., & Fuller, H. (2020). Molecular crosstalk between non-SMN-related and SMN-related spinal muscular atrophy

Most cases of spinal muscular atrophy are caused by functional loss of the survival of motor neuron 1 (SMN1) gene, while less than 5% of cases are attributed to genes other than SMN. Mutations in LMNA, the lamin A/C encoding gene, cause an adult form... Read More about Molecular crosstalk between non-SMN-related and SMN-related spinal muscular atrophy.

Impact of the implementation of an assisted peritoneal dialysis service on peritoneal dialysis initiation (2020)
Journal Article
Boyer, A., Solis-Trapala, I., Tabinor, M., Lambie, M., & Davies, S. (2020). Impact of the implementation of an assisted peritoneal dialysis service on peritoneal dialysis initiation. Nephrology Dialysis Transplantation, 35(9), 1595-1601. https://doi.org/10.1093/ndt/gfz287

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>There is limited information available on the impact that provision of an assisted peritoneal dialysis (PD) service has on the initiation of PD. The aim of this... Read More about Impact of the implementation of an assisted peritoneal dialysis service on peritoneal dialysis initiation.

Biomedical Applications of Wrinkling Polymers (2020)
Journal Article
Fu, Y., & Yang, Y. (2020). Biomedical Applications of Wrinkling Polymers. https://doi.org/10.21926/rpm.2001005

Advancements in surface engineering and material fabrication techniques have enabled the creation and replication of naturally occurring surface topographies or the extrapolation of natural patterns to become achievable targets. Polymers are used ext... Read More about Biomedical Applications of Wrinkling Polymers.

Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications (2020)
Journal Article
Finch, L., Harris, S., Solomou, G., Sen, J., Tzerakis, N., Emes, R. D., Lane, C. S., Hart, S. R., Adams, C. F., & Chari, D. M. (2020). Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications. Journal of Controlled Release, 321, 553-563. https://doi.org/10.1016/j.jconrel.2020.02.028

High transplant cell loss is a major barrier to translation of stem cell therapy for pathologies of the brain and spinal cord. Encapsulated delivery of stem cells in biomaterials for cell therapy is gaining popularity but experimental research has ov... Read More about Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications.

Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis (2020)
Journal Article
Perry, J., McCarthy, H., Bou-Gharios, G., van't Hof, R., Milner, P., Mennan, C., & Roberts, S. (2020). Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis. Osteoarthritis and Cartilage Open, 2(2), 100044 - 100044. https://doi.org/10.1016/j.ocarto.2020.100044

Objective This study investigated the effect of hUC-MSCs on osteoarthritis (OA) progression in a xenogeneic model. Design Male, 10 week-old C57Bl/6 mice underwent sham surgery (n=15) or partial medial meniscectomy (PMM;n=76). 5x105 hUC-MSCs (from 3 d... Read More about Injected human umbilical cord-derived mesenchymal stromal cells do not appear to elicit an inflammatory response in a murine model of osteoarthritis.

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model (2020)
Journal Article
Chen. (2020). Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model. Scientific reports, https://doi.org/10.1038/s41598-020-58482-w

This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD) inhibitors on PC12 cells and primary rat neurons following oxygen-glucose deprivation (OGD). At 100 µM, the PHD inhibitors did not cause cytotoxicity and apo... Read More about Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model.

Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care (OPTIMISE-HFpEF): Rationale and Protocol for a Multi-Method Study (2020)
Journal Article
Chew-Graham. (2020). Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care (OPTIMISE-HFpEF): Rationale and Protocol for a Multi-Method Study. British Journal of General Practice Open (BJGP Open), https://doi.org/10.3399/bjgpopen19X101675

Background: Heart failure with preserved ejection fraction (HFpEF) is less well understood than heart failure with reduced ejection fraction (HFrEF), with greater diagnostic difficulty and management uncertainty. Aim: Our primary aim is to develop an... Read More about Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care (OPTIMISE-HFpEF): Rationale and Protocol for a Multi-Method Study.

Age-Related Trends in the Trabecular Micro-Architecture of the Medial Clavicle: Is It of Use in Forensic Science? (2020)
Journal Article
McGivern, H., Greenwood, C., Márquez-Grant, N., Kranioti, E., Xhemali, B., & Zioupos, P. (2020). Age-Related Trends in the Trabecular Micro-Architecture of the Medial Clavicle: Is It of Use in Forensic Science?. Frontiers in Bioengineering and Biotechnology, 7, https://doi.org/10.3389/fbioe.2019.00467

The mechanical and structural properties of bone are known to change significantly with age. Within forensic and archaeological investigations, the medial end of the clavicle is typically used for estimating the age-at-death of an unknown individual.... Read More about Age-Related Trends in the Trabecular Micro-Architecture of the Medial Clavicle: Is It of Use in Forensic Science?.