Trusting Intelligent Machines (2018)
Journal Article
(2018). Trusting Intelligent Machines. https://doi.org/10.1109/mts.2018.2876107

Intelligent machines have reached capabilities that go beyond a level that a human being can fully comprehend without sufficiently detailed understanding of the underlying mechanisms. The choice of moves in the game Go (generated by Deep Mind?s Alpha... Read More about Trusting Intelligent Machines.

Chemical and morphological investigations of the Ontogenetic effects of Novel Psychoactive Substances on forensically important blowfly species (Diptera: Calliphoridae). (2018)
Thesis
Garrett, E. R. (2018). Chemical and morphological investigations of the Ontogenetic effects of Novel Psychoactive Substances on forensically important blowfly species (Diptera: Calliphoridae). (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411392

Post Mortem Interval (PMI) estimation is a key concern of forensic entomology research. Numerous factors are recognized to affect these calculations, and have shown to potentially introduce error, leading to an incorrect time of death estimation. One... Read More about Chemical and morphological investigations of the Ontogenetic effects of Novel Psychoactive Substances on forensically important blowfly species (Diptera: Calliphoridae)..

Synthesis and biological evaluation of three novel antimalarial series (2018)
Thesis
Tunstall, L. V. (2018). Synthesis and biological evaluation of three novel antimalarial series. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411425

This research explored the optimisation of three novel antimalarial series based on the MMV compound leads shown below.
Extensive research began to optimise these potent hits through exploration of multiple functional group substitutions on two or... Read More about Synthesis and biological evaluation of three novel antimalarial series.

Structural characterisation of oligosaccharide recognition by surfactant protein D (2018)
Thesis
Littlejohn, J. R. (2018). Structural characterisation of oligosaccharide recognition by surfactant protein D. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411451

Human surfactant protein D (hSP-D) is a C-type lectin and member of the collectin family that is involved in pathogen recognition as part of the innate immune response. Recognition occurs through the carbohydrate arrays on the surfaces of the pathoge... Read More about Structural characterisation of oligosaccharide recognition by surfactant protein D.

Towards an understanding of amyloidogenesis: a structural and biophysical analysis of transthyretin (2018)
Thesis
Yee, A. W. (2018). Towards an understanding of amyloidogenesis: a structural and biophysical analysis of transthyretin. (Thesis). Keele University

Human transthyretin (TTR) is heavily implicated in a range of fatal amyloid diseases. The propensity to form amyloid varies between wild-type TTR and various mutants. In all cases this occurs by tetramer dissociation to a monomeric form, which in tur... Read More about Towards an understanding of amyloidogenesis: a structural and biophysical analysis of transthyretin.