The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project. (2016)
Journal Article
(2016). The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project. Ecology and Evolution, 145 - 188. https://doi.org/10.1002/ece3.2579

The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multipl... Read More about The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project..

First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa) (2016)
Journal Article
Sangaré, I., Dabiré, R., Guiguemdé, R., Fournet, F., Price, H., Djibougou, A., …Banuls, A. (2016). First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa). Research Journal of Parasitology, 12(1), 27-32. https://doi.org/10.3923/jp.2017.27.32

Background and Objective: Human Visceral Leishmaniasis (HVL) is a systemic neglected tropical diseases and potentially lethal disease caused by infection with protozoan parasites of the Leishmania genus. In the causal, agent of HVL is L. infantum and... Read More about First Detection of Leishmania infantum in Domestic Dogs from Burkina Faso (West Africa).

Electrophysiological and behavioral responses of female African rice gall midge, Orseolia oryzivora Harris and Gagné, to host plant volatiles. (2016)
Journal Article
Ogah, E., Smart, L., Woodcock, C., Caulfield, J., Birkett, M., Pickett, J., …Bruce, T. (2016). Electrophysiological and behavioral responses of female African rice gall midge, Orseolia oryzivora Harris and Gagné, to host plant volatiles. Journal of Chemical Ecology, 13 - 16. https://doi.org/10.1007/s10886-016-0788-6

African rice gall midge, Orseolia oryzivora Harris and Gagné, is a major pest of rice in Africa. Depsite its economic importance, its chemical ecology is not well understood. Here, we assessed behavioral and electrophysiological responses of O. oryzi... Read More about Electrophysiological and behavioral responses of female African rice gall midge, Orseolia oryzivora Harris and Gagné, to host plant volatiles..

Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs (2016)
Journal Article
(2016). Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs. BMC Genomics, 859. https://doi.org/10.1186/s12864-016-3183-3

Background Malaria parasites of the genus Plasmodium possess large hyper-variable families of antigen-encoding genes. These are often variantly-expressed and are major virulence factors for immune evasion and the maintenance of chronic infections. Re... Read More about Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs.

Aphid Infestation Increases Fusarium langsethiae and T-2 and HT-2 Mycotoxins in Wheat (2016)
Journal Article
Drakulic, J., Ajigboye, O., Swarup, R., Bruce, T., & Ray, R. (2016). Aphid Infestation Increases Fusarium langsethiae and T-2 and HT-2 Mycotoxins in Wheat. Applied and Environmental Microbiology, 6548 - 6556. https://doi.org/10.1128/AEM.02343-16

Fusarium langsethiae is a fungal pathogen of cereal crops that is an increasing problem in northern Europe, but much of its epidemiology is poorly understood. The species produces the mycotoxins T-2 and HT-2, which are highly toxic. It was hypothesiz... Read More about Aphid Infestation Increases Fusarium langsethiae and T-2 and HT-2 Mycotoxins in Wheat.

A Year in The Life Of A Biochemistry Lecturer (2016)
Journal Article
(2016). A Year in The Life Of A Biochemistry Lecturer

Weekly blog detailing the highs and lows of a biochemistry lecturer.

Analysis of Social Learning Strategies when Discovering and Maintaining Behaviours Inaccessible to Incremental Genetic Evolution (2016)
Book Chapter
Channon, A., Jolley, B., & Borg, J. (2016). Analysis of Social Learning Strategies when Discovering and Maintaining Behaviours Inaccessible to Incremental Genetic Evolution. In From Animals to Animats 14: The Fourteenth International Conference on Simulation of Adaptive Behavior (SAB 2016) (293-304). https://doi.org/10.1007/978-3-319-43488-9_26

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond (2016)
Journal Article
Horrocks. (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLOS pathogens a peer-reviewed open-access journal published by the Public Library of Science, https://doi.org/10.1371/journal.ppat.1005763

A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still larg... Read More about Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils (2016)
Journal Article
Stewart, K. L., Hughes, E., Yates, E. A., Akien, G. R., Huang, T., Andrade De Lima, M., …Middleton, D. A. (2016). Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils. Journal of the American Chemical Society, 138(27), 8328-8331. https://doi.org/10.1021/jacs.6b02816

The amyloid plaques associated with Alzheimer’s disease (AD) comprise fibrillar amyloid-ß (Aß) peptides as well as non-protein factors including glycosaminoglycan (GAG) polysaccharides. GAGs affect the kinetics and pathway of Aß self-assembly and can... Read More about Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils.

The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells (2016)
Journal Article
(2016). The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells. Cellular Signalling, 1389-1400. https://doi.org/10.1016/j.cellsig.2016.06.011

Background
The control of breast cell survival is of critical importance for preventing breast cancer initiation and progression. The activity of many proteins which regulate cell survival is controlled by reversible phosphorylation, so that the rel... Read More about The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells.

Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine (2016)
Journal Article
Li, W., & Richardson, A. (2016). Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine. Phytotherapy Research, 1533-1539. https://doi.org/10.1002/ptr.5660

Triclisia subcordata Oliv (Menispermeaceae) is a medicinal plant traditionally used for the treatment of various diseases in West Africa. The ethanol extract of T.?subcordata and its fractions were screened for in vitro anti-ovarian cancer activities... Read More about Cytotoxicity effects and apoptosis induction by cycleanine and tetrandrine.

Awareness of rabies and response to dog bites in a Bangladesh community (2016)
Journal Article
Ghosh, S., Chowdhury, S., Haider, N., Bhowmik, R., Rana, M., Prue Marma, A., …Ahmed, B. (2016). Awareness of rabies and response to dog bites in a Bangladesh community. Veterinary Medicine and Science, 161 - 169. https://doi.org/10.1002/vms3.30

Community awareness regarding rabies and treatment seeking behaviours are critical both for the prevention and control of the disease in human and animals. We conducted a study to explore people's awareness about rabies, their attitudes towards dogs... Read More about Awareness of rabies and response to dog bites in a Bangladesh community.

Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion (2016)
Journal Article
Vasques, E., Cunha, J., Coelho, A., Sampietre, S., Patzina, R., Abdo, E., …D’Albuquerque, L. A. (2016). Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion. PloS one, 11, e0149630--e0149630. https://doi.org/10.1371/journal.pone.0149630

Background
Ischemia and reperfusion (I/R) causes tissue damage and intracellular calcium levels are a factor of cell death. Sodium calcium exchanger (NCX) regulates calcium extrusion and Trisulfated Disaccharide (TD) acts on NCX decreasing intracell... Read More about Trisulfate disaccharide decreases calcium overload and protects liver injury secondary to liver ischemia/reperfusion.

The genomic basis of parasitism in the Strongyloides clade of nematodes. (2016)
Journal Article
(2016). The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature genetics, 299 - 307. https://doi.org/10.1038/ng.3495

Soil-transmitted nematodes, including the Strongyloides genus, cause one of the most prevalent neglected tropical diseases. Here we compare the genomes of four Strongyloides species, including the human pathogen Strongyloides stercoralis, and their c... Read More about The genomic basis of parasitism in the Strongyloides clade of nematodes..

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae (2016)
Journal Article
Hammond, A., Galizi, R., Kyrou, K., Simoni, A., Siniscalchi, C., Katsanos, D., …Nolan, T. (2016). A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nature Biotechnology, 78 - 83. https://doi.org/10.1038/nbt.3439

Gene drive systems that enable super-Mendelian inheritance of a transgene have the potential to modify insect populations over a timeframe of a few years. We describe CRISPR-Cas9 endonuclease constructs that function as gene drive systems in Anophele... Read More about A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae.