Aluminum Exposure for 60 days at Human Dietary Levels Impairs Spermatogenesis and Sperm Quality in Rats (2017)
Journal Article
(2017). Aluminum Exposure for 60 days at Human Dietary Levels Impairs Spermatogenesis and Sperm Quality in Rats. Reproductive Toxicology, 128-141. https://doi.org/10.1016/j.reprotox.2017.08.008

Abstract Concerns about environmental aluminum (Al) and reproductive health have been raised. We investigated the effects of Al exposure at a human relevant dietary level and a high level exposure to Al. Experiment 1 (Lower level) rats were treated o... Read More about Aluminum Exposure for 60 days at Human Dietary Levels Impairs Spermatogenesis and Sperm Quality in Rats.

Males and females of Juniperus communis L. and Taxus baccata L. show different seasonal patterns of nitrogen and carbon content in needles (2017)
Journal Article
(2017). Males and females of Juniperus communis L. and Taxus baccata L. show different seasonal patterns of nitrogen and carbon content in needles. Acta physiologiae plantarum / Polish Academy of Sciences, Committee of Plant Physiology Genetics and Breeding, https://doi.org/10.1007/s11738-017-2489-3

Genders of dioecious species often show secondary sexual dimorphisms (not directly related to the sex organs), which may be related to reproductive demand for resources during the year. Our working hypothesis stated that phenology influences yearly s... Read More about Males and females of Juniperus communis L. and Taxus baccata L. show different seasonal patterns of nitrogen and carbon content in needles.

Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex (2017)
Journal Article
Glazewski, S., Greenhill, S., & Fox, K. (2017). Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex. Philosophical Transactions B: Biological Sciences, 372(1715), https://doi.org/10.1098/rstb.2016.0150

Recent studies have shown that ocular dominance plasticity in layer 2/3 of the visual cortex exhibits a form of homeostatic plasticity that is related to synaptic scaling and depends on TNFa. In this study, we tested whether a similar form of plastic... Read More about Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex.

19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy (2016)
Journal Article
Lima, M. A., Cavalheiro, R. P., Viana, G. M., Meneghetti, M. C., Rudd, T. R., Skidmore, M., Powell, A. K., & Yates, E. A. (2016). 19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Glycoconjugate Journal, 34, 405-410. https://doi.org/10.1007/s10719-016-9723-x

Studying polysaccharide-protein interactions under physiological conditions by conventional techniques is challenging. Ideally, macromolecules could be followed by both in vitro spectroscopy experiments as well as in tissues using microscopy, to enab... Read More about 19 F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy.

Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses. (2016)
Journal Article
(2016). Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses. Angewandte Chemie International Edition, 9438-9442. https://doi.org/10.1002/ange.201602747

It is well established that the formation of transthyretin (TTR) amyloid fibrils is linked to the destabilization and dissociation of its tetrameric structure into insoluble aggregates. Isotope labeling is used for the study of TTR by NMR, neutron di... Read More about Impact of Deuteration on the Assembly Kinetics of Transthyretin Monitored by Native Mass Spectrometry and Implications for Amyloidoses..

Unique Insights in the Cervicovaginal Lactobacillus iners and L. crispatus Proteomes and Their Associations with Microbiota Dysbiosis. (2016)
Journal Article
Wastling. (2016). Unique Insights in the Cervicovaginal Lactobacillus iners and L. crispatus Proteomes and Their Associations with Microbiota Dysbiosis. PloS one, e0150767 -?. https://doi.org/10.1371/journal.pone.0150767

BACKGROUND: A Lactobacillus-dominated cervicovaginal microbiota (VMB) protects women from adverse reproductive health outcomes, but the role of L. iners in the VMB is poorly understood. Our aim was to explore the association between the cervicovagina... Read More about Unique Insights in the Cervicovaginal Lactobacillus iners and L. crispatus Proteomes and Their Associations with Microbiota Dysbiosis..

Identification of Novel O-Linked Glycosylated Toxoplasma Proteins by Vicia villosa Lectin Chromatography. (2016)
Journal Article
(2016). Identification of Novel O-Linked Glycosylated Toxoplasma Proteins by Vicia villosa Lectin Chromatography. PloS one, e0150561 -?. https://doi.org/10.1371/journal.pone.0150561

Toxoplasma gondii maintains its intracellular life cycle using an extraordinary arsenal of parasite-specific organelles including the inner membrane complex (IMC), rhoptries, micronemes, and dense granules. While these unique compartments play critic... Read More about Identification of Novel O-Linked Glycosylated Toxoplasma Proteins by Vicia villosa Lectin Chromatography..

Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum (2015)
Journal Article
(2015). Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum. Malaria Journal, 490-?. https://doi.org/10.1186/s12936-015-1014-7

Background
Plasmodium falciparum, the causative agent of severe human malaria, is an early-diverging protozoan whose lifecycle has many unusual features, including its modes of replication. Research on the Plasmodium cell cycle, which occurs primari... Read More about Transfection with thymidine kinase permits bromodeoxyuridine labelling of DNA replication in the human malaria parasite Plasmodium falciparum.

Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region (2015)
Journal Article
Russo, I. (2015). Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region. PloS one, e0142509 - e0142509. https://doi.org/10.1371/journal.pone.0142509

Malaria is an infectious disease caused by Plasmodium parasites. It results in an annual death-toll of ~ 600,000. Resistance to all medications currently in use exists, and novel antimalarial drugs are urgently needed. Plasmepsin V (PmV) is an essent... Read More about Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.

Odorant receptor-based discovery of natural repellents of human lice (2015)
Journal Article
(2015). Odorant receptor-based discovery of natural repellents of human lice. Journal of Chemical Ecology, 103 - 109. https://doi.org/10.1016/j.ibmb.2015.10.009

The body louse, Pediculus humanus humanus, is an obligate blood-feeding ectoparasite and an important insect vector that mediates the transmission of diseases to humans. The analysis of the body louse genome revealed a drastic reduction of the chemos... Read More about Odorant receptor-based discovery of natural repellents of human lice.

Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti (2013)
Journal Article
(2013). Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti. Biology open BiO / Company of Biologists, 1192 -1202. https://doi.org/10.1242/bio.20135603

Dramatic structural changes in microtubules (MT) and the assembly of complicated intercellular connections are seen during the development of the cellular matrix of the sense organ for hearing, the organ of Corti. This report examines the expression... Read More about Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti.

Imaging African trypanosomes (2013)
Journal Article
MacLean, L., Myburgh, E., Rodgers, J., & Price, H. (2013). Imaging African trypanosomes. Parasite immunology, 35(9-10), 283 -294. https://doi.org/10.1111/pim.12046

Trypanosoma brucei are extracellular kinetoplastid parasites transmitted by the blood-sucking tsetse fly. They are responsible for the fatal disease human African trypanosomiasis (HAT), also known as sleeping sickness. In late-stage infection, trypan... Read More about Imaging African trypanosomes.

Evaluation of bioluminescence-based assays of anti-malarial drug activity (2013)
Journal Article
Horrocks. (2013). Evaluation of bioluminescence-based assays of anti-malarial drug activity. Malaria Journal, 58 - ?. https://doi.org/10.1186/1475-2875-12-58

Transgenic Plasmodium falciparum expressing luciferase offers an attractive bioluminescence-based assay platform for the investigation of the pharmacological properties of anti-malarial drugs. Here a side-by-side comparison of bioluminescence and flu... Read More about Evaluation of bioluminescence-based assays of anti-malarial drug activity.

Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells (2011)
Journal Article
(2011). Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells. PloS one, e19183 - ?. https://doi.org/10.1371/journal.pone.0019183

Immunocytochemical studies have shown that protocadherin-15 (PCDH15) and cadherin-23 (CDH23) are associated with tip links, structures thought to gate the mechanotransducer channels of hair cells in the sensory epithelia of the inner ear. The present... Read More about Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.

Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells (2011)
Journal Article
(2011). Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells. PLoS Biology, 1-17. https://doi.org/10.1371/journal.pbio.1001048a

Hair cells of the mammalian cochlea are specialized for the dynamic coding of sound stimuli. The transduction of sound waves into electrical signals depends upon mechanosensitive hair bundles that project from the cell's apical surface. Each stereoci... Read More about Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells.

Rapid, learning-induced inhibitory synaptogenesis in murine barrel field (2010)
Journal Article
(2010). Rapid, learning-induced inhibitory synaptogenesis in murine barrel field. Journal of Neuroscience, 1176 - 1184. https://doi.org/10.1523/JNEUROSCI.2970-09.2010

The structure of neurons changes during development and in response to injury or alteration in sensory experience. Changes occur in the number, shape, and dimensions of dendritic spines together with their synapses. However, precise data on these cha... Read More about Rapid, learning-induced inhibitory synaptogenesis in murine barrel field.

Ecological immunology of mosquito-malaria interactions: Of non-natural versus natural model systems and their inferences (2009)
Journal Article
(2009). Ecological immunology of mosquito-malaria interactions: Of non-natural versus natural model systems and their inferences. Parasitology, 1935 -1942. https://doi.org/10.1017/S0031182009006234

There has been a recent shift in the literature on mosquito/Plasmodium interactions with an increasingly large number of theoretical and experimental studies focusing on their population biology and evolutionary processes. Ecological immunology of mo... Read More about Ecological immunology of mosquito-malaria interactions: Of non-natural versus natural model systems and their inferences.

PfeIK1, a eukaryotic initiation factor 2a kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation (2009)
Journal Article
Russo, I. (2009). PfeIK1, a eukaryotic initiation factor 2a kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation. Malaria Journal, 99 - 99. https://doi.org/10.1186/1475-2875-8-99

Background: Post-transcriptional control of gene expression is suspected to play an important role in malaria parasites. In yeast and metazoans, part of the stress response is mediated through phosphorylation of eukaryotic translation initiation fact... Read More about PfeIK1, a eukaryotic initiation factor 2a kinase of the human malaria parasite Plasmodium falciparum, regulates stress-response to amino-acid starvation.

Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus (2009)
Journal Article
Russo, I. (2009). Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus. Molecular Microbiology, 229 - 245. https://doi.org/10.1111/j.1365-2958.2009.06639.x

The Plasmodium falciparum genome encodes a single calpain. By generating P. falciparum clones expressing C-terminally tagged calpain, we localized this protein to the nucleolus. Pf_calpain possesses an unusual and long N-terminal domain in which we i... Read More about Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus.

Cooperative blood-feeding and the function and implications of feeding aggregations in the sand fly, Lutzomyia longipalpis (Diptera: Psychodidae) (2009)
Journal Article
(2009). Cooperative blood-feeding and the function and implications of feeding aggregations in the sand fly, Lutzomyia longipalpis (Diptera: Psychodidae). PLoS Neglected Tropical Diseases, e503 - ?. https://doi.org/10.1371/journal.pntd.0000503

Given the importance that the evolution of cooperation bears in evolutionary biology and the social sciences, extensive theoretical work has focused on identifying conditions that promote cooperation among individuals. In insects, cooperative or altr... Read More about Cooperative blood-feeding and the function and implications of feeding aggregations in the sand fly, Lutzomyia longipalpis (Diptera: Psychodidae).