Bacterial lipopolysaccharide recognition by surfactant protein D (2021)
Presentation / Conference
Shrive, & Greenhough. (2021, August). Bacterial lipopolysaccharide recognition by surfactant protein D. Presented at XXV IUCr Congress, Prague, Czech Republic

Human surfactant protein D is a collectin and member of the C-type lectin superfamily of proteins that forms an essential part of the mammalian innate immune system. The collectins have been recognised to not only bind to invading pathogens, allowing... Read More about Bacterial lipopolysaccharide recognition by surfactant protein D.

Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein (2020)
Journal Article
Williams, R. D., Moran, J. A., Fryer, A. A., Littlejohn, J. R., Williams, H. M., Greenhough, T. J., & Shrive, A. K. (2020). Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein. Frontiers in Immunology, 11, Article ARTN 115. https://doi.org/10.3389/fimmu.2020.00115

A monomeric form of C-reactive protein (CRP) which precipitates with cell wall pneumococcal C polysaccharide (CWPS) and retains the ability to reversibly bind to its ligand phosphocholine has been produced through urea-induced dissociation at an opti... Read More about Monomeric C-Reactive Protein in Serum With Markedly Elevated CRP Levels Shares Common Calcium-Dependent Ligand Binding Properties With an in vitro Dissociated Form of C-Reactive Protein.

Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides 1 reveals alternative binding modes for the same LPS (2018)
Journal Article
Littlejohn, J. R., da Silva, R. F., Neale, W. A., Smallcombe, C. C., Clark, H. W., Mackay, R. A., …Shrive, A. K. (2018). Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides 1 reveals alternative binding modes for the same LPS. PloS one, https://doi.org/10.1371/journal.pone.0199175

The crystal structures of a biologically and therapeutically active recombinant homotrimeric fragment of native human SP-D (hSP-D) complexed with the inner core oligosaccharide of the Salmonella enterica sv Minnesota rough strains R5 and R7 (rough mu... Read More about Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides 1 reveals alternative binding modes for the same LPS.

Crystal structure of a complex of Surfactant Protein D and Haemophilus influenzae lipopolysaccharide reveals shielding of core structures in SP-D resistant strains (2016)
Journal Article
Shrive, A., & Greenhough, T. (2016). Crystal structure of a complex of Surfactant Protein D and Haemophilus influenzae lipopolysaccharide reveals shielding of core structures in SP-D resistant strains. Infection and Immunity, 1585-1592. https://doi.org/10.1128/IAI.01239-15

The carbohydrate recognition domains (CRDs) of lung collectin surfactant protein D (SP-D) recognize sugar patterns on the surface of lung pathogens and promote phagocytosis. Using Haemophilus influenzae Eagan strains expressing well-characterized lip... Read More about Crystal structure of a complex of Surfactant Protein D and Haemophilus influenzae lipopolysaccharide reveals shielding of core structures in SP-D resistant strains.