A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts. (2025)
Journal Article
Wiseman, J., Basit, R. H., Suto, A., Middya, S., Kabiri, B., Evans, M., …Chari, D. M. (in press). A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts. Neural Regeneration Research, 20(12), 3539-3552. https://doi.org/10.4103/NRR.NRR-D-24-00422

Functional recovery in penetrating neurological injury is hampered by a lack of clinical regenerative therapies. Biomaterial therapies show promise as medical materials for neural repair through immunomodulation, structural support, and delivery of t... Read More about A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts..

Augmentation with the inferior extensor retinaculum may facilitate earlier recovery in all-inside arthroscopic management of chronic lateral ankle instability (2025)
Journal Article
Luo, X., Xue, C., Xue, Y., Fehske, K., Zhang, Z.-H., Maffulli, N., …Feng, S.-M. (in press). Augmentation with the inferior extensor retinaculum may facilitate earlier recovery in all-inside arthroscopic management of chronic lateral ankle instability. Journal of Orthopaedic Surgery and Research, 20(1), 1-11. https://doi.org/10.1186/s13018-024-05437-w

Background: To compare the clinical outcomes of inferior extensor retinaculum (IER) augmentation following repair of the anterior talofibular ligament (ATFL) with isolated ATFL repair in patients with an arthroscopically confirmed grade 3 lesion of t... Read More about Augmentation with the inferior extensor retinaculum may facilitate earlier recovery in all-inside arthroscopic management of chronic lateral ankle instability.

Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study. (2024)
Journal Article
Maffulli, N., Christidis, G., Gougoulias, N., Christidis, P., Poku, D., Hassan, R., …Oliva, F. (in press). Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study. British Medical Bulletin, 1-9. https://doi.org/10.1093/bmb/ldae019

The present prospective comparative study included patients with acute Achilles tendon rupture (ATR) who underwent percutaneous repair with one knot compared to percutaneous repair with two knots. All patients underwent the procedure under local anes... Read More about Percutaneous repair of the Achilles tendon with one knot offers equivalent results as the same procedure with two knots. A comparative prospective study..

Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review (2024)
Journal Article
Baroncini, A., Maffulli, N., Pilone, M., Pipino, G., Memminger, M. K., Pappalardo, G., & Migliorini, F. (2024). Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review. Journal of Clinical Medicine, 13(22), 1-27. https://doi.org/10.3390/jcm13226864

Background: Low back pain is common. For patients with mechanic or non-specific chronic LBP (cLBP), the current guidelines suggest conservative, nonpharmacologic treatment as a first-line treatment. Among the available strategies, physiotherapy repre... Read More about Prognostic Factors in Patients Undergoing Physiotherapy for Chronic Low Back Pain: A Level I Systematic Review.

Subsidence of the Corail stem in total hip arthroplasty: no influence of bony contact (2024)
Journal Article
Migliorini, F., Maffulli, N., Pilone, M., Kämmer, D., Hofmann, U. K., Nobili, A., …Bell, A. (2024). Subsidence of the Corail stem in total hip arthroplasty: no influence of bony contact. Journal of Orthopaedics and Traumatology, 25(1), 1-9. https://doi.org/10.1186/s10195-024-00794-y

Introduction: This study investigated stem subsidence following primary total hip arthroplasty (THA) with a Corail stem in patients who underwent two-staged bilateral THA. The second outcome of interest was to investigate whether a specific single co... Read More about Subsidence of the Corail stem in total hip arthroplasty: no influence of bony contact.

Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review (2024)
Journal Article
Migliorini, F., Pilone, M., Ascani, J., Schäfer, L., Jeyaraman, M., & Maffulli, N. (2024). Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review. British Medical Bulletin, 1-13. https://doi.org/10.1093/bmb/ldae016

Introduction Knee osteoarthritis (OA) is a common degenerative joint condition and a major cause of disability in the general population. Source of data Recent published literature identified from PubMed, EMBASE, Google Scholar, and Scopus. Areas of... Read More about Management of knee osteoarthritis using bone marrow aspirate concentrate: a systematic review.

High-volume injections in Achilles tendinopathy: a systematic review (2024)
Journal Article
Hassan, R., Poku, D., Miah, N., & Maffulli, N. (2024). High-volume injections in Achilles tendinopathy: a systematic review. British Medical Bulletin, 1-13. https://doi.org/10.1093/bmb/ldae015

Introduction Achilles tendinopathy (AT) is common, particularly in runners. High-volume injections (HVIs) may be beneficial in the management of AT compared to other conservative management options, including exercise regimens, platelet-rich plasma (... Read More about High-volume injections in Achilles tendinopathy: a systematic review.

Optical attenuation coefficient-based automatic segmentation of limbal epithelium and age-related differences (2024)
Conference Proceeding
Zhang, Y., Dimmock, R., Yang, Y., & Huang, Z. (2024). Optical attenuation coefficient-based automatic segmentation of limbal epithelium and age-related differences. In 2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium (UFFC-JS) (1-4). https://doi.org/10.1109/uffc-js60046.2024.10793631

The limbus, located at the cornea-conjunctiva junction, houses limbal epithelial stem cells that maintain the corneal epithelium and respond to tissue damage. The limbal epithelial thickness is an indicator of corneal structural or functional alterat... Read More about Optical attenuation coefficient-based automatic segmentation of limbal epithelium and age-related differences.

An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells (2022)
Thesis
Kavousi, N. (2022). An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells. (Thesis). Keele University

The serine/threonine protein phosphatase 4 holoenzyme consists of PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits (PP4R1, PP4R2, PP4R3, PP4R4). Previous studies have shown that PP4c acts as a tumour suppressor an... Read More about An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells.

The unequivocal identification and visualisation of aluminium in human brain tissues using novel techniques. (2017)
Thesis
Mirza, A. (2017). The unequivocal identification and visualisation of aluminium in human brain tissues using novel techniques. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/409155

The aim of this thesis was to optimise a method for the unequivocal identification of aluminium (Al) in human brain tissue. The second aim was to devise a protocol that was simple to implement and as such could be carried out without the need for sop... Read More about The unequivocal identification and visualisation of aluminium in human brain tissues using novel techniques..

Generation and fitness of transgenic Anopheles gambiae and the impact of multiple feeding on anti-malarial properties of the vida3 transgene
Thesis
(2011). Generation and fitness of transgenic Anopheles gambiae and the impact of multiple feeding on anti-malarial properties of the vida3 transgene

Malaria, the leading cause of death due to vector-borne disease. is responsible for around 250 million cases and 1 million deaths annually, mostly in sub-Saharan Africa where Anopheles gambiae is the major vector.
Novel approaches to malaria control... Read More about Generation and fitness of transgenic Anopheles gambiae and the impact of multiple feeding on anti-malarial properties of the vida3 transgene.

Characterisation of molecular variations in human C-reactive protein
Thesis
(2017). Characterisation of molecular variations in human C-reactive protein

The research described here focuses on the molecular variations, clinical significance and structural interactions of the innate immune protein, C-reactive protein (CRP).

Monomeric CRP (mCRP) was produced through urea-induced dissociation, at an o... Read More about Characterisation of molecular variations in human C-reactive protein.

Small angle scattering studies of chromatin proteins in the human malarial parasite
Thesis
Jordan, A. (2017). Small angle scattering studies of chromatin proteins in the human malarial parasite

This thesis describes the biochemical, biophysical and structural characterisation of two
proteins believed to play an important role in active gene silencing mechanisms present in
the human malarial parasite, Plasmodium falciparum. These investiga... Read More about Small angle scattering studies of chromatin proteins in the human malarial parasite.

Activation of endothelial cells and its potential involvement in blood-brain barrier damage in cerebral malaria: an in vitro study
Thesis
Mohd Nasir, M. H. (2015). Activation of endothelial cells and its potential involvement in blood-brain barrier damage in cerebral malaria: an in vitro study

One of the severe complications of a Plasmodium falciparum infection is cerebral malaria (CM). CM is characterised by the accumulation of mature infected red blood cells (RBC) in the brain microvasculature. One of the consistent detrimental effects o... Read More about Activation of endothelial cells and its potential involvement in blood-brain barrier damage in cerebral malaria: an in vitro study.