Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach (2018)
Thesis
AL-Jumaily, R. M. K. (2018). Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412295

Oxygen is an essential factor for life in many organisms. Oxygen concentrations vary widely across different human tissues, but in general, are much lower than the 21% oxygen in atmospheric air. In spite of this, most research continues to be based o... Read More about Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach.

A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials (2018)
Thesis
Potts, J. E. (2018). A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412318

Most analyses in stroke clinical trials assess the primary outcome at a single time point and do not consider conducting a longitudinal analysis, even when the outcome has been recorded at several time points. Efforts to improve the quality of statis... Read More about A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials.

An investigation into the role of protein phosphatase 4 in breast cancer (2018)
Thesis
Mohammed, H. N. (2018). An investigation into the role of protein phosphatase 4 in breast cancer. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412025

Breast cancer is the most common malignant tumour among females world-wide. The complexity of the pathogenesis of the disease and its heterogeneous clinical presentation, with an increasing incidence of the development of chemotherapeutic resistant c... Read More about An investigation into the role of protein phosphatase 4 in breast cancer.

Investigation into the role of protein phosphatase 4 catalytic subunit on the survival of leukaemic cell lines (2018)
Thesis
Al-Khazraji, S. K. A. (2018). Investigation into the role of protein phosphatase 4 catalytic subunit on the survival of leukaemic cell lines. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412024

Background: Serine/Threonine protein phosphatase 4 (PP4) plays a crucial role in cell signalling, proliferation and apoptosis, and its catalytic subunit has been reported as an important regulator in many types of cancer, including breast and lung ca... Read More about Investigation into the role of protein phosphatase 4 catalytic subunit on the survival of leukaemic cell lines.

Investigation of cellular and scaffold strategies for engineering articular cartilage (2018)
Thesis
Abu Owida, H. (2018). Investigation of cellular and scaffold strategies for engineering articular cartilage. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412022

Articular cartilage is a thin hydrated tissue, which covers articulating surfaces. In the native articular cartilage tissue, the extracellular matrix (ECM) is a fibrillar mesh of interacting proteoglycans, collagens, and other non-collagenous protein... Read More about Investigation of cellular and scaffold strategies for engineering articular cartilage.

Automated analysis of ultrasound imaging of muscle and tendon in the upper limb using artificial intelligence methods (2018)
Thesis
Jabbar, S. I. (2018). Automated analysis of ultrasound imaging of muscle and tendon in the upper limb using artificial intelligence methods. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412015

Accurate estimation of geometric musculoskeletal parameters from medical imaging has a number of applications in healthcare analysis and modelling. In vivo measurement of key morphological parameters of an individual’s upper limb opens up a new era f... Read More about Automated analysis of ultrasound imaging of muscle and tendon in the upper limb using artificial intelligence methods.

Digital drug screening to detect falsified, expired andrecalled medicines (2018)
Thesis
Naughton, B. D. (2018). Digital drug screening to detect falsified, expired andrecalled medicines. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411443

Falsified medicines are a global health and pharmaceutical sector issue which affect supply chains in low, middle and high-income countries. There are many methods to identify substandard and falsified medicines. However, the European Union has intro... Read More about Digital drug screening to detect falsified, expired andrecalled medicines.

Silicon in health: A beneficial element in reducing the body burden of aluminium (2018)
Thesis
Jones, K. L. (2018). Silicon in health: A beneficial element in reducing the body burden of aluminium. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411347

The essentiality of silicon and the toxicity of aluminium within humans are both topics of much debate; the current conception is that silicon is essential in ameliorating aluminium toxicity, however, the evidence for this remains inconclusive.

T... Read More about Silicon in health: A beneficial element in reducing the body burden of aluminium.

The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management (2018)
Thesis
Lindsay, C. (2018). The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411458

Introduction
Patients surviving a severe stroke are at risk of developing contractures. Evidence suggests that spasticity may be a cause of contractures, particularly in patients who have not recovered functional movement. The relationship and the t... Read More about The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management.

Action research: towards excellence in teaching, assessment and feedback for clinical consultation skills (2018)
Thesis
Lefroy, J. (2018). Action research: towards excellence in teaching, assessment and feedback for clinical consultation skills. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411453

Background
Consultation skills are the core competencies required at graduation of the doctor as a practitioner. Every medical school has its own system of teaching and assessing consultation skills. These are generally amalgams of previous curricu... Read More about Action research: towards excellence in teaching, assessment and feedback for clinical consultation skills.

Primary care decision-making for shoulder pain: identifying treatment effect moderators using clinical expertise (2018)
Thesis
McRobert, C. (2018). Primary care decision-making for shoulder pain: identifying treatment effect moderators using clinical expertise. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411441

Background
Shoulder pain is a common, costly condition with variable prognosis. Commonly used treatments for shoulder pain in primary care include: (i) advice & analgesia, (ii) exercise and/or manual therapy, and (iii) corticosteroid injection. Curr... Read More about Primary care decision-making for shoulder pain: identifying treatment effect moderators using clinical expertise.

Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation (2018)
Thesis
Ali, I. F. (2018). Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411432

The emergence and spread of resistance to antimalarial drugs has highlighted the demand to search for new drugs that target novel pathways in the human malaria parasite Plasmodium falciparum. This thesis explores the potential for targeting of the Pf... Read More about Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation.

Risk factors for the onset of musculoskeletal pain in children and adolescents (2018)
Thesis
Andreucci, A. (2018). Risk factors for the onset of musculoskeletal pain in children and adolescents. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411391

Background

Musculoskeletal pain is a major burden on society. Research in adults has identified risk factors associated with musculoskeletal pain onset, however at present evidence for risk factors in children and adolescents is limited.

Aims... Read More about Risk factors for the onset of musculoskeletal pain in children and adolescents.

Validating models of injury risk prediction in football players (2018)
Thesis
Philp, F. D. (2018). Validating models of injury risk prediction in football players. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411140

Association football (soccer) is a popular sport and there is a high risk of injury for participants. Within the context of professional clubs, the risk of injury is also associated with the risk of financial costs. Therefore, injury reduction proces... Read More about Validating models of injury risk prediction in football players.

Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis (2018)
Thesis
Musa, F. (2018). Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411162

In this project, we have designed, constructed, and validated a human tissue-engineered blood vessel construct (TEBV) to assess whether it could be used as a new model system in which to study thrombus formation under physiologically relevant conditi... Read More about Development of a human 3D tissue-engineered blood vessel model for the study of haemostasis.

Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery (2018)
Thesis
Narayanasamy, K. K. (2018). Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411161

With the advent of powerful gene editing tools such as CRISPR/Cas9, advances in gene therapy have gained a second wind. Despite this, disease therapy still has not progressed beyond clinical trials due to limitations in current delivery methods. The... Read More about Preparation and Evaluation of Polymer Coated Magnetic Nanoparticles for Applications in Gene Delivery.

Development of a clinical care pathway for anaemic patients (2018)
Thesis
Ballal, M. (2018). Development of a clinical care pathway for anaemic patients. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/418240

Improving cancer survival in the UK is one of the leading items on the agenda of the government. Survival from gastrointestinal cancer is yet to come into line with Europe. In 2000 the department of health (DoH) introduced guidelines for referral of... Read More about Development of a clinical care pathway for anaemic patients.

Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology (2018)
Thesis
Ahmed, M. A. (2018). Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/410299

Oxygen is an important molecule in life and is essential for a broad spectrum of physiological reactions that include, but are not restricted to, cell metabolism, respiration and growth. Under physiological conditions, oxygen levels vary from one tis... Read More about Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology.

Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy (2018)
Thesis
Abo Donia, M. N. A. (2018). Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/410399

Ovarian cancer is a complex disease characterized by low incidence, accounting for about 4% of cancer diagnoses in women, but with rapid progression and higher mortality rate than any other gynecological malignancy. Approximately 70 % of the cases ar... Read More about Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy.

Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression (2018)
Thesis
Merkhan, M. M. (2018). Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/410396

Human mesenchymal stem cells (hMSCs) have multiple potential roles in regenerative medicine. These roles revolve around the exploitation of their multipotent differentiation potential, their immunogenic privilege, or the broad range of molecules they... Read More about Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression.