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EFAS Score - Validation of Danish Version by the Score Committee of the European Foot and Ankle Society (EFAS). (2024)
Journal Article
Richter, M., Agren, P.-H., Besse, J.-L., Coester, M., Kofoed, H., Maffulli, N., …Johansen, J. K. (in press). EFAS Score - Validation of Danish Version by the Score Committee of the European Foot and Ankle Society (EFAS). Foot and Ankle Surgery, 30(4), 294-298. https://doi.org/10.1016/j.fas.2024.03.009

The Score Committee of the European Foot and Ankle Society (EFAS) developed, validated, and published the EFAS Score in 13 languages. Currently, the Danish version completed data acquisition and underwent further validation. The data were collected p... Read More about EFAS Score - Validation of Danish Version by the Score Committee of the European Foot and Ankle Society (EFAS)..

World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention (2023)
Journal Article
Roffe. (2023). World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention. Postępy w Kardiologii Interwencyjnej, 19(1), 6-13. https://doi.org/10.5114/aic.2023.124742

Introduction: Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most cou... Read More about World Federation for Interventional Stroke Treatment (WIST) multispecialty training guidelines for endovascular stroke intervention.

Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial (2022)
Journal Article
Roffe. (2022). Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. BMC Emergency Medicine, https://doi.org/10.1186/s12873-021-00560-x

Background: Prehospital stroke trials will inevitably recruit patients with non-stroke conditions, so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in patients with mimics in the second Rapid Intervention with Glyc... Read More about Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial.

Use of path analysis to predict changes to community pharmacy and GP emergency hormonal contraception (EHC) provision in England (2022)
Journal Article
Thayer, N., White, S., & Frisher, M. (2022). Use of path analysis to predict changes to community pharmacy and GP emergency hormonal contraception (EHC) provision in England. BMJ Open, 12(11), Article e059039. https://doi.org/10.1136/bmjopen-2021-059039

Objectives:
In 2014/2015, 46% of community pharmacies were commissioned by local authorities to provide emergency hormonal contraception (EHC) free without prescription in England. Commissioning EHC services influences EHC prescribing from General... Read More about Use of path analysis to predict changes to community pharmacy and GP emergency hormonal contraception (EHC) provision in England.

Elderly Patients' Perspectives on the Acceptability of Deprescribing Medicines: A Qualitative Study Protocol (2022)
Journal Article
Channa, K. K., Venables, R., & White, S. (2022). Elderly Patients' Perspectives on the Acceptability of Deprescribing Medicines: A Qualitative Study Protocol. International Journal of Qualitative Methods, 21, https://doi.org/10.1177/16094069221116975

The ageing population has resulted in an increase in multimorbidity and polypharmacy, and subsequently the complexity of optimising elderly patients’ medicines. The need for deprescribing can arise from factors such as increased susceptibility to adv... Read More about Elderly Patients' Perspectives on the Acceptability of Deprescribing Medicines: A Qualitative Study Protocol.

Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells (2022)
Journal Article
Kitchen, Li, & Reynisson. (2022). Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells. https://doi.org/10.1016/j.prmcm.2022.100074

Inappropriate DNA methylation of tumour suppressor genes can affect their expression and function, and as such, DNA methylation has been a promising target for anti-cancer therapy. In gynaecological malignancy, ovarian cancer has the highest associat... Read More about Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells.

Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice (2022)
Journal Article
Allinson, M., Black, P., & White, S. (2022). Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice. American journal of pharmaceutical education, 86(5), Article 8643. https://doi.org/10.5688/ajpe8643

Objective. For many UK pharmacy students there are minimal opportunities to learn, or be exposed to, different ways of dealing with ethical and professional dilemmas in real life practice during undergraduate education. This study aimed to explore th... Read More about Professional Dilemmas Experienced by Pharmacy Graduates in the United Kingdom When Transitioning to Practice.

Identification of foods that affect the anti-cancer activity of pitavastatin in cells (2022)
Journal Article
Jawad, M., Ibrahim, S., Kumar, M., Burgert, C., Li, W., & Richardson, A. (2022). Identification of foods that affect the anti-cancer activity of pitavastatin in cells. Oncology Letters, https://doi.org/10.3892/ol.2022.13193

Statins inhibit the synthesis of mevalonate, a precursor isoprenoid molecule to geranylgeraniol that is necessary for the post-translational modification of several small GTPase oncogenes. Despite numerous preclinical studies suggesting that statins... Read More about Identification of foods that affect the anti-cancer activity of pitavastatin in cells.

Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic (2022)
Journal Article
(2022). Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic. Advances in therapy, https://doi.org/10.1007/s12325-022-02056-x

The COVID-19 pandemic has brought a renewed focus on appropriate management of chronic respiratory conditions with a heightened awareness of respiratory symptoms and the requirement for differential diagnosis between an asthma attack and COVID-19 inf... Read More about Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic.

Medication optimisation in severe mental illness (MEDIATE): protocol for a realist review (2022)
Journal Article
Jacklin, Maidment, I., Wong, G., Duddy, C., Upthegrove, R., Oduola, S., …MacPhee, M. (2022). Medication optimisation in severe mental illness (MEDIATE): protocol for a realist review. BMJ Open, 12(1), e058524 - ?. https://doi.org/10.1136/bmjopen-2021-058524

INTRODUCTION: Severe mental illness (SMI) is associated with significant morbidity and mortality. People living with SMI often receive complex medication regimens. Optimising these regimens can be challenging. Non-adherence is common and addressing i... Read More about Medication optimisation in severe mental illness (MEDIATE): protocol for a realist review.

Pre-hospital Transdermal Glyceryl Trinitrate in Patients With Stroke Mimics: Data From the Right-2 Randomised-controlled Ambulance Trial (2022)
Journal Article
Tunnage, B., Woodhouse, L. J., Dixon, M., Anderson, C., Ankolekar, S., Appleton, J., …Investigators, R. (in press). Pre-hospital Transdermal Glyceryl Trinitrate in Patients With Stroke Mimics: Data From the Right-2 Randomised-controlled Ambulance Trial. BMC Emergency Medicine, 22, Article 2. https://doi.org/10.1186/s12873-021-00560-x

Background: Prehospital stroke trials will inevitably recruit patients with non-stroke conditions, so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in patients with mimics in the second Rapid Intervention with Glyc... Read More about Pre-hospital Transdermal Glyceryl Trinitrate in Patients With Stroke Mimics: Data From the Right-2 Randomised-controlled Ambulance Trial.

Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device (2021)
Journal Article
Wragg, N. (2021). Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device. Molecular Therapy - Methods and Clinical Development, 551-566. https://doi.org/10.1016/j.omtm.2021.10.015

Hemophilia A (HA) is a rare bleeding disorder caused by deficiency/dysfunction of the FVIII protein. As current therapies based on frequent FVIII infusions are not a definitive cure, long-term expression of FVIII in endothelial cells through lentivir... Read More about Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device.

Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial. (2021)
Journal Article
Roffe. (2021). Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial. Stroke, 1141-1148. https://doi.org/10.1161/STROKEAHA.121.035191

BACKGROUND: Seeking consent rapidly in acute stroke trials is crucial as interventions are time sensitive. We explored the association between consent pathways and time to enrollment in the TICH-2 (Tranexamic Acid in Intracerebral Haemorrhage-2) rand... Read More about Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial..

Testosterone Therapy: Increase in Hematocrit is Associated with Decreased Mortality (2021)
Journal Article
(2021). Testosterone Therapy: Increase in Hematocrit is Associated with Decreased Mortality. Androgens, 150 - 159. https://doi.org/10.1089/andro.2021.0019

Objective: Testosterone therapy (TTh) may reduce morbidity/mortality in men with adult-onset testosterone deficiency (TD), though some cardiovascular safety concerns remain. Increased hematocrit (HCT), a recognized effect of therapy, may be associate... Read More about Testosterone Therapy: Increase in Hematocrit is Associated with Decreased Mortality.

Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance (2021)
Journal Article
Pearson. (2021). Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance. Molecules, 6581 - 6581. https://doi.org/10.3390/molecules26216581

Glyceryl trinitrate (GTN) is one of the earliest known treatments for angina with a fascinating history that bridges three centuries. However, despite its central role in the nitric oxide (NO) story as a NO-donating compound, establishing the precise... Read More about Glyceryl Trinitrate: History, Mystery, and Alcohol Intolerance.

Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature (2021)
Journal Article
Migliorini, F., La Padula, G., Torsiello, E., Spiezia, F., Oliva, F., & Maffulli, N. (2021). Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature. European Journal of Medical Research, 26(1), Article ARTN 118. https://doi.org/10.1186/s40001-021-00593-9

Large bone defects resulting from musculoskeletal tumours, infections, or trauma are often unable to heal spontaneously. The challenge for surgeons is to avoid amputation, and provide the best functional outcomes. Allograft, vascularized fibular or i... Read More about Strategies for large bone defect reconstruction after trauma, infections or tumour excision: a comprehensive review of the literature.

Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study (2021)
Journal Article
McClelland, D., Blackwell, J. R., O’Beirne, S., Grocott, N. E., & Ogrodnik, P. (2022). Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study. Journal of Shoulder and Elbow Surgery, 31(2), 413-419. https://doi.org/10.1016/j.jse.2021.08.018

Hypothesis: To determine the angle of osteotomy that produces a circular humeral cut surface.
Methods: 49 cadaveric shoulders, from 25 cadavers, underwent sequential humeral head osteotomy from 180 degrees (vertical, in line with the humeral diaphys... Read More about Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study.

Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial. (2021)
Journal Article
Kuiper. (2021). Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial. European Journal of Applied Physiology, 3551-3559. https://doi.org/10.1007/s00421-021-04812-3

PURPOSE: To investigate the effects of cross-education (CE) exercise on strength and performance at 10 and 24 weeks post anterior cruciate ligament (ACL) surgery.

METHODS: Design: randomised controlled trial. N?=?44 ACL-reconstruction patients, r... Read More about Contralateral strength training attenuates muscle performance loss following anterior cruciate ligament (ACL) reconstruction: a randomised-controlled trial..

Proceedings of International Conference on Biomedical Engineering (2021)
Presentation / Conference
Yang, & Naire. (2021, September). Proceedings of International Conference on Biomedical Engineering. Presented at International Conference on Biomedical Engineering (ICoBE 2021), UniMAP, Malaysia (Virtual)

Aspiration thrombectomy is a life-saving interventional procedure to remove a blood clot from the brain of stroke patients. The pressure and blood flow dynamics during this procedure are crucial in determining the clinical outcomes. A mathematical mo... Read More about Proceedings of International Conference on Biomedical Engineering.