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Change in angiogram-derived management strategy of patients with chest pain when some FFR data are available: How consistent is the effect? (2017)
Journal Article
Mamas. (2017). Change in angiogram-derived management strategy of patients with chest pain when some FFR data are available: How consistent is the effect?. Cardiovascular Revascularization Medicine, 320-327. https://doi.org/10.1016/j.carrev.2017.01.014

Background
The assessment of patients presenting with angina using invasive angiography alone is imperfect. By contrast, fractional flow reserve (FFR) allows for assessment of lesion-specific ischemia, which is predictive of clinical outcome. A seri... Read More about Change in angiogram-derived management strategy of patients with chest pain when some FFR data are available: How consistent is the effect?.

Preeclampsia and Future Cardiovascular Health (2017)
Journal Article
Wu, P., Haththotuwa, R., Shing Kwok, C., Babu, A., Kotronias, R. A., Rushton, C., …Mamas, M. A. (2017). Preeclampsia and Future Cardiovascular Health. Circulation: Cardiovascular Quality and Outcomes, 10(2), https://doi.org/10.1161/circoutcomes.116.003497

Background—
Preeclampsia is a pregnancy-specific disorder resulting in hypertension and multiorgan dysfunction. There is growing evidence that these effects persist after pregnancy. We aimed to systematically evaluate and quantify the evidence on th... Read More about Preeclampsia and Future Cardiovascular Health.

Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom (2017)
Journal Article
Hulme, W., Sperrin, M., Kontopantelis, E., Ratib, K., Ludman, P., Sirker, A., …Mamas, M. (2017). Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom. Circulation: Cardiovascular Interventions, 10(2), 4279. https://doi.org/10.1161/CIRCINTERVENTIONS.116.004279

Background—
The radial artery is increasingly adopted as the primary access site for cardiac catheterization because of patient preference, lower bleeding rates, cost effectiveness, and reduced risk of mortality in high-risk patient groups. Concerns... Read More about Increased radial access is not associated with worse femoral outcomes for PCI in the United Kingdom.

Variation in emergency percutaneous coronary intervention in ventilated patients in the UK: insights from a national database (2017)
Journal Article
Mamas. (2017). Variation in emergency percutaneous coronary intervention in ventilated patients in the UK: insights from a national database. Cardiovascular Revascularization Medicine, 250-254. https://doi.org/10.1016/j.carrev.2017.02.005

Aims
Pre-procedural ventilation is a marker of high risk in PCI patients. Causes include out-of-hospital cardiac arrest (OHCA) and cardiogenic shock. OHCA occurs in approximately 60,000 patients in the UK per annum. No consensus exists regarding the... Read More about Variation in emergency percutaneous coronary intervention in ventilated patients in the UK: insights from a national database.

Impact of HIV on inpatient mortality and complications in stroke in Thailand; A National Database Study (2017)
Journal Article
Mamas. (2017). Impact of HIV on inpatient mortality and complications in stroke in Thailand; A National Database Study. Epidemiology and Infection, 1285-1291. https://doi.org/10.1017/S095026881600340X

The co-existence of stroke and HIV has increased in recent years, but the impact of HIV on post-stroke outcomes is poorly understood. We examined the impact of HIV on inpatient mortality, length of acute hospital stay and complications (pneumonia, re... Read More about Impact of HIV on inpatient mortality and complications in stroke in Thailand; A National Database Study.

Endothelial progenitor cells: exploring the pleiotropic effects of statins (2017)
Journal Article
Mamas. (2017). Endothelial progenitor cells: exploring the pleiotropic effects of statins. World Journal of Cardiology, 1-13. https://doi.org/10.4330/wjc.v9.i1.1

Statins have become a cornerstone of risk modification for ischaemic heart disease patients. A number of studies have shown that they are effective and safe. However studies have observed an early benefit in terms of a reduction in recurrent infarct... Read More about Endothelial progenitor cells: exploring the pleiotropic effects of statins.

Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis (2016)
Journal Article
Nagaraja, V., Ooi, S., Nolan, J., Large, A., De Belder, M., Ludman, P., …Mamas, M. A. (2016). Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 5(12), https://doi.org/10.1161/JAHA.116.004598

Background
Up to half of patients undergoing percutaneous coronary intervention have multivessel coronary artery disease (MVD) with conflicting data regarding optimal revascularization strategy in such patients. This paper assesses the evidence for... Read More about Impact of incomplete percutaneous revascularization in patients with multi-vessel coronary artery disease: a systematic review and meta-analysis.

Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry (2016)
Journal Article
Mamas, M. A., Shing Kwok, C., Kontopantelis, E., Fryer, A. A., Buchan, I., Bachmann, M. O., …Myint, P. K. (2016). Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry. Journal of the American Heart Association, 5(11), https://doi.org/10.1161/JAHA.116.003348

BACKGROUND: We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort. METHODS AND... Read More about Relationship Between Anemia and Mortality Outcomes in a National Acute Coronary Syndrome Cohort: Insights from the UK Myocardial Ischemia National Audit Project Registry.

Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis (2016)
Journal Article
Wu, P., Shing Kwok, C., Haththotuwa, R., Kotronias, R. A., Babu, A., Fryer, A. A., …Mamas, M. A. (2016). Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis. Diabetologia, 59, 2518-2526. https://doi.org/10.1007/s00125-016-4098-x

Aims/hypothesis: Pre-eclampsia is a pregnancy-specific multi-system disorder and a state of physiological insulin resistance. Our aim is to systematically evaluate and quantify the evidence on the relationship between pre-eclampsia and the future ris... Read More about Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis.

Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis (2016)
Journal Article
Mamas. (2016). Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis. International Journal of Clinical Practice, 791-805. https://doi.org/10.1111/ijcp.12841

Background
Soft drink consumption is associated with adverse health behaviours that predispose to adverse cardiovascular risk factor profiles; however, it is unclear whether their intake independently leads to an increased risk of cardiovascular eve... Read More about Soft drinks and sweetened beverages and the risk of cardiovascular disease and mortality: a systematic review and meta-analysis.

Transcatheter Aortic Valve Implantation With or Without Pre-implantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta-analysis (2016)
Journal Article
Bagur, R., Shing Kwok, C., Nombela-Franco, L., Ludman, P., de Belder, M., Sponga, S., …Mamas, M. (2016). Transcatheter Aortic Valve Implantation With or Without Pre-implantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta-analysis. Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease, 67(13), 411-411. https://doi.org/10.1016/S0735-1097%2816%2930412-0

Objectives: Pre-implantation balloon-aortic valvuloplasty (BAV) is considered routine procedure during transcatheter aortic valve implantation (TAVI) to facilitate prosthesis implantation and expansion; however, it has been speculated that fewer embo... Read More about Transcatheter Aortic Valve Implantation With or Without Pre-implantation Balloon Aortic Valvuloplasty: A Systematic Review and Meta-analysis.

Risk Related to Pre–Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction (2016)
Journal Article
Mamas. (2016). Risk Related to Pre–Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction. Circulation: Heart Failure, https://doi.org/10.1161/CIRCHEARTFAILURE.115.002560

Background—
The prevalence of pre–diabetes mellitus and its consequences in patients with heart failure and reduced ejection fraction are not known. We investigated these in the Prospective Comparison of ARNI With ACEI to Determine Impact on Global... Read More about Risk Related to Pre–Diabetes Mellitus and Diabetes Mellitus in Heart Failure With Reduced Ejection Fraction.

Long-term glycaemic variability and risk of adverse outcomes: a systematic review and meta-analysis (2015)
Journal Article
Mamas. (2015). Long-term glycaemic variability and risk of adverse outcomes: a systematic review and meta-analysis. Diabetes Care, 2354-2369. https://doi.org/10.2337/dc15-1188

OBJECTIVE Glycemic variability is emerging as a measure of glycemic control, which may be a reliable predictor of complications. This systematic review and meta-analysis evaluates the association between HbA1c variability and micro- and macrovascular... Read More about Long-term glycaemic variability and risk of adverse outcomes: a systematic review and meta-analysis.

Coronary perforation complicating percutaneous coronary intervention in patients with a history of coronary artery bypass surgery: an analysis of 309 perforation cases from the British Cardiovascular Intervention Society database (2015)
Journal Article
Mamas. (2015). Coronary perforation complicating percutaneous coronary intervention in patients with a history of coronary artery bypass surgery: an analysis of 309 perforation cases from the British Cardiovascular Intervention Society database. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/CIRCINTERVENTIONS.117.005581

Background: The evidence base for coronary perforation (CP) occurring during percutaneous coronary intervention in patients with a history of bypass surgery (PCI-CABG) is limited and the long-term effects unclear. Using a national PCI database, the i... Read More about Coronary perforation complicating percutaneous coronary intervention in patients with a history of coronary artery bypass surgery: an analysis of 309 perforation cases from the British Cardiovascular Intervention Society database.

A Two-stage Dynamic Model to Enable Updating of Clinical Risk Prediction from Longitudinal Health Record Data: illustrated with Kidney Function (2015)
Book Chapter
Mamas. (2015). A Two-stage Dynamic Model to Enable Updating of Clinical Risk Prediction from Longitudinal Health Record Data: illustrated with Kidney Function. In Medinfo 2015: Proceedings of the 15th World Congress on Health and Biomedical Informatics (696-700). https://doi.org/10.3233/978-1-61499-564-7-696

We demonstrate the use of electronic records and repeated measures of risk factors therein, to enable deeper understanding of the relationship between the full longitudinal trajectory of risk factors and outcomes. To illustrate, dynamic mixed effect... Read More about A Two-stage Dynamic Model to Enable Updating of Clinical Risk Prediction from Longitudinal Health Record Data: illustrated with Kidney Function.

Outcomes following percutaneous coronary intervention in Non-ST-segment elevation myocardial infarction patients with previous coronary artery bypass grafts surgery
Presentation / Conference
Shoaib, A., Kinnaird, T., Curzen, N., Ludman, P., Belder, M., Rashid, M., …Mamas, M. Outcomes following percutaneous coronary intervention in Non-ST-segment elevation myocardial infarction patients with previous coronary artery bypass grafts surgery. Paper presented at European-Society-of-Cardiology Congress 2018 - AUG 25-29, 2018, Munich, GERMANY

SEX DIFFERENCES IN HIGH-RISK BUT INDICATED CORONARY INTERVENTIONS. NATIONAL REPORT FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY REGISTRY
Presentation / Conference
Mamas, & Rashid. SEX DIFFERENCES IN HIGH-RISK BUT INDICATED CORONARY INTERVENTIONS. NATIONAL REPORT FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY REGISTRY. Presented at ACC.22

Background: Complex and high-risk but indicated percutaneous coronary intervention (CHiP) is increasingly common in contemporary PCI practice. Data on sex differences in the type of CHiP procedures undertaken or their associated clinical outcomes are... Read More about SEX DIFFERENCES IN HIGH-RISK BUT INDICATED CORONARY INTERVENTIONS. NATIONAL REPORT FROM THE BRITISH CARDIOVASCULAR INTERVENTION SOCIETY REGISTRY.

Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset
Presentation / Conference
Mamas, & Rashid. Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset. Presented at Transcatheter Cardiovascular Therapeutics

Background This study was designed to evaluate temporal trends in elective rates of percutaneous coronary intervention (PCI) for stable angina and, specifically, to study the impact of the COURAGE and ORBITA trials on real-life practice. Methods We a... Read More about Fifteen-Year Trends in the Rates of Elective Percutaneous Coronary Intervention and Impact of COURAGE and ORBITA Trials: Insights From British Cardiovascular Intervention Society Dataset.