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Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis (2023)
Journal Article
Istanbuly, O., Belcher, J., Tabinor, M., Solis-Trapala, I., Lambie, M., & Davies, S. J. (in press). Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis. BMC Nephrology, 24(1), Article 312. https://doi.org/10.1186/s12882-023-03370-4

Background: Systemic inflammation, measured as circulating Interleukin-6 (IL-6) levels, is associated with cardiovascular and all-cause mortality in chronic kidney disease. However, this has not been convincingly demonstrated in a systematic review o... Read More about Estimating the association between systemic Interleukin-6 and mortality in the dialysis population. Re-analysis of the global fluid study, systematic review and meta-analysis.

Home dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. (2023)
Journal Article
Davies. (2023). Home dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney International, 103(5), 842-858. https://doi.org/10.1016/j.kint.2023.01.006

Home dialysis modalities (home hemodialysis [HD] and peritoneal dialysis [PD]) are associated with greater patient autonomy and treatment satisfaction compared with in-center modalities, yet the level of home-dialysis use worldwide is low. Reasons fo... Read More about Home dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference..

IMPROVE-PD Finder: A Web-Based Platform to Search and Share Peritoneal Dialysis Biobank, Registry, and Clinical Trial Metadata (2023)
Journal Article
Devuyst, O., Jakulj, L., Vervloet, M., Ruiz-Ortega, M., Rossignol, P., Rutherford, P., …Johnson, D. (2023). IMPROVE-PD Finder: A Web-Based Platform to Search and Share Peritoneal Dialysis Biobank, Registry, and Clinical Trial Metadata. Kidney International Reports, 8(4), 912-915. https://doi.org/10.1016/j.ekir.2023.01.003

Peritoneal dialysis (PD) is a life-sustaining kidney replacement therapy for the increasing number of people with permanent kidney failure across all age groups worldwide. Although PD potentially offers socioeconomic and performance benefits over hem... Read More about IMPROVE-PD Finder: A Web-Based Platform to Search and Share Peritoneal Dialysis Biobank, Registry, and Clinical Trial Metadata.

Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR (2022)
Journal Article
Lindley, E., Keane, D., Belcher, J., Fernandes Da Silva Jeffcoat, N., Davies, S., & trial investigators, B. (2022). Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR. Physiological Measurement, 43(8), Article 08NT01. https://doi.org/10.1088/1361-6579/ac80e8

OBJECTIVE: With growing recognition of the benefits of preserving residual kidney function (RKF) and use of incremental treatment regimes, the incentive to measure residual clearance in haemodialysis patients is increasing. Interdialytic urine collec... Read More about Monitoring residual kidney function in haemodialysis patients using timed urine collections: validation of the use of estimated blood results to calculate GFR.

International Icodextrin Use and Association with Peritoneal Membrane Function, Fluid Removal, Patient and Technique Survival (2022)
Journal Article
Davies, S., Zhao, J., McCullough, K. P., Kim, Y., Wang, A. Y., Badve, S. V., …Perl, J. (2022). International Icodextrin Use and Association with Peritoneal Membrane Function, Fluid Removal, Patient and Technique Survival. Kidney360, 3(5), 872-882. https://doi.org/10.34067/kid.0006922021

Key Points There are important national and center differences in the prescription of icodextrin, with the United States a clear outlier; across all countries, icodextrin was more likely to be used if membrane function tests indicated reduced ultrafi... Read More about International Icodextrin Use and Association with Peritoneal Membrane Function, Fluid Removal, Patient and Technique Survival.

Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis (2022)
Journal Article
Davies, & Lambie. (2022). Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis. Kidney International Reports, https://doi.org/10.1016/j.ekir.2022.02.016

Introduction
Transition to hemodialysis (HD) is a common outcome in peritoneal dialysis (PD), but the associated mortality risk is poorly understood. This study sought to identify rates of and risk factors for mortality after transitioning from PD t... Read More about Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis.

Understand the difference between clinical measured ultrafiltrationand real ultrafiltration in peritoneal dialysis. (2021)
Journal Article
Yu, Z., Wang, Z., Wang, Q., Zhang, M., Jin, H., Ding, L., …Ni, Z. (2021). Understand the difference between clinical measured ultrafiltrationand real ultrafiltration in peritoneal dialysis. BMC Nephrology, 22, Article 382. https://doi.org/10.1186/s12882-021-02589-3

BACKGROUND: It has been noticed for years that ultrafiltration (UF) is important for survival in peritoneal dialysis. On the other hand, precise and convenient UF measurement suitable for patient daily practice is not as straight forward as it is to... Read More about Understand the difference between clinical measured ultrafiltrationand real ultrafiltration in peritoneal dialysis..

AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. (2021)
Journal Article
Morelle, J., Marechal, C., Yu, Z., Debaix, H., Corre, T., Lambie, M., …Devuyst, O. (2021). AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. New England Journal of Medicine, 385, 1570 - 1580. https://doi.org/10.1056/NEJMoa2034279

BACKGROUND: Variability in ultrafiltration influences prescriptions and outcomes in patients with kidney failure who are treated with peritoneal dialysis. Variants in AQP1, the gene that encodes the archetypal water channel aquaporin-1, may contribut... Read More about AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis..

Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis. (2021)
Journal Article
Lambie, & Davies. (2021). Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis. Trends in Endocrinology and Metabolism, 721 - 730. https://doi.org/10.1016/j.tem.2021.06.001

Diabetic nephropathy is highly correlated with the occurrence of other complications of type 1 diabetes (T1D) and type 2 diabetes (T2D) mellitus; for example, hypertension with cardiovascular disease (CVD) being the most frequent cause of death in pa... Read More about Insulin resistance in cardiovascular disease, uremia, and peritoneal dialysis..

A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis. (2021)
Journal Article
Davies, & Lambie. (2021). A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis. Kidney International, 1101-1111. https://doi.org/10.1016/j.kint.2021.05.037

Movement of solutes across the peritoneum allows for the use of peritoneal dialysis to treat kidney failure. However, there is a large inter-individual variability in the peritoneal solute transfer rate (PSTR). Here, we tested the hypothesis that com... Read More about A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis..

PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS (2021)
Presentation / Conference
Lambie, M., Zhao, J., McCullough, K. P., Davies, S., Kawanishi, H., Johnson, D. W., …Perl, J. (2021, June). PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS. Presented at 58th ERA-EDTA Congress, CityCube Berlin, Berlin, Germany

Background and Aims Comparing and interpreting regional differences in peritoneal dialysis (PD) time on therapy needs to consider differences in the rates of permanent transfer to hemodialysis (HDT), death or kidney transplantation. Here we describe... Read More about PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS.

MO681PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS (2021)
Journal Article
Lambie, & Davies. (2021). MO681PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS. Nephrology Dialysis Transplantation,

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background and Aims</jats:title> <jats:p>Comparing and interpreting regional differences in peritoneal dialysis (PD) time on therapy needs to consider differences in the rates of permanent tran... Read More about MO681PERITONEAL DIALYSIS TIME ON THERAPY AND REGIONAL DIFFERENCES IN DEATH, TRANSFER TO HEMODIALYSIS AND KIDNEY TRANSPLANTATION: RESULTS FROM THE PDOPPS.

MO680INTERNATIONAL COMPARISONS OF ICODEXTRIN PRESCRIPTION PRACTICE AND ITS ASSOCIATION WITH FLUID REMOVAL, BLOOD PRESSURE, PATIENT AND TECHNIQUE SURVIVAL* (2021)
Journal Article
Davies. (2021). MO680INTERNATIONAL COMPARISONS OF ICODEXTRIN PRESCRIPTION PRACTICE AND ITS ASSOCIATION WITH FLUID REMOVAL, BLOOD PRESSURE, PATIENT AND TECHNIQUE SURVIVAL*. Nephrology Dialysis Transplantation, https://doi.org/10.1093/ndt/gfab101.002

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background and Aims</jats:title> <jats:p>Icodextrin is designed to maintain ultrafiltration during the long dwell, especially when there is a risk of increased fluid reabsorption (fast peritone... Read More about MO680INTERNATIONAL COMPARISONS OF ICODEXTRIN PRESCRIPTION PRACTICE AND ITS ASSOCIATION WITH FLUID REMOVAL, BLOOD PRESSURE, PATIENT AND TECHNIQUE SURVIVAL*.

Expanding Utilization of Home Dialysis: An Action Agenda From the First International Home Dialysis Roundtable (2021)
Journal Article
Davies. (2021). Expanding Utilization of Home Dialysis: An Action Agenda From the First International Home Dialysis Roundtable. KIDNEY MEDICINE, 635-643. https://doi.org/10.1016/j.xkme.2021.04.004

In a groundbreaking meeting, leading global kidney disease organizations came together in the fall of 2020 as an International Home Dialysis Roundtable (IHDR) to address strategies to increase access to and uptake of home dialysis, both peritoneal di... Read More about Expanding Utilization of Home Dialysis: An Action Agenda From the First International Home Dialysis Roundtable.

Outcome measures for technique survival reported in peritoneal dialysis: A systematic review. (2021)
Journal Article
Lambie, & Davies. (2021). Outcome measures for technique survival reported in peritoneal dialysis: A systematic review. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, https://doi.org/10.1177/0896860821989874

BACKGROUND: Peritoneal dialysis (PD) technique survival is an important outcome for patients, caregivers and health professionals, however, the definition and measures used for technique survival vary. We aimed to assess the scope and consistency of... Read More about Outcome measures for technique survival reported in peritoneal dialysis: A systematic review..

ISPD recommendations for the evaluation of peritoneal membrane dysfunction in adults: Classification, measurement, interpretation and rationale for intervention. (2021)
Journal Article
Davies, & Lambie. (2021). ISPD recommendations for the evaluation of peritoneal membrane dysfunction in adults: Classification, measurement, interpretation and rationale for intervention. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 352-372. https://doi.org/10.1177/0896860820982218

GUIDELINE 1: A pathophysiological taxonomy: A pathophysiological classification of membrane dysfunction, which provides mechanistic links to functional characteristics, should be used when prescribing individualized dialysis or when planning modality... Read More about ISPD recommendations for the evaluation of peritoneal membrane dysfunction in adults: Classification, measurement, interpretation and rationale for intervention..

Low Serum Potassium Levels and Clinical Outcomes in Peritoneal Dialysis—International Results from PDOPPS (2021)
Journal Article
Davies. (2021). Low Serum Potassium Levels and Clinical Outcomes in Peritoneal Dialysis—International Results from PDOPPS. Kidney International Reports, 313-324. https://doi.org/10.1016/j.ekir.2020.11.021

Introduction
Hypokalemia, including normal range values <4 mEq/l, has been associated with increased peritonitis and mortality in patients with peritoneal dialysis. This study sought to describe international variation in hypokalemia, potential modi...

How do patients and their family members experience the transition from peritoneal dialysis to incentre haemodialysis? A multisite qualitative study in England and Australia. (2020)
Journal Article
Allen, K., Damery, S. L., Sein, K., Johnson, D. W., Davies, S. J., Lambie, M., …Combes, G. M. (2020). How do patients and their family members experience the transition from peritoneal dialysis to incentre haemodialysis? A multisite qualitative study in England and Australia. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 42(3), https://doi.org/10.1177/0896860820975596

BACKGROUND: While numerous studies have explored the patient experience of dialysis or other end-stage kidney disease (ESKD) treatments, few have explored the process of transitioning between dialysis modalities. This study aimed to develop an in-dep... Read More about How do patients and their family members experience the transition from peritoneal dialysis to incentre haemodialysis? A multisite qualitative study in England and Australia..

The osmo-metabolic approach: a novel and tantalizing glucose-sparing strategy in peritoneal dialysis. (2020)
Journal Article
Bonomini, M., Zammit, V., Divino-Filho, J. C., Davies, S. J., Di Liberato, L., Arduini, A., & Lambie, M. (2020). The osmo-metabolic approach: a novel and tantalizing glucose-sparing strategy in peritoneal dialysis. Journal of Nephrology, 34, Article 503–519. https://doi.org/10.1007/s40620-020-00804-2

Peritoneal dialysis (PD) is a viable but under-prescribed treatment for uremic patients. Concerns about its use include the bio-incompatibility of PD fluids, due to their potential for altering the functional and anatomical integrity of the peritonea... Read More about The osmo-metabolic approach: a novel and tantalizing glucose-sparing strategy in peritoneal dialysis..