Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case-control and cohort study using large electronic health records in four European countries. (2022)
Journal Article
Zhang, W., Runhaar, J., Dell'Isola, A., Turkiewicz, A., Swain, S., Kamps, A., …Bierma-Zeinstra, S. (2022). Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case-control and cohort study using large electronic health records in four European countries. BMJ Open, e052816 - ?. https://doi.org/10.1136/bmjopen-2021-052816

INTRODUCTION: Osteoarthritis (OA) is one of the leading chronic conditions in the older population. People with OA are more likely to have one or more other chronic conditions than those without. However, the temporal associations, clusters of the co... Read More about Comorbidities in osteoarthritis (ComOA): a combined cross-sectional, case-control and cohort study using large electronic health records in four European countries..

COMPARATIVE ANALYSIS OF PERCUTANEOUS REVASCULARIZATION PRACTICE IN THE UNITED STATES AND THE UNITED KINGDOM: INSIGHTS FROM THE BMC2 AND BCIS DATABASES (2022)
Presentation / Conference
Mamas. (2022, April). COMPARATIVE ANALYSIS OF PERCUTANEOUS REVASCULARIZATION PRACTICE IN THE UNITED STATES AND THE UNITED KINGDOM: INSIGHTS FROM THE BMC2 AND BCIS DATABASES. Presented at ACC 22, Washington DC, USA

Background: We compared clinical practice patterns, procedural outcomes, and trends in percutaneous coronary intervention (PCI) utilization using a state-wide PCI registry in the United States and a national registry from the United Kingdom (UK).... Read More about COMPARATIVE ANALYSIS OF PERCUTANEOUS REVASCULARIZATION PRACTICE IN THE UNITED STATES AND THE UNITED KINGDOM: INSIGHTS FROM THE BMC2 AND BCIS DATABASES.

Acceptability of, and preferences for, remote consulting during COVID-19 among older patients with two common long-term musculoskeletal conditions: findings from three qualitative studies and recommendations for practice (2022)
Journal Article
Paskins, Z., Bullock, L., Manning, F., Bishop, S., Campbell, P., Cottrell, E., …Ryan, S. (2022). Acceptability of, and preferences for, remote consulting during COVID-19 among older patients with two common long-term musculoskeletal conditions: findings from three qualitative studies and recommendations for practice. BMC Musculoskeletal Disorders, 23, Article 312. https://doi.org/10.1186/s12891-022-05273-1

Background Guidance for choosing face-to-face vs remote consultations (RCs) encourages clinicians to consider patient preferences, however, little is known about acceptability of, and preferences for RCs, particularly amongst patients with musculoske... Read More about Acceptability of, and preferences for, remote consulting during COVID-19 among older patients with two common long-term musculoskeletal conditions: findings from three qualitative studies and recommendations for practice.

Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results (2022)
Journal Article
Bundred, N., Porta, N., Brunt, A. M., Cramer, A., Hanby, A., Shaaban, A. M., …Bliss, J. M. (2022). Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results. Clinical Cancer Research, 28(7), 1323 - 1334. https://doi.org/10.1158/1078-0432.CCR-21-3177

PURPOSE: EPHOS-B aimed to determine whether perioperative anti-HER2 therapy inhibited proliferation and/or increased apoptosis in HER2-positive breast cancer. PATIENTS AND METHODS: This randomized phase II, two-part, multicenter trial included newly... Read More about Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results.

EVIDENCE-INFORMED RECOMMENDATIONS TO SUPPORT IMPLEMENTATION OF BEST PRACTICE THERAPEUTIC EXERCISE FOR PEOPLE WITH KNEE AND/OR HIP OSTEOARTHRITIS: AN INTERNATIONAL CONSENSUS PROCESS (2022)
Journal Article
Holden. (2022). EVIDENCE-INFORMED RECOMMENDATIONS TO SUPPORT IMPLEMENTATION OF BEST PRACTICE THERAPEUTIC EXERCISE FOR PEOPLE WITH KNEE AND/OR HIP OSTEOARTHRITIS: AN INTERNATIONAL CONSENSUS PROCESS. Osteoarthritis and Cartilage, S402 - S403. https://doi.org/10.1016/j.joca.2022.02.541

Comparative Effectiveness of Statins on Non-HDL Cholesterol by Type and Intensity in People with Diabetes and at Risk of Cardiovascular Disease: Systematic Review and Network Meta-Analysis (2022)
Journal Article
Hodkinson, A., Tsimpida, D., Kontopantelis, E., Rutter, M. K., Mamas, M., & Panagioti, M. (2022). Comparative Effectiveness of Statins on Non-HDL Cholesterol by Type and Intensity in People with Diabetes and at Risk of Cardiovascular Disease: Systematic Review and Network Meta-Analysis. BMJ, 376, Article e067731. https://doi.org/10.1136/bmj-2021-067731

Objective: To compare the efficacy of different statin treatments by intensity on levels of non-high density lipoprotein cholesterol (non-HDL-C) for the prevention of cardiovascular disease in people with diabetes.

Design: Systematic review and ne... Read More about Comparative Effectiveness of Statins on Non-HDL Cholesterol by Type and Intensity in People with Diabetes and at Risk of Cardiovascular Disease: Systematic Review and Network Meta-Analysis.

Getting it right for polymyalgia rheumatica (2022)
Journal Article
Mukhtyar, C. B., Twohig, H., & Hodgson, H. (2022). Getting it right for polymyalgia rheumatica. Rheumatology, 61(11), 4221–4222. https://doi.org/10.1093/rheumatology/keac187

Long‐Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study (2022)
Journal Article
Jordan, K. P., Rathod‐Mistry, T., Bailey, J., Chen, Y., Clarson, L., Denaxas, S., …Mamas, M. A. (2022). Long‐Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study. Journal of the American Heart Association, 11(7), Article e023146. https://doi.org/10.1161/JAHA.121.023146

Background Most adults presenting with chest pain will not receive a diagnosis and be recorded with unattributed chest pain. The objective was to assess if they have increased risk of cardiovascular disease compared with those with noncoronary chest... Read More about Long‐Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study.

A clinical tool to identify older women with back pain at high risk of osteoporotic vertebral fractures (Vfrac): a population-based cohort study with exploratory economic evaluation (2022)
Journal Article
Paskins. (2022). A clinical tool to identify older women with back pain at high risk of osteoporotic vertebral fractures (Vfrac): a population-based cohort study with exploratory economic evaluation. Age and ageing, https://doi.org/10.1093/ageing/afac031

Background: Osteoporotic vertebral fractures (OVFs) identify people at high risk of future fractures, but despite this, less than a third come to clinical attention. The objective of this study was to develop a clinical tool to aid healthcare profess... Read More about A clinical tool to identify older women with back pain at high risk of osteoporotic vertebral fractures (Vfrac): a population-based cohort study with exploratory economic evaluation.

The impact of nursing staff education on diabetes inpatient glucose management: a pilot cluster randomised controlled trial (2022)
Journal Article
Piya, M., Zarora, R., Yu, D., Fletcher, T., Myint, K., & Simmons, D. (2022). The impact of nursing staff education on diabetes inpatient glucose management: a pilot cluster randomised controlled trial. BMC Endocrine Disorders, 22, Article 61. https://doi.org/10.1186/s12902-022-00975-y

Background: An increasing number of patients in hospital have diabetes, with most of them cared for by non-specialist staff. The effect of diabetes education for staff on patient outcomes, as well as the most effective method of staff education is un... Read More about The impact of nursing staff education on diabetes inpatient glucose management: a pilot cluster randomised controlled trial.

Development and preliminary validation of the challenges of living with cystic fibrosis (CLCF) questionnaire: a 46-item measure of treatment burden for parent/carers of children with CF (2022)
Journal Article
Glasscoe, C., Hope, H. F., Lancaster, G. A., McCray, G., West, K., Patel, L., …Southern, K. W. (2023). Development and preliminary validation of the challenges of living with cystic fibrosis (CLCF) questionnaire: a 46-item measure of treatment burden for parent/carers of children with CF. Psychology and Health, 38(10), 1309-1344. https://doi.org/10.1080/08870446.2021.2013483

OBJECTIVE: Treatments for cystic fibrosis (CF) are complex, labour-intensive, and perceived as highly burdensome by caregivers of children with CF. An instrument assessing burden of care is needed. DESIGN: A stepwise, qualitative design was used to c... Read More about Development and preliminary validation of the challenges of living with cystic fibrosis (CLCF) questionnaire: a 46-item measure of treatment burden for parent/carers of children with CF.

COMPLEX, HIGH-RISK BUT INDICATED PERCUTANEOUS CORONARY INTERVENTIONS (CHIP) TYPES AND OUTCOMES AMONG DIFFERENT AGE GROUPS. AN INSIGHT FROM A NATIONAL REGISTRY (2022)
Journal Article
Rashid, & Mamas. (2022). COMPLEX, HIGH-RISK BUT INDICATED PERCUTANEOUS CORONARY INTERVENTIONS (CHIP) TYPES AND OUTCOMES AMONG DIFFERENT AGE GROUPS. AN INSIGHT FROM A NATIONAL REGISTRY. Journal of the American College of Cardiology, 855 - 855. https://doi.org/10.1016/s0735-1097%2822%2901846-0

Background: Studies looking at Complex, High-risk but Indicated Percutaneous coronary intervention (CHiP) type and outcomes among the octogenarian are limited. Methods: Data on PCI for stable angina from 1st January 2006 to 31st December 2017 was obt... Read More about COMPLEX, HIGH-RISK BUT INDICATED PERCUTANEOUS CORONARY INTERVENTIONS (CHIP) TYPES AND OUTCOMES AMONG DIFFERENT AGE GROUPS. AN INSIGHT FROM A NATIONAL REGISTRY.

Assessing the Effectiveness of Bisphosphonates for the Prevention of Fragility Fractures: An Updated Systematic Review and Network Meta‐Analyses (2022)
Journal Article
Bastounis, A., Langley, T., Davis, S., Paskins, Z., Gittoes, N., Leonardi‐Bee, J., & Sahota, O. (2022). Assessing the Effectiveness of Bisphosphonates for the Prevention of Fragility Fractures: An Updated Systematic Review and Network Meta‐Analyses. JBMR Plus, 6(5), S270 - S270. https://doi.org/10.1002/jbm4.10620

Bisphosphonates have been found to be effective in preventing fragility fractures. However, their comparative effectiveness in populations at risk has yet to be defined. In light of recent clinical trials, we aimed to compare four bisphosphonates (al... Read More about Assessing the Effectiveness of Bisphosphonates for the Prevention of Fragility Fractures: An Updated Systematic Review and Network Meta‐Analyses.

Do recommended interventions widen or narrow inequalities in musculoskeletal health? An equity-focussed systematic review of differential effectiveness (2022)
Journal Article
Peat, G., Jordan, K., Wilkie, R., Corp, N., Van Der Windt, D., Yu, D., …Ali, N. (2022). Do recommended interventions widen or narrow inequalities in musculoskeletal health? An equity-focussed systematic review of differential effectiveness. Journal of Public Health, 44(3), e376–e387. https://doi.org/10.1093/pubmed/fdac014

Background It is unclear whether seven interventions recommended by Public Health England for preventing and managing common musculoskeletal conditions reduce or widen health inequalities in adults with musculoskeletal conditions. Methods We used cit... Read More about Do recommended interventions widen or narrow inequalities in musculoskeletal health? An equity-focussed systematic review of differential effectiveness.

Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis (2022)
Journal Article
Davies, & Lambie. (2022). Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis. Kidney International Reports, https://doi.org/10.1016/j.ekir.2022.02.016

Introduction
Transition to hemodialysis (HD) is a common outcome in peritoneal dialysis (PD), but the associated mortality risk is poorly understood. This study sought to identify rates of and risk factors for mortality after transitioning from PD t... Read More about Mortality Trends After Transfer From Peritoneal Dialysis to Hemodialysis.

GRAPPA Treatment Recommendations: 2021 Update (2022)
Journal Article
Coates, L. C., Corp, N., Van Der Windt, D., O'Sullivan, D., Soriano, E. R., & Kavanaugh, A. (2022). GRAPPA Treatment Recommendations: 2021 Update. The Journal of Rheumatology, 49(6 (S1)), 52-54. https://doi.org/10.3899/jrheum.211331

Since its inception, one of the central missions of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (G RAPPA) has been the development of treatment recommendations for patients with psoriatic arthritis (PsA). The initial gu... Read More about GRAPPA Treatment Recommendations: 2021 Update.

Primary care for people with severe mental illness and comorbid obstructive airways disease: a qualitative study of patient perspectives with integrated stakeholder feedback (2022)
Journal Article
Mitchell, C., Zuraw, N., Delaney, B., Twohig, H., Dolan, N., Walton, E., …Hulin, J. (2022). Primary care for people with severe mental illness and comorbid obstructive airways disease: a qualitative study of patient perspectives with integrated stakeholder feedback. BMJ Open, 12(3), Article e057143. https://doi.org/10.1136/bmjopen-2021-057143

OBJECTIVES: To explore patient and stakeholder perspectives on primary respiratory care for people with severe mental illness (SMI) and comorbid obstructive airways disease (OAD). DESIGN: Qualitative, semistructured qualitative interviews were undert... Read More about Primary care for people with severe mental illness and comorbid obstructive airways disease: a qualitative study of patient perspectives with integrated stakeholder feedback.

Ethnicity-dependent performance of the GRACE risk score for prediction of non-ST-segment elevation myocardial infarction in-hospital mortality: Nationwide cohort study (2022)
Journal Article
Mamas. (2022). Ethnicity-dependent performance of the GRACE risk score for prediction of non-ST-segment elevation myocardial infarction in-hospital mortality: Nationwide cohort study. European Heart Journal, https://doi.org/10.1093/eurheartj/ehac052

Background: The Global Registry of Acute Coronary Events (GRACE) score was developed to evaluate risk in patients with acute coronary syndrome with or without ST-segment elevation. Little is known about its performance at predicting in-hospital morta... Read More about Ethnicity-dependent performance of the GRACE risk score for prediction of non-ST-segment elevation myocardial infarction in-hospital mortality: Nationwide cohort study.

Diagnostic delay in axial spondyloarthritis: a systematic review (2022)
Journal Article
Hay, C., Packham, J., Ryan, S., Mallen, C., Chatzixenitidis, A., & Prior, J. (2022). Diagnostic delay in axial spondyloarthritis: a systematic review. Clinical Rheumatology, 41(1939–1950), https://doi.org/10.1007/s10067-022-06100-7

Identification of axial spondyloarthritis (axSpA) remains challenging, frequently resulting in a diagnostic delay for patients. Current benchmarks of delay are usually reported as mean data, which are typically skewed and therefore may be overestimat... Read More about Diagnostic delay in axial spondyloarthritis: a systematic review.

Trends in the Annual Consultation Incidence and Prevalence of Low Back Pain and Osteoarthritis in England from 2000 to 2019: Comparative Estimates from Two Clinical Practice Databases (2022)
Journal Article
Yu, D., Missen, M., P Jordan, K., Edwards, J., Bailey, J., Wilkie, R., …Peat, G. (2022). Trends in the Annual Consultation Incidence and Prevalence of Low Back Pain and Osteoarthritis in England from 2000 to 2019: Comparative Estimates from Two Clinical Practice Databases. Clinical Epidemiology, 14, 179-189. https://doi.org/10.2147/CLEP.S337323

Purpose: To compare estimates of annual person-consulting incidence and prevalence of low back pain (LBP) and osteoarthritis for two national English electronic health record databases (Clinical Practice Research Datalink (CPRD) Aurum and CPRD GOLD).... Read More about Trends in the Annual Consultation Incidence and Prevalence of Low Back Pain and Osteoarthritis in England from 2000 to 2019: Comparative Estimates from Two Clinical Practice Databases.