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Direct Oral Anticoagulants Versus Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Trials (2022)
Journal Article
Mamas, M. A., Elbadawi, A., Dang, A. T., Sedhom, R., Hamed, M., Eid, M., …Elgendy, I. Y. (2022). Direct Oral Anticoagulants Versus Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Trials. Circulation: Cardiovascular Interventions, 15(9), Article e012194. https://doi.org/10.1161/circinterventions.122.012194

Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial (2022)
Journal Article
Beard, D. J., Davies, L., Cook, J. A., Stokes, J., Leal, J., Fletcher, H., …Mohammed, A. (2022). Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial. The Lancet, 400, 605 - 615. https://doi.org/10.1016/S0140-6736%2822%2901424-6

Background
Anterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate the best management strategy between reconstructive surgery and non-surgical treatment for patients w... Read More about Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial.

Incidence and 1-year outcome of periprocedural myocardial infarction following cardiac surgery: are the Universal Definition and Society for Cardiovascular Angiography and Intervention criteria fit for purpose? (2022)
Journal Article
Mamas. (2022). Incidence and 1-year outcome of periprocedural myocardial infarction following cardiac surgery: are the Universal Definition and Society for Cardiovascular Angiography and Intervention criteria fit for purpose?. European Journal of Cardio-Thoracic Surgery, https://doi.org/10.1093/ejcts/ezac019

OBJECTIVES: The diagnosis and clinical implications of periprocedural myocardial infarction (PPMI) following coronary artery bypass grafting (CABG) are contentious, especially the importance of PPMI in the interpretation of trial data. METHODS: Conse... Read More about Incidence and 1-year outcome of periprocedural myocardial infarction following cardiac surgery: are the Universal Definition and Society for Cardiovascular Angiography and Intervention criteria fit for purpose?.

Mirels’ score for upper limb metastatic lesions: do we need a different cutoff for recommending prophylactic fixation? (2022)
Journal Article
Hoban, K. A., Downie, S., Adamson, D. J., MacLean, J. G., Cool, P., & Jariwala, A. C. (2022). Mirels’ score for upper limb metastatic lesions: do we need a different cutoff for recommending prophylactic fixation?. https://doi.org/10.1016/j.jseint.2022.03.006

The aim of this study was to investigate the reproducibility, reliability and accuracy of Mirels’s score in upper limb bony metastatic disease and validate its use in predicting pathological fractures. Methods 45 patients with upper limb bony metasta... Read More about Mirels’ score for upper limb metastatic lesions: do we need a different cutoff for recommending prophylactic fixation?.

OPIOID USE PRIOR TO TOTAL KNEE REPLACEMENT: COMPARATIVE ANALYSIS OF TRENDS IN ENGLAND AND SWEDEN (2022)
Presentation / Conference
Englund, M., Dell'Isola, A., Thomas, G., Turkiewicz, A., Peat, G., Hellberg, C., …Appleyard, T. (2022, April). OPIOID USE PRIOR TO TOTAL KNEE REPLACEMENT: COMPARATIVE ANALYSIS OF TRENDS IN ENGLAND AND SWEDEN. Presented at 2022 OARSI World Congress on Osteoarthritis, Berlin, Germany

Purpose: Opioids are still frequently used in the pain management of knee osteoarthritis (OA), despite increasing evidence of limited effectiveness, increased morbidity and mortality, as well as risk of addiction. Our aim was to describe and compare... Read More about OPIOID USE PRIOR TO TOTAL KNEE REPLACEMENT: COMPARATIVE ANALYSIS OF TRENDS IN ENGLAND AND SWEDEN.

Clinical and angiographic success and safety comparison of coronary intravascular lithotripsy: An updated meta-analysis (2022)
Journal Article
Mamas, M. (2022). Clinical and angiographic success and safety comparison of coronary intravascular lithotripsy: An updated meta-analysis. https://doi.org/10.1016/j.ijcha.2022.100975

Background
Intravascular lithotripsy (IVL) can be used to assist stent deployment in severe coronary artery calcifications (CAC).

Methods
Studies employing IVL for CAC lesions were included. The primary outcomes included clinical and angiographi... Read More about Clinical and angiographic success and safety comparison of coronary intravascular lithotripsy: An updated meta-analysis.

Opioid use prior to total knee replacement: comparative analysis of trends in England and Sweden (2022)
Journal Article
Yu, D., Hellberg, C., Appleyard, T., Dell'Isola, A., Thomas, G. E. R., Turkiewicz, A., …Peat, G. (2022). Opioid use prior to total knee replacement: comparative analysis of trends in England and Sweden. Osteoarthritis and Cartilage, 30(6), 815-822. https://doi.org/10.1016/j.joca.2022.02.621

Objectives To describe and compare trends in the frequency of opioid prescribing/dispensing in English and Swedish patients with osteoarthritis prior to total knee replacement (TKR). Methods 49,043 patients from an English national database (Clinical... Read More about Opioid use prior to total knee replacement: comparative analysis of trends in England and Sweden.

Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression (2022)
Journal Article
Mamas. (2022). Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression. American Journal of Cardiology, https://doi.org/10.1016/j.amjcard.2022.01.045

There are limited data on the clinical outcomes of percutaneous coronary intervention (PCI) in patients with acquired immunosuppression who are frequently underrepresented in clinical trials. All PCI procedures between October 2015 and December 2018... Read More about Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression.

Association Between Handover of Anesthesiology Care and 1-Year Mortality Among Adults Undergoing Cardiac Surgery (2022)
Journal Article
Mamas, M., Sun, L. Y., Jones, P. M., Wijeysundera, D. N., Mamas, M. A., Bader Eddeen, A., …O’Connor, J. (2022). Association Between Handover of Anesthesiology Care and 1-Year Mortality Among Adults Undergoing Cardiac Surgery. Jama Network Open, 5(2), Article ARTN e2148161. https://doi.org/10.1001/jamanetworkopen.2021.48161

Importance Handovers of anesthesia care from one anesthesiologist to another is an important intraoperative event. Despite its association with adverse events after noncardiac surgery, its impact in the context of cardiac surgery remains unclear.... Read More about Association Between Handover of Anesthesiology Care and 1-Year Mortality Among Adults Undergoing Cardiac Surgery.

Arthroscopic hip surgery compared with personalised hip therapy in people over 16 years old with femoroacetabular impingement syndrome: UK FASHIoN RCT. (2022)
Journal Article
Griffin, D. R., Dickenson, E. J., Achana, F., Griffin, J., Smith, J., Wall, P. D., …Donovan, J. (2022). Arthroscopic hip surgery compared with personalised hip therapy in people over 16 years old with femoroacetabular impingement syndrome: UK FASHIoN RCT. Health Technology Assessment, 26(16), 1-236. https://doi.org/10.3310/fxii0508

Background Femoroacetabular impingement syndrome is an important cause of hip pain in young adults. It can be treated by arthroscopic hip surgery or with physiotherapist-led conservative care. Objective To compare the clinical effectiveness and cost-... Read More about Arthroscopic hip surgery compared with personalised hip therapy in people over 16 years old with femoroacetabular impingement syndrome: UK FASHIoN RCT..

Drivers and outcomes of variation in surgical versus transcatheter aortic valve replacement in Ontario, Canada: a population-based study. (2022)
Journal Article
Mamas. (2022). Drivers and outcomes of variation in surgical versus transcatheter aortic valve replacement in Ontario, Canada: a population-based study. Open Heart, https://doi.org/10.1136/openhrt-2021-001881

OBJECTIVES: To understand the patient and hospital level drivers of the variation in surgical versus trascatheter aortic valve replacement (SAVR vs TAVR) for patients with aortic stenosis (AS) and to explore whether this variation translates into dif... Read More about Drivers and outcomes of variation in surgical versus transcatheter aortic valve replacement in Ontario, Canada: a population-based study..

'You know where we are if you need us.' The role of primary care in supporting patients following pancreaticoduodenectomy for cancer: a qualitative study. (2022)
Journal Article
Chew-Graham. (2022). 'You know where we are if you need us.' The role of primary care in supporting patients following pancreaticoduodenectomy for cancer: a qualitative study. British Journal of General Practice Open (BJGP Open), https://doi.org/10.3399/BJGPO.2021.0154

BACKGROUND: Ten percent of patients diagnosed with pancreatic cancer undergo pancreaticoduodenectomy. It is known that these patients have unmet psychological support needs, and GPs are key in enabling effective coordination of care for people living... Read More about 'You know where we are if you need us.' The role of primary care in supporting patients following pancreaticoduodenectomy for cancer: a qualitative study..

Beyond the revised cardiac risk index: Validation of the hospital frailty risk score in non-cardiac surgery (2022)
Journal Article
Mamas. (2022). Beyond the revised cardiac risk index: Validation of the hospital frailty risk score in non-cardiac surgery. PloS one, e0262322 - e0262322. https://doi.org/10.1371/journal.pone.0262322

Frailty is an established risk factor for adverse outcomes following non-cardiac surgery. The Hospital Frailty Risk Score (HFRS) is a recently described frailty assessment tool that harnesses administrative data and is composed of 109 International C... Read More about Beyond the revised cardiac risk index: Validation of the hospital frailty risk score in non-cardiac surgery.

Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis (2022)
Journal Article
Ullah, W., Gul, S., Saleem, S., Syed, M. A., Khan, M. Z., Zahid, S., …Fischman, D. L. (2022). Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis. European Heart Journal Open, 2(1), Article oeac002. https://doi.org/10.1093/ehjopen/oeac002

Aims: Combined mitral valve replacement (MVR) and coronary artery bypass graft (CABG) procedures have been the norm for patients with concomitant mitral valve disease (MVD) and coronary artery disease (CAD) with no large-scale data on their safety an... Read More about Trend, predictors, and outcomes of combined mitral valve replacement and coronary artery bypass graft in patients with concomitant mitral valve and coronary artery disease: a National Inpatient Sample database analysis.

Outcomes and regional differences in practice in a worldwide coronary stent registry (2022)
Journal Article
Mamas. (2022). Outcomes and regional differences in practice in a worldwide coronary stent registry. Heart, https://doi.org/10.1136/heartjnl-2021-320116

Objective: The primary objective was to assess the performance of a new generation thin-strut sirolimus-eluting coronary stent with abluminal biodegradable polymer in an all comer population. The secondary objective was to detail differences in conte... Read More about Outcomes and regional differences in practice in a worldwide coronary stent registry.

Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality (2021)
Journal Article
Mamas. (2021). Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality. MedRxiv, https://doi.org/10.1101/2021.11.11.21266212

<h4>Objectives</h4> To provide estimates for how different treatment pathways for the management of severe aortic stenosis (AS) may affect NHS England waiting list duration and associated mortality. <h4>Design</h4> We constructed a mathematical model... Read More about Aortic stenosis post-COVID-19: A mathematical model on waiting lists and mortality.

Predictors of postoperative hospital length of stay after total knee arthroplasty. (2021)
Journal Article
(2021). Predictors of postoperative hospital length of stay after total knee arthroplasty. https://doi.org/10.11622/smedj.2021142

INTRODUCTION: To collect and analyse clinical and functional variables of patients undergoing rehabilitation after total knee arthroplasty (TKA), in order to identify which amongst them could influence the post-operative length of hospital stay (LOS)... Read More about Predictors of postoperative hospital length of stay after total knee arthroplasty..

Does pre-existing morbidity influences risks and benefits of total hip replacement for osteoarthritis: a prospective study of 6682 patients from linked national datasets in England (2021)
Journal Article
Ferguson, R., Prieto-Alhambra, D., Peat, G., Delmestri, A., P Jordan, K., Y Strauss, V., …Silman, A. (2021). Does pre-existing morbidity influences risks and benefits of total hip replacement for osteoarthritis: a prospective study of 6682 patients from linked national datasets in England. BMJ Open, e046712 - ?. https://doi.org/10.1136/bmjopen-2020-046712

Total hip arthroplasty (THA) surgery for elderly people with multimorbidity increases the risk of serious health hazards including mortality. Whether such background morbidity reduces the clinical benefit is less clear. OBJECTIVE: To evaluate how pre... Read More about Does pre-existing morbidity influences risks and benefits of total hip replacement for osteoarthritis: a prospective study of 6682 patients from linked national datasets in England.

Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study (2021)
Journal Article
McClelland, D., Blackwell, J. R., O’Beirne, S., Grocott, N. E., & Ogrodnik, P. (2022). Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study. Journal of Shoulder and Elbow Surgery, 31(2), 413-419. https://doi.org/10.1016/j.jse.2021.08.018

Hypothesis: To determine the angle of osteotomy that produces a circular humeral cut surface.
Methods: 49 cadaveric shoulders, from 25 cadavers, underwent sequential humeral head osteotomy from 180 degrees (vertical, in line with the humeral diaphys... Read More about Determining the ideal osteotomy for stemless total shoulder replacement – a cadaveric study.