Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug (2024)
Journal Article
Porter, J., Noble, A. R., Signoret, N., Fascione, M. A., & Miller, G. J. (in press). Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug. ACS Omega, 9(29), 31703-31713. https://doi.org/10.1021/acsomega.4c02417

Nucleoside analogues are established treatments for cancer and viral infection. Gemcitabine is a commonly employed nucleoside analogue displaying anticancer properties against a range of tumor types but is rapidly inactivated in vivo. Efforts to bols... Read More about Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug.

Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. (2022)
Journal Article
Cosgrove, S. C., & Miller, G. J. (2022). Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. Expert Opinion on Drug Discovery, 17(4), 355-364. https://doi.org/10.1080/17460441.2022.2039620

INTRODUCTION: Nucleoside analogues represent a cornerstone of achievement in drug discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery over the last 60 years. Traditionally accessed using chemical synthesis... Read More about Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues..

Sweet targets: sugar nucleotide biosynthesis inhibitors. (2022)
Journal Article
Ahmadipour, S., Reynisson, J., Field, R. A., & Miller, G. J. (2022). Sweet targets: sugar nucleotide biosynthesis inhibitors. Future Medicinal Chemistry, 14(5), 295-298. https://doi.org/10.4155/fmc-2021-0286

'Editorial Material'

Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. (2020)
Journal Article
Guinan, M., Benckendorff, C., Smith, M., & Miller, G. (2020). Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. Molecules, 25(9), https://doi.org/10.3390/molecules25092050

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. However, thes... Read More about Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues..