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Diels Alder-mediated release of gemcitabine from nanoparticles: developing improved methods for pancreatic cancer drug delivery
Thesis
(2017). Diels Alder-mediated release of gemcitabine from nanoparticles: developing improved methods for pancreatic cancer drug delivery

Pancreatic cancer or pancreatic ductal adenocarcinoma (PDAC), is the deadliest type of cancerous malignancy with a survival rate of only 3.7 % after 5 years. The first line current treatment is a drug called gemcitabine, which has been shown to displ... Read More about Diels Alder-mediated release of gemcitabine from nanoparticles: developing improved methods for pancreatic cancer drug delivery.

Preparation and evaluation of hybrid gold-iron oxide nanoparticles as a multifunctional platform for diagnosis and therapy of pancreatic cancer
Thesis
Malekigorji, M. (2016). Preparation and evaluation of hybrid gold-iron oxide nanoparticles as a multifunctional platform for diagnosis and therapy of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is the most common epithelial, exocrine pancreatic malignancy. Gemcitabine, as the only chemotherapy clinically available for pancreatic cancer, proves effective only in 23.8% of patients. Recently, iron oxide-... Read More about Preparation and evaluation of hybrid gold-iron oxide nanoparticles as a multifunctional platform for diagnosis and therapy of pancreatic cancer.

Improving Leukaemia diagnosis and management with Selected Ion Flow Tube Mass Spectrometry and vibrational spectroscopy techniques
Thesis
Rashid Siddique, M. (2017). Improving Leukaemia diagnosis and management with Selected Ion Flow Tube Mass Spectrometry and vibrational spectroscopy techniques

Leukaemia is 11th most common cancer worldwide, associated with poor prognosis. The 10 years’ survival for leukaemia is between 44% - 47%. One of the main reasons for this is the disease being diagnosed in late stages. Most of leukaemia screening tec... Read More about Improving Leukaemia diagnosis and management with Selected Ion Flow Tube Mass Spectrometry and vibrational spectroscopy techniques.

Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer
Thesis
(2016). Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer

Autotaxin is an extracellular phospholipase D that catalyses the hydrolysis of lysophosphatidyl choline (LPC) to bioactive lipid lysophosphatidic acid (LPA). LPA has been implicated in many pathological processes relevant to cancer, including cell mi... Read More about Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer.

A role for the human mesenchymal stem cell secretome in attenuation of cytokine-induced apoptosis in pancreatic beta cells
Thesis
Al-Azzawi, B. (2017). A role for the human mesenchymal stem cell secretome in attenuation of cytokine-induced apoptosis in pancreatic beta cells

Diabetes is a lifelong condition caused by an inability of the body to break down glucose due to a defect in either insulin synthesis or the target cells becoming resistant to secreted insulin. There are two main types of diabetes, type 1 diabetes me... Read More about A role for the human mesenchymal stem cell secretome in attenuation of cytokine-induced apoptosis in pancreatic beta cells.

The preclinical evaluation of simvastatin and pitavastatin for the treatment of ovarian cancer
Thesis
Robinson, E. (2015). The preclinical evaluation of simvastatin and pitavastatin for the treatment of ovarian cancer

Ovarian cancer is the fifth most common cancer which affects women in the United Kingdom. The 5-year survival rate is less than 45% despite improvements in chemotherapeutic regimens. Platinum-based therapy in combination with other chemotherapy inclu... Read More about The preclinical evaluation of simvastatin and pitavastatin for the treatment of ovarian cancer.

Developing a Customised Programme of Exercise to Reduce Fatigue and Improve Societal Participation in Kuwaiti Patients with Multiple Sclerosis
Thesis
Ashour, A. F. (2016). Developing a Customised Programme of Exercise to Reduce Fatigue and Improve Societal Participation in Kuwaiti Patients with Multiple Sclerosis

Background: It is now widely accepted that physical training therapy is more reliable and effective than medication in improving fatigue in patients with Multiple Sclerosis (MS). However, efforts are still being made to maximise the benefits of train... Read More about Developing a Customised Programme of Exercise to Reduce Fatigue and Improve Societal Participation in Kuwaiti Patients with Multiple Sclerosis.

Improving the management of lung cancer using mass spectrometry and spectroscopy techniques
Thesis
Rutter, A. V. (2016). Improving the management of lung cancer using mass spectrometry and spectroscopy techniques

Lung cancer is a worldwide health problem associated with poor prognosis. The survival at 5 years remains between 5% and 15% in spite of the development of new drugs. One of the main reasons for this is the disease being diagnosed in late stages when... Read More about Improving the management of lung cancer using mass spectrometry and spectroscopy techniques.

A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum
Thesis
Ullah, I. (2016). A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum

Massive screens of chemical libraries for antimalarial activity have identified thousands of compounds that exhibit sub-micromolar potency against the blood stage of the malaria parasite Plasmodium falciparum. Triaging these compounds to establish pr... Read More about A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum.

Local membrane versus systemic consequences of peritoneal dialysis treatment
Thesis
Lambie, M. R. (2015). Local membrane versus systemic consequences of peritoneal dialysis treatment

The primary intent of this thesis is to delineate the relative roles of local membrane and systemic consequences of peritoneal dialysis therapy, with particular reference to the role of inflammation and a severe, uncommon complication, encapsulating... Read More about Local membrane versus systemic consequences of peritoneal dialysis treatment.

Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair
Thesis
Sharma, R. (2016). Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair

Background: An injury to the wrist and hand can impact different anatomical structures. Any damage or cut to the flexor tendons can leave a devastating impact if not treated well and can therefore compromise our daily physical activities. Surgery and... Read More about Developing a non-invasive method for in vivo monitoring of forearm flexor tendon excursions during rehabilitation following surgical tendon repair.