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Barriers to administering non-oral formulations in a paediatric population: A semi-structured interview study (2015)
Journal Article
Venables. (2015). Barriers to administering non-oral formulations in a paediatric population: A semi-structured interview study. International Journal of Pharmaceutics, 12 - 17. https://doi.org/10.1016/j.ijpharm.2015.11.010

There is a paucity of research exploring barriers to non-oral medicines administration in paediatric patients; however, these undoubtedly influence medicines adherence. Studies conducted with healthcare professionals have identified various issues wi... Read More about Barriers to administering non-oral formulations in a paediatric population: A semi-structured interview study.

Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies (2015)
Journal Article
(2015). Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies. Expert Opinion on Drug Metabolism and Toxicology, 1203-1217. https://doi.org/10.1517/17425255.2015.1037278

Introduction: The pharmacokinetic properties of anti-infective drugs are a determinant part of treatment success. Pathogen replication is inhibited if adequate drug levels are achieved in target sites, whereas excessive drug concentrations linked to... Read More about Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies.

Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter (2015)
Journal Article
(2015). Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter. Frontiers in Pharmacology, https://doi.org/10.3389/fphar.2015.00078

The SLC22A1 influx transporter is expressed on the basolateral membrane of hepatocytes and is involved in the excretion of numerous cations. Inhibition of SLC22A1 by several antiretrovirals, such as the protease inhibitor darunavir, has not previousl... Read More about Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter.

Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 (2015)
Journal Article
(2015). Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1. Proceedings of the National Academy of Sciences of the United States of America, 755-760. https://doi.org/10.1073/pnas.1416611112

Cytochrome bc1 is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism responsible for malaria, has generated a global effort in designing new classes of drugs. Muc... Read More about Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1.