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The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation (2020)
Thesis
Richardson, C. L. (2020). The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation. (Thesis). Keele University

Introduction
Patients commencing new medications, particularly those that are high risk such as non-vitamin K oral anticoagulants (NOACs), require counselling to ensure safe, effective and empowering use of the medicine. Pharmacists are well placed... Read More about The use of a virtual patient to simulate a pharmacist-patient anticoagulation consultation: a mixed methods evaluation.

An Experimental Intervention Study Assessing the Impact of a Thin Silicone Gel Surface Overlay on Interface Pressure (2020)
Journal Article
(2020). An Experimental Intervention Study Assessing the Impact of a Thin Silicone Gel Surface Overlay on Interface Pressure. Radiology Research and Practice, 3246531 - ?. https://doi.org/10.1155/2020/3246531

Introduction: The incidence of pressure ulcers (PUs) presents a substantial threat to patients, especially geriatric patients, those with restricted mobility, and patients suffering from chronic diseases such as cancer. PUs creates a huge financial b... Read More about An Experimental Intervention Study Assessing the Impact of a Thin Silicone Gel Surface Overlay on Interface Pressure.

Translational studies to support the use of pitavastatin as a cancer therapeutic (2020)
Thesis
Jawad, M. J. (2020). Translational studies to support the use of pitavastatin as a cancer therapeutic. (Thesis). Keele University

Ovarian cancer is the fifth leading cause of death associated with cancer. Initially, the disease responds to surgical cytoreduction, followed by chemotherapy. The primary response rate for chemotherapy is about 80%. Unfortunately, most patients rela... Read More about Translational studies to support the use of pitavastatin as a cancer therapeutic.

Can the early use of botulinum toxin in post stroke spasticity reduce contracture development? A randomised controlled trial (2020)
Journal Article
(2020). Can the early use of botulinum toxin in post stroke spasticity reduce contracture development? A randomised controlled trial. Clinical Rehabilitation, https://doi.org/10.1177/0269215520963855

Objective:
Does early treatment of spasticity with botulinum-toxin (BoNTA), in (hyper)acute stroke patients without arm-function, reduce contractures and improve function.

Design:
Randomised placebo-controlled-trial

Setting:
Specialised stro... Read More about Can the early use of botulinum toxin in post stroke spasticity reduce contracture development? A randomised controlled trial.

Culturally adapted trauma-focused CBT-based guided self-help (CatCBT GSH) for female victims of domestic violence in Pakistan: feasibility randomized controlled trial. (2020)
Journal Article
Farooq. (2020). Culturally adapted trauma-focused CBT-based guided self-help (CatCBT GSH) for female victims of domestic violence in Pakistan: feasibility randomized controlled trial. Behavioural and Cognitive Psychotherapy, 50-61. https://doi.org/10.1017/S1352465820000685

BACKGROUND: Cognitive behaviour therapy (CBT), self-help and guided self-help interventions have been found to be efficacious and cost effective for victims of trauma, but there are limited data from low- and middle-income countries on culturally ada... Read More about Culturally adapted trauma-focused CBT-based guided self-help (CatCBT GSH) for female victims of domestic violence in Pakistan: feasibility randomized controlled trial..

Re-designing preclinical neuropharmacology teaching to enhance student engagement and active learning (2020)
Journal Article
Horn. (2020). Re-designing preclinical neuropharmacology teaching to enhance student engagement and active learning. The Journal of Academic Development and Education, https://doi.org/10.21252/t8b0-4b93

Group-based teaching can be an effective means of promoting active learning. As part of a medical degree, these sessions often focus on a clinical case. The students work collaboratively to build on previous knowledge and gain a deeper understanding... Read More about Re-designing preclinical neuropharmacology teaching to enhance student engagement and active learning.

Single-dwell treatment with a low-sodium solution in hypertensive peritoneal dialysis patients. (2020)
Journal Article
Davies. (2020). Single-dwell treatment with a low-sodium solution in hypertensive peritoneal dialysis patients. https://doi.org/10.1177/0896860820924136

BACKGROUND: Patients on peritoneal dialysis (PD) may suffer from sodium (Na) and fluid overload, hypertension and increased cardiovascular risk. Low-Na dialysis solution, by increasing the diffusive removal of Na, might improve blood pressure (BP) ma... Read More about Single-dwell treatment with a low-sodium solution in hypertensive peritoneal dialysis patients..

Virtual patients as a tool for training pre-registration pharmacists and increasing their preparedness to practice: A qualitative study (2020)
Journal Article
Thompson, J., White, S., & Chapman, S. (2020). Virtual patients as a tool for training pre-registration pharmacists and increasing their preparedness to practice: A qualitative study. PloS one, 15(8), Article e0238226. https://doi.org/10.1371/journal.pone.0238226

Virtual patients are an active learning pedagogical tool which simulate clinical scenarios in a three-dimensional environment. Their use in pharmacy education is under-researched in comparison to other healthcare professions. In the United Kingdom, p... Read More about Virtual patients as a tool for training pre-registration pharmacists and increasing their preparedness to practice: A qualitative study.

Liposomes for Intra-Articular Analgesic Drug Delivery in Orthopedics: State-of-Art and Future Perspectives. Insights from a Systematic Mini-Review of the Literature. (2020)
Journal Article
(2020). Liposomes for Intra-Articular Analgesic Drug Delivery in Orthopedics: State-of-Art and Future Perspectives. Insights from a Systematic Mini-Review of the Literature. Medicina, https://doi.org/10.3390/medicina56090423

Background and objectives: Liposomal structures are artificial vesicles composed of one or several lamellae of phospholipids which surround an inner aqueous core. Given the amphoteric nature of phospholipids, liposomes are promising systems for drug... Read More about Liposomes for Intra-Articular Analgesic Drug Delivery in Orthopedics: State-of-Art and Future Perspectives. Insights from a Systematic Mini-Review of the Literature..

Actual vs. Perceived Competency Development-How Can Virtual Patients Impact Pharmacist Pre-Registration Training? (2020)
Journal Article
Thompson, J., White, S., & Chapman, S. (2020). Actual vs. Perceived Competency Development-How Can Virtual Patients Impact Pharmacist Pre-Registration Training?. Pharmacy, 8(3), Article 138. https://doi.org/10.3390/pharmacy8030138

Virtual patients are an active learning pedagogical tool that simulate clinical scenarios. There is an established disparity in pre-registration examination pass rates depending on whether individuals complete their training in a community or hospita... Read More about Actual vs. Perceived Competency Development-How Can Virtual Patients Impact Pharmacist Pre-Registration Training?.

A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors (2020)
Journal Article
Barnes, N. G., Parker, A. W., Ahmed Mal Ullah, A. A., Ragazzon, P. A., & Hadfield, J. A. (2020). A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors. Bioorganic and Medicinal Chemistry, 28(19), Article 115684. https://doi.org/10.1016/j.bmc.2020.115684

A series of combretastatin derivatives were designed and synthesised by a two-step stereoselective synthesis by use of Wittig olefination followed by Suzuki cross-coupling. Interestingly, all new compounds (2a-2i) showed potent cell-based antiprolife... Read More about A 2-step synthesis of Combretastatin A-4 and derivatives as potent tubulin assembly inhibitors.

Self-management support for people with Multiple Sclerosis (2020)
Thesis
Al Abbad, B. K. N. (2020). Self-management support for people with Multiple Sclerosis. (Thesis). Keele University

Background
Self-management programmes help people with long term conditions, such as Multiple Sclerosis (MS), manage symptoms, and contain utilization of health-care resources. However, the optimum level and type of support for people with MS (PwMS... Read More about Self-management support for people with Multiple Sclerosis.

Glycosphingolipid expression at breast cancer stem cells after novel thieno[2,3-b]pyridine anticancer compound treatment. (2020)
Journal Article
Reynisson. (2020). Glycosphingolipid expression at breast cancer stem cells after novel thieno[2,3-b]pyridine anticancer compound treatment. Scientific reports, 11876 - ?. https://doi.org/10.1038/s41598-020-68516-y

Glycosphingolipid expression differs between human breast cancer stem cells (CSC) and cancer non-stem cells (non-CSC). We performed studies of viability, type of cell death, cancer stem cell percent and glycosphingolipid expression on CSC and non-CSC... Read More about Glycosphingolipid expression at breast cancer stem cells after novel thieno[2,3-b]pyridine anticancer compound treatment..

Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies (2020)
Thesis
Morgan, R. L. (2020). Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies. (Thesis). Keele University

Cells secrete small membrane-bound extracellular vesicles (sEVs) called exosomes. These vesicles contain a mixture of protein, lipids, nucleic acids and saccharides (known collectively as cargo) that mediate therapeutic effects similar to their produ... Read More about Uncovering the role of heparan sulphate proteoglycans in small extracellular vesicle production: potential tools for optimised regenerative medicine therapies.

Human cell therapies in preclinical and clinical studies of cartilage repair (2020)
Thesis
Perry, J. K. L. (2020). Human cell therapies in preclinical and clinical studies of cartilage repair. (Thesis). Keele University

Cell therapy offers potential to repair and regenerate damaged tissues. An established example of its use in the clinic is for treating cartilage defects. This thesis addresses this topic, both studying the use of imaging in such patients having had... Read More about Human cell therapies in preclinical and clinical studies of cartilage repair.

An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research (2020)
Thesis
Shenton, J. J. L. (2020). An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417292

Background
Research in the NHS is essential to provide evidence to improve services and patient outcomes. The Government’s continued commitment to research has been made clear through the inclusion of research in key NHS policy documents including t... Read More about An exploration of hospital pharmacists’ attitudes and opinions towards undertaking research.

Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer (2020)
Thesis
Ali Asgari, M. (2020). Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer. (Thesis). Keele University

Pancreatic cancer is the 4th most aggressive cancer in the Western world. There are very little drugs available as chemotherapies for the treatment of pancreatic cancer. Of the ones used, most of them become eliminated by first pass metabolism before... Read More about Use of hybrid iron oxide-silver nanoparticles for thermo-responsive drug delivery in pancreatic cancer.

Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis (2020)
Thesis
Kirkby, M. (2020). Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis. (Thesis). Keele University

Chlorhexidine digluconate (CHG) is a cationic bisbiguanide that has been used extensively for the past half century as a topical antiseptic, due to its ability to effectively kill surface bacteria with minimal reports of resistance. However, bacteria... Read More about Enhanced topical delivery of chlorhexidine digluconate for improved skin antisepsis.

Somatosensory stimulation to improve lower-limb recovery after stroke (2020)
Thesis
Aries, A. M. (2020). Somatosensory stimulation to improve lower-limb recovery after stroke. (Thesis). Keele University

Introduction
Increasing lower-limb sensation could improve walking post-stroke but evidence for this is limited.
This thesis reports:
1) Review of published literature on somatosensory stimulation of the foot to enhance lower-limb function post-st... Read More about Somatosensory stimulation to improve lower-limb recovery after stroke.