Epidrug-mediated reversal of epigenetic changes associated with pituitary adenomas
Thesis
(2013). Epidrug-mediated reversal of epigenetic changes associated with pituitary adenomas

The genesis and outgrowth of pituitary adenomas is consequent to the combined contributions of genetic and epigenetic aberrations. Although the relative contribution of each is not known it is likely that particular aberration may be common or partic... Read More about Epidrug-mediated reversal of epigenetic changes associated with pituitary adenomas.

An investigation into the role of dendrimers as potential enhancers of the dermal delivery of topically applied chlorhexidine
Thesis
(2013). An investigation into the role of dendrimers as potential enhancers of the dermal delivery of topically applied chlorhexidine

The reduction of bacteria on the skin results in prophylactic and therapeutic benefits by reducing the occurrence of skin infections. Currently, chlorhexidine digluconate, a conventional topical antiseptic, permeates the skin poorly leaving viable op... Read More about An investigation into the role of dendrimers as potential enhancers of the dermal delivery of topically applied chlorhexidine.

The association between non-specific factors and response to primary care treatments for low back pain: a synthesis of evidence
Thesis
to primary care treatments for low back pain: a synthesis of evidence

Findings from randomised controlled trials (RCTs) on primary care treatments for non-specific low back pain (NSLBP) often show modest or non-significant differences in responses to treatments. The overall response to treatment within arms, however, i... Read More about The association between non-specific factors and response to primary care treatments for low back pain: a synthesis of evidence.

The role of coping in primary care low back pain patients
Thesis
(2011). The role of coping in primary care low back pain patients

Low back pain affects a large proportion of the general population. For some individuals, back pain becomes chronic, complex and difficult to treat effectively, with patients reporting continued pain and disability. A biopsychosocial framework has be... Read More about The role of coping in primary care low back pain patients.

Deciding to consult the general practitioner for joint pain: a choice-based conjoint analysis study
Thesis
(2013). Deciding to consult the general practitioner for joint pain: a choice-based conjoint analysis study

A substantial proportion of older adults with non inflammatory joint pain do not consult their general practitioner (GP) despite apparent clinical need. This thesis describes the development, execution, and interpretation of an original study using c... Read More about Deciding to consult the general practitioner for joint pain: a choice-based conjoint analysis study.

Ageing well with chronic pain in rural environments; a mixed methods exploratory study
Thesis
(2017). Ageing well with chronic pain in rural environments; a mixed methods exploratory study

Over half of the United Kingdom (UK) population, aged 75 or over, experience chronic pain. Chronic pain can negatively affect activities of daily living, quality of life and an individual’s ability to maintain an independent lifestyle. UK rural popul... Read More about Ageing well with chronic pain in rural environments; a mixed methods exploratory study.

Identification, semi-synthesis and evaluation of anti-ovarian cancer compounds from plants used in traditional medicines
Thesis
(2017). Identification, semi-synthesis and evaluation of anti-ovarian cancer compounds from plants used in traditional medicines

Ovarian cancer is the second leading cause of death among women in the gynaecological category of cancers. The current post surgery treatment which involves the use of platinum-based therapy with its attendant adverse drug-resistance often results in... Read More about Identification, semi-synthesis and evaluation of anti-ovarian cancer compounds from plants used in traditional medicines.

Quality indicators for the care of osteoarthritis in general practice: identification, synthesis, and implementation
Thesis
(2017). Quality indicators for the care of osteoarthritis in general practice: identification, synthesis, and implementation

Background
Previous studies have demonstrated suboptimal management of care for osteoarthritis (OA). The objectives of this study were to (i) identify indicators of quality of care for OA in general practice, (ii) measure quality of care using routi... Read More about Quality indicators for the care of osteoarthritis in general practice: identification, synthesis, and implementation.

Preparation and evaluation of hybrid gold-iron oxide nanoparticles as a multifunctional platform for diagnosis and therapy of pancreatic cancer
Thesis
Malekigorji, M. (2016). Preparation and evaluation of hybrid gold-iron oxide nanoparticles as a multifunctional platform for diagnosis and therapy of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is the most common epithelial, exocrine pancreatic malignancy. Gemcitabine, as the only chemotherapy clinically available for pancreatic cancer, proves effective only in 23.8% of patients. Recently, iron oxide-... Read More about Preparation and evaluation of hybrid gold-iron oxide nanoparticles as a multifunctional platform for diagnosis and therapy of pancreatic cancer.

Improving Leukaemia diagnosis and management with Selected Ion Flow Tube Mass Spectrometry and vibrational spectroscopy techniques
Thesis
Rashid Siddique, M. (2017). Improving Leukaemia diagnosis and management with Selected Ion Flow Tube Mass Spectrometry and vibrational spectroscopy techniques

Leukaemia is 11th most common cancer worldwide, associated with poor prognosis. The 10 years’ survival for leukaemia is between 44% - 47%. One of the main reasons for this is the disease being diagnosed in late stages. Most of leukaemia screening tec... Read More about Improving Leukaemia diagnosis and management with Selected Ion Flow Tube Mass Spectrometry and vibrational spectroscopy techniques.

Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer
Thesis
(2016). Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer

Autotaxin is an extracellular phospholipase D that catalyses the hydrolysis of lysophosphatidyl choline (LPC) to bioactive lipid lysophosphatidic acid (LPA). LPA has been implicated in many pathological processes relevant to cancer, including cell mi... Read More about Synthesis and biological evaluation of polymer-autotaxin inhibitor conjugates for the treatment of ovarian cancer.

A role for the human mesenchymal stem cell secretome in attenuation of cytokine-induced apoptosis in pancreatic beta cells
Thesis
Al-Azzawi, B. (2017). A role for the human mesenchymal stem cell secretome in attenuation of cytokine-induced apoptosis in pancreatic beta cells

Diabetes is a lifelong condition caused by an inability of the body to break down glucose due to a defect in either insulin synthesis or the target cells becoming resistant to secreted insulin. There are two main types of diabetes, type 1 diabetes me... Read More about A role for the human mesenchymal stem cell secretome in attenuation of cytokine-induced apoptosis in pancreatic beta cells.

Exploring the effect of dopaminergic medication on recognition memory in idiopathic Parkinson’s disease: Trials and Challenges.
Thesis
Shepherd, T. A. (2016). Exploring the effect of dopaminergic medication on recognition memory in idiopathic Parkinson’s disease: Trials and Challenges

Parkinson’s disease (PD) is caused by the degeneration of dopaminergic cells in the substantia nigra (SN) and ventral tegmental area (VTA) of the midbrain. Until recently, PD research predominantly focused on motor symptoms which are synonymous with... Read More about Exploring the effect of dopaminergic medication on recognition memory in idiopathic Parkinson’s disease: Trials and Challenges..

Investigation of the BH3-mimetics navitoclax and obatoclax as potential therapeutics for ovarian cancer
Thesis
Stamelos, V. A. (2014). Investigation of the BH3-mimetics navitoclax and obatoclax as potential therapeutics for ovarian cancer

Ovarian cancer is treated in most cases with a combination of surgery and chemotherapy.
However, despite the overall improvement in survival rates, over the last 30 years there has not been a break-through therapeutic development. Following first-li... Read More about Investigation of the BH3-mimetics navitoclax and obatoclax as potential therapeutics for ovarian cancer.

Engineering Surfaces to Control Neurogenesis
Thesis
Wright, R. (2015). Engineering Surfaces to Control Neurogenesis

Producing therapeutic neural cell populations in vitro to treat neurodegenerative diseases is a key aim of regenerative medicine. Various protocols have been developed to produce a wide range of neural cell types in vitro, but the protocols are labou... Read More about Engineering Surfaces to Control Neurogenesis.

Developing a Customised Programme of Exercise to Reduce Fatigue and Improve Societal Participation in Kuwaiti Patients with Multiple Sclerosis
Thesis
Ashour, A. F. (2016). Developing a Customised Programme of Exercise to Reduce Fatigue and Improve Societal Participation in Kuwaiti Patients with Multiple Sclerosis

Background: It is now widely accepted that physical training therapy is more reliable and effective than medication in improving fatigue in patients with Multiple Sclerosis (MS). However, efforts are still being made to maximise the benefits of train... Read More about Developing a Customised Programme of Exercise to Reduce Fatigue and Improve Societal Participation in Kuwaiti Patients with Multiple Sclerosis.

Chronic cough: An exploration of impact and an evaluation of non-pharmacological management in adults
Thesis
Chamberlain Mitchell, S. A. F. (2016). Chronic cough: An exploration of impact and an evaluation of non-pharmacological management in adults

Chronic cough is defined as a cough that lasts for greater than 8 weeks in duration and has been estimated to have a prevalence of 11-13% of the population. Limited research has been conducted exploring its impact on the wider community. In up to 42%... Read More about Chronic cough: An exploration of impact and an evaluation of non-pharmacological management in adults.

Improving the management of lung cancer using mass spectrometry and spectroscopy techniques
Thesis
Rutter, A. V. (2016). Improving the management of lung cancer using mass spectrometry and spectroscopy techniques

Lung cancer is a worldwide health problem associated with poor prognosis. The survival at 5 years remains between 5% and 15% in spite of the development of new drugs. One of the main reasons for this is the disease being diagnosed in late stages when... Read More about Improving the management of lung cancer using mass spectrometry and spectroscopy techniques.

A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum
Thesis
Ullah, I. (2016). A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum

Massive screens of chemical libraries for antimalarial activity have identified thousands of compounds that exhibit sub-micromolar potency against the blood stage of the malaria parasite Plasmodium falciparum. Triaging these compounds to establish pr... Read More about A novel in vitro bioluminescence rate-of-kill (BRoK) assay to study the pharmacodynamic properties of antimalarial drug action in Plasmodium falciparum.

Occupational therapy for the upper limb after stroke: implementing evidence-based constraint induced movement therapy into practice
Thesis
implementing evidence-based constraint induced movement therapy into practice

Background
Constraint induced movement therapy (CIMT), an intervention to increase upper limb (UL) function post-stroke, is not used routinely by therapists in the United Kingdom; reasons for this are unknown. Using the Promoting Action on Research... Read More about Occupational therapy for the upper limb after stroke: implementing evidence-based constraint induced movement therapy into practice.