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Managing work participation for people with rheumatic and musculoskeletal diseases. (2020)
Journal Article
Wilkie, R., & Lynch, M. (2020). Managing work participation for people with rheumatic and musculoskeletal diseases. https://doi.org/10.1016/j.berh.2020.101517

Improving work participation for individuals with rheumatic and musculoskeletal diseases (RMDs), has gained increasing interest over the last 10 years. New approaches are based upon increasing adoption of a biopsychosocial approach to improving work... Read More about Managing work participation for people with rheumatic and musculoskeletal diseases..

Pharmacological properties of rutin and its potential uses for Alzheimer’s disease. (2020)
Journal Article
Chen, R., Hassan, H., Rawlinson, C., & Morgan, D. (2020). Pharmacological properties of rutin and its potential uses for Alzheimer’s disease. Journal of Experimental Stroke and Translational Medicine, 13(2), 1-12

Rutin, a flavonoid with a wide range of biological activities, has a long history of use in nutritional supplements owing to its action against oxidative stress, inflammation, and hyperglycemia. Because of its pharmacological properties such as antio... Read More about Pharmacological properties of rutin and its potential uses for Alzheimer’s disease..

Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal. (2020)
Journal Article
(2020). Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal. BMJ, https://doi.org/10.1136/bmj.m1328

OBJECTIVE: To review and critically appraise published and preprint reports of prediction models for diagnosing coronavirus disease 2019 (covid-19) in patients with suspected infection, for prognosis of patients with covid-19, and for detecting peopl... Read More about Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal..

Pain in community-dwelling people with dementia: a mixed methods study (2020)
Thesis
Bullock, L. (2020). Pain in community-dwelling people with dementia: a mixed methods study. (Thesis). Keele University

Introduction
Dementia and pain are common in older adults. Clinical features of dementia such as communication difficulties may complicate the identification, assessment, and management of pain. This thesis therefore aimed to investigate pain ident... Read More about Pain in community-dwelling people with dementia: a mixed methods study.

Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core (2020)
Thesis
Jihad, T. W. J. (2020). Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core. (Thesis). Keele University

Calix[4]resorcinarenes functionalised with glycosidic ligands on their lower rim have received little interest compared to analogues bearing carbohydrates on the upper rim. In this study, series of novel macrocyclic glycoclusters bearing mono- or dis... Read More about Development of water-soluble tetravalent glycoclusters based around a calix[4]resorcinarene core.

An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering (2020)
Thesis
Foster, N. C. (2020). An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering. (Thesis). Keele University

Articular cartilage is prone to degradation as a result of aging, disease and injury, which can lead to the onset of osteoarthritis (OA). The avascular nature of the tissue renders its endogenous repair capacity notoriously poor and its aneural natur... Read More about An investigation of protocols for 2D and 3D models of human embryonic stem cell chondrogenic differentiation and tissue engineering.

Bleeding complications after hospital discharge following acute coronary syndrome: an electronic health records database study (2020)
Thesis
Ismail, N. (2020). Bleeding complications after hospital discharge following acute coronary syndrome: an electronic health records database study. (Thesis). Keele University

The management of acute coronary syndrome (ACS) with antithrombotic medication achieves the desired goal of reducing the risk of future ischaemic events. However, these reductions are accompanied by increased risk of bleeding complications. A systema... Read More about Bleeding complications after hospital discharge following acute coronary syndrome: an electronic health records database study.

Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes (2020)
Thesis
Osborn, A. H. (2020). Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes. (Thesis). Keele University

Fibrocyte degeneration in the cochlear lateral wall is one possible pathology of age-related metabolic hearing loss (presbyacusis). Fibrocytes play a role in potassium recycling and maintenance of the endocochlear potential (EP). It has been proposed... Read More about Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes.

Expression of ALS-linked SOD1 mutation in motoneurons or myotubes induces differential effects on neuromuscular function in vitro (2020)
Journal Article
Benlefki, S., Sanchez-Vicente, A., Milla, V., Lucas, O., Soulard, C., Younes, R., …Hilaire, C. (2020). Expression of ALS-linked SOD1 mutation in motoneurons or myotubes induces differential effects on neuromuscular function in vitro. Neuroscience, 435, 33-43. https://doi.org/10.1016/j.neuroscience.2020.03.044

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that selectively affects upper and lower motoneurons. Dismantlement of the neuromuscular junction (NMJ) is an early pathological hallmark of the disease whose cellular origin re... Read More about Expression of ALS-linked SOD1 mutation in motoneurons or myotubes induces differential effects on neuromuscular function in vitro.

Rapid changes in the ATG5-ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT) (2020)
Journal Article
Crowley, E., Leung, E., Reynisson, J., & Richardson, A. (2020). Rapid changes in the ATG5-ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT). The FEBS Journal, 287(22), 4917-4932. https://doi.org/10.1111/febs.15275

Autophagy plays a role in several human diseases, but each of the current methods to measure autophagy have significant drawbacks. ATG5 and ATG16L1 are regulators necessary for autophagy therefore, drugs which inhibit the interaction of these protein... Read More about Rapid changes in the ATG5-ATG16L1 complex following nutrient deprivation measured using NanoLuc Binary Technology (NanoBIT).

How, in what contexts, and why do quality dashboards lead to improvements in care quality in acute hospitals? Protocol for a realist feasibility evaluation. (2020)
Journal Article
Mamas. (2020). How, in what contexts, and why do quality dashboards lead to improvements in care quality in acute hospitals? Protocol for a realist feasibility evaluation. BMJ Open, e033208 - ?. https://doi.org/10.1136/bmjopen-2019-033208

INTRODUCTION: National audits are used to monitor care quality and safety and are anticipated to reduce unexplained variations in quality by stimulating quality improvement (QI). However, variation within and between providers in the extent of engage... Read More about How, in what contexts, and why do quality dashboards lead to improvements in care quality in acute hospitals? Protocol for a realist feasibility evaluation..

Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications (2020)
Journal Article
Finch, L., Harris, S., Solomou, G., Sen, J., Tzerakis, N., Emes, R. D., …Chari, D. M. (2020). Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications. Journal of Controlled Release, 321, 553-563. https://doi.org/10.1016/j.jconrel.2020.02.028

High transplant cell loss is a major barrier to translation of stem cell therapy for pathologies of the brain and spinal cord. Encapsulated delivery of stem cells in biomaterials for cell therapy is gaining popularity but experimental research has ov... Read More about Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications.

ACTN3's R577X Single Nucleotide Polymorphism Allele Distribution Differs Significantly in Professional Football Players according to Their Field Position. (2020)
Journal Article
(2020). ACTN3's R577X Single Nucleotide Polymorphism Allele Distribution Differs Significantly in Professional Football Players according to Their Field Position. Medical Principles and Practice, 92 - 97. https://doi.org/10.1159/000509089

INTRODUCTION: Football is characterised by intermittent high-intensity efforts varying according to the field position of a player. We aimed to ascertain whether polymorphisms in the ACTN3 gene are associated with different playing positions in elite... Read More about ACTN3's R577X Single Nucleotide Polymorphism Allele Distribution Differs Significantly in Professional Football Players according to Their Field Position..

Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study. (2020)
Journal Article
Pan, S., Tsakok, T., Dand, N., Lonsdale, D. O., Loeff, F. C., Bloem, K., …Study Group, B. (2020). Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study. Clinical and Translational Science, 13(2), 400 - 409. https://doi.org/10.1111/cts.12725

Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real-world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first-line... Read More about Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study..

Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care (OPTIMISE-HFpEF): Rationale and Protocol for a Multi-Method Study (2020)
Journal Article
Chew-Graham. (2020). Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care (OPTIMISE-HFpEF): Rationale and Protocol for a Multi-Method Study. British Journal of General Practice Open (BJGP Open), https://doi.org/10.3399/bjgpopen19X101675

Background: Heart failure with preserved ejection fraction (HFpEF) is less well understood than heart failure with reduced ejection fraction (HFrEF), with greater diagnostic difficulty and management uncertainty. Aim: Our primary aim is to develop an... Read More about Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care (OPTIMISE-HFpEF): Rationale and Protocol for a Multi-Method Study.

A scoping literature review of studies assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions (2020)
Journal Article
Healy, A., Farmer, S., Eddison, N., Allcock, J., Perry, T., Pandyan, A., & Chockalingam, N. (2020). A scoping literature review of studies assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions. Disability and Rehabilitation: Assistive Technology, 15(1), 60-66. https://doi.org/10.1080/17483107.2018.1523953

PURPOSE
Approximately 1.5% of the world's population (~100 million people) need a prosthesis/orthosis. The objective of the study was to establish an overview of the literature that has examined prosthetic and orthotic interventions with a view to i... Read More about A scoping literature review of studies assessing effectiveness and cost-effectiveness of prosthetic and orthotic interventions.

Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia (2019)
Thesis
Bratt, J. A. (2019). Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/415216

Bronchopulmonary dysplasia (BPD) is a neonatal disease affecting the lungs of premature infants. Prematurely born infants have under-developed lungs and require invasive ventilation technologies to provide sufficient oxygen for survival. Artificial v... Read More about Developing an alveolar model to test the regenerative potential of placental membrane mesenchymal stem cells in bronchopulmonary dysplasia.

If it's 'only' asthma, why are children still dying? (2019)
Journal Article
(2019). If it's 'only' asthma, why are children still dying?. Archives of Disease in Childhood, 494 - 498. https://doi.org/10.1136/archdischild-2019-318215

Outcomes for children with asthma in the UK continue to lag behind other European countries. Mortality remains unacceptably high and in contrast to adults with asthma, most deaths occur in the 1 in 20 children with asthma who have severe asthma. Desp... Read More about If it's 'only' asthma, why are children still dying?.