Impact of Infliximab and Etanercept Biosimilars on Biological Disease-Modifying Antirheumatic Drugs Utilisation and NHS Budget in the UK. (2017)
Journal Article
(2017). Impact of Infliximab and Etanercept Biosimilars on Biological Disease-Modifying Antirheumatic Drugs Utilisation and NHS Budget in the UK. BioDrugs, 533 - 544. https://doi.org/10.1007/s40259-017-0252-3

OBJECTIVE: Biological disease-modifying antirheumatic drugs (bDMARDs) are effective but expensive options for treating rheumatoid arthritis. The introduction of infliximab and etanercept biosimilars presents a significant potential cost saving in a f... Read More about Impact of Infliximab and Etanercept Biosimilars on Biological Disease-Modifying Antirheumatic Drugs Utilisation and NHS Budget in the UK..

Factors Influencing Allopurinol Initiation in Primary Care. (2017)
Journal Article
Roddy, Mallen, Clarson, Belcher, & Hider. (2017). Factors Influencing Allopurinol Initiation in Primary Care. Annals of Family Medicine, 15(6), 557 - 560. https://doi.org/10.1370/afm.213

Despite guidance on appropriate initiation, urate-lowering therapy is prescribed for only a minority of patients with gout. Electronic health records for 8,142 patients with gout were used to investigate the effect of age, sex, comorbidities, number... Read More about Factors Influencing Allopurinol Initiation in Primary Care..

In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line (2017)
Journal Article
(2017). In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. https://doi.org/10.1002/jin2.32

The antiretroviral drug efavirenz displays many desirable pharmacokinetic properties such as a long half-life enabling once daily dosing but suffers from central nervous system safety issues. Various nanotechnologies have been explored to mitigate so... Read More about In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line.

Nanotechnologies in Pancreatic Cancer Therapy. (2017)
Journal Article
Manzur, A., Hoskins, C., Oluwasanmi, A., Moss, D., & Curtis, A. (2017). Nanotechnologies in Pancreatic Cancer Therapy. Pharmaceutics, https://doi.org/10.3390/pharmaceutics9040039

Pancreatic cancer has been classified as a cancer of unmet need. After diagnosis the patient prognosis is dismal with few surviving over 5 years. Treatment regimes are highly patient variable and often the patients are too sick to undergo surgical re... Read More about Nanotechnologies in Pancreatic Cancer Therapy..

Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy (2017)
Journal Article
Oluwasanmi, A., Al-Shakarchi, W., Manzur, A., Aldebasi, M. H., Elsini, R. S., Albusair, M. K., Haxton, K. J., Curtis, A. D., & Hoskins, C. (2017). Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy. Journal of Controlled Release, 355-364. https://doi.org/10.1016/j.jconrel.2017.09.027

Hybrid nanoparticles (HNPs) have shown huge potential as drug delivery vehicles for pancreatic cancer. Currently, the first line treatment, gemcitabine, is only effective in 23.8% of patients. To improve this, a thermally activated system was develop... Read More about Diels Alder-mediated release of gemcitabine from hybrid nanoparticles for enhanced pancreatic cancer therapy.

The potential clinical benefits of medicines optimisation through comprehensive geriatric assessment, carried out by secondary care geriatricians, in a general practice care setting in North Staffordshire, UK: a feasibility study. (2017)
Journal Article
(2017). The potential clinical benefits of medicines optimisation through comprehensive geriatric assessment, carried out by secondary care geriatricians, in a general practice care setting in North Staffordshire, UK: a feasibility study. BMJ Open, e015278 - ?. https://doi.org/10.1136/bmjopen-2016-015278

OBJECTIVES: To evaluate the feasibility and potential clinical benefits of medicines optimisation through comprehensive geriatric assessment (CGA) of frail patients with multiple conditions, by secondary care geriatricians in a general practice care... Read More about The potential clinical benefits of medicines optimisation through comprehensive geriatric assessment, carried out by secondary care geriatricians, in a general practice care setting in North Staffordshire, UK: a feasibility study..

EAHP statements survey 2016: sections 1, 3 and 4 of the European Statements of Hospital Pharmacy (2017)
Journal Article
(2017). EAHP statements survey 2016: sections 1, 3 and 4 of the European Statements of Hospital Pharmacy. European Journal of Hospital Pharmacy, 258 -265. https://doi.org/10.1136/ejhpharm-2017-001334

Background
The 2016 European Association of Hospital Pharmacists (EAHP) Statements survey builds on previous surveys and focuses on sections 1, 3 and 4.

Objective To collect statistical data about the level of implementation of the Statements, an... Read More about EAHP statements survey 2016: sections 1, 3 and 4 of the European Statements of Hospital Pharmacy.

Patient's Understanding and Attititudes Towards Infliximab and Etanercept Biosimilars (2017)
Journal Article
(2017). Patient's Understanding and Attititudes Towards Infliximab and Etanercept Biosimilars. BioDrugs, 1-8. https://doi.org/10.1007/s40259-017-0238-1

Background
Infliximab and etanercept biosimilars present significant potential cost savings to the NHS. Patients need to be involved in the decision to use these medicines but there is a limited published literature on their knowledge and attitudes... Read More about Patient's Understanding and Attititudes Towards Infliximab and Etanercept Biosimilars.

Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate (2017)
Journal Article
Watkinson. (2017). Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/AAC.00105-17

Tenofovir disoproxil fumarate (TDF), a prodrug of tenofovir, has oral bioavailability (25%) limited by intestinal transport (P-glycoprotein), and intestinal degradation (carboxylesterase). However, the influence of luminal pancreatic enzymes is not f... Read More about Simulating Intestinal Transporter and Enzyme Activity in a Physiologically Based Pharmacokinetic Model for Tenofovir Disoproxil Fumarate.

Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer (2017)
Journal Article
de Wolf, E., Abdullah, M. I., Jones, S. M., Menezes, K., Moss, D. M., Drijfhout, F., Hart, S., Hoskins, C., Stronach, E. A., & Richardson, A. (2017). Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer. Scientific reports, https://doi.org/10.1038/s41598-017-05595-4

Pre-clinical and retrospective studies of patients using statins to reduce plasma cholesterol have suggested that statins may be useful to treat cancer. However, prospective clinical trials have yet to demonstrate significant efficacy. We have previo... Read More about Dietary geranylgeraniol can limit the activity of pitavastatin as a potential treatment for drug-resistant ovarian cancer.

Knowledge, attitude and practice of healthcare professionals towards infliximab and insulin glargine biosimilars: result of a UK web-based survey (2017)
Journal Article
Chapman, S. R., Fitzpatrick, R. W., & Aladul, M. I. (2017). Knowledge, attitude and practice of healthcare professionals towards infliximab and insulin glargine biosimilars: result of a UK web-based survey. BMJ Open, 7(6), e016730 - ?. https://doi.org/10.1136/bmjopen-2017-016730

OBJECTIVE: To investigate healthcare professionals' knowledge and attitudes towards infliximab and insulin glargine biosimilars and the factors influencing their prescribing. Then, to compare healthcare professionals' attitudes with the utilisation o... Read More about Knowledge, attitude and practice of healthcare professionals towards infliximab and insulin glargine biosimilars: result of a UK web-based survey.

A retrospective cohort study into the relationship between oral corticosteroids and the incidence of glaucoma and cataracts in COPD patients (2017)
Presentation / Conference Contribution
Richardson, C., Frisher, M., Johal, J., Jenkins, D., & Chapman, S. A retrospective cohort study into the relationship between oral corticosteroids and the incidence of glaucoma and cataracts in COPD patients

Drug development: Lessons from nature. (2017)
Other
(2017). Drug development: Lessons from nature

Natural products have been acknowledged for numerous years as a vital source of active ingredients in therapeutic agents. In particular, the use of active ingredients derived from plants for use in microbial natural products have long been used befor... Read More about Drug development: Lessons from nature..

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis (2017)
Journal Article
(2017). Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.6b01718

A high-throughput screen (HTS) was undertaken against the respiratory chain dehydrogenase component, NADH:menaquinone oxidoreductase (Ndh) of Mycobacterium tuberculosis (Mtb). The 11000 compounds were selected for the HTS based on the known phenothia... Read More about Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.

Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice (2017)
Journal Article
Chen. (2017). Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice. Brain, Behavior, and Immunity, 226-275. https://doi.org/10.1016/j.bbi.2017.04.013

Abstract High altitude cerebral edema (HACE) is a life-threatening illness that develops during the rapid ascent to high altitudes, but its underlying mechanisms remain unclear. Growing evidence has implicated inflammation in the susceptibility to an... Read More about Hypoxia augments LPS-induced inflammation and triggers high altitude cerebral edema in mice.

Pharmacy staff perspectives on the role of community pharmacy in the provision of first aid and responding to emergencies: a qualitative study. (2017)
Presentation / Conference
Liaskou, M., White, S., Moss, G., Ratcliffe, N., & Cook, J. (2017, April). Pharmacy staff perspectives on the role of community pharmacy in the provision of first aid and responding to emergencies: a qualitative study. Presented at Health Services Research and Pharmacy Practice Conference, University of Nottingham, UK

No abstract

Trainee perceptions on the usefulness of Virtual Patients and other support during the pre-registration year. (2017)
Journal Article
White, S. (2017). Trainee perceptions on the usefulness of Virtual Patients and other support during the pre-registration year. International Journal of Pharmacy Practice, 33 - 34. https://doi.org/10.1111/ijpp.12367

No abstract

UKCPA viewpoint: Yellow Card reporting (2017)
Journal Article
Gunnell. (2017). UKCPA viewpoint: Yellow Card reporting

Effectiveness of medicines authentication technology to detect counterfeit, recalled and expired medicines: a two-stage quantitative secondary care study. (2016)
Journal Article
(2016). Effectiveness of medicines authentication technology to detect counterfeit, recalled and expired medicines: a two-stage quantitative secondary care study. BMJ Open, e013837 - ?. https://doi.org/10.1136/bmjopen-2016-013837

OBJECTIVES: To identify the authentication and detection rate of serialised medicines using medicines authentication technology. DESIGN AND INTERVENTION: 4192 serialised medicines were entered into a hospital dispensary over two separate 8-week stage... Read More about Effectiveness of medicines authentication technology to detect counterfeit, recalled and expired medicines: a two-stage quantitative secondary care study..

Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation (2016)
Journal Article
(2016). Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/AAC.01841-16

Adequate concentrations of efavirenz in the central nervous system (CNS) are necessary to suppress viral replication, but high concentrations may increase the likelihood of CNS adverse drug reactions. The aim of this investigation was to evaluate the... Read More about Efavirenz Is Predicted To Accumulate in Brain Tissue: an In Silico, In Vitro, and In Vivo Investigation.