3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells. (2021)
Journal Article
Camilla Ciardulli, M., Lovecchio, J., Scala, P., Pavel Lamparelli, E., Dale, T., Giudice, V., …Della Porta, G. (2021). 3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells. Pharmaceutics, 13(9), https://doi.org/10.3390/pharmaceutics13091448

The present work described a bio-functionalized 3D fibrous construct, as an interactive teno-inductive graft model to study tenogenic potential events of human mesenchymal stem cells collected from Wharton's Jelly (hWJ-MSCs). The 3D-biomimetic and bi... Read More about 3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells..

Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors (2021)
Journal Article
(2021). Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors. Journal of Patient Safety and Risk Management, 214 - 220. https://doi.org/10.1177/25160435211036672

Background Prescribing errors are common, occurring in 7% of in-patient medication orders in UK hospitals. Foundation Year 1 (F1) doctors have reported a lack of feedback on prescribing as a cause of errors. Aim To evaluate the effect of implementing... Read More about Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors.

Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy (2021)
Journal Article
Bowerman. (2021). Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy. JCI insight, 1-24. https://doi.org/10.1172/jci.insight.149446

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure. We aimed to identify novel treatments to alleviate muscle pathology... Read More about Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy.

The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins (2021)
Thesis
Njoroge, W. (2021). The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins. (Thesis). Keele University

Cardiovascular disease (CVD) has been identified as the leading cause of mortality in westernised society. The triggering factor for the majority of cardiovascular diseases is atherosclerosis, defined as an accumulation of fatty materials in the vasc... Read More about The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins.

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. (2021)
Journal Article
Reynisson, J. (2021). Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. Oncology and Therapy,

Cancer chemotherapy sensitizers hold the key to maximizing the potential of standard anticancer treatments. We have a long-standing interest in developing and validating inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) as ch... Read More about Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs..

Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students (2021)
Journal Article
White, S., Gifford, A., & Frisher, M. (2021). Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students. Pharmacy Education, 21(1), 56 - 64. https://doi.org/10.46542/pe.2021.211.5664

Description: Students in small groups designed, delivered and evaluated real-life health promotion campaigns in the local community. A peer assessed component was included from the fifth cohort onwards. Evaluation: Six successive cohorts of pharmacy... Read More about Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students.

DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells (2021)
Journal Article
Kitchen. (2021). DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells. Cells, 1032 - 1032. https://doi.org/10.3390/cells10051032

The application of physiological oxygen (physoxia) concentrations is becoming increasingly commonplace within a mammalian stem cell culture. Human mesenchymal stem cells (hMSCs) attract widespread interest for clinical application due to their unique... Read More about DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells.

Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review. (2021)
Journal Article
Farooq, S. (2021). Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review. Chronic Respiratory Disease, -. https://doi.org/10.1177/14799731211003937

We aimed to review the literature on interventions for treating Common Mental Disorders (CMD) in people with Tuberculosis (TB). We followed PRISMA guidelines and the protocol was registered at PROSPERO. The electronic databases (PsycInfo, CINAHL, Med... Read More about Pharmacological or non-pharmacological interventions for treatment of common mental disorders associated with Tuberculosis: A systematic review..

Isolated medial patellofemoral ligament reconstruction for recurrent patellofemoral instability: analysis of outcomes and risk factors. (2021)
Journal Article
(2021). Isolated medial patellofemoral ligament reconstruction for recurrent patellofemoral instability: analysis of outcomes and risk factors. Journal of Orthopaedic Surgery and Research, 239 - ?. https://doi.org/10.1186/s13018-021-02383-9

BACKGROUND: The medial patellofemoral ligament (MPFL) is always damaged after patellar dislocation. In selected patients, MPFL reconstruction is necessary to restore a correct patellar tracking. Despite the large number of different techniques report... Read More about Isolated medial patellofemoral ligament reconstruction for recurrent patellofemoral instability: analysis of outcomes and risk factors..

Electrospun Shape Memory Polymer Micro-/Nanofibers and Tailoring Their Roles for Biomedical Applications (2021)
Journal Article
Zare, M., Davoodi, P., & Ramakrishna, S. (2021). Electrospun Shape Memory Polymer Micro-/Nanofibers and Tailoring Their Roles for Biomedical Applications. Nanomaterials, 11(4), 1 - 25. https://doi.org/10.3390/nano11040933

Shape memory polymers (SMPs) as a relatively new class of smart materials have gained increasing attention in academic research and industrial developments (e.g., biomedical engineering, aerospace, robotics, automotive industries, and smart textiles)... Read More about Electrospun Shape Memory Polymer Micro-/Nanofibers and Tailoring Their Roles for Biomedical Applications.

Pharmacy graduates' perceived impact of long-term undergraduate use of an ethical decision-support tool on their early practice. (2021)
Journal Article
White, S., Allinson, M., & Black, P. (2021). Pharmacy graduates' perceived impact of long-term undergraduate use of an ethical decision-support tool on their early practice. Currents in Pharmacy Teaching and Learning, 13(7), 760 - 769. https://doi.org/10.1016/j.cptl.2021.03.001

INTRODUCTION: Values-based practice is an important concept within healthcare decision-making that sits alongside evidence-based practice. Values Exchange (Vx) (http://www.vxcommunity.com) is an online tool that supports the development of ethical an... Read More about Pharmacy graduates' perceived impact of long-term undergraduate use of an ethical decision-support tool on their early practice..

Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation (2021)
Journal Article
Curtis, A., Alsuraifi, A., Mathew, E., Lamprou, D. A., & Hoskins, C. (2021). Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation. International Journal of Pharmaceutics, 601, Article ARTN 120570. https://doi.org/10.1016/j.ijpharm.2021.120570

Thermally active polymers, can respond structurally to temperature changes, making them interesting as potential drug delivery vehicles. Polymers of N-(3-aminopropyl) methacrylamide hydrochloride (APMA) are cationic with primary amine groups in their... Read More about Thermally reactive N-(2-hydroxypropyl)methacrylamide (HPMA) amphiphiles for drug solubilisation.

A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors (2021)
Thesis
Odingo, M. O. (2021). A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors. (Thesis). Keele University

Introduction
A new class of lipid lowering agent Proprotein Convertase Subtilisin/Kexin Type 9 inhibitors (PCSK9) was launched in 2015 for the treatment of heterozygous familial hypercholesterolemia (HeFH) in combination with statin therapy. There a... Read More about A multi-methods study of the factors influencing the adoption of proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors.

Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors. (2021)
Journal Article
Reynisson. (2021). Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors. Molecules, https://doi.org/10.3390/molecules26071945

A new type of berberine derivatives was obtained by the reaction of berberrubine with aliphatic sulfonyl chlorides. The new polycyclic compounds have a sultone ring condensed to C and D rings of a protoberberine core. The reaction conditions were dev... Read More about Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors..

Superior outcomes with Argatroban for heparin-induced thrombocytopenia: a Bayesian network meta-analysis (2021)
Journal Article
(2021). Superior outcomes with Argatroban for heparin-induced thrombocytopenia: a Bayesian network meta-analysis. International Journal of Clinical Pharmacy, https://doi.org/10.1007/s11096-021-01260-z

Background Argatroban, lepirudin, desirudin, bivalirudin, and danaparoid are commonly used to manage heparin-induced thrombocytopenia related complications. However, the most suitable drug for this condition still remains controversial. Aim of the re... Read More about Superior outcomes with Argatroban for heparin-induced thrombocytopenia: a Bayesian network meta-analysis.

Advances in Anticancer Drug Discovery (2021)
Journal Article
Reynisson. (2021). Advances in Anticancer Drug Discovery. Molecules, https://doi.org/10.3390/molecules26071821

Editorial.

Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier (2021)
Journal Article
Dale, T., Forsyth, N., & Maffulli, N. (2021). Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier. Pharmaceutics,

Tissue engineering strategies can be relevant for cartilage repair and regeneration. A collagen matrix was functionalized with the addition of poly-lactic-co-glycolic acid microcarriers (PLGA-MCs) carrying a human Transforming Growth Factor ß1 (hTFG-... Read More about Chondrogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells in a Perfused Collagen Hydrogel Functionalized with hTGF-ß1-Releasing PLGA Microcarrier.

What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline? (2021)
Journal Article
Mallen. (2021). What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?. Rheumatology, https://doi.org/10.1093/rheumatology/keab254

OBJECTIVES: To examine incidence of treatment changes due to abnormal blood-test results and, to explore rates of treatment changes due to liver, kidney and haematological blood-test abnormalities in autoimmune rheumatic diseases (AIRD) treated with... Read More about What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.

ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study (2021)
Journal Article
Mamas, & Mallen. (2021). ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study. Rheumatology, https://doi.org/10.1093/rheumatology/keab234

OBJECTIVES: To examine the association between ß-blocker prescription and first primary-care consultation for knee osteoarthritis (OA), hip OA, knee pain and hip pain. METHODS: Data source: Clinical Practice Research Datalink. Participants aged =40?y... Read More about ß-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study.

The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models (2021)
Journal Article
Njoroge, W., Hernández Hernández, A. C., Idris Musa, F., Butler, R., Harper, A. G. S., & Yang, Y. (2021). The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models. Pharmaceutics, 13(3), Article 340. https://doi.org/10.3390/pharmaceutics13030340

Cardiovascular disease is a major cause of death globally. This has led to significant efforts to develop new anti-thrombotic therapies or re-purpose existing drugs to treat cardiovascular diseases. Due to difficulties of obtaining healthy human bloo... Read More about The Combination of Tissue-Engineered Blood Vessel Constructs and Parallel Flow Chamber Provides a Potential Alternative to In Vivo Drug Testing Models.