Opposing effects of final population density and stress on Escherichia coli mutation rate (2018)
Journal Article
Channon. (2018). Opposing effects of final population density and stress on Escherichia coli mutation rate. ISME Journal, 2981-2987. https://doi.org/10.1038/s41396-018-0237-3

Evolution depends on mutations. For an individual genotype, the rate at which mutations arise is known to increase with various stressors (stress-induced mutagenesis-SIM) and decrease at high final population density (density-associated mutation-rate... Read More about Opposing effects of final population density and stress on Escherichia coli mutation rate.

Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development (2018)
Thesis
Hadfield, L. C. (2018). Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411146

The biologically and medically important heparan sulphate and heparin polysaccharides have previously been shown to modulate the activity of an aspartyl protease, ß-secretase (BACE1), implicated in the aetiology of Alzheimer’s disease. Research group... Read More about Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development.

The copulation behaviour of the western flower thrips (2018)
Thesis
Akinyemi, A. O. (2018). The copulation behaviour of the western flower thrips. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411431

The western flower thrips Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae) is a major pest of agricultural and horticultural importance in most parts of the world. It damages crops by feeding and transmission of viruses. There is a nee... Read More about The copulation behaviour of the western flower thrips.

Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite (2018)
Journal Article
Russo. (2018). Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite. PLoS Pathogens, https://doi.org/10.1371/journal.ppat.1007031

Parasite egress from infected erythrocytes and invasion of new red blood cells are essential processes for the exponential asexual replication of the malaria parasite. These two tightly coordinated events take place in less than a minute and are in p... Read More about Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.

Evaluation of analogues of furan-amidines as inhibitors of NQO2 (2018)
Journal Article
Russo. (2018). Evaluation of analogues of furan-amidines as inhibitors of NQO2. Bioorganic and Medicinal Chemistry Letters, 1292 - 1297. https://doi.org/10.1016/j.bmcl.2018.03.025

Inhibitors of the enzyme NQO2 (NRH: quinone oxidoreductase 2) are of potential use in cancer chemotherapy and malaria. We have previously reported that non-symmetrical furan amidines are potent inhibitors of NQO2 and here novel analogues are evaluate... Read More about Evaluation of analogues of furan-amidines as inhibitors of NQO2.

Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition (2018)
Journal Article
Russo. (2018). Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition. Proceedings of the National Academy of Sciences of the United States of America, E2801 - E2810. https://doi.org/10.1073/pnas.1707929115

Owing to the prevalence of tumor-associated macrophages (TAMs) in cancer and their unique influence upon disease progression and malignancy, macrophage-targeted interventions have attracted notable attention in cancer immunotherapy. However, tractabl... Read More about Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition.