Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study. (2024)
Journal Article
Lawford, B. J., Allison, K., Nelligan, R., Campbell, P., Hinman, R. S., Jones, S. E., …Bennell, K. L. (2024). Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study. Arthritis Care & Research, https://doi.org/10.1002/acr.25401

Explore the experiences of people with knee osteoarthritis who received a very low energy diet (VLED) and exercise program from a physiotherapist. Mixed methods study involving questionnaires (n=42) and semi-structured interviews (n=22) with randomiz... Read More about Exploring Experiences of People With Knee Osteoarthritis Who Received a Physiotherapist-Delivered Dietary Weight Loss and Exercise Intervention: A Mixed Methods Study..

Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial. (2022)
Journal Article
Holden. (2022). Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial. BMC Musculoskeletal Disorders, 733 - ?. https://doi.org/10.1186/s12891-022-05685-z

BACKGROUND: Obesity is associated with knee osteoarthritis (OA). Weight loss, alongside exercise, is a recommended treatment for individuals with knee OA and overweight/obesity. However, many patients cannot access weight loss specialists such as die... Read More about Effectiveness of a telehealth physiotherapist-delivered intensive dietary weight loss program combined with exercise in people with knee osteoarthritis and overweight or obesity: study protocol for the POWER randomized controlled trial..

EVIDENCE-INFORMED RECOMMENDATIONS TO SUPPORT IMPLEMENTATION OF BEST PRACTICE THERAPEUTIC EXERCISE FOR PEOPLE WITH KNEE AND/OR HIP OSTEOARTHRITIS: AN INTERNATIONAL CONSENSUS PROCESS (2022)
Journal Article
Holden. (2022). EVIDENCE-INFORMED RECOMMENDATIONS TO SUPPORT IMPLEMENTATION OF BEST PRACTICE THERAPEUTIC EXERCISE FOR PEOPLE WITH KNEE AND/OR HIP OSTEOARTHRITIS: AN INTERNATIONAL CONSENSUS PROCESS. Osteoarthritis and Cartilage, S402 - S403. https://doi.org/10.1016/j.joca.2022.02.541

Guidance for Implementing Best Practice Therapeutic Exercise for Patients With Knee and Hip Osteoarthritis: What Does the Current Evidence Base Tell Us? (2020)
Journal Article
Holden, M. A., Button, K., Collins, N. J., Henrotin, Y., Hinman, R. S., Larsen, J. B., …Bennell, K. (2021). Guidance for Implementing Best Practice Therapeutic Exercise for Patients With Knee and Hip Osteoarthritis: What Does the Current Evidence Base Tell Us?. Arthritis Care and Research, 73(12), 1746-1753. https://doi.org/10.1002/acr.24434

Therapeutic exercise is a recommended first‐line treatment for patients with knee and hip osteoarthritis (OA); however, there is little specific advice or practical resources to guide clinicians in its implementation. As the first in a series of proj... Read More about Guidance for Implementing Best Practice Therapeutic Exercise for Patients With Knee and Hip Osteoarthritis: What Does the Current Evidence Base Tell Us?.

Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials (2020)
Journal Article
Van Der Windt, Healey, & Holden. (2020). Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2020.02.263

Meta-analyses of randomised controlled trials (RCTs) of exercise interventions in people with knee and hip osteoarthritis (OA) provide strong evidence of, on average, a small-to-medium effect on pain and function outcomes compared to comparison inter... Read More about Moderators of the effects of exercise for hip and knee osteoarthritis: a systematic review of subgroup analyses from randomised controlled trials.

Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments (2020)
Journal Article
Paskins, Holden, Mallen, Jinks, Hawarden, & Roddy. (2020). Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments. Rheumatology, https://doi.org/10.1093/rheumatology/keaa111.125

Background
The HIT trial compared ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hydrochloride combined with best current treatment (BCT) with (i) BCT alone and (ii) an USGI of 1% lidocaine only co... Read More about Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments.

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials (2018)
Report
Hay, E., Dziedzic, K., Foster, N., Peat, G., van der Windt, D., Bartlam, B., …Croft, P. (2018). Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials. NIHR. PGfAR as project number RP-PG-0407-10386. Secretary of State for Health and Social Care

<jats:sec id="abs1-1"> <jats:title>Background</jats:title> <jats:p>Osteoarthritis (OA) is the most common long-term condition managed in UK general practice. However, care is suboptimal despite evidence that primary care and community-based intervent... Read More about Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials.

Cost-utility analysis of interventions to improve effectiveness of exercise therapy for adults with knee osteoarthritis: the BEEP trial. (2018)
Journal Article
Kigozi, J., Jowett, S., Nicholls, E., Tooth, S., Hay, E., Foster, N. E., & Holden, M. (2018). Cost-utility analysis of interventions to improve effectiveness of exercise therapy for adults with knee osteoarthritis: the BEEP trial. Rheumatology Advances in Practice, rky018 - ?. https://doi.org/10.1093/rap/rky018

Objectives: Evidence regarding the cost-effectiveness of enhancing physical therapy exercise programmes in order to improve outcomes for patients with knee OA remains unclear. This study investigates the cost-effectiveness of two enhanced physical th... Read More about Cost-utility analysis of interventions to improve effectiveness of exercise therapy for adults with knee osteoarthritis: the BEEP trial..

How Do Physical Therapists in the United Kingdom Manage Patients With Hip Osteoarthritis? Results of a Cross-Sectional Survey (2018)
Journal Article
Mallen, C., & Holden, M. (2018). How Do Physical Therapists in the United Kingdom Manage Patients With Hip Osteoarthritis? Results of a Cross-Sectional Survey. Physical Therapy, 461-470. https://doi.org/10.1093/ptj/pzy013

Background: Hip osteoarthritis (OA) is common, painful and disabling. Physical therapists have an important role in managing patients with hip OA, however little is known about their current management approach and whether it aligns with clinical gui... Read More about How Do Physical Therapists in the United Kingdom Manage Patients With Hip Osteoarthritis? Results of a Cross-Sectional Survey.

Change in physical activity level and clinical outcomes in older adults with knee pain: a secondary analysis from a randomised controlled trial (2018)
Journal Article
Holden. (2018). Change in physical activity level and clinical outcomes in older adults with knee pain: a secondary analysis from a randomised controlled trial. BMC Musculoskeletal Disorders, https://doi.org/10.1186/s12891-018-1968-z

Background
Exercise interventions improve clinical outcomes of pain and function in adults with knee pain due to osteoarthritis and higher levels of physical activity are associated with lower severity of pain and higher levels of physical functioni... Read More about Change in physical activity level and clinical outcomes in older adults with knee pain: a secondary analysis from a randomised controlled trial.

Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. (2017)
Journal Article
Van Der Windt, Holden, & Dziedzic. (2017). Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. BMJ Open, e018971 - ?. https://doi.org/10.1136/bmjopen-2017-018971

INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physic... Read More about Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol..

Quality and acceptability of measures of exercise adherence in musculoskeletal settings: a systematic review. (2016)
Journal Article
McLean, S., Holden, M. A., Potia, T., Gee, M., Mallett, R., Bhanbhro, S., …Haywood, K. (2016). Quality and acceptability of measures of exercise adherence in musculoskeletal settings: a systematic review. Rheumatology, 426-438. https://doi.org/10.1093/rheumatology/kew422

OBJECTIVE: To recommend robust and relevant measures of exercise adherence for application in the musculoskeletal field. METHOD: A systematic review of measures was conducted in two phases. Phase 1 sought to identify all reproducible measures used to... Read More about Quality and acceptability of measures of exercise adherence in musculoskeletal settings: a systematic review..

Evaluating acupuncture and standard care for pregnant women and back pain: the EASE back pilot randomised controlled trial ((ISRCTN49955124) (2016)
Journal Article
Bishop, A., Ogollah, R., Bartlam, B., Barlas, P., Holden, M. A., Ismail, K. M., …Foster, N. E. (2016). Evaluating acupuncture and standard care for pregnant women and back pain: the EASE back pilot randomised controlled trial ((ISRCTN49955124). Pilot and Feasibility Studies, 2, Article 72. https://doi.org/10.1186/s40814-016-0107-6

Background
Low back pain (LBP) and pelvic girdle pain (PGP) during pregnancy are common and often accepted as a ‘normal’ part of pregnancy. Many women receive little in the way of treatment, and yet pain interferes with sleep, daily activities and w... Read More about Evaluating acupuncture and standard care for pregnant women and back pain: the EASE back pilot randomised controlled trial ((ISRCTN49955124).

Relationship between attitudes, beliefs and physical activity in older adults with knee pain: secondary analysis of a randomised controlled trial (2016)
Journal Article
Quicke, J. G., Foster, N. E., Ogollah, R. O., Croft, P. R., & Holden, M. (2016). Relationship between attitudes, beliefs and physical activity in older adults with knee pain: secondary analysis of a randomised controlled trial. Arthritis Care and Research, 1192-2000. https://doi.org/10.1002/acr.23104

Objective
To investigate how attitudes and beliefs about exercise relate to physical activity behavior in older adults with knee pain attributable to osteoarthritis (OA).

Methods
We conducted secondary data analyses of a randomized controlled tr... Read More about Relationship between attitudes, beliefs and physical activity in older adults with knee pain: secondary analysis of a randomised controlled trial.

The Role of Qualitative Research in Clinical Trial Development: The EASE Back Study (2016)
Journal Article
Holden. (2016). The Role of Qualitative Research in Clinical Trial Development: The EASE Back Study. Journal of Mixed Methods Research, 325-343. https://doi.org/10.1177/1558689816656740

This article outlines the rationale for adopting a mixed methods approach within randomized controlled trials (RCTs) and explores challenges associated in doing so. Taking the example of the EASE Back feasibility and pilot study (Evaluating Acupunctu... Read More about The Role of Qualitative Research in Clinical Trial Development: The EASE Back Study.

Barriers and Facilitators to Exercise Participation in People with Hip and/or Knee Osteoarthritis: Synthesis of the Literature Using Behavior Change Theory. (2016)
Journal Article
Holden, M. (2016). Barriers and Facilitators to Exercise Participation in People with Hip and/or Knee Osteoarthritis: Synthesis of the Literature Using Behavior Change Theory. American Journal of Physical Medicine & Rehabilitation, 372 - 389. https://doi.org/10.1097/PHM.0000000000000448

Exercise is recommended for hip and knee osteoarthritis (OA). Patient initiation of, and adherence to, exercise is key to the success of managing symptoms. This study aimed to (1) identify modifiable barriers and facilitators to participation in inte... Read More about Barriers and Facilitators to Exercise Participation in People with Hip and/or Knee Osteoarthritis: Synthesis of the Literature Using Behavior Change Theory..

Evaluating Acupuncture and Standard carE for pregnant women with Back pain (EASE Back): a feasibility study and pilot randomised trial. (2016)
Journal Article
Foster, N. E., Bishop, A., Bartlam, B., Ogollah, R., Barlas, P., Holden, M., …Young, J. (2016). Evaluating Acupuncture and Standard carE for pregnant women with Back pain (EASE Back): a feasibility study and pilot randomised trial. Health Technology Assessment, 20(33), 1 - 236. https://doi.org/10.3310/hta20330

BACKGROUND: Many pregnant women experience low back pain. Acupuncture appears to be a safe, promising intervention but evidence is needed about its clinical effectiveness and cost-effectiveness. OBJECTIVES: To assess the feasibility of a future large... Read More about Evaluating Acupuncture and Standard carE for pregnant women with Back pain (EASE Back): a feasibility study and pilot randomised trial..

Is long term physical activity safe for older adults with knee pain: a systematic review (2015)
Journal Article
Quicke, J., Foster, N., Thomas, M., & Holden, M. (2015). Is long term physical activity safe for older adults with knee pain: a systematic review. Osteoarthritis and Cartilage, 23(9), 1445-1456. https://doi.org/10.1016/j.joca.2015.05.002

Objective
To determine whether long-term physical activity is safe for older adults with knee pain.

Design
A comprehensive systematic review and narrative synthesis of existing literature was conducted using multiple electronic databases from in... Read More about Is long term physical activity safe for older adults with knee pain: a systematic review.