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Prevalence of mental health conditions amongst people living with human immunodeficiency virus in one of the most deprived localities in England. (2020)
Journal Article
(2020). Prevalence of mental health conditions amongst people living with human immunodeficiency virus in one of the most deprived localities in England. International Journal of STD & AIDS, 619 - 626. https://doi.org/10.1177/0956462420904299

Mental health conditions (MHCs) are often unrecognised which can result in detrimental physical health outcomes and poor quality of life. This can be compounded by the impact of deprivation. People living with human immunodeficiency virus (PLWH) are... Read More about Prevalence of mental health conditions amongst people living with human immunodeficiency virus in one of the most deprived localities in England..

How do older adults understand and manage distress? A qualitative study (2020)
Journal Article
Moult, A., Kingstone, T., & Chew-Graham, C. (2020). How do older adults understand and manage distress? A qualitative study. BMC Family Practice, 21, -. https://doi.org/10.1186/s12875-020-01152-7

BACKGROUND: Distress is an expected emotional response to a negative life event. Experiences common in later life may trigger distress such as bereavement or loss of physical mobility. Distress is considered to be distinct to anxiety and/or depressio... Read More about How do older adults understand and manage distress? A qualitative study.

The cost of childhood atopic dermatitis in a multi-ethnic Asian population: a cost-of-illness study (2020)
Journal Article
Thng, S., Car, J., Järbrink, K., Bajpai, R., Olsson, M., Wee, L. W. Y., Yew, Y. W., & Koh, M. J. A. (2020). The cost of childhood atopic dermatitis in a multi-ethnic Asian population: a cost-of-illness study. British Journal of Dermatology, 182(5), 1245-1252. https://doi.org/10.1111/bjd.18442

BACKGROUND: Childhood atopic dermatitis can often have a negative impact on quality of life for affected children and their caregivers. The condition contributes to increased healthcare costs and can pose heavy economic burdens on healthcare systems... Read More about The cost of childhood atopic dermatitis in a multi-ethnic Asian population: a cost-of-illness study.

Effects of in Season Multi-Directional Plyometric Training on Vertical Jump Performance, Change of Direction Speed and Dynamic Postural Control in U-21 Soccer Players (2020)
Journal Article
Jlid, M. C., Coquart, J., Maffulli, N., Paillard, T., Bisciotti, G. N., & Chamari, K. (2020). Effects of in Season Multi-Directional Plyometric Training on Vertical Jump Performance, Change of Direction Speed and Dynamic Postural Control in U-21 Soccer Players. Frontiers in Physiology, 11, -. https://doi.org/10.3389/fphys.2020.00374

The aim of the study was to assess the effects of multi-directional plyometric training (MPT) on vertical jump height, change of direction speed (CODS), and dynamic postural control (DPC) of soccer players under 21 year (U-21). Twenty-seven male socc... Read More about Effects of in Season Multi-Directional Plyometric Training on Vertical Jump Performance, Change of Direction Speed and Dynamic Postural Control in U-21 Soccer Players.

Family medicine in times of 'COVID-19': A generalists' voice. (2020)
Journal Article
Mallen. (2020). Family medicine in times of 'COVID-19': A generalists' voice. European Journal of General Practice, 58 - 60. https://doi.org/10.1080/13814788.2020.1757312

The novel coronavirus epidemic is transforming the world
in which we live. This pandemic will bring sweeping changes everywhere, not least in the field of primary care medicine. Like one of our colleagues said: ‘after this crisis, perhaps even our c... Read More about Family medicine in times of 'COVID-19': A generalists' voice..

Individual participant data meta-analysis to examine interactions between treatment effect and participant-level covariates: statistical recommendations for conduct and planning (2020)
Journal Article
Hattle. (2020). Individual participant data meta-analysis to examine interactions between treatment effect and participant-level covariates: statistical recommendations for conduct and planning. Statistics in Medicine, https://doi.org/10.1002/sim.8516

Precision medicine research often searches for treatment-covariate interactions, which refers to when a treatment effect (eg, measured as a mean difference, odds ratio, hazard ratio) changes across values of a participant-level covariate (eg, age, ge... Read More about Individual participant data meta-analysis to examine interactions between treatment effect and participant-level covariates: statistical recommendations for conduct and planning.

Role of the GP in the management of patients with self-harm behaviour: a systematic review (2020)
Journal Article
Troya, M., Mughal, F., Dikomitis, L., Chew-Graham, C. A., Corp, N., & Babatunde, O. O. (2020). Role of the GP in the management of patients with self-harm behaviour: a systematic review. British Journal of General Practice (BJGP), 70(694), E364-E373. https://doi.org/10.3399/bjgp20X708257

BACKGROUND: Self-harm is a serious risk factor for suicide, a major public health concern, and a significant burden on the NHS. Rates of self-harm presentation in primary care are rising and GPs interact with patients both before and after they have... Read More about Role of the GP in the management of patients with self-harm behaviour: a systematic review.

Epidemiological trends in surgery for rectal prolapse in England 2001-2012: An adult hospital population-based study (2020)
Journal Article
(2020). Epidemiological trends in surgery for rectal prolapse in England 2001-2012: An adult hospital population-based study. Colorectal Disease, https://doi.org/10.1111/codi.15094

Background
This study analysed trends in admission and surgery for rectal prolapse in adults in England between 2001 and 2012 as well as prolapse reoperation rates.

Methods
Analysis of data derived from a comparative longitudinal population-base... Read More about Epidemiological trends in surgery for rectal prolapse in England 2001-2012: An adult hospital population-based study.

Epidemiological trends in surgery for rectal prolapse in England 2001-2012: An adult hospital population-based study (2020)
Journal Article
(2020). Epidemiological trends in surgery for rectal prolapse in England 2001-2012: An adult hospital population-based study. Colorectal Disease, 1359-1366. https://doi.org/10.1111/codi.15094

Aim
To analyse trends in admission and surgery for rectal prolapse in adults in England between 2001 and 2012 as well as prolapse reoperation rates.

Method
Analysis of data derived from a comparative longitudinal population-based cohort study us... Read More about Epidemiological trends in surgery for rectal prolapse in England 2001-2012: An adult hospital population-based study.

Determination of cut-off and correlates of delay in treatment-seeking of febrile illness: a retrospective analysis (2020)
Journal Article
Bajpai, R. C., Tiwari, P., & Chaturvedi, H. K. (2020). Determination of cut-off and correlates of delay in treatment-seeking of febrile illness: a retrospective analysis. BMC Public Health, 20(1), Article 572. https://doi.org/10.1186/s12889-020-08660-2

Background
Early diagnosis and treatment of malaria symptoms reduces the risk of severe complication and malaria transmission. However, delay in malaria diagnosis and treatment is a major public health problem in India. The primary aim of the study... Read More about Determination of cut-off and correlates of delay in treatment-seeking of febrile illness: a retrospective analysis.

Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial (2020)
Journal Article
Brunt, A. M., Haviland, J. S., Wheatley, D. A., Sydenham, M. A., Alhasso, A., Bloomfield, D. J., Chan, C., Churn, M., Cleator, S., Coles, P. C. E., Goodman, A., Harnett, A., Hopwood, P., Kirby, A. M., Kirwan, C. C., Morris, C., Nabi, Z., Sawyer, E., Somaiah, N., Stones, L., …Management Group, F.-F. T. (2020). Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial. The Lancet, 395(10237), 1613 - 1626. https://doi.org/10.1016/S0140-6736%2820%2930932-6

BACKGROUND: We aimed to identify a five-fraction schedule of adjuvant radiotherapy (radiation therapy) delivered in 1 week that is non-inferior in terms of local cancer control and is as safe as an international standard 15-fraction regimen after pri... Read More about Hypofractionated breast radiotherapy for 1 week versus 3 weeks (FAST-Forward): 5-year efficacy and late normal tissue effects results from a multicentre, non-inferiority, randomised, phase 3 trial.

Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. (2020)
Journal Article
Guinan, M., Benckendorff, C., Smith, M., & Miller, G. (2020). Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. Molecules, 25(9), https://doi.org/10.3390/molecules25092050

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. However, thes... Read More about Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues..

Structural characteristics associated with radiographic severity of first metatarsophalangeal joint osteoarthritis (2020)
Journal Article
Roddy, E., Buldt, A. K., Munteanu, S. E., Allan, J. J., Tan, J. M., Auhl, M., Landorf, K. B., & Menz, H. B. (2021). Structural characteristics associated with radiographic severity of first metatarsophalangeal joint osteoarthritis. Arthritis and Rheumatism, 73(7), 1023-1030. https://doi.org/10.1002/acr.24227

Objective
To determine whether foot structure varies according to the presence and radiographic severity of first metatarsophalangeal joint osteoarthritis (first MTPJ OA).

Methods
Weight-bearing dorso-plantar and lateral radiographs were obtaine... Read More about Structural characteristics associated with radiographic severity of first metatarsophalangeal joint osteoarthritis.

Bringing osteoporosis up to date: time to address the identity crisis (2020)
Journal Article
Paskins, Z., Ong, T., & Armstrong, D. J. (2020). Bringing osteoporosis up to date: time to address the identity crisis. Age and ageing, 49(3), 329 - 331. https://doi.org/10.1093/ageing/afaa022

The WHO definition no longer relates to the population for whom osteoporosis drugs are recommended.

Confusion about what osteoporosis is, and what bone density scan results mean, contributes to poor treatment uptake.

A consistent international... Read More about Bringing osteoporosis up to date: time to address the identity crisis.

Laparoscopic ablation or excision with helium thermal coagulator versus electrodiathermy for the treatment of mild-to-moderate endometriosis: randomized controlled trial (2020)
Journal Article
Misra, G., Sim, J., El-Gizawy, Z., Watts, K., Jerreat, S., Coia, T., Ritchie, J., & O'Brien, S. (2020). Laparoscopic ablation or excision with helium thermal coagulator versus electrodiathermy for the treatment of mild-to-moderate endometriosis: randomized controlled trial. BJOG: An International Journal of Obstetrics and Gynaecology, https://doi.org/10.1111/1471-0528.16279

Objective: To compare electrodiathermy with helium thermal coagulation in laparoscopic treatment of mild-to-moderate endometriosis. Design: Parallel-group randomized controlled trial. Setting: A UK endometriosis centre. Population: Non-pregnant women... Read More about Laparoscopic ablation or excision with helium thermal coagulator versus electrodiathermy for the treatment of mild-to-moderate endometriosis: randomized controlled trial.

'We're the First Port of Call' - Perspectives of Ambulance Staff on Responding to Deaths by Suicide: A Qualitative Study (2020)
Journal Article
Chew-Graham. (2020). 'We're the First Port of Call' - Perspectives of Ambulance Staff on Responding to Deaths by Suicide: A Qualitative Study. Frontiers in Psychology, 722 -?. https://doi.org/10.3389/fpsyg.2020.00722

Introduction: Exposure to suicide is a known risk factor for suicide. Ambulance staff are exposed to work-related stressors including attending suicides, which may elevate their risk for mental health problems/suicide. Little is known about ambulance... Read More about 'We're the First Port of Call' - Perspectives of Ambulance Staff on Responding to Deaths by Suicide: A Qualitative Study.

Institutional use of National Clinical Audits by healthcare providers (2020)
Journal Article
Mamas. (2020). Institutional use of National Clinical Audits by healthcare providers. Journal of Evaluation in Clinical Practice, https://doi.org/10.1111/jep.13403

Abstract Rationale, aims, and objectives Healthcare systems worldwide devote significant resources towards collecting data to support care quality assurance and improvement. In the United Kingdom, National Clinical Audits are intended to contribute t... Read More about Institutional use of National Clinical Audits by healthcare providers.

Adherence to Pre-operative Exercise and the Response to Prehabilitation in Oesophageal Cancer Patients (2020)
Journal Article
Halliday, L. J., Doganay, E., Wynter-Blyth, V., Osborn, H., Buckley, J., & Moorthy, K. (2021). Adherence to Pre-operative Exercise and the Response to Prehabilitation in Oesophageal Cancer Patients. Journal of Gastrointestinal Surgery, 25(4), 890-899. https://doi.org/10.1007/s11605-020-04561-2

BACKGROUND: Prehabilitation is thought to reduce post-operative respiratory complications by optimising fitness before surgery. This prospective, single-centre study aimed to establish the effect of pre-operative exercise on cardiorespiratory fitness... Read More about Adherence to Pre-operative Exercise and the Response to Prehabilitation in Oesophageal Cancer Patients.

Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments (2020)
Journal Article
Paskins, Holden, Mallen, Jinks, Hawarden, & Roddy. (2020). Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments. Rheumatology, https://doi.org/10.1093/rheumatology/keaa111.125

Background
The HIT trial compared ultrasound-guided intra-articular hip injection (USGI) of triamcinolone acetonide and 1% lidocaine hydrochloride combined with best current treatment (BCT) with (i) BCT alone and (ii) an USGI of 1% lidocaine only co... Read More about Qualitative findings from the Hip Injection Trial (HIT): experiences of living with hip osteoarthritis and receiving trial treatments.