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AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. (2021)
Journal Article
Morelle, J., Marechal, C., Yu, Z., Debaix, H., Corre, T., Lambie, M., …Devuyst, O. (2021). AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. New England Journal of Medicine, 385, 1570 - 1580. https://doi.org/10.1056/NEJMoa2034279

BACKGROUND: Variability in ultrafiltration influences prescriptions and outcomes in patients with kidney failure who are treated with peritoneal dialysis. Variants in AQP1, the gene that encodes the archetypal water channel aquaporin-1, may contribut... Read More about AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis..

Outcomes of intravascular ultrasound versus optical coherence tomography guided percutaneous coronary angiography: A meta regression-based analysis. (2021)
Journal Article
Mamas, M. A., Sattar, Y., Abdul Razzack, A., Kompella, R., Alhajri, N., Arshad, J., …Alraies, M. C. (2022). Outcomes of intravascular ultrasound versus optical coherence tomography guided percutaneous coronary angiography: A meta regression-based analysis. Catheterization and Cardiovascular Interventions, 99(1), E1 - E11. https://doi.org/10.1002/ccd.29976

BACKGROUND: Studies comparing clinical outcomes with intravascular ultrasound (IVUS) versus optical coherence tomography (OCT) guidance for percutaneous coronary intervention (PCI) in patients presenting with coronary artery disease, including stable... Read More about Outcomes of intravascular ultrasound versus optical coherence tomography guided percutaneous coronary angiography: A meta regression-based analysis..

Examining the Trends in Online Health Information–Seeking Behavior About Chronic Obstructive Pulmonary Disease in Singapore: Analysis of Data From Google Trends and the Global Burden of Disease Study (2021)
Journal Article
Fang, Y., Shepherd, T. A., & E Smith, H. (2021). Examining the Trends in Online Health Information–Seeking Behavior About Chronic Obstructive Pulmonary Disease in Singapore: Analysis of Data From Google Trends and the Global Burden of Disease Study. Journal of Medical Internet Research, 23(10), https://doi.org/10.2196/19307

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally, and timely health care seeking is imperative for its prevention, early detection, and management. While online health information-seeking behavior... Read More about Examining the Trends in Online Health Information–Seeking Behavior About Chronic Obstructive Pulmonary Disease in Singapore: Analysis of Data From Google Trends and the Global Burden of Disease Study.

Meta-Analysis of Transradial Versus Transfemoral Access for Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease. (2021)
Journal Article
Mamas. (2021). Meta-Analysis of Transradial Versus Transfemoral Access for Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease. American Journal of Cardiology, 8 - 14. https://doi.org/10.1016/j.amjcard.2021.07.018

Data comparing outcomes of transradial (TR) versus transfemoral (TF) access for percutaneous coronary intervention (PCI) in chronic kidney disease (CKD) including patients with eGFR< 30 ml/min/1.73m2 and patients with end-stage renal disease on dialy... Read More about Meta-Analysis of Transradial Versus Transfemoral Access for Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease..

Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study (2021)
Journal Article
Rathod-Mistry, T., Mamas, M., Bailey, J., Chen, Y., Clarson, L., Denaxas, S., …Jordan, K. (2021). Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study. European Heart Journal, 42(S1), https://doi.org/10.1093/eurheartj/ehab724.1350

Background
Patients presenting to primary care with chest pain are often not given a cause. Patients with such unattributed chest pain have an increased risk of future cardiovascular disease (CVD) compared to patients with diagnosed non-coronary che... Read More about Comparison of risk factors for coronary event in people with unattributed and non-coronary chest pain: an electronic health record cohort study.

Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis. (2021)
Journal Article
Holland, D., Heald, A. H., Stedman, M., Hanna, F., Wu, P., Duff, C., …Fryer, A. A. (2021). Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis. Journal of Clinical Pathology, 76(3), https://doi.org/10.1136/jclinpath-2021-207776

AIMS: The COVID-19 pandemic, and the focus on mitigating its effects, has disrupted diabetes healthcare services worldwide. We aimed to quantify the effect of the pandemic on diabetes diagnosis/management, using glycated haemoglobin (HbA1c) as surrog... Read More about Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis..

Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade (2021)
Journal Article
Pooler. (2021). Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade. Journal of Global Health, 1-13. https://doi.org/10.7189/jogh.11.15003

Background The global prevalence of chronic obstructive pulmonary disease (COPD) has increased markedly in recent decades. Given the scarcity of resources available to address global health challenges and respiratory medicine being relatively under-i... Read More about Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade.

The association between socioeconomic status, sex, race/ethnicity and in-hospital mortality among patients hospitalized for heart failure (2021)
Journal Article
Mamas. (2021). The association between socioeconomic status, sex, race/ethnicity and in-hospital mortality among patients hospitalized for heart failure. Journal of Cardiac Failure, https://doi.org/10.1016/j.cardfail.2021.09.012

Background The association between socioeconomic status (SES), sex, race/ethnicity and outcomes during hospitalization for heart failure (HF) has not previously been investigated. Methods We analyzed HF hospitalizations in the United States National... Read More about The association between socioeconomic status, sex, race/ethnicity and in-hospital mortality among patients hospitalized for heart failure.

Prevalence and factors associated with low back pain in retired Great Britain’s Olympians: a cross-sectional study (2021)
Journal Article
Cooper, D., Batt, M., O'Hanlon, M., & Palmer, D. (2021). Prevalence and factors associated with low back pain in retired Great Britain’s Olympians: a cross-sectional study. Translational Sports Medicine, 807-816. https://doi.org/10.1002/tsm2.284

This study determined the point prevalence and factors associated with low back pain (LBP) in retired Great Britain’s (GB) Olympians. Six hundred and thirteen retired athletes completed a cross-sectional survey. Prevalence of LBP (pain on most days i... Read More about Prevalence and factors associated with low back pain in retired Great Britain’s Olympians: a cross-sectional study.

Changes in received quality of care for knee osteoarthritis after a multicomponent intervention in a general practice in Denmark (2021)
Journal Article
Baumbach, L., Roos, E. M., Ankerst, D., Nyberg, L. A., Cottrell, E., & Lykkegaard, J. (2021). Changes in received quality of care for knee osteoarthritis after a multicomponent intervention in a general practice in Denmark. Health Science Reports, 4(4), Article e402. https://doi.org/10.1002/hsr2.402

Objective: First-line treatment for patients with knee osteoarthritis should ideally prescribe patient education, exercise, and if needed, weight loss. In practice, however, adjunctive treatments, including painkillers and referrals to specialists, a... Read More about Changes in received quality of care for knee osteoarthritis after a multicomponent intervention in a general practice in Denmark.

Implementing a Stratified Vocational Advice Intervention for People on Sick Leave with Musculoskeletal Disorders: A Multimethod Process Evaluation. (2021)
Journal Article
Aanesen, F., Øiestad, B., Grotle, M., Løchting, I., Solli, R., Sowden, G., …Eik, H. (2021). Implementing a Stratified Vocational Advice Intervention for People on Sick Leave with Musculoskeletal Disorders: A Multimethod Process Evaluation. Journal of Occupational Rehabilitation, https://doi.org/10.1007/s10926-021-10007-6

Purpose To perform a process evaluation of a stratified vocational advice intervention (SVAI), delivered by physiotherapists in primary care, for people on sick leave with musculoskeletal disorders participating in a randomised controlled trial. The... Read More about Implementing a Stratified Vocational Advice Intervention for People on Sick Leave with Musculoskeletal Disorders: A Multimethod Process Evaluation..

Investigation of the blood proteome in response to spinal cord injury in rodent models (2021)
Journal Article
Hulme, C. H., Fuller, H. R., Riddell, J., Shirran, S. L., Botting, C. H., Osman, A., & Wright, K. T. (2022). Investigation of the blood proteome in response to spinal cord injury in rodent models. Spinal Cord, 60(4), 320-325. https://doi.org/10.1038/s41393-021-00692-8

STUDY DESIGN: Explanatory and Mechanistic Study
OBJECTIVES: A better understanding of the ‘whole-body’ response following spinal cord injury (SCI) is needed to guide future research aimed at developing novel therapeutic interventions and identifying... Read More about Investigation of the blood proteome in response to spinal cord injury in rodent models.

Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales (2021)
Journal Article
Mamas, & Rashid. (2021). Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales. https://doi.org/10.1016/j.cjco.2021.09.026

Background Studies of racial disparities in patients admitted with an OHCA in the setting of AMI have shown inconsistent results. Whether these differences in care exist in a universal healthcare system in England is unknown. Methods Patients admitte... Read More about Racial disparities in management and outcomes of out-of-hospital cardiac arrest complicating myocardial infarction; a national study from England and Wales.

Managing chronic wet cough in children: another piece of the puzzle. (2021)
Journal Article
Gilchrist. (2021). Managing chronic wet cough in children: another piece of the puzzle. Lancet Respiratory Medicine, 1078 - 1079. https://doi.org/10.1016/S2213-2600%2821%2900159-4

Chronic wet cough is the hallmark of chronic obstructive pulmonary disease in older people and bronchiectasis in adults and older children. In young children, the commonest cause of chronic wet cough is protracted bacterial bronchitis (PBB) but there... Read More about Managing chronic wet cough in children: another piece of the puzzle..

Effect of the Timing of Admission of Out of Hospital Cardiac Arrest Complicating Acute Myocardial Infarction on Management and Outcome. (2021)
Journal Article
(2021). Effect of the Timing of Admission of Out of Hospital Cardiac Arrest Complicating Acute Myocardial Infarction on Management and Outcome. https://doi.org/10.1016/j.amjcard.2021.06.042

There is limited data regarding the impact of time of admission on clinical outcomes of out of hospital cardiac arrest (OHCA) complicating acute myocardial infarction (AMI). We investigated the patient characteristics, management, and outcomes of OHC... Read More about Effect of the Timing of Admission of Out of Hospital Cardiac Arrest Complicating Acute Myocardial Infarction on Management and Outcome..

Clinical Prediction Models in Sports Medicine: A Guide for Clinicians and Researchers. (2021)
Journal Article
(2021). Clinical Prediction Models in Sports Medicine: A Guide for Clinicians and Researchers. Journal of Orthopaedic & Sports Physical Therapy, 517 - 525. https://doi.org/10.2519/jospt.2021.10697

SYNOPSIS: Participating in sport carries inherent risk of injury. Clinicians execute high-level clinical reasoning and decision making to support athletes to achieve the best outcomes. Accurately diagnosing a problem, estimating prognosis, or selecti... Read More about Clinical Prediction Models in Sports Medicine: A Guide for Clinicians and Researchers..

Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission. (2021)
Journal Article
Mamas. (2021). Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission. https://doi.org/10.1111/ijcp.14554

BACKGROUND: In recent years, there has been a growing interest in outcomes of patients with acute myocardial infarction (AMI) using large administrative datasets. The present study was designed to compare the characteristics, management strategies an... Read More about Distribution, management and outcomes of AMI according to principal diagnosis priority during inpatient admission..

Developing a core outcome set for community and primary care musculoskeletal services: A consensus approach. (2021)
Journal Article
Lewis, M., & Hill, J. (2021). Developing a core outcome set for community and primary care musculoskeletal services: A consensus approach. Musculoskeletal Science and Practice, 1- 10. https://doi.org/10.1016/j.msksp.2021.102415

BACKGROUND: At present there is no core outcome set (COS) for use in community and primary care Musculoskeletal (MSK) services across the UK. Services are therefore collecting different MSK outcomes and metrics in different ways and at different time... Read More about Developing a core outcome set for community and primary care musculoskeletal services: A consensus approach..

Dystrophin involvement in peripheral circadian SRF signalling (2021)
Journal Article
Bowerman. (2021). Dystrophin involvement in peripheral circadian SRF signalling. https://doi.org/10.26508/lsa.202101014

Absence of dystrophin, an essential sarcolemmal protein required for muscle contraction, leads to the devastating muscle-wasting disease Duchenne muscular dystrophy. Dystrophin has an actin-binding domain, which binds and stabilises filamentous-(F)-a... Read More about Dystrophin involvement in peripheral circadian SRF signalling.