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New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties..

Outcomes of Bone Marrow-Derived Mononuclear Cell Transplantation for Patients in Persistent Vegetative State After Drowning: Report of Five Cases (2020)
Journal Article
(2020). Outcomes of Bone Marrow-Derived Mononuclear Cell Transplantation for Patients in Persistent Vegetative State After Drowning: Report of Five Cases. Frontiers in Pediatrics, 564. https://doi.org/10.3389/fped.2020.00564

Aim: Anoxic brain injury (ABI) due to non-fatal drowning may cause persistent vegetative state (VS) that is currently incurable. The aim of this paper is to present the safety and feasibility of autologous bone marrow-derived mononuclear cell (BMMNC)... Read More about Outcomes of Bone Marrow-Derived Mononuclear Cell Transplantation for Patients in Persistent Vegetative State After Drowning: Report of Five Cases.

If it's 'only' asthma, why are children still dying? (2019)
Journal Article
(2019). If it's 'only' asthma, why are children still dying?. Archives of Disease in Childhood, 494 - 498. https://doi.org/10.1136/archdischild-2019-318215

Outcomes for children with asthma in the UK continue to lag behind other European countries. Mortality remains unacceptably high and in contrast to adults with asthma, most deaths occur in the 1 in 20 children with asthma who have severe asthma. Desp... Read More about If it's 'only' asthma, why are children still dying?.

Radiation dose from common radiological investigations and cumulative exposure in children with cystic fibrosis: an observational study from a single UK centre. (2017)
Journal Article
(2017). Radiation dose from common radiological investigations and cumulative exposure in children with cystic fibrosis: an observational study from a single UK centre. BMJ Open, e017548 - ?. https://doi.org/10.1136/bmjopen-2017-017548

OBJECTIVES: Cumulative radiation exposure is associated with increased risk of malignancy. This is important in cystic fibrosis (CF) as frequent imaging is required to monitor disease progression and diagnose complications. Previous estimates of cumu... Read More about Radiation dose from common radiological investigations and cumulative exposure in children with cystic fibrosis: an observational study from a single UK centre..

Telemedicine is the way forward for the management of Cystic Fibrosis - The case against (2017)
Journal Article
(2017). Telemedicine is the way forward for the management of Cystic Fibrosis - The case against. Paediatric Respiratory Reviews, 22-23. https://doi.org/10.1016/j.prrv.2017.03.005

It is reasonable to suggest that Telemedicine could help in the management of chronic diseases by giving patients more flexibility to remain at home with opportunities to forward electronic data to healthcare professionals, reduce hospital emergency... Read More about Telemedicine is the way forward for the management of Cystic Fibrosis - The case against.

Assessing chronic cough in children (2016)
Journal Article
Gilchrist. (2016). Assessing chronic cough in children. Paediatrics and Child Health, 273-275. https://doi.org/10.1016/j.paed.2016.03.002

Cough is a protective physiological reflex that aids the clearance of airway secretions and aspirated material. As such, it is normal to cough. Coughing becomes abnormal when the frequency or severity impacts on the child's ability to eat, sleep, pla... Read More about Assessing chronic cough in children.

A review of prednisolone prescribing for children with acute asthma in the UK (2016)
Journal Article
Gilchrist, F. J., Ahmad, A. N., Batchelor, H. K., Marriott, J. F., & Lenney, W. (2016). A review of prednisolone prescribing for children with acute asthma in the UK. Journal of Asthma, 53(6), 563 -566. https://doi.org/10.3109/02770903.2015.1118498

INTRODUCTION: Worldwide asthma guidelines recommend short courses of oral prednisolone in children with acute exacerbations generating high prescription numbers. There is a paucity of evidence to inform the optimal dose and course duration. This has... Read More about A review of prednisolone prescribing for children with acute asthma in the UK.

Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis. (2016)
Journal Article
(2016). Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis. BMC Pharmacology and Toxicology, 14 - ?. https://doi.org/10.1186/s40360-016-0054-0

BACKGROUND: Chronic infection with Burkholderia cepacia complex (BCC) has a detrimental effect on morbidity and mortality for patients with cystic fibrosis (CF). It is therefore logical to attempt to eradicate new isolates however there is a paucity... Read More about Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis..

Research is the Future, the Future is……. (2015)
Journal Article
Gilchrist, F. J. (2015). Research is the Future, the Future is……. Paediatric Respiratory Reviews, 17, 32 - 33. https://doi.org/10.1016/j.prrv.2015.08.008

Over the past two decades, Professor Lenney has established the Paediatric Respiratory Department at the Royal Stoke University Hospital as a centre recognised for high quality research. A broad portfolio of clinical and laboratory based research is... Read More about Research is the Future, the Future is……..

Changes in gait which occur before and during the adolescent growth spurt in children treated by selective dorsal rhizotomy. (2015)
Journal Article
McFall, J., Stewart, C., Kidgell, V., Postans, N., Jarvis, S., Freeman, R., & Roberts, A. (2015). Changes in gait which occur before and during the adolescent growth spurt in children treated by selective dorsal rhizotomy. Gait and Posture, 42(3), 317 - 322. https://doi.org/10.1016/j.gaitpost.2015.06.187

This paper presents long term follow up results from 17 children (6 girls, 11 boys, GMFCS levels II-IV), treated by means of selective dorsal rhizotomy (SDR). The particular focus is on the effect of the adolescent growth spurt on patients who had pr... Read More about Changes in gait which occur before and during the adolescent growth spurt in children treated by selective dorsal rhizotomy..

Global impact of asthma on children and adolescents' daily lives: the room to breathe survey (2012)
Journal Article
(2012). Global impact of asthma on children and adolescents' daily lives: the room to breathe survey. Pediatric Pulmonology, 346-357. https://doi.org/10.1002/ppul.21557

Objective
To establish children and adolescents' perspectives regarding their asthma and its impact upon their daily lives.

Design
A 14-item questionnaire.

Setting
Canada, Greece, Hungary, The Netherlands, the United Kingdom, and South Afric... Read More about Global impact of asthma on children and adolescents' daily lives: the room to breathe survey.

Parent misperception of control in childhood/adolescent asthma: the Room to Breathe survey (2012)
Journal Article
(2012). Parent misperception of control in childhood/adolescent asthma: the Room to Breathe survey. European Respiratory Journal, 90-96. https://doi.org/10.1183/09031936.00048911

The aim of our study was to determine how often asthma control is achieved in children and adolescents, and how asthma affects parents' and children's daily lives.

Interviews, including the childhood asthma control test (C-ACT), were conducted wit... Read More about Parent misperception of control in childhood/adolescent asthma: the Room to Breathe survey.

Is there any evidence for influenza vaccination in children with asthma? (2007)
Journal Article
(2007). Is there any evidence for influenza vaccination in children with asthma?. Archives of Disease in Childhood, 644-645. https://doi.org/10.1136/adc.2007.117085

A 12 year old boy presents for a routine asthma follow-up appointment during the autumn. He takes 200 µg per day of inhaled budesonide and uses his salbutamol 3–4 times per week. His mother asks if the flu vaccine will make it less likely that he wil... Read More about Is there any evidence for influenza vaccination in children with asthma?.

Drug therapy in the management of acute asthma. (2007)
Journal Article
(2007). Drug therapy in the management of acute asthma. Archives of Disease in Childhood: Education & Practice, ep82 - ep86. https://doi.org/10.1136/adc.2006.107631

If our management of children with asthma was optimal, there would be no need for this article as we would be able to prevent the development and progression of any asthma exacerbation. In reality, we are quite a long way from optimal care of childho... Read More about Drug therapy in the management of acute asthma..

Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. (2005)
Journal Article
Carroll, W., Lenney, W., Jones, P., Strange, R., Child, F., Whyte, M., …Fryer, A. (2005). Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. Clinical and Experimental Allergy, 35(9), 1155 - 1161. https://doi.org/10.1111/j.1365-2222.2005.02313.x

RATIONALE: Previous data have suggested that glutathione-S-transferase (GST) genotypes are important in determining the rate of lung function growth in childhood. This effect was most marked in Caucasian children with asthma. OBJECTIVES: We investiga... Read More about Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families..

Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. (2005)
Journal Article
Carroll, W., Lenney, W., Child, F., Strange, R., Jones, P., & Fryer, A. (2005). Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. Pediatric Allergy and Immunology, 16(1), 32 - 39. https://doi.org/10.1111/j.1399-3038.2005.00249.x

Maternal factors are known to influence the heritability and expression of asthma and atopy. We report the association of maternal, paternal and proband GSTP1 genotype with lung function in 145 Caucasian children with asthma. GSTP1 Val105/Val105 and... Read More about Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma..