Gabapentinoid prescriptions in patients with osteoarthritis: an analysis of data from the Clinical Practice Research Datalink (2018)
Thesis
Appleyard, T. (2018). Gabapentinoid prescriptions in patients with osteoarthritis: an analysis of data from the Clinical Practice Research Datalink. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417947

Amid a substantial rise in gabapentin and pregabalin (gabapentinoid) prescribing and increasing concerns with their potential for misuse and diversion, there are anecdotal reports of their use for osteoarthritis. The aim of my thesis was to understan... Read More about Gabapentinoid prescriptions in patients with osteoarthritis: an analysis of data from the Clinical Practice Research Datalink.

Strategies to prevent kidney injury from antibiotics in individuals with cystic fibrosis (2018)
Thesis
Ditchfield, N. (2018). Strategies to prevent kidney injury from antibiotics in individuals with cystic fibrosis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417942

Kidney damage in cystic fibrosis (CF) patients is most commonly caused by antibiotics, such as aminoglycosides, which are used to treat Pseudomonas aeruginosa (PA). I conducted a survey of UK CF centres which showed a high rate of use of aminoglycosi... Read More about Strategies to prevent kidney injury from antibiotics in individuals with cystic fibrosis.

Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. (2018)
Journal Article
Holmes, A. M., Heylings, J. R., Wan, K., & Moss, G. P. (2019). Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens. International Journal of Antimicrobial Agents, 53(4), 500-507. https://doi.org/10.1016/j.ijantimicag.2018.12.012

The aim of this study was to investigate a range of poly(amidoamine) (PAMAM) dendrimer generations against Gram-positive and Gram-negative skin pathogens and to determine any differences in antimicrobial potency for different generations, characteris... Read More about Antimicrobial efficacy and mechanism of action of poly(amidoamine) (PAMAM) dendrimers against opportunistic pathogens..

Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up. (2018)
Journal Article
Slater, N., Rowley, C., Venables, R., White, S., & Frisher, M. (2018). Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up. BMJ Open, 8(12), https://doi.org/10.1136/bmjopen-2018-025394

OBJECTIVES: Conflicting results have been reported when the associations between metabolic health, obesity and depression were examined previously. The primary aim of this study was to determine whether metabolic health or obesity are independently a... Read More about Evaluating associations between metabolic health, obesity and depressive symptoms: a prospective analysis of data from the English Longitudinal Study of Ageing (ELSA) with a 2-year follow-up..

The extra-articular impacts of rheumatoid arthritis: moving towards holistic care (2018)
Journal Article
Scott, I., Machin, A., Mallen, C., & Hider, S. (2018). The extra-articular impacts of rheumatoid arthritis: moving towards holistic care. BMC Rheumatology, 2, Article 32. https://doi.org/10.1186/s41927-018-0039-2

Although treat-to-target has revolutionised the outcomes of patients with rheumatoid arthritis (RA) there is emerging evidence that attaining the target of remission is insufficient to normalise patients' quality of life, and ameliorate the extra-art... Read More about The extra-articular impacts of rheumatoid arthritis: moving towards holistic care.

The poor design of clinical trials of statins in oncology may explain their failure – lessons for drug repurposing (2018)
Journal Article
Abdullah, M., Jawad, M., Richardson, A., & Wolf, E. (2018). The poor design of clinical trials of statins in oncology may explain their failure – lessons for drug repurposing. Cancer Treatment Reviews, 84-89. https://doi.org/10.1016/j.ctrv.2018.06.010

Statins are widely used to treat hypercholesterolaemia. However, by inhibiting the production of mevalonate, they also reduce the production of several isoprenoids that are necessary for the function of small GTPase oncogenes such as Ras. As such, st... Read More about The poor design of clinical trials of statins in oncology may explain their failure – lessons for drug repurposing.

Stimuli Responsive Polymeric Systems for Cancer Therapy. (2018)
Journal Article
Curtis, A., Lamprou, D., Hoskins, C., & Alsuraifi, A. (2018). Stimuli Responsive Polymeric Systems for Cancer Therapy. Pharmaceutics, https://doi.org/10.3390/pharmaceutics10030136

Nanoscale polymers systems have dominated the revolution of drug delivery advancement. Their potential in the fight against cancer is unrivalled with other technologies. Their functionality increase, targeting ability and stimuli responsive nature ha... Read More about Stimuli Responsive Polymeric Systems for Cancer Therapy..

A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. (2018)
Journal Article
Holden, M., Whittle, R., Waterfield, J., Chesterton, L., Cottrell, E., Quicke, J., & Mallen, C. (2019). A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. Physiotherapy, 105(3), 328 - 337. https://doi.org/10.1016/j.physio.2018.08.003

OBJECTIVE: To explore how physiotherapists currently address analgesic use among patients with hip osteoarthritis, and their beliefs about the acceptability of prescribing for these patients. METHODS: A cross-sectional questionnaire was mailed to 312... Read More about A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis..

Bereavement and loss support for adults with learning disabilities: An exploratory study using Photovoice (2018)
Thesis
Tajuria, G. (2018). Bereavement and loss support for adults with learning disabilities: An exploratory study using Photovoice. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411462

Background: Loss and bereavement are devastating life experiences for all human beings belonging to any social group, and adults with learning disabilities are not exempt from the effects of loss. Recent research has shown that adults with learning d... Read More about Bereavement and loss support for adults with learning disabilities: An exploratory study using Photovoice.

Evidence based hydrotherapy: a community of practice approach (2018)
Thesis
Smith, P. J. (2018). Evidence based hydrotherapy: a community of practice approach. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/418140

Health Care Professionals and patients report that hydrotherapy is valuable in managing inflammatory arthritis and musculoskeletal pain. However, clinical services are increasingly required to justify the clinical and cost effectiveness of hydrothera... Read More about Evidence based hydrotherapy: a community of practice approach.

Pharmacists in general medical practice: a case study of clinical commissioning groups (2018)
Thesis
Saunders, R. E. (2018). Pharmacists in general medical practice: a case study of clinical commissioning groups. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411341

Pharmacists have been identified to address the increasing workload in United Kingdom (UK) general practice. A pilot has been commissioned by National Health Service England (NHSE) to upskill pharmacists for this purpose. Evaluation is underway and e... Read More about Pharmacists in general medical practice: a case study of clinical commissioning groups.

AZD5363 plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (PAKT): A randomised, double-blind, placebo-controlled, phase II trial (2018)
Presentation / Conference
Schmid, P., Abraham, J., Chan, S., Wheatley, D., Brunt, M., Nemsadze, G., …Turner, N. C. (2018, June). AZD5363 plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (PAKT): A randomised, double-blind, placebo-controlled, phase II trial. Presented at 2018 ASCO Annual Meeting I, Chicago, IL, USA

Background: The PI3K/AKT signalling pathway is frequently activated in triple-negative breast cancer (TNBC). AZD5363 is a highly-selective, oral, small molecule AKT inhibitor. The PAKT trial investigated the addition of AZD5363 to paclitaxel as 1st-l... Read More about AZD5363 plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (PAKT): A randomised, double-blind, placebo-controlled, phase II trial.

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial (2018)
Journal Article
Roffe. (2018). Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial. Lancet, 2107-2115. https://doi.org/10.1016/S0140-6736%2818%2931033-X

Background
Tranexamic acid can prevent death due to bleeding after trauma and post-partum haemorrhage. We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in adults with stroke due to intracerebral haemorrhage... Read More about Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial.

Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues (2018)
Journal Article
Reynisson. (2018). Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues. Peptide Science, e24076. https://doi.org/10.1002/pep2.24076

This work demonstrates that the human autophagy 16 polypeptide (Atg16) has antibacterial and antibiofilm potential, perturbs both Gram positive and negative bacterial membranes and subsequently also produces ROS in compromised bacteria. Engineered At... Read More about Synthesis, antibacterial, and antibiofilm potential of human autophagy 16 polypeptide and analogues.

Comparison of Drug Discontinuation, Effectiveness, and Safety Between Clinical Trial Eligible and Ineligible Patients in BADBIR. (2018)
Journal Article
Mason, K. (2018). Comparison of Drug Discontinuation, Effectiveness, and Safety Between Clinical Trial Eligible and Ineligible Patients in BADBIR. JAMA Dermatology, 154(5), 581 - 588. https://doi.org/10.1001/jamadermatol.2018.0183

Importance: Patients with psoriasis enrolled in clinical trials of biologics may not be representative of the real-world population. There is evidence that patients ineligible for such trials have a greater risk of serious adverse events (SAEs), but... Read More about Comparison of Drug Discontinuation, Effectiveness, and Safety Between Clinical Trial Eligible and Ineligible Patients in BADBIR..

New 4-aryl-1,3,2-oxathiazolylium-5-olates: chemical synthesis and photochemical stability of a novel series of S-nitrosothiols (2018)
Journal Article
(2018). New 4-aryl-1,3,2-oxathiazolylium-5-olates: chemical synthesis and photochemical stability of a novel series of S-nitrosothiols. Bioorganic and Medicinal Chemistry Letters, 1106-1110. https://doi.org/10.1016/j.bmcl.2018.01.059

Abstract S-Nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by-product. However, alligning these com... Read More about New 4-aryl-1,3,2-oxathiazolylium-5-olates: chemical synthesis and photochemical stability of a novel series of S-nitrosothiols.

Randomised feasibility study to compare the use of Therabite® with wooden spatulas to relieve and prevent trismus in patients with cancer of the head and neck. (2018)
Journal Article
(2018). Randomised feasibility study to compare the use of Therabite® with wooden spatulas to relieve and prevent trismus in patients with cancer of the head and neck. https://doi.org/10.1016/j.bjoms.2018.02.012

Our aim was to compare the efficacy of the Therabite® jaw motion rehabilitation system (Atos Medical) with that of wooden spatulas to relieve and prevent trismus in patients who have had radiotherapy for stage three and four oral and oropharyngeal ca... Read More about Randomised feasibility study to compare the use of Therabite® with wooden spatulas to relieve and prevent trismus in patients with cancer of the head and neck..

Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression (2018)
Journal Article
Moss. (2018). Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression. Journal of Pharmacy and Pharmacology, 361-373. https://doi.org/10.1111/jphp.12863

Objectives
The aim of this study was to investigate how to improve predictions from Gaussian Process models by optimising the model hyperparameters.

Methods
Optimisation methods, including Grid Search, Conjugate Gradient, Random Search, Evoluti... Read More about Model fitting for small skin permeability data sets: hyperparameter optimisation in Gaussian Process Regression.

Post discharge medicines use review (dMUR) service for older patients: Cost-savings from community pharmacist interventions (2018)
Journal Article
(2018). Post discharge medicines use review (dMUR) service for older patients: Cost-savings from community pharmacist interventions. Research in Social and Administrative Pharmacy, 203-206. https://doi.org/10.1016/j.sapharm.2017.02.007

No abstract

Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance (2018)
Journal Article
Curtis, A., Kumar, M., & Hoskins, C. (2018). Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance. Pharmaceutics, https://doi.org/10.3390/pharmaceutics10010011

Anti-microbial resistance is a growing problem that has impacted the world and brought about the beginning of the end for the old generation of antibiotics. Increasingly, more antibiotics are being prescribed unnecessarily and this reckless practice... Read More about Application of Nanoparticle Technologies in the Combat against Anti-Microbial Resistance.