New developments in osteoarthritis pharmacological therapies. (2021)
Journal Article
(2021). New developments in osteoarthritis pharmacological therapies. Rheumatology, vi1 - vi11. https://doi.org/10.1093/rheumatology/keab679

OA is an increasingly common, painful condition with complex aetiology and limited therapies. Approaches to expanding our therapeutic armamentarium have included repurposing existing therapies used for other rheumatological conditions, modifying exis... Read More about New developments in osteoarthritis pharmacological therapies..

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2. (2021)
Journal Article
Reynisson. (2021). New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2. Molecules, https://doi.org/10.3390/molecules27010072

A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and 2 (TDP2) enzymes. In addition, 1,2,4- and 1,3,4-oxadiazole derivatives were synthesized to... Read More about New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2..

Development of an optimised physiotherapist-led treatment protocol for lateral elbow tendinopathy: a consensus study using an online nominal group technique (2021)
Journal Article
Bateman, M., Saunders, B., Littlewood, C., & Hill, J. (2021). Development of an optimised physiotherapist-led treatment protocol for lateral elbow tendinopathy: a consensus study using an online nominal group technique. BMJ Open, 11(12), Article e053841. https://doi.org/10.1136/bmjopen-2021-053841

OBJECTIVES: There are a wide range of physiotherapy treatment options for people with lateral elbow tendinopathy (LET); however, previous studies have reported inconsistent approaches to treatment and a lack of evidence demonstrating clinical effecti... Read More about Development of an optimised physiotherapist-led treatment protocol for lateral elbow tendinopathy: a consensus study using an online nominal group technique.

Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. (2021)
Journal Article
Mamas. (2021). Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. https://doi.org/10.1016/j.jaccao.2021.11.001

Background: Myocardial infarction is a cardiac adverse event associated with 5-fluorouracil (5-FU). There are limited data on the incidence, risk, and prognosis of 5-FU-associated myocardial infarction. Objectives: The aim of this study was to examin... Read More about Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study..

Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine (2021)
Journal Article
Harper. (2022). Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine. Cell Calcium, 101, 102522 - 102522. https://doi.org/10.1016/j.ceca.2021.102522

Human platelets regulate agonist-evoked Ca2+ signalling through Ca2+ release from and sequestration into acidic organelles. Previous studies have pharmacologically characterised the presence of a Ca2+-H+ exchanger in these organelles. This exchanger... Read More about Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine.

Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells (2021)
Journal Article
Luo, L., Foster, N. C., Man, K. L., Brunet, M., Hoey, D. A., Cox, S. C., …El Haj, A. J. (2021). Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells. Biotechnology Journal, 17(4), https://doi.org/10.1002/biot.202100401

AbstractMechanical stimulation plays in an important role in regulating stem cell differentiation and their release of extracellular vesicles (EVs). In this study, effects of low magnitude hydrostatic pressure (HP) on the chondrogenic differentiation... Read More about Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells.

UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. (2021)
Journal Article
Corrà, F., Crudele, F., Baldassari, F., Bianchi, N., Galasso, M., Minotti, L., …Volinia, S. (2021). UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. Genes, 12(12), Article 1978. https://doi.org/10.3390/genes12121978

In the human genome, there are about 600 ultra-conserved regions (UCRs), long DNA sequences extremely conserved in vertebrates. We performed a large-scale study to quantify transcribed UCR (T-UCR) and miRNA levels in over 6000 cancer and normal tissu... Read More about UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines..

Mobilizing physiotherapy knowledge: Understanding the best evidence and barriers to implementation of hydrotherapy for musculoskeletal disease. (2021)
Journal Article
Dziedzic. (2021). Mobilizing physiotherapy knowledge: Understanding the best evidence and barriers to implementation of hydrotherapy for musculoskeletal disease. Physiotherapy Theory and Practice, 1 - 8. https://doi.org/10.1080/09593985.2021.2010847

OBJECTIVES: To explore two linked strategies to highlight the best current available evidence for hydrotherapy and to explore the barriers and enablers to mobilizing this evidence into practice. METHOD: Phase 1: The best published evidence for hydrot... Read More about Mobilizing physiotherapy knowledge: Understanding the best evidence and barriers to implementation of hydrotherapy for musculoskeletal disease..

Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial. (2021)
Journal Article
Roffe. (2021). Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial. Stroke, 1141-1148. https://doi.org/10.1161/STROKEAHA.121.035191

BACKGROUND: Seeking consent rapidly in acute stroke trials is crucial as interventions are time sensitive. We explored the association between consent pathways and time to enrollment in the TICH-2 (Tranexamic Acid in Intracerebral Haemorrhage-2) rand... Read More about Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial..

Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions (2021)
Journal Article
Hafezi, M., Nouri Khorasani, S., Zare, M., Esmaeely Neisiany, R., & Davoodi, P. (2021). Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions. Polymers, 13(23), Article 4199. https://doi.org/10.3390/polym13234199

Cartilage is a tension- and load-bearing tissue and has a limited capacity for intrinsic self-healing. While microfracture and arthroplasty are the conventional methods for cartilage repair, these methods are unable to completely heal the damaged tis... Read More about Advanced Hydrogels for Cartilage Tissue Engineering: Recent Progress and Future Directions.

Facile synthesis and biological evaluation of chrysin derivatives (2021)
Journal Article
Omonga, N., Zia, Z., Ghanbour, H., Ragazzon-Smith, A., Foster, H., Hadfield, J., & Ragazzon, P. (2021). Facile synthesis and biological evaluation of chrysin derivatives. Journal of Chemical Research, 1083-1092. https://doi.org/10.1177/17475198211057467

In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds were purified, characterised and tested on different cell lines and bacterial strains. From this family, 7-(2,... Read More about Facile synthesis and biological evaluation of chrysin derivatives.

Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. (2021)
Journal Article
Chen. (2021). Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain. Alzheimer's Research and Therapy, 194 - ?. https://doi.org/10.1186/s13195-021-00935-z

BACKGROUND: Alzheimer's disease (AD) is a progressive, degenerative, and terminal disease without cure. There is an urgent need for a new strategy to treat AD. The aim of this study was to investigate the effects of intermittent hypoxic treatment (IH... Read More about Intermittent hypoxia treatment alleviates memory impairment in the 6-month-old APPswe/PS1dE9 mice and reduces amyloid beta accumulation and inflammation in the brain..

Analgesic prescribing in patients with inflammatory arthritis in England: an observational study using electronic healthcare record data (2021)
Journal Article
Scott, I. C., Bailey, J., White, C. R., Mallen, C., & Muller, S. (2022). Analgesic prescribing in patients with inflammatory arthritis in England: an observational study using electronic healthcare record data. Rheumatology, 61(8), 3201–3211. https://doi.org/10.1093/rheumatology/keab870

OBJECTIVES: International data suggest inflammatory arthritis (IA) pain management frequently involves opioid prescribing, despite little evidence of efficacy, and potential harms. We evaluated analgesia prescribing in English National Health Service... Read More about Analgesic prescribing in patients with inflammatory arthritis in England: an observational study using electronic healthcare record data.

Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles (2021)
Journal Article
Curtis. (2021). Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles. Nanomaterials, 2976 - 2976. https://doi.org/10.3390/nano11112976

Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or 'know-how'. Additionally, standard protocols do no... Read More about Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles.

Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters (2021)
Journal Article
Perera-Solis, D., Zholobenko, V., Whiting, A., & Greenwell, H. (2021). Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters. RSC advances, 11(56), 35575 - 35584. https://doi.org/10.1039/D1RA06871G

Ketonic decarboxylation has gained significant attention in recent years as a pathway to reduce the oxygen content within biomass-derived oils, and to produce sustainable ketones. The reaction is base catalysed, with MgO an economic, accessible and h... Read More about Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters.

Assisted peritoneal dialysis across Europe: Practice variation and factors associated with availability (2021)
Journal Article
Davies. (2021). Assisted peritoneal dialysis across Europe: Practice variation and factors associated with availability. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 533-541. https://doi.org/10.1177/08968608211049882

Background:
In Europe, the number of elderly end-stage kidney disease patients is increasing. Few of those patients receive peritoneal dialysis (PD), as many cannot perform PD autonomously. Assisted PD programmes are available in most European coun... Read More about Assisted peritoneal dialysis across Europe: Practice variation and factors associated with availability.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes (2021)
Journal Article
Alexander, S. P. H., Fabbro, D., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., …Wong, S. S. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. British Journal of Pharmacology, 178(S1), S313 - S411. https://doi.org/10.1111/bph.15542

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select... Read More about THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes.

Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors (2021)
Journal Article
(2021). Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors. Journal of Patient Safety and Risk Management, 214 - 220. https://doi.org/10.1177/25160435211036672

Background Prescribing errors are common, occurring in 7% of in-patient medication orders in UK hospitals. Foundation Year 1 (F1) doctors have reported a lack of feedback on prescribing as a cause of errors. Aim To evaluate the effect of implementing... Read More about Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors.

Reducing risks associated with medicines and lifestyle in a residential care population with intellectual disabilities: evaluation of a pharmacy review initiative in England (2021)
Journal Article
Thayer, N., White, S., Islam, J., Jones, W., Kenzie, S., & Kullu, R. (2021). Reducing risks associated with medicines and lifestyle in a residential care population with intellectual disabilities: evaluation of a pharmacy review initiative in England. BMJ Open, 11(8), Article e046630. https://doi.org/10.1136/bmjopen-2020-046630

OBJECTIVES: A collaborative service initiative involving community pharmacists and a specialist mental health pharmacist was developed to provide pharmacist reviews for care home residents with intellectual disabilities (IDs). This study aimed to cha... Read More about Reducing risks associated with medicines and lifestyle in a residential care population with intellectual disabilities: evaluation of a pharmacy review initiative in England.

Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy (2021)
Journal Article
Bowerman. (2021). Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy. JCI insight, 1-24. https://doi.org/10.1172/jci.insight.149446

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure. We aimed to identify novel treatments to alleviate muscle pathology... Read More about Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy.