New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2. (2021)
Journal Article
Reynisson. (2021). New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2. Molecules, https://doi.org/10.3390/molecules27010072

A series of deoxycholic acid (DCA) amides containing benzyl ether groups on the steroid core were tested against the tyrosyl-DNA phosphodiesterase 1 (TDP1) and 2 (TDP2) enzymes. In addition, 1,2,4- and 1,3,4-oxadiazole derivatives were synthesized to... Read More about New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2..

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., …Treadwell, K. (2021). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), 126 - 126. https://doi.org/10.3390/ijms23010126

<jats:p>Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine (2021)
Journal Article
Harper. (2022). Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine. Cell Calcium, 101, 102522 - 102522. https://doi.org/10.1016/j.ceca.2021.102522

Human platelets regulate agonist-evoked Ca2+ signalling through Ca2+ release from and sequestration into acidic organelles. Previous studies have pharmacologically characterised the presence of a Ca2+-H+ exchanger in these organelles. This exchanger... Read More about Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine.

EAHP European Statements Survey 2018, focusing on Section 1: Introductory Statements and Governance, Section 3: Production and Compounding, and Section 4: Clinical Pharmacy Services (2021)
Journal Article
(2021). EAHP European Statements Survey 2018, focusing on Section 1: Introductory Statements and Governance, Section 3: Production and Compounding, and Section 4: Clinical Pharmacy Services. European Journal of Hospital Pharmacy, 26-32. https://doi.org/10.1136/ejhpharm-2019-002028

Objectives
The 2018 EAHP European Statements Survey focused on sections 1, 3 and 4 of the European Statements of Hospital Pharmacy. Statistical data on the level of implementation and on the main barriers to implementation of the Statements were col... Read More about EAHP European Statements Survey 2018, focusing on Section 1: Introductory Statements and Governance, Section 3: Production and Compounding, and Section 4: Clinical Pharmacy Services.

The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM) (2021)
Journal Article
Stedman, M., Rea, R., Duff, C. J., Livingston, M., McLoughlin, K., Wong, L., …Heald, A. H. (2022). The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM). https://doi.org/10.1002/edm2.302

BACKGROUND: Finger prick blood glucose (BG) monitoring remains a mainstay of management in people with type 2 diabetes (T2DM) who take sulphonylurea (SU) drugs or insulin. We recently examined patient experience of BG monitoring in people with type 1... Read More about The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM).

Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial. (2021)
Journal Article
Roffe. (2021). Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial. Stroke, 1141-1148. https://doi.org/10.1161/STROKEAHA.121.035191

BACKGROUND: Seeking consent rapidly in acute stroke trials is crucial as interventions are time sensitive. We explored the association between consent pathways and time to enrollment in the TICH-2 (Tranexamic Acid in Intracerebral Haemorrhage-2) rand... Read More about Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial..

Facile synthesis and biological evaluation of chrysin derivatives (2021)
Journal Article
Omonga, N., Zia, Z., Ghanbour, H., Ragazzon-Smith, A., Foster, H., Hadfield, J., & Ragazzon, P. (2021). Facile synthesis and biological evaluation of chrysin derivatives. Journal of Chemical Research, 1083-1092. https://doi.org/10.1177/17475198211057467

In this paper, novel synthetic methods, including microwave O-alkylation, were used to produce several chrysin derivatives. These compounds were purified, characterised and tested on different cell lines and bacterial strains. From this family, 7-(2,... Read More about Facile synthesis and biological evaluation of chrysin derivatives.

Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles (2021)
Journal Article
Curtis. (2021). Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles. Nanomaterials, 2976 - 2976. https://doi.org/10.3390/nano11112976

Hybrid iron oxide-gold nanoparticles are of increasing interest for applications in nanomedicine, photonics, energy storage, etc. However, they are often difficult to synthesise without experience or 'know-how'. Additionally, standard protocols do no... Read More about Investigation into the Use of Microfluidics in the Manufacture of Metallic Gold-Coated Iron Oxide Hybrid Nanoparticles.

Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters (2021)
Journal Article
Perera-Solis, D., Zholobenko, V., Whiting, A., & Greenwell, H. (2021). Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters. RSC advances, 11(56), 35575 - 35584. https://doi.org/10.1039/D1RA06871G

Ketonic decarboxylation has gained significant attention in recent years as a pathway to reduce the oxygen content within biomass-derived oils, and to produce sustainable ketones. The reaction is base catalysed, with MgO an economic, accessible and h... Read More about Heterogeneous ketonic decarboxylation of dodecanoic acid: studying reaction parameters.

Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells (2021)
Thesis
Fadayomi, I. E. (2021). Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells. (Thesis). Keele University

Ovarian cancer is a gynaecological malignancy associated with the highest level of death. Its resistance against anti-cancer drugs in recent time has exacerbated the problem. Hence, the search for novel drugs from plants used in traditional medicine... Read More about Antiproliferative, proapoptotic and DNA methylation activity of sesqui- and diterpenoids in ovarian cancer cells.

Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study (2021)
Thesis
Chatzixenitidis, A. (2021). Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study. (Thesis). Keele University

Background and aim: Information support is an integral part of cancer care, but its provision can be problematic in busy health settings. The aim of this project was to develop and evaluate a health app to facilitate the provision of information supp... Read More about Development and evaluation of a novel virtual agent-based app for patients with colorectal cancer: A mixed methods study.

Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation. (2021)
Journal Article
(2021). Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation. Cells, https://doi.org/10.3390/cells10112819

BACKGROUND: Liver transplantation remains the only viable therapy for liver failure but has a severely restricted utility. Here, we aimed to decellularize rat livers to form acellular 3D bio-scaffolds suitable for seeding with induced pluripotent cel... Read More about Functional Recellularization of Acellular Rat Liver Scaffold by Induced Pluripotent Stem Cells: Molecular Evidence for Wnt/B-Catenin Upregulation..

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. (2021)
Journal Article
Alexander, S. P. H., Christopoulos, A., Davenport, A. P., Kelly, E., Mathie, A., Peters, J. A., …Ye, R. D. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors. British Journal of Pharmacology, 178(S1), S27 - S156. https://doi.org/10.1111/bph.15538

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select... Read More about THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors..

3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells. (2021)
Journal Article
Camilla Ciardulli, M., Lovecchio, J., Scala, P., Pavel Lamparelli, E., Dale, T., Giudice, V., …Della Porta, G. (2021). 3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells. Pharmaceutics, 13(9), https://doi.org/10.3390/pharmaceutics13091448

The present work described a bio-functionalized 3D fibrous construct, as an interactive teno-inductive graft model to study tenogenic potential events of human mesenchymal stem cells collected from Wharton's Jelly (hWJ-MSCs). The 3D-biomimetic and bi... Read More about 3D Biomimetic Scaffold for Growth Factor Controlled Delivery: An In-Vitro Study of Tenogenic Events on Wharton's Jelly Mesenchymal Stem Cells..

Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors (2021)
Journal Article
(2021). Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors. Journal of Patient Safety and Risk Management, 214 - 220. https://doi.org/10.1177/25160435211036672

Background Prescribing errors are common, occurring in 7% of in-patient medication orders in UK hospitals. Foundation Year 1 (F1) doctors have reported a lack of feedback on prescribing as a cause of errors. Aim To evaluate the effect of implementing... Read More about Implementation and evaluation of a good prescribing tip email to reduce junior doctors' prescribing errors.

Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy (2021)
Journal Article
Bowerman. (2021). Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy. JCI insight, 1-24. https://doi.org/10.1172/jci.insight.149446

Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by loss of survival motor neuron (SMN) protein. While SMN restoration therapies are beneficial, they are not a cure. We aimed to identify novel treatments to alleviate muscle pathology... Read More about Combining multi-omics and drug perturbation profiles to identify muscle-specific treatments for spinal muscular atrophy.

The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins (2021)
Thesis
Njoroge, W. (2021). The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins. (Thesis). Keele University

Cardiovascular disease (CVD) has been identified as the leading cause of mortality in westernised society. The triggering factor for the majority of cardiovascular diseases is atherosclerosis, defined as an accumulation of fatty materials in the vasc... Read More about The establishment and use of tissue engineered vascular models to investigate the pleiotropic effects of statins.

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. (2021)
Journal Article
Reynisson, J. (2021). Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs. Oncology and Therapy,

Cancer chemotherapy sensitizers hold the key to maximizing the potential of standard anticancer treatments. We have a long-standing interest in developing and validating inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) as ch... Read More about Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs..

Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students (2021)
Journal Article
White, S., Gifford, A., & Frisher, M. (2021). Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students. Pharmacy Education, 21(1), 56 - 64. https://doi.org/10.46542/pe.2021.211.5664

Description: Students in small groups designed, delivered and evaluated real-life health promotion campaigns in the local community. A peer assessed component was included from the fifth cohort onwards. Evaluation: Six successive cohorts of pharmacy... Read More about Experiential learning in public health: evaluation of a health promotion campaign assessment for pharmacy students.

DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells (2021)
Journal Article
Kitchen. (2021). DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells. Cells, 1032 - 1032. https://doi.org/10.3390/cells10051032

The application of physiological oxygen (physoxia) concentrations is becoming increasingly commonplace within a mammalian stem cell culture. Human mesenchymal stem cells (hMSCs) attract widespread interest for clinical application due to their unique... Read More about DNMT3B Is an Oxygen-Sensitive De Novo Methylase in Human Mesenchymal Stem Cells.