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SBOL Visual 2 Ontology (2019)
Presentation / Conference
Misirli, G. (2019, July). SBOL Visual 2 Ontology. Presented at 11th International Workshop on Bio-Design Automation (IWBDA 2019), Cambridge

Conference paper.

In Vivo Water Dynamics in Shewanella oneidensis Bacteria at High Pressure. (2019)
Journal Article
(2019). In Vivo Water Dynamics in Shewanella oneidensis Bacteria at High Pressure. Scientific reports, 8716 -?. https://doi.org/10.1038/s41598-019-44704-3

Following observations of survival of microbes and other life forms in deep subsurface environments it is necessary to understand their biological functioning under high pressure conditions. Key aspects of biochemical reactions and transport processe... Read More about In Vivo Water Dynamics in Shewanella oneidensis Bacteria at High Pressure..

Cuticular Hydrocarbon Analysis in Forensic Entomology: A Review (2019)
Journal Article
Shemilt. (2019). Cuticular Hydrocarbon Analysis in Forensic Entomology: A Review. Archaeological and Environmental Forensic Science, 127 - 138. https://doi.org/10.1558/aefs.36241

Blowflies are the first inhabitants of decomposing remains and are therefore of forensic relevance for post mortem interval estimations. Forensic entomology is becoming widely accepted as a branch of forensic science and is being utilised more within... Read More about Cuticular Hydrocarbon Analysis in Forensic Entomology: A Review.

An evaluation of the antiparasitic activities of a novel natural product and open-access Pathogen Box libraries (2019)
Thesis
Hameed, H. N. (2019). An evaluation of the antiparasitic activities of a novel natural product and open-access Pathogen Box libraries. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413079

Using a novel library of natural products isolated from temperate zone plants, the antiparasitic activity of 643 Phytopure library compounds were determined against intraerytrocytic P. falciparum, the blood-stream form of T. b brucei and axenic amast... Read More about An evaluation of the antiparasitic activities of a novel natural product and open-access Pathogen Box libraries.

Biophysical studies of dynamic CD4 changes implicated in HIV-1 infection (2019)
Thesis
Channell, J. A. (2019). Biophysical studies of dynamic CD4 changes implicated in HIV-1 infection. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413133

Cluster of differentiation 4 (CD4) is a receptor protein found on the surface of cells of the immune system and is the primary receptor of the human immuno-deficiency virus-1 (HIV-1) envelope glycoprotein 120 (gp120). The extracellular portion of CD4... Read More about Biophysical studies of dynamic CD4 changes implicated in HIV-1 infection.

Evaluating donor variability of ovine adult stem cells - implications for orthopaedic animal models (2019)
Thesis
Muhammad Hassan, E. (2019). Evaluating donor variability of ovine adult stem cells - implications for orthopaedic animal models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413084

Articular cartilage is a specialised tissue which covers the articulating surfaces at the end of the mammalian bone. This thin layer performs essential functions such as load bearing and shock absorption in joints. However, it lacks the ability to sa... Read More about Evaluating donor variability of ovine adult stem cells - implications for orthopaedic animal models.

Biochemical, biophysical, and structural studies of seed proteins from Moringa oleifera and implications for traditional water purification (2019)
Thesis
Moulin, M. (2019). Biochemical, biophysical, and structural studies of seed proteins from Moringa oleifera and implications for traditional water purification. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413067

Moringa oleifera is a tropical plant that belongs to the Moringaceae family and is native to northern India. Moringa oleifera is called The Miracle Tree because many of its parts have valuable applications. In particular, seed extracts from the plant... Read More about Biochemical, biophysical, and structural studies of seed proteins from Moringa oleifera and implications for traditional water purification.

Harmonizing semantic annotations for computational models in biology (2019)
Journal Article
(2019). Harmonizing semantic annotations for computational models in biology. Briefings in Bioinformatics, 540 -550. https://doi.org/10.1093/bib/bby087

Life science researchers use computational models to articulate and test hypotheses about the behavior of biological systems. Semantic annotation is a critical component for enhancing the interoperability and reusability of such models as well as for... Read More about Harmonizing semantic annotations for computational models in biology.

Opposing effects of final population density and stress on Escherichia coli mutation rate (2018)
Journal Article
Channon. (2018). Opposing effects of final population density and stress on Escherichia coli mutation rate. ISME Journal, 2981-2987. https://doi.org/10.1038/s41396-018-0237-3

Evolution depends on mutations. For an individual genotype, the rate at which mutations arise is known to increase with various stressors (stress-induced mutagenesis-SIM) and decrease at high final population density (density-associated mutation-rate... Read More about Opposing effects of final population density and stress on Escherichia coli mutation rate.

Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development (2018)
Thesis
Hadfield, L. C. (2018). Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411146

The biologically and medically important heparan sulphate and heparin polysaccharides have previously been shown to modulate the activity of an aspartyl protease, ß-secretase (BACE1), implicated in the aetiology of Alzheimer’s disease. Research group... Read More about Heparin and heparin-like molecules inhibit the Alzheimer’s ß-secretase (BACE1): considerations for biological assay and future therapeutic development.

The copulation behaviour of the western flower thrips (2018)
Thesis
Akinyemi, A. O. (2018). The copulation behaviour of the western flower thrips. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/411431

The western flower thrips Frankliniella occidentalis (Pergande) (Thysanoptera: Thripidae) is a major pest of agricultural and horticultural importance in most parts of the world. It damages crops by feeding and transmission of viruses. There is a nee... Read More about The copulation behaviour of the western flower thrips.

Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite (2018)
Journal Article
Russo. (2018). Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite. PLoS Pathogens, https://doi.org/10.1371/journal.ppat.1007031

Parasite egress from infected erythrocytes and invasion of new red blood cells are essential processes for the exponential asexual replication of the malaria parasite. These two tightly coordinated events take place in less than a minute and are in p... Read More about Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.

Evaluation of analogues of furan-amidines as inhibitors of NQO2 (2018)
Journal Article
Russo. (2018). Evaluation of analogues of furan-amidines as inhibitors of NQO2. Bioorganic and Medicinal Chemistry Letters, 1292 - 1297. https://doi.org/10.1016/j.bmcl.2018.03.025

Inhibitors of the enzyme NQO2 (NRH: quinone oxidoreductase 2) are of potential use in cancer chemotherapy and malaria. We have previously reported that non-symmetrical furan amidines are potent inhibitors of NQO2 and here novel analogues are evaluate... Read More about Evaluation of analogues of furan-amidines as inhibitors of NQO2.

Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition (2018)
Journal Article
Russo. (2018). Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition. Proceedings of the National Academy of Sciences of the United States of America, E2801 - E2810. https://doi.org/10.1073/pnas.1707929115

Owing to the prevalence of tumor-associated macrophages (TAMs) in cancer and their unique influence upon disease progression and malignancy, macrophage-targeted interventions have attracted notable attention in cancer immunotherapy. However, tractabl... Read More about Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition.

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion (2017)
Journal Article
Russo. (2017). Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion. Science, 518 - 522. https://doi.org/10.1126/science.aan1478

Proteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involved in diverse cellular processes. Most have been studied e... Read More about Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.

Biological Flora of the British Isles: Sorbus torminalis (2017)
Journal Article
(2017). Biological Flora of the British Isles: Sorbus torminalis. Journal of Ecology, 1806-1831. https://doi.org/10.1111/1365-2745.12857

1.This account presents information on all aspects of the biology of Sorbus torminalis (L.) Crantz (Wild Service-tree) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard... Read More about Biological Flora of the British Isles: Sorbus torminalis.

Aluminum Exposure for 60 days at Human Dietary Levels Impairs Spermatogenesis and Sperm Quality in Rats (2017)
Journal Article
(2017). Aluminum Exposure for 60 days at Human Dietary Levels Impairs Spermatogenesis and Sperm Quality in Rats. Reproductive Toxicology, 128-141. https://doi.org/10.1016/j.reprotox.2017.08.008

Abstract Concerns about environmental aluminum (Al) and reproductive health have been raised. We investigated the effects of Al exposure at a human relevant dietary level and a high level exposure to Al. Experiment 1 (Lower level) rats were treated o... Read More about Aluminum Exposure for 60 days at Human Dietary Levels Impairs Spermatogenesis and Sperm Quality in Rats.

Males and females of Juniperus communis L. and Taxus baccata L. show different seasonal patterns of nitrogen and carbon content in needles (2017)
Journal Article
(2017). Males and females of Juniperus communis L. and Taxus baccata L. show different seasonal patterns of nitrogen and carbon content in needles. Acta physiologiae plantarum / Polish Academy of Sciences, Committee of Plant Physiology Genetics and Breeding, https://doi.org/10.1007/s11738-017-2489-3

Genders of dioecious species often show secondary sexual dimorphisms (not directly related to the sex organs), which may be related to reproductive demand for resources during the year. Our working hypothesis stated that phenology influences yearly s... Read More about Males and females of Juniperus communis L. and Taxus baccata L. show different seasonal patterns of nitrogen and carbon content in needles.

Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex (2017)
Journal Article
Glazewski, S., Greenhill, S., & Fox, K. (2017). Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex. Philosophical Transactions B: Biological Sciences, 372(1715), https://doi.org/10.1098/rstb.2016.0150

Recent studies have shown that ocular dominance plasticity in layer 2/3 of the visual cortex exhibits a form of homeostatic plasticity that is related to synaptic scaling and depends on TNFa. In this study, we tested whether a similar form of plastic... Read More about Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex.