Skip to main content

Research Repository

Advanced Search

Is it time for biocatalysis in fragment-based drug discovery? (2020)
Journal Article
Cosgrove. (2020). Is it time for biocatalysis in fragment-based drug discovery?. Chemical Science, 11104 - 11112. https://doi.org/10.1039/D0SC04103C

The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature... Read More about Is it time for biocatalysis in fragment-based drug discovery?.

Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. (2020)
Journal Article
Guinan, M., Benckendorff, C., Smith, M., & Miller, G. (2020). Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues. Molecules, 25(9), https://doi.org/10.3390/molecules25092050

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers. Several such compounds, including gemcitabine and cytarabine, are the go-to option in first-line treatments. However, thes... Read More about Recent Advances in the Chemical Synthesis and Evaluation of Anticancer Nucleoside Analogues..

Hopf-Galois module structure of tamely ramified radical extensions of prime degree (2019)
Journal Article
Truman, P. J. (2020). Hopf-Galois module structure of tamely ramified radical extensions of prime degree. Journal of Pure and Applied Algebra, 224(5), Article 106231. https://doi.org/10.1016/j.jpaa.2019.106231

Let K be a number field and let L/K be a tamely ramified radical extension of prime degree p. If K contains a primitive p th root of unity then L/K is a cyclic Kummer extension; in this case the group algebra K[G] (with G = Gal(L/K)) gives the unique... Read More about Hopf-Galois module structure of tamely ramified radical extensions of prime degree.

Search protocols for hidden forensic objects beneath floors and within walls (2014)
Journal Article
Ruffell, A., Pringle, J. K., & Forbes, S. (2014). Search protocols for hidden forensic objects beneath floors and within walls. Forensic Science International, 237, 137 -145. https://doi.org/10.1016/j.forsciint.2013.12.036

The burial of objects (human remains, explosives, weapons) below or behind concrete, brick, plaster or tiling may be associated with serious crime and are difficult locations to search. These are quite common forensic search scenarios but little has... Read More about Search protocols for hidden forensic objects beneath floors and within walls.