Chinese Students’ Expectations Versus Reality When Studying on a UK-China Transnational Chemistry Degree Program (2019)
Journal Article
Cranwell, P. B., Edwards, M. G., Jane Haxton, K., Hyde, J., Page, E. M., Plana, D., …Wright, J. S. (2019). Chinese Students’ Expectations Versus Reality When Studying on a UK-China Transnational Chemistry Degree Program. New Directions in the Teaching of Physical Sciences, 14(1), https://doi.org/10.29311/ndtps.v0i14.3325

An extensive study has been conducted into the experiences of Chinese chemistry students studying on transnational education (TNE) programs at four UK institutions partnered with Chinese universities; in particular, student expectations regarding stu... Read More about Chinese Students’ Expectations Versus Reality When Studying on a UK-China Transnational Chemistry Degree Program.

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy (2019)
Journal Article
Reynisson. (2019). Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms21010126

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new chemosensitizing agents due to its ability to remove DNA damage caused by topoisomerase 1 (To... Read More about Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.

An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+ (2019)
Journal Article
Watkinson, M., Fang, L., Trigiante, G., Crespo-Otero, R., Philpott, M. P., & Jones, C. R. (2019). An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+. Organic and Biomolecular Chemistry, 17(47), 10013-10019. https://doi.org/10.1039/c9ob01855g

Zn2+ is involved in a number of biological processes and its wide-ranging roles at the subcellular level, especially in specific organelles, have not yet been fully established due to a lack of tools to image it effectively. We report a new and effic... Read More about An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+.

Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+ (2019)
Journal Article
Fang, L., Trigiante, G., Crespo-Otero, R., Hawes, C. S., Philpott, M. P., Jones, C. R., & Watkinson, M. (2019). Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+. Chemical Science, 10(47), 10881-10887. https://doi.org/10.1039/C9SC04300D

Zn2+ plays an important role in the normal function of the endoplasmic reticulum (ER) and its deficiency can cause ER stress, which is related to a wide range of diseases. In order to provide tools to better understand the role of mobile Zn2+ in ER p... Read More about Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+.

Exploring anomeric glycosylation of phosphoric acid: Optimisation and scope for non-native substrates. (2019)
Journal Article
Beswick, L., Ahmadipour, S., Hofman, G., Wootton, H., Dimitriou, E., Reynisson, J., …Miller, G. J. (2020). Exploring anomeric glycosylation of phosphoric acid: Optimisation and scope for non-native substrates. Carbohydrate Research, 488, 107896. https://doi.org/10.1016/j.carres.2019.107896

'No abstract'

Surface structural phase transition induced by the formation of metal–organic networks on the Si(111)-v7×v3-In surface (2019)
Journal Article
Suzuki, T., Lawrence, J., Morbec, J., Kratzer, P., & Costantini, G. (2019). Surface structural phase transition induced by the formation of metal–organic networks on the Si(111)-v7×v3-In surface. Nanoscale, 21790-21798. https://doi.org/10.1039/C9NR07074E

We studied the adsorption of 7,7,8,8-tetracyanoquinodimethane (TCNQ) on the Si(111)v7×v3 In surface, a known surface superconductor. Scanning tunneling microscopy shows the development of a surface-confined metal–organic network (SMON) where TCNQ mol... Read More about Surface structural phase transition induced by the formation of metal–organic networks on the Si(111)-v7×v3-In surface.

The Molecule-Metal Bond of Alternant versus Nonalternant Aromatic Systems on Coinage Metal Surfaces: Naphthalene versus Azulene on Ag(111) and Cu(111) (2019)
Journal Article
Klein, B. P., Morbec, J. M., Franke, M., Greulich, K. K., Sachs, M., Parhizkar, S., …Michael Gottfried, J. (2019). The Molecule-Metal Bond of Alternant versus Nonalternant Aromatic Systems on Coinage Metal Surfaces: Naphthalene versus Azulene on Ag(111) and Cu(111). Journal of Physical Chemistry C, 29219-29230. https://doi.org/10.1021/acs.jpcc.9b08824

Interfaces between polycyclic p-electron systems and metals play prominent roles in organic or graphene-based (opto)electronic devices, in which performance-related parameters depend critically on the properties of metal/semiconductor contacts. Here,... Read More about The Molecule-Metal Bond of Alternant versus Nonalternant Aromatic Systems on Coinage Metal Surfaces: Naphthalene versus Azulene on Ag(111) and Cu(111).

Calcification Microstructure Reflects Breast Tissue Microenvironment (2019)
Journal Article
Gosling, S., Scott, R., Greenwood, C., Bouzy, P., Nallala, J., D. Lyburn, I., …Rogers, K. (2019). Calcification Microstructure Reflects Breast Tissue Microenvironment. Journal of Mammary Gland Biology and Neoplasia, 333-342. https://doi.org/10.1007/s10911-019-09441-3

Microcalcifications are important diagnostic indicators of disease in breast tissue. Tissue microenvironments differ in many aspects between normal and cancerous cells, notably extracellular pH and glycolytic respiration. Hydroxyapatite microcalcific... Read More about Calcification Microstructure Reflects Breast Tissue Microenvironment.

Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. (2019)
Journal Article
Reynisson. (2019). Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. Bioorganic and Medicinal Chemistry, 115234 - ?. https://doi.org/10.1016/j.bmc.2019.115234

Spinocerebellar ataxia syndrome with axonal neuropathy (SCAN1) is a debilitating neurological disease that is caused by the mutation the Tyrosyl-DNA phosphodiesterase 1 (TDP1) DNA repair enzyme. The crucial His493 in TDP1's binding site is replaced w... Read More about Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening..

Ion-exchanged Zeolite P as a Nanostructured Catalyst for Biodiesel Production (2019)
Journal Article
Al-Ani, A., Mordvinova, N., Lebedev, O., Khodakov, A., & Zholobenko, V. (2019). Ion-exchanged Zeolite P as a Nanostructured Catalyst for Biodiesel Production. Energy Reports, 357 -363. https://doi.org/10.1016/j.egyr.2019.03.003

Nano-crystalline synthetic gismondine modified via cation exchange has been utilised as a highly active and selective catalyst for the production of biofuel. In comparison with low silica zeolites FAU and LTA, K-form of gismondine, based on the maxim... Read More about Ion-exchanged Zeolite P as a Nanostructured Catalyst for Biodiesel Production.

Nanostructured materials as catalysts for the production of green fuels and platform chemicals (2019)
Thesis
Al-Ani, A. A. T. (2019). Nanostructured materials as catalysts for the production of green fuels and platform chemicals. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414937

A range of nano-structured materials were prepared and utilised in this work as catalysts for the production of biofuels and platform chemicals. Titanosilicate (ETS-10), Linde type-zeolite A, faujasites (FAU), zeolite MAP and sepiolite, were synthesi... Read More about Nanostructured materials as catalysts for the production of green fuels and platform chemicals.

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90) (2019)
Journal Article
Reynisson. (2019). Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90). International Journal of Molecular Sciences, https://doi.org/10.3390/ijms20215333

The molecular chaperone heat shock protein 90 (Hsp90) is a current inhibition target for the treatment of diseases, including cancer. In humans, there are two major cytosolic isoforms of Hsp90 (Hsp90a and Hsp90ß). Hsp90a is inducible and Hsp90ß is co... Read More about Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90).

Detection of aluminum in lumbar spinal cord of sheep subcutaneously inoculated with aluminum-hydroxide containing products (2019)
Journal Article
(2019). Detection of aluminum in lumbar spinal cord of sheep subcutaneously inoculated with aluminum-hydroxide containing products. Journal of Inorganic Biochemistry, -. https://doi.org/10.1016/j.jinorgbio.2019.110871

The use of vaccines containing aluminum (Al) adjuvants is widespread in ovine production. Al adjuvants induce an effective immune-response but lead to the formation of post-vaccination granulomas from which Al can disseminate. This work aims to study... Read More about Detection of aluminum in lumbar spinal cord of sheep subcutaneously inoculated with aluminum-hydroxide containing products.

Semi-Automated Data Analysis for Ion-Selective Electrodes and Arrays Using the R Package ISEtools. (2019)
Journal Article
(2019). Semi-Automated Data Analysis for Ion-Selective Electrodes and Arrays Using the R Package ISEtools. Sensors, https://doi.org/10.3390/s19204544

A new software package, ISEtools, is introduced for use within the popular open-source programming language R that allows Bayesian statistical data analysis techniques to be implemented in a straightforward manner. Incorporating all collected data si... Read More about Semi-Automated Data Analysis for Ion-Selective Electrodes and Arrays Using the R Package ISEtools..

A Further Unique Chondroitin Sulfate from the shrimp Litopenaeus vannamei with Antithrombin Activity that Modulates Acute Inflammation (2019)
Journal Article
Palhares, L., Brito, A., Andrade De Lima, M., Nader, H., London, J., Barsukov, I., …Chavante, S. (2019). A Further Unique Chondroitin Sulfate from the shrimp Litopenaeus vannamei with Antithrombin Activity that Modulates Acute Inflammation. Carbohydrate Polymers, 115031--115031. https://doi.org/10.1016/j.carbpol.2019.115031

The detailed structure of a further Chondroitin Sulfate from Litopenaeus vannamei shrimp (sCS) is described. The backbone structure was established by 1H/13C NMR, which identified 3-O-sulfated GlcA, 4-O-sulfated GalNAc, 6-O-sulfated GalNAc, and 4,6-d... Read More about A Further Unique Chondroitin Sulfate from the shrimp Litopenaeus vannamei with Antithrombin Activity that Modulates Acute Inflammation.

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors. (2019)
Journal Article
Reynisson, J. (2019). New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors. Molecules, https://doi.org/10.3390/molecules24203711

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can potentially improve therapeutic response to many chemotherapeutic regimes. A new set of usni... Read More about New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors..

Exploring a glycosylation methodology for the synthesis of hydroxamate-modified alginate building blocks (2019)
Journal Article
Dimitriou, E., & Miller, G. (2019). Exploring a glycosylation methodology for the synthesis of hydroxamate-modified alginate building blocks. Organic and Biomolecular Chemistry, 17(42), 9321-9335. https://doi.org/10.1039/c9ob02053e

Alginate, an anionic polysaccharide, is an important industrial biomaterial naturally harvested from seaweed. Many of its important physicochemical properties derive from the presence of charged carboxylate groups presented as uronic acids within the... Read More about Exploring a glycosylation methodology for the synthesis of hydroxamate-modified alginate building blocks.

Experimental and theoretical studies into the release of blood droplets from weapon tips (2019)
Journal Article
(2019). Experimental and theoretical studies into the release of blood droplets from weapon tips. Forensic Science International, 109934 - 109934. https://doi.org/10.1016/j.forsciint.2019.109934

The formation and release under gravity of blood droplets from simulated weapon tips has been investigated experimentally and the results analysed and interpreted using established theoretical models for detached pendent drops. Droplets were produced... Read More about Experimental and theoretical studies into the release of blood droplets from weapon tips.

International Group Work for Sustainable Chemistry (2019)
Journal Article
Haxton, K., & Darton, R. (2019). International Group Work for Sustainable Chemistry. New Directions in the Teaching of Physical Sciences, https://doi.org/10.29311/ndtps.v0i14.2821

As part of a transnational degree programme, students in the UK and China were linked together to carry out group work. This was enabled by having two versions of our FHEQ Level 4 Sustainable Chemistry module; in person for UK students, and by distan... Read More about International Group Work for Sustainable Chemistry.

Atomic-resolution crystal structures of the immune protein conglutinin from cow reveal specific interactions of its binding site with N-acetylglucosamine. (2019)
Journal Article
Paterson, J. M., Shaw, A. J., Burns, I., Dodds, A. W., Prasad, A., Reid, K. B., …Shrive, A. K. (2019). Atomic-resolution crystal structures of the immune protein conglutinin from cow reveal specific interactions of its binding site with N-acetylglucosamine. Journal of biological chemistry, 294(45), 17155-17165. https://doi.org/10.1074/jbc.RA119.010271

Bovine conglutinin is an immune protein that is involved in host resistance to microbes and parasites and interacts with complement component iC3b, agglutinates erythrocytes, and neutralizes influenza A virus. Here, we determined the high-resolution... Read More about Atomic-resolution crystal structures of the immune protein conglutinin from cow reveal specific interactions of its binding site with N-acetylglucosamine..