Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. (2023)
Journal Article
Turnbull, J. (2023). Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. Glia, 71(7), 1683-1698. https://doi.org/10.1002/glia.24363

There is an urgent need for therapies that target the multicellular pathology of central nervous system (CNS) disease. Modified, nonanticoagulant heparins mimic the heparan sulfate glycan family and are known regulators of multiple cellular processes... Read More about Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination..

Synthesis of α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands and their corresponding luminescent Tb(iii) complexes (2023)
Journal Article
Hegarty, I. N., Hawes, C. S., & Gunnlaugsson, T. (2023). Synthesis of α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands and their corresponding luminescent Tb(iii) complexes. Organic Chemistry Frontiers, 10(8), 1915-1926. https://doi.org/10.1039/D3QO00232B

The synthesis of chiral a-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands 4-6 designed by combining the coordination properties of two well-known ligand structures within a single unit is described. The self-assembly formation bet... Read More about Synthesis of α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands and their corresponding luminescent Tb(iii) complexes.

Fine-tuning of the size of supramolecular nanotoroids suppresses the subsequent catenation of nano-[2]catenane (2023)
Journal Article
Itabashi, H., Datta, S., Tsukuda, R., Hollamby, M. J., & Yagai, S. (2023). Fine-tuning of the size of supramolecular nanotoroids suppresses the subsequent catenation of nano-[2]catenane. Chemical Science, 14(12), 3270 - 3276. https://doi.org/10.1039/D2SC07063D

A judicious combination of ring-closing supramolecular polymerization and secondary nucleation can hierarchically organize a diphenylnaphthalene barbiturate monomer bearing a 3,4,5-tri(dodecyloxy)benzyloxy unit into self-assembled nano-polycatenanes... Read More about Fine-tuning of the size of supramolecular nanotoroids suppresses the subsequent catenation of nano-[2]catenane.

Colloidal III-V quantum dots: a synthetic perspective (2023)
Journal Article
Gazis, T. A., Cartlidge, A. J., & Matthews, P. D. (2023). Colloidal III-V quantum dots: a synthetic perspective. Journal of Materials Chemistry C, 11(12), 3926-3935. https://doi.org/10.1039/d2tc05234b

With the advent of stricter environmental regulation, quantum dots based on cadmium, lead and other heavy metals have become anathema. III–V semiconductors constitute a promising alternative because they not only match but indeed surpass the optoelec... Read More about Colloidal III-V quantum dots: a synthetic perspective.

Environmental Applications of Zeolites: Hydrophobic Sn-BEA as a Selective Gas Sensor for Exhaust Fumes (2023)
Journal Article
Dubray, F., Jendrlin, M., Grand, J., Lakiss, L., El Fallah, J., Mintova, S., …Zholobenko, V. (2023). Environmental Applications of Zeolites: Hydrophobic Sn-BEA as a Selective Gas Sensor for Exhaust Fumes. Chemistry, 334 - 347. https://doi.org/10.3390/chemistry5010025

Environmental monitoring of pollutants, such as NOx and COx, which can be facilitated by a range of gas sensors, is of considerable fundamental and practical importance. This work has been focused on the synthesis and evaluation of zeolite beta with... Read More about Environmental Applications of Zeolites: Hydrophobic Sn-BEA as a Selective Gas Sensor for Exhaust Fumes.

Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. (2023)
Journal Article
Devlin, A. J., Mycroft-West, C. J., Turnbull, J. E., Andrade De Lima, M., Guerrini, M., Yates, E. A., & Skidmore, M. A. (2023). Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. ACS Central Science, 9, 381-392. https://doi.org/10.1021/acscentsci.2c01176

Heparin is a polydisperse, heterogeneous polysaccharide of the glycosaminoglycan (GAG) class that has found widespread clinical use as a potent anticoagulant and is classified as an essential medicine by the World Health Organization. The importance... Read More about Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State..

High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. (2023)
Journal Article
Maciej-Hulme, M. L., Leprince, A. C., Lavin, A., Guimond, S. E., Turnbull, J. E., Pelletier, J., …Skidmore, M. A. (2023). High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. Analytical Methods, 15(11), 1461-1469. https://doi.org/10.1039/d2ay01803a

The fine structure of heparan sulfate (HS), the glycosaminoglycan polysaccharide component of cell surface and extracellular matrix HS proteoglycans, coordinates the complex cell signalling processes that control homeostasis and drive development in... Read More about High sensitivity (zeptomole) detection of BODIPY- labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts..

Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors (2023)
Journal Article
Clennell, B., Steward, T. G., Hanman, K., Needham, T., Benachour, J., Jepson, M., …Whitcomb, D. J. (2023). Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors. Brain Stimulation, 16(2), https://doi.org/10.1016/j.brs.2023.01.1674

Background
Focused ultrasound stimulation (FUS) has the potential to provide non-invasive neuromodulation of deep brain regions with unparalleled spatial precision. However, the cellular and molecular consequences of ultrasound stimulation on neuron... Read More about Ultrasound modulates neuronal potassium currents via ionotropic glutamate receptors.

A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1). (2023)
Journal Article
Mycroft-West, C., Devlin, A., Cooper, L., Guimond, S., Procter, P., Miller, G., …Skidmore, M. (2023). A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1). Carbohydrate Research, 525, Article 108747. https://doi.org/10.1016/j.carres.2023.108747

The clinically important anticoagulant heparin, a member of the glycosaminoglycan family of carbohydrates that is extracted predominantly from porcine and bovine tissue sources, has previously been shown to inhibit the ß-site amyloid precursor protei... Read More about A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease ß-site amyloid precursor protein cleaving enzyme 1 (BACE-1)..

Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose. (2023)
Journal Article
Porter, J., Lima, M. A., Pongener, I., & Miller, G. (2023). Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose. Carbohydrate Research, 524, Article 108759. https://doi.org/10.1016/j.carres.2023.108759

Sulfur containing glycosides offer an exciting prospect for inclusion within noncanonical glycan sequences, particularly as enabling probes for chemical glycobiology and for carbohydrate-based therapeutic development. In this context, we required acc... Read More about Synthesis of 4-thio-d-glucopyranose and interconversion to 4-thio-d-glucofuranose..

Geographical Variation of Cuticular Hydrocarbon Profiles of Adult Flies and Empty Puparia Amongst Three Populations of Calliphora vicina (Diptera: Calliphoridae). (2023)
Journal Article
Kula, C., Amendt, J., Drijfhout, F., & Moore, H. (2023). Geographical Variation of Cuticular Hydrocarbon Profiles of Adult Flies and Empty Puparia Amongst Three Populations of Calliphora vicina (Diptera: Calliphoridae). Journal of Medical Entomology, 14 - 23. https://doi.org/10.1093/jme/tjac167

Blowflies (Diptera: Calliphoridae) are of great importance in forensic entomology and in determining the minimum post-mortem interval, as they may be the first group of insects to colonize decomposing remains. Reliable species identification is an es... Read More about Geographical Variation of Cuticular Hydrocarbon Profiles of Adult Flies and Empty Puparia Amongst Three Populations of Calliphora vicina (Diptera: Calliphoridae)..

Teaching remote laboratories using smart phone sensors: determining the density of air (2023)
Journal Article
Wye. (2023). Teaching remote laboratories using smart phone sensors: determining the density of air. Physics Education, 58(1), 015002 - 015002. https://doi.org/10.1088/1361-6552/ac9816

<jats:title>Abstract</jats:title> <jats:p>During the COVID-19 pandemic and subsequent lockdown, both schools and universities faced significant challenges in moving teaching from an <jats:italic>in-situ</jats:italic> setting to a remote one, this inc... Read More about Teaching remote laboratories using smart phone sensors: determining the density of air.

Cholera toxin B-subunit glycopeptide conjugates (2022)
Dataset
Dolan, J. P., Webb, M. E., & Turnbull, W. . B. (2022). Cholera toxin B-subunit glycopeptide conjugates. [Dataset]. https://doi.org/10.5518/1194

Investigating the interaction between dengue viral envelope proteins and host receptor molecules (2022)
Thesis
Hyatt, J. G. (2022). Investigating the interaction between dengue viral envelope proteins and host receptor molecules. (Thesis). Keele University

Infection of dengue remains to this date a major socio-economic and public health challenge for large parts of the world, especially low- and middle- income countries in the tropics and sub-tropics. Despite the prevalence of the associated neglected... Read More about Investigating the interaction between dengue viral envelope proteins and host receptor molecules.

Synthesis of a B-Antigen Hexasaccharide, a B-Lewis b Heptasaccharide and Glycoconjugates Thereof to Investigate Binding Properties of Helicobacter pylori (2022)
Journal Article
Reihill, M., Fournière, V., Cheallaigh, A. N., Edlund, J. O., Miller, G. J., Borén, T., …Oscarson, S. (2023). Synthesis of a B-Antigen Hexasaccharide, a B-Lewis b Heptasaccharide and Glycoconjugates Thereof to Investigate Binding Properties of Helicobacter pylori. Chemistry - A European Journal, 29(16), Article e202203672. https://doi.org/10.1002/chem.202203672

AbstractInfecting the stomach of almost 50 % of people, Helicobacter pylori is a causative agent of gastritis, peptic ulcers and stomach cancers. Interactions between bacterial membrane‐bound lectin, Blood group Antigen Binding Adhesin (BabA), and hu... Read More about Synthesis of a B-Antigen Hexasaccharide, a B-Lewis b Heptasaccharide and Glycoconjugates Thereof to Investigate Binding Properties of Helicobacter pylori.

Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds (2022)
Journal Article
Mogas Barcons, A., Chowdhury, F., Chari, D. M., & Adams, C. (2022). Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds. Materials, 16(1), Article 124. https://doi.org/10.3390/ma16010124

Spinal cord injury is debilitating with functional loss often permanent due to a lack of neuro-regenerative or neuro-therapeutic strategies. A promising approach to enhance biological function is through implantation of tissue engineered constructs,... Read More about Systematic Alignment Analysis of Neural Transplant Cells in Electrospun Nanofibre Scaffolds.

Reeling them in: Ph2PSiMe3 in the sequential formation of InP magic-sized clusters (2022)
Journal Article
Gazis, T. A., & Matthews, P. D. (2022). Reeling them in: Ph2PSiMe3 in the sequential formation of InP magic-sized clusters. Chemical Communications, 58(99), 13799 - 13802. https://doi.org/10.1039/D2CC06204F

Indium phosphide magic-sized clusters (MSCs) have been identified as a key step in the growth of InP quantum dots (QDs). However, the need for elevated temperatures to form QDs from MSCs has limited our understanding of this transformation. Herein, w... Read More about Reeling them in: Ph2PSiMe3 in the sequential formation of InP magic-sized clusters.

Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis (2022)
Journal Article
Cosgrove, Miller, & Dolan. (2022). Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis. JACS Au, 47-61. https://doi.org/10.1021/jacsau.2c00529

While the field of biocatalysis has bloomed over the past 20–30 years, advances in the understanding and improvement of carbohydrate-active enzymes, in particular, the sugar nucleotides involved in glycan building block biosynthesis, have progressed... Read More about Biocatalytic Approaches to Building Blocks for Enzymatic and Chemical Glycan Synthesis.

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. (2022)
Journal Article
Rotherham, M., Moradi, Y., Nahar, T., Mosses, D., Telling, N., & El Haj, A. (2022). Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. Frontiers in Medical Technology, 4, Article 981421. https://doi.org/10.3389/fmedt.2022.981421

TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders. TREK1 gating is controlled by a wide range of exter... Read More about Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells..

Effect of trivalent rare earth doping in cadmium silicates hosts: a theoretical study (2022)
Journal Article
Santos, A., Bispo, G., Freire, E., Macedo, Z., Jackson, R., & Valerio, M. (2022). Effect of trivalent rare earth doping in cadmium silicates hosts: a theoretical study. Physica Scripta, https://doi.org/10.1088/1402-4896/aca228

The objective of the present work is to investigate the possibilities for extrinsic defects in the three cadmium silicate matrices, CdSiO3, Cd2SiO4 and Cd3SiO5 and understand the final geometry of the most energetically favourable defects, which are... Read More about Effect of trivalent rare earth doping in cadmium silicates hosts: a theoretical study.