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Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum (2022)
Journal Article
Anagu, L. O., Hulse, D. R., Horrocks, P. D., & Chakravorty, S. J. (2022). Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum. Molecular and Biochemical Parasitology, 111458 - 111458. https://doi.org/10.1016/j.molbiopara.2022.111458

Background
In Plasmodium falciparum the monoallelic expression of var virulence genes is regulated through epigenetic mechanisms. A study in the Gambia showed that an increase in var gene expression is associated with fever, high blood lactate with... Read More about Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum.

Primary care for people with severe mental illness and comorbid obstructive airways disease: a qualitative study of patient perspectives with integrated stakeholder feedback (2022)
Journal Article
Mitchell, C., Zuraw, N., Delaney, B., Twohig, H., Dolan, N., Walton, E., …Hulin, J. (2022). Primary care for people with severe mental illness and comorbid obstructive airways disease: a qualitative study of patient perspectives with integrated stakeholder feedback. BMJ Open, 12(3), Article e057143. https://doi.org/10.1136/bmjopen-2021-057143

OBJECTIVES: To explore patient and stakeholder perspectives on primary respiratory care for people with severe mental illness (SMI) and comorbid obstructive airways disease (OAD). DESIGN: Qualitative, semistructured qualitative interviews were undert... Read More about Primary care for people with severe mental illness and comorbid obstructive airways disease: a qualitative study of patient perspectives with integrated stakeholder feedback.

To what extent are patients involved in researching safety in acute mental healthcare? (2022)
Journal Article
Brierley-Jones, L., Ramsey, L., Canvin, K., Kendal, S., & Baker, J. (2022). To what extent are patients involved in researching safety in acute mental healthcare?. Research Involvement and Engagement, https://doi.org/10.1186/s40900-022-00337-x

Background
There is a growing need to involve patients in the development of patient safety interventions. Mental health services, despite their strong history of patient involvement, have been slow to develop patient safety interventions, particula... Read More about To what extent are patients involved in researching safety in acute mental healthcare?.

370 Scrotal Ultrasound in Young Men with Acute Scrotal Pain: A Retrospective Consecutive Case Series Audit (2022)
Journal Article
Kitchen. (2022). 370 Scrotal Ultrasound in Young Men with Acute Scrotal Pain: A Retrospective Consecutive Case Series Audit. British Journal of Surgery, https://doi.org/10.1093/bjs/znac039.249

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Introduction</jats:title> <jats:p>Although not recommended by EAU guidelines, many men with acute scrotal pain undergo ultrasound (US) to screen for occult tumours. This has low diagnostic yiel... Read More about 370 Scrotal Ultrasound in Young Men with Acute Scrotal Pain: A Retrospective Consecutive Case Series Audit.

Fear of movement and emotional distress as prognostic factors for disability in patients with shoulder pain: a prospective cohort study (2022)
Journal Article
Major, D., Røe, Y., Småstuen, M., Jæger, M., Grotle, M., Van Der Windt, D., & Sandbakk, T. (2022). Fear of movement and emotional distress as prognostic factors for disability in patients with shoulder pain: a prospective cohort study. BMC Musculoskeletal Disorders, 23, Article 183. https://doi.org/10.1186/s12891-022-05139-6

Background: Shoulder pain is a prevalent and often long-lasting musculoskeletal disorder. The overall prognosis of shoulder pain is highly variable with 40-50% of patients reporting persistent pain 6-12 months after consulting a clinician. The eviden... Read More about Fear of movement and emotional distress as prognostic factors for disability in patients with shoulder pain: a prospective cohort study.

Helping women through the perimenopause (2022)
Journal Article
Walker, N., Keeling, J., Jervis, J., & Finney, A. (2022). Helping women through the perimenopause. Practice Nurse,

Context
Standard setting is critically important to assessment decisions in medical education. Recent research has demonstrated variations between medical schools in the standards set for shared items. Despite the centrality of judgement to criterio... Read More about Helping women through the perimenopause.

Perspectives of an international sample of adults with Trichotillomania on the acceptability and feasibility of an asynchronous qualitative email interview method (2022)
Journal Article
(2022). Perspectives of an international sample of adults with Trichotillomania on the acceptability and feasibility of an asynchronous qualitative email interview method. Research Methods in Medicine & Health Sciences, https://doi.org/10.1177/26320843221080733

<jats:sec><jats:title>Purpose</jats:title><jats:p> Trichotillomania (TTM) is characterised by the recurrent pulling out of one’s own hair, resulting in hair loss. It is a poorly understood disorder with no consensus on aetiology or epidemiology. Nest... Read More about Perspectives of an international sample of adults with Trichotillomania on the acceptability and feasibility of an asynchronous qualitative email interview method.

The Excessive Regulation of Early Abortion Medication in the UK: The Case for Reform. (2022)
Journal Article
Parsons, J. A. (2022). The Excessive Regulation of Early Abortion Medication in the UK: The Case for Reform. Medical Law Review, 4 - 32. https://doi.org/10.1093/medlaw/fwab042

Early medical abortion (EMA) involves the administration of two medications-mifepristone and misoprostol-24-48 hours apart. These routinely used medications are recognised as safe and effective by the World Health Organization which recommends this c... Read More about The Excessive Regulation of Early Abortion Medication in the UK: The Case for Reform..

A method for the madness: An international survey of Health Professions Education authors’ journal choice (2022)
Journal Article
Rees. (2022). A method for the madness: An international survey of Health Professions Education authors’ journal choice. Perspectives on Medical Education, 11(3), 165-172. https://doi.org/10.1007/s40037-022-00698-9

Introduction
Scholarship is a key activity in health professions education (HPE). When disseminating scholarly work, how one selects the journal to which they submit is often argued to be a key determinant of subsequent success. To draw more evidenc... Read More about A method for the madness: An international survey of Health Professions Education authors’ journal choice.

In‐Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology (2022)
Journal Article
Wu, P., V. Sharma, G., S. Mehta, L., Chew-Graham, C., P. Lundberg, G., A. Nerenberg, K., …A. Mamas, M. (2022). In‐Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology. Journal of the American Heart Association, 11(5), Article ARTN e022658. https://doi.org/10.1161/JAHA.121.022658

Background Assisted reproductive technology (ART) has emerged as a common treatment option for infertility, a problem that affects an estimated 48 million couples worldwide. Advancing maternal age with increasing prepregnancy cardiovascular risk fact... Read More about In‐Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology.

Comparing medication adherence in patients receiving bisphosphonates for preventing fragility fractures: a comprehensive systematic review and network meta-analysis. (2022)
Journal Article
Paskins. (2022). Comparing medication adherence in patients receiving bisphosphonates for preventing fragility fractures: a comprehensive systematic review and network meta-analysis. Osteoporosis International, https://doi.org/10.1007/s00198-022-06350-w

BACKGROUND: Bisphosphonates are effective in preventing fragility fractures; however, high rates of adherence are needed to preserve clinical benefits. OBJECTIVE: To investigate persistence and compliance to oral and intravenous bisphosphonates (alen... Read More about Comparing medication adherence in patients receiving bisphosphonates for preventing fragility fractures: a comprehensive systematic review and network meta-analysis..

Diagnostic delay in axial spondyloarthritis: a systematic review (2022)
Journal Article
Hay, C., Packham, J., Ryan, S., Mallen, C., Chatzixenitidis, A., & Prior, J. (2022). Diagnostic delay in axial spondyloarthritis: a systematic review. Clinical Rheumatology, 41(1939–1950), https://doi.org/10.1007/s10067-022-06100-7

Identification of axial spondyloarthritis (axSpA) remains challenging, frequently resulting in a diagnostic delay for patients. Current benchmarks of delay are usually reported as mean data, which are typically skewed and therefore may be overestimat... Read More about Diagnostic delay in axial spondyloarthritis: a systematic review.

International Foot and Ankle Osteoarthritis Consortium review and research agenda for diagnosis, epidemiology, burden, outcome assessment and treatments. (2022)
Journal Article
Osteoarthritis Consortium, I. F. A. A., Arnold, J., Bowen, C., Chapman, L., Gates, L., Golightly, Y., …Thomas, M. (2022). International Foot and Ankle Osteoarthritis Consortium review and research agenda for diagnosis, epidemiology, burden, outcome assessment and treatments. Osteoarthritis and Cartilage, 30(7), 945-955. https://doi.org/10.1016/j.joca.2022.02.603

OBJECTIVE: To summarise the available evidence relating to the diagnosis, epidemiology, burden, outcome assessment and treatment of foot and ankle osteoarthritis (OA) and to develop an agenda to guide future research. METHOD: Members of the Internati... Read More about International Foot and Ankle Osteoarthritis Consortium review and research agenda for diagnosis, epidemiology, burden, outcome assessment and treatments..

Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation, and region in England and Wales during 2020: A registry-based study (2022)
Journal Article
Mamas. (2022). Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation, and region in England and Wales during 2020: A registry-based study. PLoS Medicine, e1003904 - e1003904. https://doi.org/10.1371/journal.pmed.1003904

Background

Deaths in the first year of the Coronavirus Disease 2019 (COVID-19) pandemic in England and Wales were unevenly distributed socioeconomically and geographically. However, the full scale of inequalities may have been underestimated to da... Read More about Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation, and region in England and Wales during 2020: A registry-based study.

Community engagement in cutaneous leishmaniasis research in Brazil, Ethiopia, and Sri Lanka: a decolonial approach for global health (2022)
Journal Article
Polidano, K., Agampodi, T., Parton, L., Agampodi, S., Haileselassie, B., Lalani, J., …Zerihun, Z. (2022). Community engagement in cutaneous leishmaniasis research in Brazil, Ethiopia, and Sri Lanka: a decolonial approach for global health. Frontiers in Public Health, 10, https://doi.org/10.3389/fpubh.2022.823844

Cutaneous leishmaniasis (CL) is a parasitic skin disease endemic in at least 88 countries where it presents an urgent, albeit often "neglected" public health problem. In this paper, we discuss our model of decolonial community engagement in the ECLIP... Read More about Community engagement in cutaneous leishmaniasis research in Brazil, Ethiopia, and Sri Lanka: a decolonial approach for global health.

Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic (2022)
Journal Article
(2022). Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic. Advances in therapy, https://doi.org/10.1007/s12325-022-02056-x

The COVID-19 pandemic has brought a renewed focus on appropriate management of chronic respiratory conditions with a heightened awareness of respiratory symptoms and the requirement for differential diagnosis between an asthma attack and COVID-19 inf... Read More about Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic.

Healthy working life expectancy at age 50 for people with and without osteoarthritis in local and national English populations (2022)
Journal Article
Lynch, M., Bucknall, M., Jagger, C., & Wilkie, R. (2022). Healthy working life expectancy at age 50 for people with and without osteoarthritis in local and national English populations. Scientific reports, 12(1), Article 2408. https://doi.org/10.1038/s41598-022-06490-3

Retirement ages are rising in many countries to offset the challenges of population ageing, but osteoarthritis is an age-associated disease that is becoming more prevalent and may limit capacity to work until older ages. We aimed to assess the impact... Read More about Healthy working life expectancy at age 50 for people with and without osteoarthritis in local and national English populations.

Association Between Handover of Anesthesiology Care and 1-Year Mortality Among Adults Undergoing Cardiac Surgery (2022)
Journal Article
Mamas, M., Sun, L. Y., Jones, P. M., Wijeysundera, D. N., Mamas, M. A., Bader Eddeen, A., …O’Connor, J. (2022). Association Between Handover of Anesthesiology Care and 1-Year Mortality Among Adults Undergoing Cardiac Surgery. Jama Network Open, 5(2), Article ARTN e2148161. https://doi.org/10.1001/jamanetworkopen.2021.48161

Importance Handovers of anesthesia care from one anesthesiologist to another is an important intraoperative event. Despite its association with adverse events after noncardiac surgery, its impact in the context of cardiac surgery remains unclear.... Read More about Association Between Handover of Anesthesiology Care and 1-Year Mortality Among Adults Undergoing Cardiac Surgery.

The potential of general practice to support young people who self-harm: a narrative review (2022)
Journal Article
Mughal, F., Dikomitis, L., Babatunde, O., & Chew-Graham, C. (2022). The potential of general practice to support young people who self-harm: a narrative review. British Journal of General Practice Open (BJGP Open), BJGPO.2021.0159 - BJGPO.2021.0159. https://doi.org/10.3399/BJGPO.2021.0159

<jats:sec><jats:title>Background</jats:title><jats:p>Self-harm in young people is a growing public health concern. Young people commonly present to their GP for help with self-harm, and thus general practice may be a key setting to support young peop... Read More about The potential of general practice to support young people who self-harm: a narrative review.