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Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries. (2019)
Journal Article
Mallen. (2019). Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries. Journal of General Internal Medicine, 1751-1757. https://doi.org/10.1007/s11606-018-4795-x

BACKGROUND:
Statins are widely used to prevent cardiovascular disease (CVD). With advancing age, the risks of statins might outweigh the potential benefits. It is unclear which factors influence general practitioners' (GPs) advice to stop statins i... Read More about Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries..

New insight to the characteristics and clinical course of clusters of patients with imaging confirmed disc-related sciatica. (2019)
Journal Article
Stynes. (2019). New insight to the characteristics and clinical course of clusters of patients with imaging confirmed disc-related sciatica. European Journal of Pain, https://doi.org/10.1002/ejp.1475

BACKGROUND: Referral to secondary care is common for a considerable proportion of patients with persistent sciatica symptoms. It is unclear if information from clinical assessment can further identify distinct subgroups of disc-related sciatica, with... Read More about New insight to the characteristics and clinical course of clusters of patients with imaging confirmed disc-related sciatica..

Do pharmacy and medical students share the same views on telling the truth? (2019)
Presentation / Conference
Allinson. (2019, August). Do pharmacy and medical students share the same views on telling the truth?. Presented at The International Association for Medical Education (AMEE) Conference, Vienna, Austira

Background: The requirement for health-care professionals (HCPs) to tell the truth is articulated in the guidance of UK professional bodies. This study explores undergraduate healthcare students’ views on truth telling. Summary of Work: Fourth year m... Read More about Do pharmacy and medical students share the same views on telling the truth?.

Frailty Levels In Geriatric Hospital paTients (FLIGHT)-the prevalence of frailty among geriatric populations within hospital ward settings: a systematic review protocol. (2019)
Journal Article
(2019). Frailty Levels In Geriatric Hospital paTients (FLIGHT)-the prevalence of frailty among geriatric populations within hospital ward settings: a systematic review protocol. BMJ Open, e030147 -?. https://doi.org/10.1136/bmjopen-2019-030147

INTRODUCTION
Frailty is a common and clinically significant condition in geriatric populations, associated with adverse health outcomes such as hospitalisation, disability and mortality. Although there are systematic reviews/meta-analyses assessing... Read More about Frailty Levels In Geriatric Hospital paTients (FLIGHT)-the prevalence of frailty among geriatric populations within hospital ward settings: a systematic review protocol..

Characteristics of patients with giant cell arteritis who experience visual symptoms (2019)
Journal Article
Shen Chean, C., Prior, J., Helliwell, T., Belcher, J., Mackie, S. L., Hider, S., …Mallen, C. (2019). Characteristics of patients with giant cell arteritis who experience visual symptoms. Rheumatology International, 39, 1789-1796. https://doi.org/10.1007/s00296-019-04422-5

Permanent vision loss is one of the most serious complications of giant cell arteritis (GCA) and therefore prompt diagnosis is paramount. However, diagnosis of GCA remains challenging due to its frequently non-specific presentation. Our aim was to id... Read More about Characteristics of patients with giant cell arteritis who experience visual symptoms.

Risk factors for episodes of back pain in emerging adults. A systematic review (2019)
Journal Article
Elin Øiestad, B., Hilde, G., Therese Tveter, A., Peat, G. G., Thomas, M. J., Dunn, K. M., & Grotle, M. (2020). Risk factors for episodes of back pain in emerging adults. A systematic review. European Journal of Pain, 24(1), 19-38. https://doi.org/10.1002/ejp.1474

BACKGROUND AND OBJECTIVE: The transition from adolescence to adulthood is a sensitive period in life for health outcomes, including back pain. The objective was to synthesize evidence on risk factors for new episodes of back pain in emerging adults (... Read More about Risk factors for episodes of back pain in emerging adults. A systematic review.

Health Effects of Underground Workspaces cohort: study design and baseline characteristics (2019)
Journal Article
Dunleavy, G., Bajpai, R., Yap, H. S., Roberts, A. C., Quoc, T., Tonon, A. C., …Car, J. (2019). Health Effects of Underground Workspaces cohort: study design and baseline characteristics. Epidemiology and Health, 41, Article ARTN e2019025. https://doi.org/10.4178/epih.e2019025

The development of underground workspaces is a strategic effort towards healthy urban growth in ever-increasing land-scarce cities. Despite the growth in underground workspaces, there is limited information regarding the impact of this environment on... Read More about Health Effects of Underground Workspaces cohort: study design and baseline characteristics.

Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics (2019)
Journal Article
Mamas, & Wu. (2019). Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics. Journal of Women's Health, 1037 - 1050. https://doi.org/10.1089/jwh.2018.7480

Globally, cardiovascular disease (CVD) is the most common cause of mortality in women accounting for one in three deaths. There remains an under recognition of CVD as well as a lack of awareness of risk in women. Promotion of CVD prevention is essent... Read More about Pregnancy As a Predictor of Maternal Cardiovascular Disease: The Era of CardioObstetrics.

Predictors of pain interference and potential gain from intervention in community dwelling adults with joint pain: A prospective cohort study. (2019)
Journal Article
Blagojevic-Bucknall, M., Thomas, M. J., Wulff, J., Porcheret, M., Dziedzic, K. S., Peat, G. M., …Van Der Windt, D. A. (2019). Predictors of pain interference and potential gain from intervention in community dwelling adults with joint pain: A prospective cohort study. Musculoskeletal Care, 231-240. https://doi.org/10.1002/msc.1406

INTRODUCTION: There is little research on identifying modifiable risk factors that predict future interference of pain with daily activity in people with joint pain, and the estimation of the corresponding population attributable risk (PAR). The pres... Read More about Predictors of pain interference and potential gain from intervention in community dwelling adults with joint pain: A prospective cohort study..

Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study (2019)
Journal Article
Mallen, Muller, Hider, & Helliwell. (2019). Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study. BMC Medicine, https://doi.org/10.1186/s12916-019-1394-6

Background
Antibiotic-induced disturbances of the human microbiota have been implicated in the development of chronic autoimmune conditions. This study aimed to assess whether antibiotic use is associated with the onset of rheumatoid arthritis (RA).... Read More about Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study.

Do ß-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink. (2019)
Journal Article
Mallen, & Mamas. (2019). Do ß-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink. BMJ Open, e032050 - ?. https://doi.org/10.1136/bmjopen-2019-032050

INTRODUCTION: To investigate if ß-adrenoreceptor blocking drug (ß-blocker) prescription reduces the risk of knee or hip osteoarthritis, total joint replacement and analgesic prescription. SETTING: Primary care. METHODS AND ANALYSIS: This is a cohort... Read More about Do ß-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population? A primary care-based, prospective cohort study using the Clinical Practice Research Datalink..

Lost cost savings to the NHS in England due to the delayed entry of multiple generic low-dose transdermal buprenorphine: a case scenario analysis (2019)
Journal Article
(2019). Lost cost savings to the NHS in England due to the delayed entry of multiple generic low-dose transdermal buprenorphine: a case scenario analysis. BMJ Open, e026817 - ?. https://doi.org/10.1136/+bmjopen-2018-026817

OBJECTIVE: Originator pharmaceutical companies prolonging the patent of a medicine prevents rivals' entry to the market and competition. As the entry of generic alternatives usually results in price reduction, any delay in their entry potentially dep... Read More about Lost cost savings to the NHS in England due to the delayed entry of multiple generic low-dose transdermal buprenorphine: a case scenario analysis.

The influence of Elixhauser comorbidity index on percutaneous coronary intervention outcomes (2019)
Journal Article
Potts, J., Nagaraja, V., Al suwaidi, J., Brugaletta, S., Martinez, S., Alraies, C., …Kwok, C. (2019). The influence of Elixhauser comorbidity index on percutaneous coronary intervention outcomes. Catheterization and Cardiovascular Interventions, 94(2), 195-203. https://doi.org/10.1002/ccd.28072

Background
Clinical outcomes with respect to the evolution of comorbidity burden in national cohorts of patients undergoing PCI have not been reported.

Objectives
We sought to explore the association between comorbidity burden and periprocedural... Read More about The influence of Elixhauser comorbidity index on percutaneous coronary intervention outcomes.

Non-traditional support workers delivering a brief psychosocial intervention for older people with anxiety and depression: the NOTEPAD feasibility study (2019)
Report
Burroughs, H., Bartlam, B., Bullock, P., Lovell, K., Ogollah, R., Ray, M., …Chew-Graham, C. (2019). Non-traditional support workers delivering a brief psychosocial intervention for older people with anxiety and depression: the NOTEPAD feasibility study. NIHR

BACKGROUND:Anxiety and depression often coexist in older people. These disorders are often underdiagnosed and undertreated, and are associated with increased use of health and social care services, and raised mortality. Barriers to diagnosis include... Read More about Non-traditional support workers delivering a brief psychosocial intervention for older people with anxiety and depression: the NOTEPAD feasibility study.

An individual participant data (IPD) meta-analysis to develop and validate a prediction model for fat mass in children and adolescents (2019)
Journal Article
(2019). An individual participant data (IPD) meta-analysis to develop and validate a prediction model for fat mass in children and adolescents. BMJ, 1 - 10. https://doi.org/10.1136/bmj.l4293

Objectives
To develop and validate a prediction model for fat mass in children aged 4-15 years using routinely available risk factors of height, weight, and demographic information without the need for more complex forms of assessment.

Design
In... Read More about An individual participant data (IPD) meta-analysis to develop and validate a prediction model for fat mass in children and adolescents.

Comparison of Clinical Trial Changes in Primary Outcome and Reported Intervention Effect Size Between Trial Registration and Publication (2019)
Journal Article
Yu. (2019). Comparison of Clinical Trial Changes in Primary Outcome and Reported Intervention Effect Size Between Trial Registration and Publication. Jama Network Open, 2(7), Article e197242. https://doi.org/10.1001/jamanetworkopen.2019.7242

IMPORTANCE
Primary outcome change could threaten the validity of a clinical trial; however, evidence about the consequences on the reported intervention effect size is unclear.

OBJECTIVES
To examine the status of randomized clinical trials whose... Read More about Comparison of Clinical Trial Changes in Primary Outcome and Reported Intervention Effect Size Between Trial Registration and Publication.

Primary Care Diagnosis of Gout Compared to a Primary Care Diagnostic Rule for Gout and to Classification Criteria (2019)
Journal Article
WATSON, L., MULLER, S., & RODDY, E. (2019). Primary Care Diagnosis of Gout Compared to a Primary Care Diagnostic Rule for Gout and to Classification Criteria. Journal of Rheumatology, 46(11), Article 1542. https://doi.org/10.3899/jrheum.190495

We read with interest the recent study by Dehlin and colleagues1, investigating the validity of a gout diagnosis in primary care. We have also investigated how a primary care diagnosis of gout compares to a primary care diagnostic rule for gout and t... Read More about Primary Care Diagnosis of Gout Compared to a Primary Care Diagnostic Rule for Gout and to Classification Criteria.

Development And External Validation Of A Patient-level Prediction Model For 60-day Mortality Following Total Knee Arthroplasty: A Multinational Cohort Study (2019)
Journal Article
Yu. (2019). Development And External Validation Of A Patient-level Prediction Model For 60-day Mortality Following Total Knee Arthroplasty: A Multinational Cohort Study. Osteoporosis International, S178 -S179. https://doi.org/10.1101/2020.12.14.20240994

Objective
Total knee replacement (TKR) is the most effective intervention available for the treatment of severe knee osteoarthritis. A small proportion of patients undergoing TKR are at risk of postoperative complications. We aimed to develop and ex... Read More about Development And External Validation Of A Patient-level Prediction Model For 60-day Mortality Following Total Knee Arthroplasty: A Multinational Cohort Study.