One-Year Outcomes after PCI Strategies in Cardiogenic Shock. (2018)
Journal Article
Mamas. (2018). One-Year Outcomes after PCI Strategies in Cardiogenic Shock. New England Journal of Medicine, 1699 - 1710. https://doi.org/10.1056/NEJMoa1808788

BACKGROUND: Among patients with acute myocardial infarction, cardiogenic shock, and multivessel coronary artery disease, the risk of a composite of death from any cause or severe renal failure leading to renal-replacement therapy at 30 days was found... Read More about One-Year Outcomes after PCI Strategies in Cardiogenic Shock..

Meta-analysis of prediction model performance across multiple studies: Which scale helps ensure between-study normality for the C-statistic and calibration measures? (2018)
Journal Article
(2018). Meta-analysis of prediction model performance across multiple studies: Which scale helps ensure between-study normality for the C-statistic and calibration measures?. Statistical Methods in Medical Research, 3505-3522. https://doi.org/10.1177/0962280217705678

If individual participant data are available from multiple studies or clusters, then a prediction model can be externally validated multiple times. This allows the model's discrimination and calibration performance to be examined across different set... Read More about Meta-analysis of prediction model performance across multiple studies: Which scale helps ensure between-study normality for the C-statistic and calibration measures?.

Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: converging roads to therapeutic development (2018)
Journal Article
Bowerman, M., Murray, L., Scamps, F., Schneider, B., Kothary, R., & Raoul, C. (2018). Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: converging roads to therapeutic development. European Journal of Medical Genetics, 685-698. https://doi.org/10.1016/j.ejmg.2017.12.001

Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are the two most common motoneuron disorders, which share typical pathological hallmarks while remaining genetically distinct. Indeed, SMA is caused by deletions or mutations in th... Read More about Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: converging roads to therapeutic development.

Explaining North-South disparities in mortality rates among 25-44 year olds in England: a longitudinal population study (2018)
Journal Article
Mamas. (2018). Explaining North-South disparities in mortality rates among 25-44 year olds in England: a longitudinal population study. The Lancet Public Health, https://doi.org/10.1016/s2468-2667%2818%2930177-4

Background: There has been a marked recent increase in excess mortality for adults aged 25-44 in the North compared to the South of England. We examined the underlying causes of the excess mortality and the relative contribution of socioeconomic depr... Read More about Explaining North-South disparities in mortality rates among 25-44 year olds in England: a longitudinal population study.

Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR) (2018)
Journal Article
Kessler, D. S., MacNeill, S. J., Tallon, D., Lewis, G., Peters, T. J., Hollingworth, W., …Wiles, N. J. (2018). Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR). BMJ, k4218 - ?. https://doi.org/10.1136/bmj.k4218

OBJECTIVE: To investigate the effectiveness of combining mirtazapine with serotonin-noradrenaline reuptake inhibitor (SNRI) or selective serotonin reuptake inhibitor (SSRI) antidepressants for treatment resistant depression in primary care. DESIGN: T... Read More about Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR).

Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink (2018)
Journal Article
J. Ferguson, R., Prieto‐Alhambra, D., Walker, C., Yu, D., M. Valderas, J., Judge, A., …J. Silman, A. (2019). Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink. Pharmacoepidemiology and Drug Safety, 187-193. https://doi.org/10.1002/pds.4673

PURPOSE:
The diagnosis of hip osteoarthritis is subject to several uncertainties, especially in primary care. The aims of this study were to determine (i) the diagnostic accuracy of coding of hip osteoarthritis by primary care physicians in the UK... Read More about Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink.

The extra-articular impacts of rheumatoid arthritis: moving towards holistic care (2018)
Journal Article
Scott, I., Machin, A., Mallen, C., & Hider, S. (2018). The extra-articular impacts of rheumatoid arthritis: moving towards holistic care. BMC Rheumatology, 2, Article 32. https://doi.org/10.1186/s41927-018-0039-2

Although treat-to-target has revolutionised the outcomes of patients with rheumatoid arthritis (RA) there is emerging evidence that attaining the target of remission is insufficient to normalise patients' quality of life, and ameliorate the extra-art... Read More about The extra-articular impacts of rheumatoid arthritis: moving towards holistic care.

Self-management of a musculoskeletal condition for people from harder to reach groups: a qualitative patient interview study. (2018)
Journal Article
Protheroe. (2018). Self-management of a musculoskeletal condition for people from harder to reach groups: a qualitative patient interview study. Disability and Rehabilitation, 1 - 9. https://doi.org/10.1080/09638288.2018.1485182

BACKGROUND: This study recorded the functional health literacy levels of people with musculoskeletal (MSK) conditions from harder to reach groups and explored their experiences in engaging with health care professionals to self-manage their MSK condi... Read More about Self-management of a musculoskeletal condition for people from harder to reach groups: a qualitative patient interview study..

Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. (2018)
Journal Article
Gilchrist. (2018). Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres. BMJ Paediatrics Open, e000367 - ?. https://doi.org/10.1136/bmjpo-2018-000367

Objectives: Chest CT is increasingly used to monitor disease progression in children with cystic fibrosis (CF) but there is no national guideline regarding its use. Our objective was to assess the indications for undertaking chest CT and the protocol... Read More about Clinical indications and scanning protocols for chest CT in children with cystic fibrosis: a survey of UK tertiary centres..

The humanistic and economic burden of chronic wounds: A systematic review (2018)
Journal Article
Olsson, M., Jarbrink, K., Divakar, U., Bajpai, R., Upton, Z., Schmidtchen, A., & Car, J. (2019). The humanistic and economic burden of chronic wounds: A systematic review. Wound Repair and Regeneration, 27(1), 114 -125. https://doi.org/10.1111/wrr.12683

Chronic wounds are a health problem that have devastating consequences for patients and contribute major costs to healthcare systems and societies. To understand the magnitude of this health issue, a systematic review was undertaken. Searches were co... Read More about The humanistic and economic burden of chronic wounds: A systematic review.

Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol. (2018)
Journal Article
Mallen. (2018). Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol. BMJ Open, e022205 - ?. https://doi.org/10.1136/bmjopen-2018-022205

INTRODUCTION: Neurogenic claudication due to spinal stenosis is common in older adults. The effectiveness of conservative interventions is not known. The aim of the study is to estimate the clinical and cost-effectiveness of a physiotherapist-deliver... Read More about Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol..

The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial. (2018)
Journal Article
Chesterton, L. S., Blagojevic-Bucknall, M., Burton, C., Dziedzic, K. S., Davenport, G., Jowett, S. M., …Roddy, E. (2018). The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial. The Lancet, 392(10156), 1423 - 1433. https://doi.org/10.1016/s0140-6736%2818%2931572-1

Background
To our knowledge, the comparative effectiveness of commonly used conservative treatments for carpal tunnel syndrome has not been evaluated previously in primary care. We aimed to compare the clinical and cost-effectiveness of night splint... Read More about The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial..

Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink (2018)
Journal Article
Yu, D., Jordan, K. P., Snell, K. I. E., Riley, R. D., Bedson, J., James Edwards, J., …Peat, G. (2018). Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2018-213894

Abstract
Objectives The ability to efficiently and accurately predict future risk of primary total hip and knee replacement (THR/TKR) in earlier stages of osteoarthritis (OA) has potentially important applications. We aimed to develop and validate t... Read More about Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink.

Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis (2018)
Journal Article
(2018). Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology, https://doi.org/10.1016/S2468-1253%2818%2930301-7

Background
In patients with rectal cancer who achieve clinical complete response after neoadjuvant chemoradiotherapy, watch and wait is a novel management strategy with potential to avoid major surgery. Study-level meta-analyses have reported wide v... Read More about Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis.

Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study (2018)
Journal Article
Partington, R., Muller, S., Helliwell, T., Mallen, C., & Abdul Sultan, A. (2018). Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study. Annals of the Rheumatic Diseases, 77(12), 1750-1756. https://doi.org/10.1136/annrheumdis-2018-213883

Objective
Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatic disease in older people. Contemporary estimates of the incidence and prevalence are lacking, and no previous study has assessed treatment patterns at a population level... Read More about Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study.

Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study (2018)
Journal Article
Mallen. (2018). Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study. Rheumatology, 1726-1734. https://doi.org/10.1093/rheumatology/key156

Objectives
To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination.

Methods
From the Clinical Practice Research Datalink, 32 751 people with auto-i... Read More about Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study.

Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis. (2018)
Journal Article
Chew-Graham. (2018). Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis. JAMA Internal Medicine, 1317 - 1330. https://doi.org/10.1001/jamainternmed.2018.3713

Importance: Physician burnout has taken the form of an epidemic that may affect core domains of health care delivery, including patient safety, quality of care, and patient satisfaction. However, this evidence has not been systematically quantified.... Read More about Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis..

Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: a matched cohort study in the Clinical Practice Research Datalink. (2018)
Journal Article
Dunn. (2018). Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: a matched cohort study in the Clinical Practice Research Datalink. European Journal of Pain, 1701-1708. https://doi.org/10.1002/ejp.1256

BACKGROUND: One fifth of primary care attendees suffer chronic non-cancer pain, with musculoskeletal conditions the leading cause. 12% of patients with chronic non-cancer pain are prescribed strong opioids. Evidence suggests long-term opioid use is r... Read More about Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: a matched cohort study in the Clinical Practice Research Datalink..

Seasonal aggravation of acne in summers and the effect of temperature and humidity in a study in a tropical setting (2018)
Journal Article
Narang, I., Sardana, K., Bajpai, R., & Garg, V. K. (2019). Seasonal aggravation of acne in summers and the effect of temperature and humidity in a study in a tropical setting. Journal of Cosmetic Dermatology, 18(4), 1098-1104. https://doi.org/10.1111/jocd.12777

Summary Background Effect of seasonality on acne and acne flare has varied interpretations depending on the geographical area of study. In tropical areas, factors like high temperature and humidity may cause acne flares. Aims To assess the seasonal v... Read More about Seasonal aggravation of acne in summers and the effect of temperature and humidity in a study in a tropical setting.

DEDICATE: proposal for a conceptual framework to develop dementia-friendly integrated eCare support. (2018)
Journal Article
(2018). DEDICATE: proposal for a conceptual framework to develop dementia-friendly integrated eCare support. BioMedical Engineering OnLine, 121 - ?. https://doi.org/10.1186/s12938-018-0552-y

BACKGROUND: Evidence shows that the implementation of information and communication technologies (ICT) enabled services supporting integrated dementia care represents an opportunity that faces multi-pronged challenges. First, the provision of dementi... Read More about DEDICATE: proposal for a conceptual framework to develop dementia-friendly integrated eCare support..