Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994. (2016)
Journal Article
(2016). Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994. eLife, https://doi.org/10.7554/eLife.20320

Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complet... Read More about Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994..

Evaluating acupuncture and standard care for pregnant women and back pain: the EASE back pilot randomised controlled trial ((ISRCTN49955124) (2016)
Journal Article
Bishop, A., Ogollah, R., Bartlam, B., Barlas, P., Holden, M. A., Ismail, K. M., …Foster, N. E. (2016). Evaluating acupuncture and standard care for pregnant women and back pain: the EASE back pilot randomised controlled trial ((ISRCTN49955124). Pilot and Feasibility Studies, 2, Article 72. https://doi.org/10.1186/s40814-016-0107-6

Background
Low back pain (LBP) and pelvic girdle pain (PGP) during pregnancy are common and often accepted as a ‘normal’ part of pregnancy. Many women receive little in the way of treatment, and yet pain interferes with sleep, daily activities and w... Read More about Evaluating acupuncture and standard care for pregnant women and back pain: the EASE back pilot randomised controlled trial ((ISRCTN49955124).

Feasibility of training practice nurses to deliver a psychosocial intervention within a collaborative care framework for people with depression and long-term conditions (2016)
Journal Article
Chew-Graham. (2016). Feasibility of training practice nurses to deliver a psychosocial intervention within a collaborative care framework for people with depression and long-term conditions. BMC Nursing, https://doi.org/10.1186/s12912-016-0190-2

Background
Practice nurses (PNs) deliver much of the chronic disease management in primary care and have been highlighted as appropriately placed within the service to manage patients with long-term physical conditions (LTCs) and co-morbid depressio... Read More about Feasibility of training practice nurses to deliver a psychosocial intervention within a collaborative care framework for people with depression and long-term conditions.

Controlled Interventions to Reduce Burnout in Physicians: A Systematic Review and Meta-analysis (2016)
Journal Article
Chew-Graham, C. (2016). Controlled Interventions to Reduce Burnout in Physicians: A Systematic Review and Meta-analysis. JAMA Internal Medicine, 195-205. https://doi.org/10.1001/jamainternmed.2016.7674

Importance Burnout is prevalent in physicians and can have a negative influence on performance, career continuation, and patient care. Existing evidence does not allow clear recommendations for the management of burnout in physicians.

Objective... Read More about Controlled Interventions to Reduce Burnout in Physicians: A Systematic Review and Meta-analysis.

One-stage individual participant data meta-analysis models: estimation of treatment-covariate interactions must avoid ecological bias by separating out within-trial and across-trial information. (2016)
Journal Article
(2016). One-stage individual participant data meta-analysis models: estimation of treatment-covariate interactions must avoid ecological bias by separating out within-trial and across-trial information. Statistics in Medicine, 772-789. https://doi.org/10.1002/sim.7171

Stratified medicine utilizes individual-level covariates that are associated with a differential treatment effect, also known as treatment-covariate interactions. When multiple trials are available, meta-analysis is used to help detect true treatment... Read More about One-stage individual participant data meta-analysis models: estimation of treatment-covariate interactions must avoid ecological bias by separating out within-trial and across-trial information..

Oxygen Costs of the Incremental Shuttle Walk Test in Cardiac Rehabilitation Participants: An Historical and Contemporary Analysis (2016)
Journal Article
Buckley, J., Cardoso, F., Sandercock, G., & Birkett, S. (2016). Oxygen Costs of the Incremental Shuttle Walk Test in Cardiac Rehabilitation Participants: An Historical and Contemporary Analysis. Sports Medicine, 1953 - 1962. https://doi.org/10.1007/s40279-016-0521-1

Background
The incremental shuttle walk test (ISWT) is a standardised assessment for cardiac rehabilitation. Three studies have reported oxygen costs (VO2)/metabolic equivalents (METs) of the ISWT. In spite of classic representations from these stud... Read More about Oxygen Costs of the Incremental Shuttle Walk Test in Cardiac Rehabilitation Participants: An Historical and Contemporary Analysis.

A pragmatic randomised controlled trial of healing therapy in a gastroenterology outpatient setting (2016)
Journal Article
Lee, R., Kingstone, T., Roberts, L., Edwards, S., Soundy, A., Shah, P., …Singh, S. (2016). A pragmatic randomised controlled trial of healing therapy in a gastroenterology outpatient setting. European Journal of Integrative Medicine, 110 - 119. https://doi.org/10.1016/j.eujim.2016.11.017

Introduction
To determine the benefits of healing therapy (spiritual healing) as an adjunct to conventional management in irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD).

Methods
200 outpatients with IBS or IBD were randomise... Read More about A pragmatic randomised controlled trial of healing therapy in a gastroenterology outpatient setting.

TechCare: mobile assessment and therapy for psychosis - an intervention for clients in the Early Intervention Service: A feasibility study protocol (2016)
Journal Article
Farooq, S. (2016). TechCare: mobile assessment and therapy for psychosis - an intervention for clients in the Early Intervention Service: A feasibility study protocol. SAGE Open Medicine, 2050312116669613 - ?. https://doi.org/10.1177/2050312116669613

OBJECTIVES: Technological advances in healthcare have shown promise when delivering interventions for mental health problems such as psychosis. The aim of this project is to develop a mobile phone intervention for people with psychosis and to conduct... Read More about TechCare: mobile assessment and therapy for psychosis - an intervention for clients in the Early Intervention Service: A feasibility study protocol.

Investigating the construct measured by banked gap-fill items: Evidence from eye-tracking (2016)
Journal Article
McCray. (2016). Investigating the construct measured by banked gap-fill items: Evidence from eye-tracking. Language Testing, 51-73. https://doi.org/10.1177/0265532216677105

This study investigates test-takers’ processing while completing banked gap-fill tasks, designed to test reading proficiency, in order to test theoretically based expectations about the variation in cognitive processes of test-takers across levels of... Read More about Investigating the construct measured by banked gap-fill items: Evidence from eye-tracking.

Patient experiences of a bariatric group programme for managing obesity: A qualitative interview study (2016)
Journal Article
(2016). Patient experiences of a bariatric group programme for managing obesity: A qualitative interview study. British Journal of Health Psychology, 77-93. https://doi.org/10.1111/bjhp.12218

Objectives
People with obesity experience a range of physical and psychological ill-health outcomes. This study examined patients’ experiences of a group-based programme for the management of morbid obesity delivered within the UK National Health Se... Read More about Patient experiences of a bariatric group programme for managing obesity: A qualitative interview study.

Bayesian meta-analytical methods to incorporate multiple surrogate endpoints in drug development process. (2016)
Journal Article
(2016). Bayesian meta-analytical methods to incorporate multiple surrogate endpoints in drug development process. Statistics in Medicine, 1063 - 1089. https://doi.org/10.1002/sim.6776

A number of meta-analytical methods have been proposed that aim to evaluate surrogate endpoints. Bivariate meta-analytical methods can be used to predict the treatment effect for the final outcome from the treatment effect estimate measured on the su... Read More about Bayesian meta-analytical methods to incorporate multiple surrogate endpoints in drug development process..

What Musculoskeletal (MSK) Conditions are Referred from Routine General Practice (GP) and what Impact does this have on Developing Innovative Care Models for Patients with MSK Conditions in Primary Care? (2016)
Journal Article
Heron. (2016). What Musculoskeletal (MSK) Conditions are Referred from Routine General Practice (GP) and what Impact does this have on Developing Innovative Care Models for Patients with MSK Conditions in Primary Care?. https://doi.org/10.4172/2329-9096.1000375

Introduction: The current ethos within the United Kingdom (UK) health system is to encourage community management of health problems, increasing primary care workload. Yet General Practice (GP) is currently in ‘crisis’ with significant workload press... Read More about What Musculoskeletal (MSK) Conditions are Referred from Routine General Practice (GP) and what Impact does this have on Developing Innovative Care Models for Patients with MSK Conditions in Primary Care?.

Steps in Moving Evidence-Based Health Informatics from Theory to Practice. (2016)
Journal Article
(2016). Steps in Moving Evidence-Based Health Informatics from Theory to Practice. https://doi.org/10.4258/hir.2016.22.4.255

OBJECTIVES: To demonstrate and promote the importance of applying a scientific process to health IT design and implementation, and of basing this on research principles and techniques. METHODS: A review by international experts linked to the IMIA Wor... Read More about Steps in Moving Evidence-Based Health Informatics from Theory to Practice..

The clinical and cost effectiveness of steroid injection compared with night splints for carpal tunnel syndrome (2016)
Journal Article
Chesterton, L. S., Dziedzic, K. S., Van Der Windt, D. A., Davenport, G., Myers, H. L., Rathod, T., …Hay, E. M. (2016). The clinical and cost effectiveness of steroid injection compared with night splints for carpal tunnel syndrome. BMC Musculoskeletal Disorders, 415 - ?. https://doi.org/10.1186/s12891-016-1264-8

BACKGROUND: Patients diagnosed with idiopathic mild to moderate carpal tunnel syndrome (CTS) are usually managed in primary care and commonly treated with night splints and/or corticosteroid injection. The comparative effectiveness of these intervent... Read More about The clinical and cost effectiveness of steroid injection compared with night splints for carpal tunnel syndrome.

Effects of Antiretroviral Therapy on the Survival of Human Immunodeficiency Virus-positive Adult Patients in Andhra Pradesh, India: A Retrospective Cohort Study, 2007-2013 (2016)
Journal Article
Bajpai. (2016). Effects of Antiretroviral Therapy on the Survival of Human Immunodeficiency Virus-positive Adult Patients in Andhra Pradesh, India: A Retrospective Cohort Study, 2007-2013. Journal of Preventive Medicine and Public Health, 394 - 405. https://doi.org/10.3961/jpmph.16.073

Objectives
The survival outcomes of antiretroviral treatment (ART) programs have not been systematically evaluated at the state level in India. This retrospective study assessed the survival rates and factors associated with survival among adult hum... Read More about Effects of Antiretroviral Therapy on the Survival of Human Immunodeficiency Virus-positive Adult Patients in Andhra Pradesh, India: A Retrospective Cohort Study, 2007-2013.

Are foot and ankle characteristics associated with falls in people with rheumatoid arthritis? A prospective study. (2016)
Journal Article
(2016). Are foot and ankle characteristics associated with falls in people with rheumatoid arthritis? A prospective study. Arthritis Care and Research, 1150-1155. https://doi.org/10.1002/acr.23131

OBJECTIVE: To determine whether foot and ankle characteristics are associated with falls in people with rheumatoid arthritis (RA). METHODS: Two hundred and one adults with RA were recruited from rheumatology outpatient clinics in Auckland, New Zealan... Read More about Are foot and ankle characteristics associated with falls in people with rheumatoid arthritis? A prospective study..

Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ. (2016)
Journal Article
(2016). Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ. Statistics in Medicine, 855-875. https://doi.org/10.1002/sim.7141

Meta-analysis using individual participant data (IPD) obtains and synthesises the raw, participant-level data from a set of relevant studies. The IPD approach is becoming an increasingly popular tool as an alternative to traditional aggregate data me... Read More about Meta-analysis using individual participant data: one-stage and two-stage approaches, and why they may differ..

Defining the Na(+)/H(+) exchanger NHE1 interactome in triple-negative breast cancer cells. (2016)
Journal Article
(2016). Defining the Na(+)/H(+) exchanger NHE1 interactome in triple-negative breast cancer cells. Cellular Signalling, 69 - 77. https://doi.org/10.1016/j.cellsig.2016.10.005

Mounting evidence supports a major role for the Na(+)/H(+) exchanger NHE1 in cancer progression and metastasis. NHE1 is hyperactive at the onset of oncogenic transformation, resulting in intracellular alkalinization and extracellular microenvironment... Read More about Defining the Na(+)/H(+) exchanger NHE1 interactome in triple-negative breast cancer cells..

What to do after cardiac rehabilitation programs: the role of the general practitioner in cardiovascular prevention (2016)
Journal Article
Heron. (2016). What to do after cardiac rehabilitation programs: the role of the general practitioner in cardiovascular prevention. Monaldi Archives for Chest Disease, https://doi.org/10.4081/monaldi.2016.755

This paper will review the current role of general practitioners (GPs) in providing cardiovascular prevention for patients after attendance at a cardiac rehabilitation program. Long-term implementation of preventive strategies is needed for continued... Read More about What to do after cardiac rehabilitation programs: the role of the general practitioner in cardiovascular prevention.

Applying causal mediation methods to clinical trial data: What can we learn about why our interventions (don't) work? (2016)
Journal Article
Van Der Windt. (2016). Applying causal mediation methods to clinical trial data: What can we learn about why our interventions (don't) work?. European Journal of Pain, 614-622. https://doi.org/10.1002/ejp.964

BACKGROUND: Many randomized controlled trials (RCTs) of psychosocial interventions for low back pain (LBP) have been found to have only small effects on disability outcomes. Investigations of the specific mechanisms that may lead to an improvement in... Read More about Applying causal mediation methods to clinical trial data: What can we learn about why our interventions (don't) work?.