Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues (2022)
Journal Article
Benckendorff, C., Slyusarchuk, V. D., Huang, N., Lima, M. A., Smith, M., & Miller, G. J. (2022). Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues. Organic and Biomolecular Chemistry, 20(47), 9469 - 9489. https://doi.org/10.1039/D2OB01761J

Analogues of the canonical nucleosides have a longstanding presence and proven capability within medicinal chemistry and drug discovery research. The synthesis reported herein successfully replaces furanose oxygen with CF2 and CHF in pyrimidine nucle... Read More about Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues.

A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching. (2022)
Journal Article
Collings, A., & Craik, K. (2022). A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching. Science and Justice, 814 - 821. https://doi.org/10.1016/j.scijus.2022.04.006

Forensic anthropology has traditionally relied on two-dimensional (2D) images, such as photographs and sketches, to perform analyses, and disseminate findings. However, as 3D imaging technology advances, it has become more widely implemented into for... Read More about A preliminary study into the impact of using three-dimensional models in forensic anthropology learning and teaching..

Supramolecular structural influences from remote functionality in coordination complexes of 4-picolylamine ligands (2022)
Journal Article
Slyusarchuk, V. D., O’Brien, B. J., & Hawes, C. S. (in press). Supramolecular structural influences from remote functionality in coordination complexes of 4-picolylamine ligands. Journal of Coordination Chemistry, 75(15-16), 2039-2061. https://doi.org/10.1080/00958972.2022.2130059

Supramolecular structural influences from remote functionality in coordination complexes of 4-picolylamine ligands

The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells. (2022)
Journal Article
Fettiplace, R., Furness, D. N., & Beurg, M. (2022). The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells. Proceedings of the National Academy of Sciences of the United States of America, 119(41), Article e2210849119. https://doi.org/10.1073/pnas.2210849119

Transmembrane channel-like protein 1 (TMC1) is thought to form the ion-conducting pore of the mechanoelectrical transducer (MET) channel in auditory hair cells. Using single-channel analysis and ionic permeability measurements, we characterized six m... Read More about The conductance and organization of the TMC1-containing mechanotransducer channel complex in auditory hair cells..

Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase. (2022)
Journal Article
Ahmadipour, S., Wahart, A., Dolan, J., Beswick, L., Hawes, C., Field, R., & Miller, G. (2022). Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase. Beilstein Journal of Organic Chemistry, 18, 1379 - 1384. https://doi.org/10.3762/bjoc.18.142

Sufferers of cystic fibrosis are at significant risk of contracting chronic bacterial lung infections. The dominant pathogen in these cases is mucoid Pseudomonas aeruginosa. Such infections are characterised by overproduction of the exopolysaccharide... Read More about Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase..

The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022 (2022)
Journal Article
Beard, P. (2022). The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022. Eurosurveillance, https://doi.org/10.2807/1560-7917.es.2022.27.39.2200758

<jats:p>We report results of surveillance between June and mid-September 2022 of pet animals living in households of confirmed human monkeypox (MPX) cases. Since surveillance commenced, 154 animals from 40 households with a confirmed human MPX case w... Read More about The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022.

Vertical and Horizontal Transmission of Cell Fusing Agent Virus in Aedes aegypti (2022)
Journal Article
Logan, R., Quek, S., Muthoni, J., von Eicken, A., Brettell, L., Anderson, E., …Patterson, E. (2022). Vertical and Horizontal Transmission of Cell Fusing Agent Virus in Aedes aegypti. Applied and Environmental Microbiology, https://doi.org/10.1128/aem.01062-22

Cell fusing agent virus (CFAV) is an insect-specific flavivirus (ISF) found in Aedes aegypti mosquitoes. ISFs have demonstrated the ability to modulate the infection or transmission of arboviruses such as dengue, West Nile, and Zika viruses. It is th... Read More about Vertical and Horizontal Transmission of Cell Fusing Agent Virus in Aedes aegypti.

Does iron chelation by eumelanin contribute to the ethnic link with maternal mortality? (2022)
Journal Article
(2022). Does iron chelation by eumelanin contribute to the ethnic link with maternal mortality?. European Journal of Obstetrics and Gynecology and Reproductive Biology, 107 - 108. https://doi.org/10.1016/j.ejogrb.2022.09.012

Significant disparities in maternal mortality between white and black mothers have been noted for over 80 years and remain an extremely serious problem. Black women are still four times more likely than white women to die in pregnancy or childbirth i... Read More about Does iron chelation by eumelanin contribute to the ethnic link with maternal mortality?.

Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions (2022)
Journal Article
P. Dolan, J., Machin, D. C., Dedola, S., Field2, R. A., Webb, M. E., & Bruce Turnbull, W. (2022). Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions. Frontiers in Chemistry, https://doi.org/10.3389/fchem.2022.958272

<jats:p>The chemoenzymatic synthesis of a series of dual N- and C-terminal–functionalized cholera toxin B subunit (CTB) glycoconjugates is described. Mucin 1 peptides bearing different levels of Tn antigen glycosylation [MUC1(Tn)] were prepared <jats... Read More about Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions.

Defects in MgB4O7 (pure and doped with lanthanides): A case study using a computational modelling approach (2022)
Journal Article
Bispo, G., Nascimento, D., Santana, L., Ferreira, G., Macedo, Z., Lima, H., …Valerio, M. (2022). Defects in MgB4O7 (pure and doped with lanthanides): A case study using a computational modelling approach. Physica B: Condensed Matter, 1-9. https://doi.org/10.1016/j.physb.2022.414049

Lanthanide-doped MgB4O7 is a potential dosimetric material due to its thermoluminescence (TL) and optically stimulated luminescence (OSL) properties. These properties have been largely reported, but there are few theoretical studies dedicated to unde... Read More about Defects in MgB4O7 (pure and doped with lanthanides): A case study using a computational modelling approach.

A comprehensive study on the processing of Co:ZnO nanostructured ceramics: Defect chemistry engineering and grain growth kinetics (2022)
Journal Article
da Silva, R., Morbec, J., Rahman, G., & de Carvalho, H. (2022). A comprehensive study on the processing of Co:ZnO nanostructured ceramics: Defect chemistry engineering and grain growth kinetics. Journal of Materials Science and Technology, 221-232. https://doi.org/10.1016/j.jmst.2022.07.038

In this report, we present a systematic study on the preparation of Co:ZnO ceramics via a standard solid-state route from different Co precursors (Co3O4, CoO, and metallic Co) and atmospheres (O2 and Ar). Particular emphasis is given to defect chemis... Read More about A comprehensive study on the processing of Co:ZnO nanostructured ceramics: Defect chemistry engineering and grain growth kinetics.

Structure and diffusive dynamics of aspartate a-decarboxylase (ADC) liganded with D-serine in aqueous solution. (2022)
Journal Article
Raskar, T., Niebling, S., Devos, J. M., Yorke, B. A., Härtlein, M., Huse, N., …Pearson, A. R. (2022). Structure and diffusive dynamics of aspartate a-decarboxylase (ADC) liganded with D-serine in aqueous solution. Physical Chemistry Chemical Physics, 24(34), 20336 - 20347. https://doi.org/10.1039/d2cp02063g

Incoherent neutron spectroscopy, in combination with dynamic light scattering, was used to investigate the effect of ligand binding on the center-of-mass self-diffusion and internal diffusive dynamics of Escherichia coli aspartate a-decarboxylase (AD... Read More about Structure and diffusive dynamics of aspartate a-decarboxylase (ADC) liganded with D-serine in aqueous solution..

A Reversibly Porous Supramolecular Peptide Framework** (2022)
Journal Article
Brightwell, D. F., Truccolo, G., Samanta, K., Fenn, E. J., Holder, S. J., Shepherd, H. J., …Palma, A. (2022). A Reversibly Porous Supramolecular Peptide Framework**. Chemistry - A European Journal, 28(66), https://doi.org/10.1002/chem.202202368

The ability to use bio‐inspired building blocks in the assembly of novel supramolecular frameworks is at the forefront of an exciting research field. Herein, we present the first polyproline helix to self‐assemble into a reversibly porous, crystallin... Read More about A Reversibly Porous Supramolecular Peptide Framework**.

Modality and counterfactuals: Understanding the role and context of metaphysical underpinnings for harm, benefit and identity claims arising from genome editing and genetic modification (2022)
Journal Article
Wrigley. (2022). Modality and counterfactuals: Understanding the role and context of metaphysical underpinnings for harm, benefit and identity claims arising from genome editing and genetic modification. American Journal of Bioethics, 52-54. https://doi.org/10.1080/15265161.2022.2105426

Dynamics of DNA Replication during Male Gametogenesis in the Malaria Parasite Plasmodium Falciparum (2022)
Journal Article
Matthews, H., McDonald, J., Totanes, F., & Merrick, C. (2022). Dynamics of DNA Replication during Male Gametogenesis in the Malaria Parasite Plasmodium Falciparum. Cellular Microbiology, https://doi.org/10.1155/2022/2701868

Malaria parasites undergo a single phase of sexual reproduction in their complex lifecycle. It involves specialised, sexually committed cells called gametocytes, which develop rapidly into mature gametes and mate upon entering the mosquito midgut. Ga... Read More about Dynamics of DNA Replication during Male Gametogenesis in the Malaria Parasite Plasmodium Falciparum.

Bioorthogonal, Bifunctional Linker for Engineering Synthetic Glycoproteins (2022)
Journal Article
McBerney, R., Dolan, J., E. Cawood, E., E. Webb, M., & Bruce Turnbull, W. (2022). Bioorthogonal, Bifunctional Linker for Engineering Synthetic Glycoproteins. JACS Au, https://doi.org/10.1021/jacsau.2c00312

Post-translational glycosylation of proteins results in complex mixtures of heterogeneous protein glycoforms. Glycoproteins have many potential applications from fundamental studies of glycobiology to potential therapeutics, but generating homogeneou... Read More about Bioorthogonal, Bifunctional Linker for Engineering Synthetic Glycoproteins.

An Automated Computer‐Vision “Bubble‐Counting” Technique to Characterise CO₂ Dissolution into an Acetonitrile Flow Stream in a Teflon AF‐2400 Tube‐in‐Tube Flow Device (2022)
Journal Article
O'Brien, M., & Moraru, R. (2023). An Automated Computer‐Vision “Bubble‐Counting” Technique to Characterise CO2 Dissolution into an Acetonitrile Flow Stream in a Teflon AF‐2400 Tube‐in‐Tube Flow Device. ChemPlusChem, 88(1), https://doi.org/10.1002/cplu.202200167

AbstractA Teflon AF‐2400 based tube‐in‐tube device was used to generate flow streams of CO2 in acetonitrile and a computer‐vision based ‘bubble counting’ technique was used to estimate the amount of CO2 that had passed into solution whilst in the tub... Read More about An Automated Computer‐Vision “Bubble‐Counting” Technique to Characterise CO₂ Dissolution into an Acetonitrile Flow Stream in a Teflon AF‐2400 Tube‐in‐Tube Flow Device.

Thermally dynamic examination of local order in nanocrystalline hydroxyapatite (2022)
Journal Article
Arnold, E. L., Gosling, S., Davies, S. K., Cross, H. L., Evans, P., Keeble, D. S., …Rogers, K. D. (2022). Thermally dynamic examination of local order in nanocrystalline hydroxyapatite. Journal of Solid State Chemistry, 315, Article 123474. https://doi.org/10.1016/j.jssc.2022.123474

The main mineral component of bone is hydroxyapatite, a commonly nanocrystalline material which presents many challenges for those trying to characterize it. Here, local structure is analyzed using X-ray total scattering for synthetic samples, to ena... Read More about Thermally dynamic examination of local order in nanocrystalline hydroxyapatite.

Use of strontium isotope ratios in geolocation of Guatemalan population: Potential role in identification of remains. (2022)
Journal Article
Austin, R., Fowler, G., Croxton, R., Evans, J., Thompson, D. F., Cooper, J. J., & Perez Tanchez, M. (2022). Use of strontium isotope ratios in geolocation of Guatemalan population: Potential role in identification of remains. Journal of Forensic Sciences, 67(5), 1962-1970. https://doi.org/10.1111/1556-4029.15116

Within post-conflict communities, attempts to identify and repatriate unidentified and missing individuals poses a difficult task. As current forensic strategies commonly lack the capacity to provide region of origin assessments, forensic anthropolog... Read More about Use of strontium isotope ratios in geolocation of Guatemalan population: Potential role in identification of remains..

Molecular Inhibition for Selective CO2 Conversion. (2022)
Journal Article
Creissen, C., Rivera de la Cruz, J., Karapinar, D., Taverna, D., Schreiber, M., & Fontecave, M. (2022). Molecular Inhibition for Selective CO2 Conversion. Angewandte Chemie International Edition, e202206279 - ?. https://doi.org/10.1002/anie.202206279

Electrochemical CO2 reduction presents a sustainable route to the production of chemicals and fuels. Achieving a narrow product distribution with heterogeneous Cu catalysts is challenging and conventional material modifications offer limited control... Read More about Molecular Inhibition for Selective CO2 Conversion..