A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications (2022)
Journal Article
Gosling, S., Calabrese, D., Nallala, J., Greenwood, C., Pinder, S., King, L., …Stone, N. (2022). A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications. Analyst, 147(8), 1641-1654. https://doi.org/10.1039/d1an01548f

Ductal carcinoma in situ (DCIS) is frequently associated with breast calcification. This study combines multiple analytical techniques to investigate the heterogeneity of these calcifications at the micrometre scale. X-ray diffraction, scanning elect... Read More about A multi-modal exploration of heterogeneous physico–chemical properties of DCIS breast microcalcifications.

An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions (2022)
Journal Article
Chernobryva, M., Motevalli, M., Hawes, C. S., & Watkinson, M. (2022). An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions. Journal of Molecular Structure, 1259, 132736 - 132736. https://doi.org/10.1016/j.molstruc.2022.132736

The steric influences of the triazole side chains in two tripodal chelating ligands tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine (TBTA) and tris[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]amine (TPTA) are explored through structural studies of four... Read More about An investigation into the coordination chemistry of tripodal “click” triazole ligands with Mn, Ni, Co and Zn ions.

From alchemy to modern mineralogy: dating mineral collections via chemical notation (2022)
Journal Article
Cooke, J. C., & Jeffery, A. J. (2022). From alchemy to modern mineralogy: dating mineral collections via chemical notation. Geology Today, 38(2), 58-64. https://doi.org/10.1111/gto.12382

Mineral specimens found in historical collections often include specimen labels, which may provide vital information on the nature, chemistry and origin of the material. However, the evolution of chemical notation, particularly during the eighteenth... Read More about From alchemy to modern mineralogy: dating mineral collections via chemical notation.

New anti-angiogenic compound based on chemically modified heparin (2022)
Journal Article
Kniggendorf, V., Souza, M., Russo, T., Andrade De Lima, M., Grupenmacher, A., Regatieri, C., & Dreyfuss, J. (2022). New anti-angiogenic compound based on chemically modified heparin. Graefe's Archive for Clinical and Experimental Ophthalmology, 1 - 9. https://doi.org/10.1007/s00417-022-05828-x

Purpose The purpose of this study was to measure the anti-angiogenic effect of N-desulfated Re–N-acetylated, a chemically modified heparin (mHep). Methods In vitro assays (cell tube formation, viability, proliferation, and migration) with endothelial... Read More about New anti-angiogenic compound based on chemically modified heparin.

N,N ''-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties (2022)
Journal Article
Al-Riyahee, A. A. A., Horton, P. N., Coles, S. J., Berry, C., Horrocks, P. D., Pope, S. J. A., & Amoroso, A. J. (2022). N,N ''-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties. Dalton Transactions, 51(9), 3531-3545. https://doi.org/10.1039/d1dt04091j

The synthesis of six N,N'-substituted thiourea ligands (L1a-L3b) was achieved in two steps. A corresponding extensive series of Cu(I), Cu(II), Ni(II) and Zn(II) complexes (1-24) with varying formulations were synthesised from these ligands by the rea... Read More about N,N ''-Substituted thioureas and their metal complexes: syntheses, structures and electronic properties.

Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. (2022)
Journal Article
Cosgrove, S. C., & Miller, G. J. (2022). Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues. Expert Opinion on Drug Discovery, 17(4), 355-364. https://doi.org/10.1080/17460441.2022.2039620

INTRODUCTION: Nucleoside analogues represent a cornerstone of achievement in drug discovery, rising to prominence particularly in the fields of antiviral and anticancer discovery over the last 60 years. Traditionally accessed using chemical synthesis... Read More about Advances in biocatalytic and chemoenzymatic synthesis of nucleoside analogues..

3-D thermoacoustic instability analysis based on Green's function approach (2022)
Journal Article
Wang, X., & Heckl, M. (2022). 3-D thermoacoustic instability analysis based on Green's function approach. Journal of Sound and Vibration, 537, 1-28. https://doi.org/10.1016/j.jsv.2022.116816

A fundamental analysis is made of the thermoacoustic instability in a hard-walled box. We model the flame as an acoustically compact source with a heat release characteristic described by a directional nt-law. This has the following features: it give... Read More about 3-D thermoacoustic instability analysis based on Green's function approach.

Design, chemical synthesis and antiviral evaluation of 2'-deoxy-2'-fluoro-2'-C-methyl-4'-thionucleosides. (2022)
Journal Article
Guinan, M., Huang, N., Smith, M., & Miller, G. (2022). Design, chemical synthesis and antiviral evaluation of 2'-deoxy-2'-fluoro-2'-C-methyl-4'-thionucleosides. Bioorganic and Medicinal Chemistry Letters, 61, Article 128605. https://doi.org/10.1016/j.bmcl.2022.128605

Nucleoside analogues represent an historically accomplished class of antiviral drug. Notwithstanding this, new molecular scaffolds are required to overcome their limitations and evolve pharmacophore space within this established field. Herein, we dev... Read More about Design, chemical synthesis and antiviral evaluation of 2'-deoxy-2'-fluoro-2'-C-methyl-4'-thionucleosides..

Neuroprogenitor Cells From Patients With TBCK Encephalopathy Suggest Deregulation of Early Secretory Vesicle Transport (2022)
Journal Article
Moreira, D., Suzuki, A., Silva, A., Varella-Branco, E., Meneghetti, M., Kobayashi, G., …Passos-Bueno, M. (2022). Neuroprogenitor Cells From Patients With TBCK Encephalopathy Suggest Deregulation of Early Secretory Vesicle Transport. Frontiers in Cellular Neuroscience, 15, https://doi.org/10.3389/fncel.2021.803302

<jats:p>Biallelic pathogenic variants in TBCK cause encephaloneuropathy, infantile hypotonia with psychomotor retardation, and characteristic facies 3 (IHPRF3). The molecular mechanisms underlying its neuronal phenotype are largely unexplored. In thi... Read More about Neuroprogenitor Cells From Patients With TBCK Encephalopathy Suggest Deregulation of Early Secretory Vesicle Transport.

Oxidase enzymes as sustainable oxidation catalysts (2022)
Journal Article
Wahart, A. J. C., Staniland, J., Miller, G. J., & Cosgrove, S. C. (2022). Oxidase enzymes as sustainable oxidation catalysts. Royal Society Open Science, 9(1), https://doi.org/10.1098/rsos.211572

Oxidation is one of the most important processes used by the chemical industry. However, many of the methods that are used pose significant sustainability and environmental issues. Biocatalytic oxidation offers an alternative to these methods, with a... Read More about Oxidase enzymes as sustainable oxidation catalysts.

Molecular Inhibition for Selective CO2 Conversion (2022)
Journal Article
Schreiber, M., Fontecave, M., Creissen, C., Guillermo Rivera de la Cruz, J., Karapinar, D., & Taverna, D. (2022). Molecular Inhibition for Selective CO2 Conversion. ChemRxiv, https://doi.org/10.26434/chemrxiv-2022-63b91

Electrochemical CO2 reduction presents a sustainable route to the production of chemicals and fuels. Achieving a narrow product distribution with copper catalysts is challenging and conventional material modifications offer limited control over selec... Read More about Molecular Inhibition for Selective CO2 Conversion.

Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy (2022)
Journal Article
Darling, D., Farzaneh, F., Williams, G., & Tonge, D. (2022). Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy. Scientific reports, 12, Article 182. https://doi.org/10.1038/s41598-021-03983-5

<jats:title>Abstract</jats:title><jats:p>Identification of cell fate-controlling lncRNAs is essential to our understanding of molecular cell biology. Here we present a human genome-scale forward-genetics approach for the identification of lncRNAs bas... Read More about Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy.

The use of portable XRF as a forensic geoscience non-destructive trace evidence tool for environmental and criminal investigations (2022)
Journal Article
Pringle, J., Jeffery, A., Ruffell, A., Stimpson, I., Pirrie, D., Bergslien, E., …Partridge, J. (2022). The use of portable XRF as a forensic geoscience non-destructive trace evidence tool for environmental and criminal investigations. Forensic Science International, 111175 - 111175. https://doi.org/10.1016/j.forsciint.2022.111175

Hand-held, portable X-Ray fluorescence instruments (pXRF) provide a means of rapid, in-situ chemical characterisation that has considerable application as a rapid trace evidence characterisation tool in forensic geoscience. This study presents both a... Read More about The use of portable XRF as a forensic geoscience non-destructive trace evidence tool for environmental and criminal investigations.

Tripodal 1,3,5-benzenetricarboxamide ligand with dipicolinic acid units and its binding with Eu(III) ions (2022)
Journal Article
Klangwart, N., Ruijs, C., Hawes, C. S., Gunnlaugsson, T., & Kotova, O. (2022). Tripodal 1,3,5-benzenetricarboxamide ligand with dipicolinic acid units and its binding with Eu(III) ions. Supramolecular Chemistry, 34(1), 10-19. https://doi.org/10.1080/10610278.2023.2177162

The synthesis and characterisation of tripodal ligand 1 containing 1,3,5-benzenetricarboxamide core and diethyl 4-(phenylethynyl)pyridine-2,6-dicarboxylate is described. The crystal structure of the intermediate tripodal molecule 7 exhibits an unusua... Read More about Tripodal 1,3,5-benzenetricarboxamide ligand with dipicolinic acid units and its binding with Eu(III) ions.

Indium(III) promoted oxidative P-P coupling of silylphosphines (2021)
Journal Article
Cartlidge, A. J., & Matthews, P. (2022). Indium(III) promoted oxidative P-P coupling of silylphosphines. Inorganica Chimica Acta, 120772 - 120772. https://doi.org/10.1016/j.ica.2021.120772

The reaction of indium(III) salts with Ph2PSiMe3 and PhP(SiMe3)2 gives rise to a one- and two-electron reductive P-P coupling respectively, with the formation of new P-P bonds resulting in the preparation of (Ph2P)2 and the cyclicoligophosphane compo... Read More about Indium(III) promoted oxidative P-P coupling of silylphosphines.

Monitoring of simulated clandestine graves of dismembered victims using UAVs, electrical tomography, and GPR over one year to aid investigations of human rights violations in Colombia, South America (2021)
Journal Article
Molina, C. M., Vasquez, A., Wisniewski, K., Heaton, V., Pringle, J., Avila, E. F., …Baena, A. (2022). Monitoring of simulated clandestine graves of dismembered victims using UAVs, electrical tomography, and GPR over one year to aid investigations of human rights violations in Colombia, South America. Journal of Forensic Sciences, 67(3), 1060-1071. https://doi.org/10.1111/1556-4029.14962

In most Latin American countries there are significant numbers of missing people and forced disappearances, over 90,000 in Colombia alone. Successful detection of shallow buried human remains by forensic search teams is difficult in varying terrain a... Read More about Monitoring of simulated clandestine graves of dismembered victims using UAVs, electrical tomography, and GPR over one year to aid investigations of human rights violations in Colombia, South America.

Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination. (2021)
Journal Article
Kehlenbeck, D., Traore, D. A., Josts, I., Sander, S., Moulin, M., Haertlein, M., …Tidow, H. (2022). Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination. FEBS Journal, 289(10), 2959-2970. https://doi.org/10.1111/febs.16327

The ATP-binding cassette transporter MsbA is a lipid flippase, translocating lipid A, glycolipids, and lipopolysaccharides from the inner to the outer leaflet of the inner membrane of Gram-negative bacteria. It has been used as a model system for tim... Read More about Cryo-EM structure of MsbA in saposin-lipid nanoparticles (Salipro) provides insights into nucleotide coordination..

Reaching new biocatalytic reactivity using continuous flow reactors (2021)
Journal Article
Cosgrove, S. C., & Mattey, A. P. (2022). Reaching new biocatalytic reactivity using continuous flow reactors. Chemistry - A European Journal, 28(13), https://doi.org/10.1002/chem.202103607

The use of flow reactors in biocatalysis has increased significantly in recent years. Chemists have begun to design flow systems that even allow new biocatalytic reactions to take place. This concept article will focus on the design of flow systems t... Read More about Reaching new biocatalytic reactivity using continuous flow reactors.

The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme. (2021)
Journal Article
(2021). The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme. Acta Crystallographica Section D: Structural Biology, 1579 - 1590. https://doi.org/10.1107/S2059798321010950

The biological function of a protein is intimately related to its structure and dynamics, which in turn are determined by the way in which it has been folded. In vitro refolding is commonly used for the recovery of recombinant proteins that are expre... Read More about The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme..

Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates (2021)
Journal Article
Reynisson, J., Wieczorek-Błauż, A., Kowalczyk, K., Błauż, A., Makal, A., Pawlędzio, S., …Plażuk, D. (2021). Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates. Dalton Transactions, 51(2), 491-508. https://doi.org/10.1039/d1dt03553c

The incorporation of the ferrocenyl moiety into a bioactive molecule may significantly alter the activity of the resulting conjugate. By applying this strategy, we designed ferrocenyl analogs of monastrol - the first low molecular weight kinesin spin... Read More about Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates.