Use of strontium isotope ratios in geolocation of Guatemalan population: Potential role in identification of remains. (2022)
Journal Article
Austin, R., Fowler, G., Croxton, R., Evans, J., Thompson, D. F., Cooper, J. J., & Perez Tanchez, M. (2022). Use of strontium isotope ratios in geolocation of Guatemalan population: Potential role in identification of remains. Journal of Forensic Sciences, 67(5), 1962-1970. https://doi.org/10.1111/1556-4029.15116

Within post-conflict communities, attempts to identify and repatriate unidentified and missing individuals poses a difficult task. As current forensic strategies commonly lack the capacity to provide region of origin assessments, forensic anthropolog... Read More about Use of strontium isotope ratios in geolocation of Guatemalan population: Potential role in identification of remains..

Molecular Inhibition for Selective CO2 Conversion. (2022)
Journal Article
Creissen, C., Rivera de la Cruz, J., Karapinar, D., Taverna, D., Schreiber, M., & Fontecave, M. (2022). Molecular Inhibition for Selective CO2 Conversion. Angewandte Chemie International Edition, e202206279 - ?. https://doi.org/10.1002/anie.202206279

Electrochemical CO2 reduction presents a sustainable route to the production of chemicals and fuels. Achieving a narrow product distribution with heterogeneous Cu catalysts is challenging and conventional material modifications offer limited control... Read More about Molecular Inhibition for Selective CO2 Conversion..

GASKAP-HI Pilot Survey Science III: An unbiased view of cold gas in the Small Magellanic Cloud (2022)
Journal Article
Van Loon. (2022). GASKAP-HI Pilot Survey Science III: An unbiased view of cold gas in the Small Magellanic Cloud. Publications of the Astronomical Society of Australia, https://doi.org/10.1017/pasa.2022.18

<jats:title>Abstract</jats:title> <jats:p>We present the first unbiased survey of neutral hydrogen absorption in the Small Magellanic Cloud. The survey utilises pilot neutral hydrogen observations with the Australian Square Kilometre Array Pathfinder... Read More about GASKAP-HI Pilot Survey Science III: An unbiased view of cold gas in the Small Magellanic Cloud.

Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways (2022)
Journal Article
Andrade De Lima, M., Rudd, T., Fernig, D., & Yates, E. (2022). Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways. Journal of the Royal Society. Interface, 19(193), https://doi.org/10.1098/rsif.2022.0391

<jats:p>Phosphate and sulfate groups are integral to energy metabolism and introduce negative charges into biological macromolecules. One purpose of such modifications is to elicit precise binding/activation of protein partners. The physico-chemical... Read More about Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways.

The Effects of Cucumber Mosaic Virus and Its 2a and 2b Proteins on Interactions of Tomato Plants with the Aphid Vectors Myzus persicae and Macrosiphum euphorbiae (2022)
Journal Article
Arinaitwe, W., Guyon, A., Tungadi, T., Cunniffe, N. J., Rhee, S.-J., Khalaf, A., …Carr, J. (2022). The Effects of Cucumber Mosaic Virus and Its 2a and 2b Proteins on Interactions of Tomato Plants with the Aphid Vectors Myzus persicae and Macrosiphum euphorbiae. Viruses, 14(8), 1-19. https://doi.org/10.3390/v14081703

Cucumber mosaic virus (CMV), a major tomato pathogen, is aphid-vectored in the non-persistent manner. We investigated if CMV-induced volatile organic compounds (VOCs) or other virus-induced cues alter aphid–tomato interactions. Y-tube olfactometry sh... Read More about The Effects of Cucumber Mosaic Virus and Its 2a and 2b Proteins on Interactions of Tomato Plants with the Aphid Vectors Myzus persicae and Macrosiphum euphorbiae.

Breast calcification micromorphology classification (2022)
Journal Article
Scott, R., Lyburn, I., Cornford, E., Bouzy, P., Stone, N., Greenwood, C., …Rogers, K. (2022). Breast calcification micromorphology classification. British Journal of Radiology, 95(1139), 1- 3. https://doi.org/10.1259/bjr.20220485

Objectives: The importance of consistent terminology in describing the appearance of breast calcifications in mammography is well recognised. Imaging of calcifications using electron microscopy is a globally growing field of research. We therefore su... Read More about Breast calcification micromorphology classification.

Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the O- and S-Glycoside Analogues of Heparan Sulfate. (2022)
Journal Article
Meneghetti, M., Naughton, L., O'Shea, C., Koffi Teki, D., Chagnault, V., Nader, H., …Andrade De Lima, M. (2022). Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the O- and S-Glycoside Analogues of Heparan Sulfate. ACS Omega, 7(28), 24461 - 24467. https://doi.org/10.1021/acsomega.2c02070

Heparan sulfate (HS), a sulfated linear carbohydrate that decorates the cell surface and extracellular matrix, is ubiquitously distributed throughout the animal kingdom and represents a key regulator of biological processes and a largely untapped res... Read More about Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the O- and S-Glycoside Analogues of Heparan Sulfate..

In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum (2022)
Journal Article
Okokon, J. E., Etuk, I. C., Thomas, P. S., Drijfhout, F. P., Claridge, T. D., & Li, W. (2022). In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum. Biomedicine and Pharmacotherapy, https://doi.org/10.1016/j.biopha.2022.113153

Solanum anomalum is a plant used ethnomedically for the treatment of diabetes. The study was aimed to validate ethnomedical claims in rat model and identify the likely antidiabetic compounds. Leaf extract (70–210 mg/kg/day) and fractions (140 mg/kg/d... Read More about In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum.

Nanostructured materials for sensor applications (2022)
Thesis
Jendrlin, M. (2022). Nanostructured materials for sensor applications. (Thesis). Keele University

The utilisation of zeolites as infrared spectroscopy-based gas sensors and as potentiometric sensors in zeolite modified electrodes is reported in this thesis.
Commercial zeolites (NaX, NaY, MOR, FER, BEA-12, BEA-19 and ZSM-5) and prepared Sn-BEA ze... Read More about Nanostructured materials for sensor applications.

Thinglink and the Laboratory: Interactive Simulations of Analytical Instrumentation for HE Science Curricula (2022)
Journal Article
Jeffery, A. J., Rogers, S. L., Pringle, J. K., Zholobenko, V. L., Jeffery, K. L., Wisniewski, K. D., …Emley, D. W. (2022). Thinglink and the Laboratory: Interactive Simulations of Analytical Instrumentation for HE Science Curricula. Journal of Chemical Education, 2277-2290. https://doi.org/10.1021/acs.jchemed.1c01067

Access to laboratory facilities and associated instrumentation represents a major barrier to learning in physical science education, due to constraints introduced by limited time and financial resources, cost 20 of acquisition, and health and safety... Read More about Thinglink and the Laboratory: Interactive Simulations of Analytical Instrumentation for HE Science Curricula.

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction. (2022)
Journal Article
Guimond, S., Mycroft-West, C. J., Gandhi, N. S., Tree, J. A., C.Le, T. T., Spalluto, M., …Turnbull, J. E. (2022). Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction. ACS Central Science, 8(5), 527 - 545. https://doi.org/10.1021/acscentsci.1c01293

Heparan sulfate (HS) is a cell surface polysaccharide recently identified as a coreceptor with the ACE2 protein for the S1 spike protein on SARS-CoV-2 virus, providing a tractable new therapeutic target. Clinically used heparins demonstrate an inhibi... Read More about Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike-ACE2 Interaction..

Microgravity crystallization of perdeuterated tryptophan synthase for neutron diffraction. (2022)
Journal Article
Drago, V., Devos, J., Blakeley, M., Forsyth, V., Kovalevsky, A., Schall, C., & Mueser, T. (2022). Microgravity crystallization of perdeuterated tryptophan synthase for neutron diffraction. npj Microgravity, 13 - ?. https://doi.org/10.1038/s41526-022-00199-3

Biologically active vitamin B6-derivative pyridoxal 5'-phosphate (PLP) is an essential cofactor in amino acid metabolic pathways. PLP-dependent enzymes catalyze a multitude of chemical reactions but, how reaction diversity of PLP-dependent enzymes is... Read More about Microgravity crystallization of perdeuterated tryptophan synthase for neutron diffraction..

Characterisation of the Structural Requirements for the Immunomodulatory Surfactant Protein D (SP-D) to Bind to Maltose Based Ligands (2022)
Journal Article
Shrive, & Greenhough. (2022). Characterisation of the Structural Requirements for the Immunomodulatory Surfactant Protein D (SP-D) to Bind to Maltose Based Ligands. https://doi.org/10.1164/ajrccm-conference.2022.205.1_MeetingAbstracts.A2609

Investigating pair distribution function use in analysis of nanocrystalline hydroxyapatite and carbonate-substituted hydroxyapatite (2022)
Journal Article
Arnold, E., Keeble, D., Evans, J., Greenwood, C., & Rogers, K. (2022). Investigating pair distribution function use in analysis of nanocrystalline hydroxyapatite and carbonate-substituted hydroxyapatite. Acta Crystallographica Section C: Structural Chemistry, C78(PART 5), 271 - 279. https://doi.org/10.1107/s2053229622003400

Hydroxyapatite (HA) is a complex material, which is often nanocrystalline when found within a biological setting. This work has directly compared the structural characteristics derived from data collected using a conventional laboratory-based X-ray d... Read More about Investigating pair distribution function use in analysis of nanocrystalline hydroxyapatite and carbonate-substituted hydroxyapatite.

Keeping sight of copper in single-atom catalysts for electrochemical carbon dioxide reduction (2022)
Journal Article
Creissen, C. E., & Fontecave, M. (2022). Keeping sight of copper in single-atom catalysts for electrochemical carbon dioxide reduction. Nature communications, 13(1), Article ARTN 2280. https://doi.org/10.1038/s41467-022-30027-x

In Situ and Ex Situ X-ray Diffraction and Small-Angle X-ray Scattering Investigations of the Sol-Gel Synthesis of Fe3N and Fe3C. (2022)
Journal Article
Chambers, M., Hunter, R., Hollamby, M., Pauw, B., Smith, A., Snow, T., …Schnepp, Z. (2022). In Situ and Ex Situ X-ray Diffraction and Small-Angle X-ray Scattering Investigations of the Sol-Gel Synthesis of Fe3N and Fe3C. Inorganic Chemistry, 61(18), 6742-6749. https://doi.org/10.1021/acs.inorgchem.1c03442

Iron nitride (Fe3N) and iron carbide (Fe3C) nanoparticles can be prepared via sol-gel synthesis. While sol-gel methods are simple, it can be difficult to control the crystalline composition, i.e., to achieve a Rietveld-pure product. In a previous in... Read More about In Situ and Ex Situ X-ray Diffraction and Small-Angle X-ray Scattering Investigations of the Sol-Gel Synthesis of Fe3N and Fe3C..

Bioactive Volatiles From Push-Pull Companion Crops Repel Fall Armyworm and Attract Its Parasitoids (2022)
Journal Article
Sobhy, I., Tamiru, A., Chiriboga Morales, X., Nyagol, D., Cheruiyot, D., Chidawanyika, F., …Khan, Z. (2022). Bioactive Volatiles From Push-Pull Companion Crops Repel Fall Armyworm and Attract Its Parasitoids. Frontiers in Ecology and Evolution, https://doi.org/10.3389/fevo.2022.883020

Fall armyworm, Spodoptera frugiperda, is a serious invasive pest in Africa but "Push-Pull" companion cropping can substantially reduce infestation. Here, we elucidate the underpinning chemical ecology mechanisms. We hypothesized that companion crop v... Read More about Bioactive Volatiles From Push-Pull Companion Crops Repel Fall Armyworm and Attract Its Parasitoids.

Analysis of protein-heparin interactions using a portable SPR instrument (2022)
Journal Article
Su, D., Li, Y., Yates, E., Skidmore, M., Andrade De Lima, M., & Fernig, D. (2022). Analysis of protein-heparin interactions using a portable SPR instrument. PeerJ Analytical Chemistry, 4, 1-16. https://doi.org/10.7717/peerj-achem.15

<jats:p>Optical biosensors such as those based on surface plasmon resonance (SPR) are a key analytical tool for understanding biomolecular interactions and function as well as the quantitative analysis of analytes in a wide variety of settings. The a... Read More about Analysis of protein-heparin interactions using a portable SPR instrument.

SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS (2022)
Journal Article
Dale. (2022). SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS. Tissue engineering. Part A, S451 - S452

Chronic Obstructive Pulmonary Disease (COPD) presents a significant, incurable, worldwide health burden, identifying it as a prospective regenerative medicine target. Sourcing cells for lung therapies is challenging; progress has been made in culturi... Read More about SUCCESSFUL ISOLATION AND CULTURE OF MULTIPOTENTIAL DISTAL AIRWAY STEM CELLS FROM COPD PATIENTS.

Chemical synthesis and biological evaluation of 4'-thionucleosides (2022)
Thesis
Guinan, M. (2022). Chemical synthesis and biological evaluation of 4'-thionucleosides. (Thesis). Keele University

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the treatment of a wide variety of cancers and viruses. Several such compounds, including Sofosbuvir and Gemcitabine are the go-to option in first line treatments. Ho... Read More about Chemical synthesis and biological evaluation of 4'-thionucleosides.