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Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues (2021)
Journal Article
Guinan, M., Huang, N., Hawes, C. S., Lima, M. A., Smith, M., & Miller, G. J. (2021). Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues. Organic and Biomolecular Chemistry, 20(7), 1401-1406. https://doi.org/10.1039/d1ob02097h

Analogues of the canonical nucleosides required for nucleic acid synthesis have a longstanding presence and proven capability within antiviral and anticancer research. 4'-Thionucleosides, that incorporate bioisosteric replacement of furanose oxygen w... Read More about Chemical synthesis of 4′-thio and 4′-sulfinyl pyrimidine nucleoside analogues.

Prospects for anti-Candida therapy through targeting the cell wall: A mini-review (2021)
Journal Article
Ahmadipour, S., Field, R. A., & Miller, G. (2021). Prospects for anti-Candida therapy through targeting the cell wall: A mini-review. The Cell Surface, 7, Article 100063. https://doi.org/10.1016/j.tcsw.2021.100063

The impact of fungal infections on humans is a serious public health issue that has received much less attention than bacterial infection and treatment, despite ever-increasing incidence exacerbated by an increased incidence of immunocompromised indi... Read More about Prospects for anti-Candida therapy through targeting the cell wall: A mini-review.

Laboratory exploration of mineral precipitates from Europa’s subsurface ocean (2021)
Journal Article
(2021). Laboratory exploration of mineral precipitates from Europa’s subsurface ocean. Journal of Applied Crystallography, 1455-1479. https://doi.org/10.1107/S1600576721008554

The precipitation of hydrated phases from a chondritic-like Na-Mg-Ca-SO4-Cl solution is studied using in situ synchrotron X-ray powder diffraction, under rapid (360
K hour-1, T = 250-80 K, t = 3 hours) and ultra-slow (0.3 K day-1, T= 273-245K, t = 2... Read More about Laboratory exploration of mineral precipitates from Europa’s subsurface ocean.

Developments in the Chemical Synthesis of Heparin and Heparan Sulfate (2021)
Journal Article
Pongener, I., O'Shea, C., Wootton, H., Watkinson, M., & Miller, G. J. (2021). Developments in the Chemical Synthesis of Heparin and Heparan Sulfate. Chemical Record, 21(11), 3238-3255. https://doi.org/10.1002/tcr.202100173

Heparin and heparan sulfate represent key members of the glycosaminoglycan family of carbohydrates and underpin considerable repertoires of biological importance. As such, their efficiency of synthesis represents a key requirement, to further underst... Read More about Developments in the Chemical Synthesis of Heparin and Heparan Sulfate.

Radio continuum sources behind the Large Magellanic Cloud (2021)
Journal Article
Van Loon. (2021). Radio continuum sources behind the Large Magellanic Cloud. Monthly Notices of the Royal Astronomical Society, 2885 - 2904. https://doi.org/10.1093/mnras/stab2249

We present a comprehensive multifrequency catalogue of radio sources behind the Large Magellanic Cloud (LMC) between 0.2 and 20 GHz, gathered from a combination of new and legacy radio continuum surveys. This catalogue covers an area of ~144 deg2 at... Read More about Radio continuum sources behind the Large Magellanic Cloud.

Monitoring the early aggregatory behaviour and size of Aß1-42 in the absence & presence of metal ions using dynamic light scattering. (2021)
Journal Article
(2021). Monitoring the early aggregatory behaviour and size of Aß1-42 in the absence & presence of metal ions using dynamic light scattering. Journal of Trace Elements in Medicine and Biology, 1- 9. https://doi.org/10.1016/j.jtemb.2021.126766

BACKGROUND AND AIM: Aß1-42 is an amyloidogenic peptide found within senile plaques extracted from those who died with a diagnosis of Alzheimer's disease. The potent neurotoxicity of this peptide is related to its propensity to form aggregated conform... Read More about Monitoring the early aggregatory behaviour and size of Aß1-42 in the absence & presence of metal ions using dynamic light scattering..

A Potential Barrier Halting Spherically Symmetric Relativistic Gravitational Collapse (2021)
Book Chapter
Austin, J. C. (2021). A Potential Barrier Halting Spherically Symmetric Relativistic Gravitational Collapse. In Research Trends and Challenges in Physical Science (101-113). BP International. https://doi.org/10.9734/bpi/rtcps/v1/4203f

Discussion: Scholarly discussion on any scientific article or Book or Book chapter is very important for the advancement of science. We strongly suggest all readers and authors to participate in such activities. Comment posting facility is available... Read More about A Potential Barrier Halting Spherically Symmetric Relativistic Gravitational Collapse.

Ferroelectric semiconductor junctions based on graphene/In2Se3/graphene van der Waals heterostructures (2021)
Journal Article
Xie, S., Dey, A., Yan, W., Kudrynskyi, Z., Balakrishnan, N., Kovalyuk, Z., …Patane, A. (2021). Ferroelectric semiconductor junctions based on graphene/In2Se3/graphene van der Waals heterostructures. 2D Materials, 8(4), 1-9. https://doi.org/10.1088/2053-1583/ac1ada

The miniaturization of ferroelectric devices offers prospects for non-volatile memories, low-power electrical switches and emerging technologies beyond existing Si-based integrated circuits. An emerging class of ferroelectrics is based on van der Waa... Read More about Ferroelectric semiconductor junctions based on graphene/In2Se3/graphene van der Waals heterostructures.

Bacterial lipopolysaccharide recognition by surfactant protein D (2021)
Presentation / Conference
Shrive, & Greenhough. (2021, August). Bacterial lipopolysaccharide recognition by surfactant protein D. Presented at XXV IUCr Congress, Prague, Czech Republic

Human surfactant protein D is a collectin and member of the C-type lectin superfamily of proteins that forms an essential part of the mammalian innate immune system. The collectins have been recognised to not only bind to invading pathogens, allowing... Read More about Bacterial lipopolysaccharide recognition by surfactant protein D.

Optical spectroscopy study of Eu-doped ions in BaAl2O4 phosphors (2021)
Journal Article
Rezende, M. D. S., Valerio, M., Araujo, R., Jackson, R., dos Santos Mattos, E., & dos Santos Junior, B. (2021). Optical spectroscopy study of Eu-doped ions in BaAl2O4 phosphors. Journal of Luminescence, 1-5. https://doi.org/10.1016/j.jlumin.2021.118011

Computational and experimental methodology is employed to study optical properties in Eu-doped BaAl2O4 phosphors. The symmetry and detailed geometry of the Eu-dopant site, predicted by atomistic simulation, are used to calculate the crystal field par... Read More about Optical spectroscopy study of Eu-doped ions in BaAl2O4 phosphors.

Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions (2021)
Journal Article
Barnes, N. G., Ahmed Mal Ullah, A. A., Ragazzon, P. A., Charafi, N., & Hadfield, J. A. (2021). Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions. ChemistrySelect, 6(28), 7082 - 7086. https://doi.org/10.1002/slct.202101960

Combretastatin A-4 (CA4) is a potent anti-mitotic and vascular disrupting agent. Organic chemists have been working to optimize the synthesis of CA4 for the past 3 decades, with methods requiring hazardous solvents and harsh reaction conditions. Here... Read More about Syntheses of Combretastatin A-4 and Related Stilbenes by Using Aqueous Conditions.

Effects of Surface Chemistry Interaction on Primary Neural Stem Cell Neurosphere Responses. (2021)
Journal Article
Kyriacou. (2021). Effects of Surface Chemistry Interaction on Primary Neural Stem Cell Neurosphere Responses. ACS Omega, 19901 - 19910. https://doi.org/10.1021/acsomega.1c02796

The characteristics of a material's surface are extremely important when considering their interactions with biological species. Despite surface chemistry playing a critical role in mediating the responses of cells, there remains no single rule which... Read More about Effects of Surface Chemistry Interaction on Primary Neural Stem Cell Neurosphere Responses..

Squaramide‐Based Self‐Associating Amphiphiles for Anion Recognition (2021)
Journal Article
Kumawat, L. K., Wynne, C., Cappello, E., Fisher, P., Brennan, L. E., Strofaldi, A., …Elmes, R. B. P. (2021). Squaramide‐Based Self‐Associating Amphiphiles for Anion Recognition. ChemPlusChem, 86(8), 1058-1068. https://doi.org/10.1002/cplu.202100275

The synthesis and characterisation of two novel self‐assembled amphiphiles (SSAs) SQS‐1 and SQS‐2 are reported. Both compounds, based on the squaramide motif, were fully soluble in a range of solvents and were shown to undergo self‐assembly through a... Read More about Squaramide‐Based Self‐Associating Amphiphiles for Anion Recognition.

The influence of exocyclic lone pairs on the bonding and geometry of type A mesoionic rings (2021)
Journal Article
(2021). The influence of exocyclic lone pairs on the bonding and geometry of type A mesoionic rings. Structural Chemistry, https://doi.org/10.1007/s11224-021-01798-8

Based on structures determined by X-ray crystallography, ab initio MP2 calculations on type A mesoionic rings give geometries in good agreement with observed values. A study of four mesoionic ring systems, each with exocyclic oxygen, nitrogen or carb... Read More about The influence of exocyclic lone pairs on the bonding and geometry of type A mesoionic rings.

Chemical synthesis of C6-tetrazole ᴅ-mannose building blocks and access to a bioisostere of mannuronic acid 1-phosphate (2021)
Journal Article
Dimitriou, E., & Miller, G. (2021). Chemical synthesis of C6-tetrazole ᴅ-mannose building blocks and access to a bioisostere of mannuronic acid 1-phosphate. Beilstein Journal of Organic Chemistry, 1527 - 1532. https://doi.org/10.3762/bjoc.17.110

<jats:p>Alginate is a biocompatible and industrially relevant polysaccharide that derives many of its important properties from the charged carboxylate groups within its polyuronic acid backbone. The design and inclusion of isosteric replacements for... Read More about Chemical synthesis of C6-tetrazole ᴅ-mannose building blocks and access to a bioisostere of mannuronic acid 1-phosphate.

The measurement and full statistical analysis including Bayesian methods of the aluminium content of infant vaccines. (2021)
Journal Article
(2021). The measurement and full statistical analysis including Bayesian methods of the aluminium content of infant vaccines. Journal of Trace Elements in Medicine and Biology, 1- 7. https://doi.org/10.1016/j.jtemb.2021.126762

BACKGROUND: Aluminium salts are the most common adjuvants in infant vaccines. The aluminium content of a vaccine is provided by the manufacturer and is indicated on the patient information leaflet. There is no independent verification, for example by... Read More about The measurement and full statistical analysis including Bayesian methods of the aluminium content of infant vaccines..

A Pencil-Drawn Electronic Tongue for Environmental Applications. (2021)
Journal Article
Kirsanov, D., Mukherjee, S., Pal, S., Ghosh, K., Bhattacharyya, N., Bandyopadhyay, R., …Legin, A. (2021). A Pencil-Drawn Electronic Tongue for Environmental Applications. Sensors, https://doi.org/10.3390/s21134471

We report on the development of a simple and cost-effective potentiometric sensor array that is based on manual "drawing" on the polymeric support with the pencils composed of graphite and different types of zeolites. The sensor array demonstrates di... Read More about A Pencil-Drawn Electronic Tongue for Environmental Applications..

Dispersal timescale of protoplanetary disks in the low-metallicity young cluster Dolidze 25 (2021)
Journal Article
Wright. (2021). Dispersal timescale of protoplanetary disks in the low-metallicity young cluster Dolidze 25. Astronomy & Astrophysics, 1-37. https://doi.org/10.1051/0004-6361/202140361

<jats:p><jats:italic>Context.</jats:italic> The dispersal of protoplanetary disks sets the timescale that is available for planets to assemble, and thus it is one of the fundamental parameters in theories of planetary formation. Disk dispersal is det... Read More about Dispersal timescale of protoplanetary disks in the low-metallicity young cluster Dolidze 25.