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Open‐labelled study to monitor the effect of an amino acid formula on symptom management in children with spinal muscular atrophy type I: The SMAAF pilot study (2022)
Journal Article
Bowerman, M., O'Connor, G., Edel, L., Raquq, S., Szmurlo, A., Simpson, Z., Hardy, I., Fewtrell, M., & Baranello, G. (2023). Open‐labelled study to monitor the effect of an amino acid formula on symptom management in children with spinal muscular atrophy type I: The SMAAF pilot study. Nutrition in Clinical Practice, 38(4), 871-880. https://doi.org/10.1002/ncp.10940

Background: An increasing number of families of spinal muscular atrophy (SMA) children are incorporating an amino acid-based enteral formula into their child’s feeding regimens. Other components of the amino acidbased formula include added carbohydra... Read More about Open‐labelled study to monitor the effect of an amino acid formula on symptom management in children with spinal muscular atrophy type I: The SMAAF pilot study.

Rewriting the history of leishmaniasis in Sri Lanka: An untold story since 1904. (2022)
Journal Article
Nuwangi, H., Weerakoon, K., Agampodi, T., Price, H., Dikomitis, L., & Agampodi, S. (2022). Rewriting the history of leishmaniasis in Sri Lanka: An untold story since 1904. PLoS Neglected Tropical Diseases, e0010918 - ?. https://doi.org/10.1371/journal.pntd.0010918

Leishmaniasis is widely considered a disease that emerged in Sri Lanka in the 1990s. However, a comprehensive case report from 1904 suggests that the presence of Leishmaniasis was well demonstrated in Sri Lanka long before that. The Annual Administra... Read More about Rewriting the history of leishmaniasis in Sri Lanka: An untold story since 1904..

Enhancing authenticity, diagnosticity and equivalence (AD-Equiv) in multicentre OSCE exams in health professionals education: protocol for a complex intervention study. (2022)
Journal Article
Yeates, P., Maluf, A., Kinston, R., Cope, N., McCray, G., Cullen, K., O’Neill, V., Cole, A., Goodfellow, R., Vallender, R., Chung, C.-W., McKinley, R. K., Fuller, R., & Wong, G. (2022). Enhancing authenticity, diagnosticity and equivalence (AD-Equiv) in multicentre OSCE exams in health professionals education: protocol for a complex intervention study. BMJ Open, 12(12), Article e064387. https://doi.org/10.1136/bmjopen-2022-064387

INTRODUCTION: Objective structured clinical exams (OSCEs) are a cornerstone of assessing the competence of trainee healthcare professionals, but have been criticised for (1) lacking authenticity, (2) variability in examiners' judgements which can cha... Read More about Enhancing authenticity, diagnosticity and equivalence (AD-Equiv) in multicentre OSCE exams in health professionals education: protocol for a complex intervention study..

Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis. (2022)
Journal Article
Bunnewell, S., Wells, I., Zemedikun, D., Simons, G., Mallen, C. D., Raza, K., & Falahee, M. (2022). Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis. RMD Open, https://doi.org/10.1136/rmdopen-2022-002606

OBJECTIVES: To define variables associated with perceived risk of developing rheumatoid arthritis (RA) in first-degree relatives (FDRs) of patients with RA. METHODS: Patients with RA and their FDRs were invited to complete cross-sectional surveys. FD... Read More about Predictors of perceived risk in first-degree relatives of patients with rheumatoid arthritis..

Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. (2022)
Journal Article
Rotherham, M., Moradi, Y., Nahar, T., Mosses, D., Telling, N., & El Haj, A. (2022). Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells. Frontiers in Medical Technology, 4, Article 981421. https://doi.org/10.3389/fmedt.2022.981421

TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders. TREK1 gating is controlled by a wide range of exter... Read More about Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells..

Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis. (2022)
Journal Article
Mamas, & Rashid. (2022). Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis. https://doi.org/10.1016/j.ijcha.2022.101135

Background: Individuals who present with STEMI without the standard cardiovascular risk factors (SMuRFs) of diabetes, hypercholesterolemia, hypertension, and smoking, coined SMuRF-less are not uncommon. Little is known about their outcomes as a cohor... Read More about Mortality in ST-segment elevation myocardial infarction patients without standard modifiable risk factors: A race disaggregated analysis..

Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding (2022)
Journal Article
(2022). Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding. Nature communications, https://doi.org/10.1038/s41467-021-27871-8

Pseudomonas aeruginosa employs lectins to bind to its host cells, and is known to be the major cause of lung infections. Lectin B (LecB) from Pseudomonas aeruginosa binds specifically to galactose and fucose and is important for pathogenicity, adhesi... Read More about Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding.

Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes (2022)
Journal Article
Coon, K., Hegde, S., & Hughes, G. (2022). Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes. Microbiome, 10, Article 58. https://doi.org/10.1186/s40168-022-01256-5

Background Mosquitoes harbor microbial communities that play important roles in their growth, survival, reproduction, and ability to transmit human pathogens. Microbiome transplantation approaches are often used to study host-microbe interactions and... Read More about Interspecies microbiome transplantation recapitulates microbial acquisition in mosquitoes.

Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial (2022)
Journal Article
Roffe. (2022). Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. BMC Emergency Medicine, https://doi.org/10.1186/s12873-021-00560-x

Background: Prehospital stroke trials will inevitably recruit patients with non-stroke conditions, so called stroke mimics. We undertook a pre-specified analysis to determine outcomes in patients with mimics in the second Rapid Intervention with Glyc... Read More about Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial.

Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes (2022)
Journal Article
Mamas. (2022). Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes. Scientific reports, https://doi.org/10.1038/s41598-022-04929-1

<jats:title>Abstract</jats:title><jats:p>Mitochondrial dysfunction is a feature of type I and type II diabetes, but there is a lack of consistency between reports and links to disease development. We aimed to investigate if mitochondrial structure–fu... Read More about Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes.

Psychological factors associated with reporting side effects following COVID-19 vaccination: a prospective cohort study (CoVAccS – wave 3) (2022)
Journal Article
Smith, L., Sim, J., Sherman, S., Amlot, R., Cutts, M., Dasch, H., Sevdalis, N., & Rubin, G. (2023). Psychological factors associated with reporting side effects following COVID-19 vaccination: a prospective cohort study (CoVAccS – wave 3). Journal of Psychosomatic Research, 164, Article 111104. https://doi.org/10.1016/j.jpsychores.2022.111104

Objective: To investigate symptom reporting following the first and second COVID-19 vaccine doses, attribution of symptoms to the vaccine, and factors associated with symptom reporting.
Methods: Prospective cohort study (T1: 13-15 January 2021, T2:... Read More about Psychological factors associated with reporting side effects following COVID-19 vaccination: a prospective cohort study (CoVAccS – wave 3).

Acceptability and engagement amongst patients on oral and intravenous bisphosphonates for the treatment of osteoporosis in older adults (2022)
Journal Article
Narayanasamy, M., Bishop, S., Sahota, O., Paskins, Z., Gittoes, N., & Langley, T. (2022). Acceptability and engagement amongst patients on oral and intravenous bisphosphonates for the treatment of osteoporosis in older adults. Age and ageing, https://doi.org/10.1093/ageing/afac255

Background: Osteoporosis is common in older adults leading to fragility fractures at enormous individual and economic cost. Improving long-term adherence with bisphosphonate treatments reduces fracture risk, but adherence rates for first line oral bi... Read More about Acceptability and engagement amongst patients on oral and intravenous bisphosphonates for the treatment of osteoporosis in older adults.

Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. (2022)
Journal Article
Wright, F. L., Cheema, K., Goldacre, R., Hall, N., Herz, N., Islam, N., Karim, Z., Moreno-Martos, D., Morales, D. R., O'Connell, D., Spata, E., Akbari, A., Ashworth, M., Barber, M., Briffa, N., Canoy, D., Denaxas, S., Khunti, K., Kurdi, A., Mamas, M., …Banerjee, A. (2023). Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries. European Heart Journal - Quality of Care and Clinical Outcomes, 9(4), 377-388. https://doi.org/10.1093/ehjqcco/qcac077

Background
Although morbidity and mortality from COVID-19 have been widely reported, the indirect effects of the pandemic beyond 2020 on other major diseases and health service activity have not been well described.

Methods and results
Analyses... Read More about Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries..

Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States. (2022)
Journal Article
Rashid, & Mamas. (2022). Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States. Journal of Palliative Care, 8258597221136733 - ?. https://doi.org/10.1177/08258597221136733

Objective: Limited data exist around the receipt of palliative care (PC) in patients hospitalized with common chronic conditions. We studied the independent predictors, temporal trends in rates of PC utilization in patients hospitalized with acute ex... Read More about Palliative Care Utilization Among Hospitalized Patients With Common Chronic Conditions in the United States..

A systematic review of the prediction of consumer preference using EEG measures and machine-learning in neuromarketing research. (2022)
Journal Article
Byrne, A., Bonfiglio, E., Rigby, C., & Edelstyn, N. (2022). A systematic review of the prediction of consumer preference using EEG measures and machine-learning in neuromarketing research. Brain Informatics, 27 - ?. https://doi.org/10.1186/s40708-022-00175-3

INTRODUCTION: The present paper discusses the findings of a systematic review of EEG measures in neuromarketing, identifying which EEG measures are the most robust predictor of customer preference in neuromarketing. The review investigated which TF e... Read More about A systematic review of the prediction of consumer preference using EEG measures and machine-learning in neuromarketing research..

Sensemaking in the early stages of the COVID‐19 pandemic: A narrative exploration of polarised morality in an NHS Trust (2022)
Journal Article
Faux‐Nightingale, A., Kelemen, M., Lilley, S., & Stewart, C. (2023). Sensemaking in the early stages of the COVID‐19 pandemic: A narrative exploration of polarised morality in an NHS Trust. Sociology of Health and Illness, 45(2), 386-404. https://doi.org/10.1111/1467-9566.13586

This article presents an analysis of personal diaries kept by health-care staff within a specialist NHS Trust in England during the initial 3 months of the COVID-19 pandemic. It adopts a moral sensemaking perspective to explore how NHS employees mobi... Read More about Sensemaking in the early stages of the COVID‐19 pandemic: A narrative exploration of polarised morality in an NHS Trust.

Recommendations for improving the working conditions and cultures of distressed junior doctors, based on a qualitative study and stakeholder perspectives. (2022)
Journal Article
Chew-Graham. (2022). Recommendations for improving the working conditions and cultures of distressed junior doctors, based on a qualitative study and stakeholder perspectives. BMC Health Services Research, 1333 - ?. https://doi.org/10.1186/s12913-022-08728-2

Background: Doctors, including junior doctors, are vulnerable to greater levels of distress and mental health difficulties than the public. This is exacerbated by their working conditions and cultures. While this vulnerability has been known for many... Read More about Recommendations for improving the working conditions and cultures of distressed junior doctors, based on a qualitative study and stakeholder perspectives..

Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. (2022)
Journal Article
Dhillon, K., Aizel, K., Broomhall, T., Secret, E., Goodman, T., Rotherham, M., Telling, N., Siaugue, J., Ménager, C., Fresnais, J., Coppey, M., El Haj, A., & Gates, M. (2022). Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients. Journal of the Royal Society. Interface, 19(196), https://doi.org/10.1098/rsif.2022.0576

A challenge in current stem cell therapies for Parkinson's disease (PD) is controlling neuronal outgrowth from the substantia nigra towards the targeted area where connectivity is required in the striatum. Here we present progress towards controlling... Read More about Directional control of neurite outgrowth: emerging technologies for Parkinson's disease using magnetic nanoparticles and magnetic field gradients..