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Technology enhanced assessment: Ottawa consensus statement and recommendations. (2022)
Journal Article
Fuller, R., Goddard, V. C., Nadarajah, V. D., Treasure-Jones, T., Yeates, P., Scott, K., …Pyorala, E. (2022). Technology enhanced assessment: Ottawa consensus statement and recommendations. Medical Teacher, 1 - 15. https://doi.org/10.1080/0142159X.2022.2083489

INTRODUCTION: In 2011, a consensus report was produced on technology-enhanced assessment (TEA), its good practices, and future perspectives. Since then, technological advances have enabled innovative practices and tools that have revolutionised how l... Read More about Technology enhanced assessment: Ottawa consensus statement and recommendations..

Investigating the relationship between diabetes and frozen shoulder: longitudinal analysis of primary care medical records (2022)
Thesis
Dyer, B. P. (2022). Investigating the relationship between diabetes and frozen shoulder: longitudinal analysis of primary care medical records. (Thesis). Keele University

Introduction
Frozen shoulder, a condition that can cause prolonged pain and disability, has previously been found to be common amongst people with diabetes. This thesis aimed to improve the understanding of the nature of the relationship between dia... Read More about Investigating the relationship between diabetes and frozen shoulder: longitudinal analysis of primary care medical records.

Distal Versus Conventional Radial Access for Coronary Angiography and Intervention: The DISCO RADIAL Trial. (2022)
Journal Article
Nolan. (2022). Distal Versus Conventional Radial Access for Coronary Angiography and Intervention: The DISCO RADIAL Trial. JACC: Cardiovascular Interventions, 1191 - 1201. https://doi.org/10.1016/j.jcin.2022.04.032

BACKGROUND: Currently, transradial access (TRA) is the recommended access for coronary procedures because of increased safety, with radial artery occlusion (RAO) being its most frequent complication, which will increasingly affect patients undergoing... Read More about Distal Versus Conventional Radial Access for Coronary Angiography and Intervention: The DISCO RADIAL Trial..

Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021. (2022)
Journal Article
Coates, L. C., Soriano, E. R., Corp, N., Bertheussen, H., Callis Duffin, K., Campanholo, C. B., …Recommendations domain subcommittees, G. T. (2022). Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021. Nature Reviews Rheumatology, 18, 465 - 479. https://doi.org/10.1038/s41584-022-00798-0

Since the second version of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations were published in 2015, therapeutic options for psoriatic arthritis (PsA) have advanced considerably. This work... Read More about Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021..

Baseline and Peak Cortisol Response to the Low-Dose Short Synacthen Test Relates to Indication for Testing, Age, and Sex. (2022)
Journal Article
(2022). Baseline and Peak Cortisol Response to the Low-Dose Short Synacthen Test Relates to Indication for Testing, Age, and Sex. Journal of the Endocrine Society, bvac043 - ?. https://doi.org/10.1210/jendso/bvac043

Context: Meta-analyses report that the low dose short Synacthen test (LDSST) is more sensitive but less specific than the standard dose test for the diagnosis of adrenal insufficiency, and there are concerns regarding the accuracy of dosing in the LD... Read More about Baseline and Peak Cortisol Response to the Low-Dose Short Synacthen Test Relates to Indication for Testing, Age, and Sex..

Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells (2022)
Journal Article
Kitchen, Li, & Reynisson. (2022). Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells. https://doi.org/10.1016/j.prmcm.2022.100074

Inappropriate DNA methylation of tumour suppressor genes can affect their expression and function, and as such, DNA methylation has been a promising target for anti-cancer therapy. In gynaecological malignancy, ovarian cancer has the highest associat... Read More about Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells.

Reflecting on ‘insider’ and ‘outsider’ positionality when undertaking culturally sensitive research with young Pakistani men: insights from a female researcher (2022)
Journal Article
Shivji. (2022). Reflecting on ‘insider’ and ‘outsider’ positionality when undertaking culturally sensitive research with young Pakistani men: insights from a female researcher. Nurse Researcher, 24-29. https://doi.org/10.7748/nr.2022.e1826

Background :
Conducting culturally sensitive research into male experiences can be challenging for female researchers. Despite this, there are very few published reflective accounts of how they have overcome these difficulties.

Aim:
To illustrat... Read More about Reflecting on ‘insider’ and ‘outsider’ positionality when undertaking culturally sensitive research with young Pakistani men: insights from a female researcher.

Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth (2022)
Other
Hilaire, C., Benlefki, S., Younes, R., Challuau, D., Bernard-Marissal, N., Scamps, F., …Raoul, C. (2022). Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth

Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the most common motoneuron diseases affecting adults and infants, respectively. ALS and SMA are both characterized by the selective degeneration of motoneurons. Although differ... Read More about Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth.

Clinical trial management: a profession in crisis? (2022)
Journal Article
Mitchell, E., Goodman, K., Wakefield, N., Cochran, C., Cockayne, S., Connolly, S., …Youssouf, N. (2022). Clinical trial management: a profession in crisis?. Trials, 23(1), Article ARTN 357. https://doi.org/10.1186/s13063-022-06315-8

Clinical trial managers play a vital role in the design and conduct of clinical trials in the UK. There is a current recruitment and retention crisis for this specialist role due to a complex set of factors, most likely to have come to a head due to... Read More about Clinical trial management: a profession in crisis?.

Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis (2022)
Journal Article
Peel, J. K., Miranda, R. N., Naimark, D., Woodward, G., Mamas, M. A., Madan, M., & Wijeysundera, H. C. (2022). Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis. Journal of the American Heart Association, 11(8), Article ARTN e025085. https://doi.org/10.1161/jaha.121.025085

Background Transcatheter aortic valve implantation (TAVI) is a minimally invasive therapy for patients with severe aortic stenosis, which has become standard of care. The objective of this study was to determine the maximum cost-effective investment... Read More about Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis.

Feasibility study of student telehealth interviews (2022)
Journal Article
Zaccariah, Z. R., Irvine, A. W., & Lefroy, J. E. (2022). Feasibility study of student telehealth interviews. Clinical Teacher, 19(4), 308-315. https://doi.org/10.1111/tct.13490

Background
The COVID-19 pandemic has led to medical students being taught remote clinical communication modalities (telephone and video). Junior students have not generally been included in this and have had less patient contact than previously. Thi... Read More about Feasibility study of student telehealth interviews.

Analysis of protein-heparin interactions using a portable SPR instrument (2022)
Journal Article
Su, D., Li, Y., Yates, E., Skidmore, M., Andrade De Lima, M., & Fernig, D. (2022). Analysis of protein-heparin interactions using a portable SPR instrument. PeerJ Analytical Chemistry, 4, 1-16. https://doi.org/10.7717/peerj-achem.15

<jats:p>Optical biosensors such as those based on surface plasmon resonance (SPR) are a key analytical tool for understanding biomolecular interactions and function as well as the quantitative analysis of analytes in a wide variety of settings. The a... Read More about Analysis of protein-heparin interactions using a portable SPR instrument.

A Scoping Review: Mapping the Evidence for Undergraduate Concussion Education and Proposing the Content for Medical Student Concussion Teaching. (2022)
Journal Article
Gardner, N., & Heron, N. (2022). A Scoping Review: Mapping the Evidence for Undergraduate Concussion Education and Proposing the Content for Medical Student Concussion Teaching. International Journal of Environmental Research and Public Health, https://doi.org/10.3390/ijerph19074328

INTRODUCTION: Concussion is a common yet complex condition, with each new case requiring assessment by a medical doctor. Recent research has shown that doctors working in the UK have significant knowledge deficits regarding concussion diagnosis and m... Read More about A Scoping Review: Mapping the Evidence for Undergraduate Concussion Education and Proposing the Content for Medical Student Concussion Teaching..

Intra-sphincteric botulinum toxin in the management of functional biliary pain (2022)
Journal Article
(2022). Intra-sphincteric botulinum toxin in the management of functional biliary pain. Endoscopy International Open, E521 - E527. https://doi.org/10.1055/a-1784-0061

<jats:title>Abstract</jats:title><jats:p> Background and study aims The management of functional biliary-type pain remains a clinical challenge. Intra sphincteric botulinum toxin putatively exerts an anti-spasmodic and anti-nociceptive effect. The ob... Read More about Intra-sphincteric botulinum toxin in the management of functional biliary pain.

Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results (2022)
Journal Article
Bundred, N., Porta, N., Brunt, A. M., Cramer, A., Hanby, A., Shaaban, A. M., …Bliss, J. M. (2022). Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results. Clinical Cancer Research, 28(7), 1323 - 1334. https://doi.org/10.1158/1078-0432.CCR-21-3177

PURPOSE: EPHOS-B aimed to determine whether perioperative anti-HER2 therapy inhibited proliferation and/or increased apoptosis in HER2-positive breast cancer. PATIENTS AND METHODS: This randomized phase II, two-part, multicenter trial included newly... Read More about Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results.

Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica (2022)
Thesis
Twohig, H. J. (2022). Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica. (Thesis). Keele University

Background
Polymyalgia rheumatica (PMR) causes pain, stiffness and disability in older adults. Measuring the impact of the condition from the patient’s perspective is vital to highquality research and patient-centred care, yet there are no validated... Read More about Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica.

Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar (2022)
Journal Article
Hamed, E., Alemrayat, B., Syed, M., Daher-Nashif, S., Rasheed, H., & Kane, T. (2022). Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar. International Journal of Environmental Research and Public Health, 3995 - 3995. https://doi.org/10.3390/ijerph19073995

<jats:p>This cross-sectional study examines knowledge, attitudes, and practices surrounding breast cancer awareness and screening among women residents in Qatar. Females, &gt;18 years old, registered with the Primary Health Care Corporation were invi... Read More about Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar.

Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion (2022)
Journal Article
Wong, A. M., Ding, X., Wong, A. M., Xu, M., Zhang, L., Leung, H. H., …Wong, N. (2022). Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion. Journal of Hepatology, 77(2), 410-423. https://doi.org/10.1016/j.jhep.2022.03.015

Background & Aims
Metabolic syndrome can lead to the clinical manifestation of non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) as part of the natural history of NAFLD. Despite a strong causative link, NAFLD-HCC is often... Read More about Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion.