Reflecting on ‘insider’ and ‘outsider’ positionality when undertaking culturally sensitive research with young Pakistani men: insights from a female researcher (2022)
Journal Article
Shivji. (2022). Reflecting on ‘insider’ and ‘outsider’ positionality when undertaking culturally sensitive research with young Pakistani men: insights from a female researcher. Nurse Researcher, 24-29. https://doi.org/10.7748/nr.2022.e1826

Background :
Conducting culturally sensitive research into male experiences can be challenging for female researchers. Despite this, there are very few published reflective accounts of how they have overcome these difficulties.

Aim:
To illustrat... Read More about Reflecting on ‘insider’ and ‘outsider’ positionality when undertaking culturally sensitive research with young Pakistani men: insights from a female researcher.

Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth (2022)
Other
Hilaire, C., Benlefki, S., Younes, R., Challuau, D., Bernard-Marissal, N., Scamps, F., …Raoul, C. (2022). Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth

Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are the most common motoneuron diseases affecting adults and infants, respectively. ALS and SMA are both characterized by the selective degeneration of motoneurons. Although differ... Read More about Differential effect of Fas activation on spinal muscular atrophy motoneuron death and induction of axonal growth.

Clinical trial management: a profession in crisis? (2022)
Journal Article
Mitchell, E., Goodman, K., Wakefield, N., Cochran, C., Cockayne, S., Connolly, S., …Youssouf, N. (2022). Clinical trial management: a profession in crisis?. Trials, 23(1), Article ARTN 357. https://doi.org/10.1186/s13063-022-06315-8

Clinical trial managers play a vital role in the design and conduct of clinical trials in the UK. There is a current recruitment and retention crisis for this specialist role due to a complex set of factors, most likely to have come to a head due to... Read More about Clinical trial management: a profession in crisis?.

Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis (2022)
Journal Article
Peel, J. K., Miranda, R. N., Naimark, D., Woodward, G., Mamas, M. A., Madan, M., & Wijeysundera, H. C. (2022). Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis. Journal of the American Heart Association, 11(8), Article ARTN e025085. https://doi.org/10.1161/jaha.121.025085

Background Transcatheter aortic valve implantation (TAVI) is a minimally invasive therapy for patients with severe aortic stenosis, which has become standard of care. The objective of this study was to determine the maximum cost-effective investment... Read More about Financial Incentives for Transcatheter Aortic Valve Implantation in Ontario, Canada: A Cost-Utility Analysis.

Feasibility study of student telehealth interviews (2022)
Journal Article
Zaccariah, Z. R., Irvine, A. W., & Lefroy, J. E. (2022). Feasibility study of student telehealth interviews. Clinical Teacher, 19(4), 308-315. https://doi.org/10.1111/tct.13490

Background
The COVID-19 pandemic has led to medical students being taught remote clinical communication modalities (telephone and video). Junior students have not generally been included in this and have had less patient contact than previously. Thi... Read More about Feasibility study of student telehealth interviews.

Analysis of protein-heparin interactions using a portable SPR instrument (2022)
Journal Article
Su, D., Li, Y., Yates, E., Skidmore, M., Andrade De Lima, M., & Fernig, D. (2022). Analysis of protein-heparin interactions using a portable SPR instrument. PeerJ Analytical Chemistry, 4, 1-16. https://doi.org/10.7717/peerj-achem.15

<jats:p>Optical biosensors such as those based on surface plasmon resonance (SPR) are a key analytical tool for understanding biomolecular interactions and function as well as the quantitative analysis of analytes in a wide variety of settings. The a... Read More about Analysis of protein-heparin interactions using a portable SPR instrument.

A Scoping Review: Mapping the Evidence for Undergraduate Concussion Education and Proposing the Content for Medical Student Concussion Teaching. (2022)
Journal Article
Gardner, N., & Heron, N. (2022). A Scoping Review: Mapping the Evidence for Undergraduate Concussion Education and Proposing the Content for Medical Student Concussion Teaching. International Journal of Environmental Research and Public Health, https://doi.org/10.3390/ijerph19074328

INTRODUCTION: Concussion is a common yet complex condition, with each new case requiring assessment by a medical doctor. Recent research has shown that doctors working in the UK have significant knowledge deficits regarding concussion diagnosis and m... Read More about A Scoping Review: Mapping the Evidence for Undergraduate Concussion Education and Proposing the Content for Medical Student Concussion Teaching..

Intra-sphincteric botulinum toxin in the management of functional biliary pain (2022)
Journal Article
(2022). Intra-sphincteric botulinum toxin in the management of functional biliary pain. Endoscopy International Open, E521 - E527. https://doi.org/10.1055/a-1784-0061

<jats:title>Abstract</jats:title><jats:p> Background and study aims The management of functional biliary-type pain remains a clinical challenge. Intra sphincteric botulinum toxin putatively exerts an anti-spasmodic and anti-nociceptive effect. The ob... Read More about Intra-sphincteric botulinum toxin in the management of functional biliary pain.

Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results (2022)
Journal Article
Bundred, N., Porta, N., Brunt, A. M., Cramer, A., Hanby, A., Shaaban, A. M., …Bliss, J. M. (2022). Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results. Clinical Cancer Research, 28(7), 1323 - 1334. https://doi.org/10.1158/1078-0432.CCR-21-3177

PURPOSE: EPHOS-B aimed to determine whether perioperative anti-HER2 therapy inhibited proliferation and/or increased apoptosis in HER2-positive breast cancer. PATIENTS AND METHODS: This randomized phase II, two-part, multicenter trial included newly... Read More about Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results.

Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica (2022)
Thesis
Twohig, H. J. (2022). Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica. (Thesis). Keele University

Background
Polymyalgia rheumatica (PMR) causes pain, stiffness and disability in older adults. Measuring the impact of the condition from the patient’s perspective is vital to highquality research and patient-centred care, yet there are no validated... Read More about Development and psychometric evaluation of a patient reported outcome measure for polymyalgia rheumatica.

Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar (2022)
Journal Article
Hamed, E., Alemrayat, B., Syed, M., Daher-Nashif, S., Rasheed, H., & Kane, T. (2022). Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar. International Journal of Environmental Research and Public Health, 3995 - 3995. https://doi.org/10.3390/ijerph19073995

<jats:p>This cross-sectional study examines knowledge, attitudes, and practices surrounding breast cancer awareness and screening among women residents in Qatar. Females, &gt;18 years old, registered with the Primary Health Care Corporation were invi... Read More about Breast Cancer Knowledge, Attitudes and Practices amongst Women in Qatar.

Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion (2022)
Journal Article
Wong, A. M., Ding, X., Wong, A. M., Xu, M., Zhang, L., Leung, H. H., …Wong, N. (2022). Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion. Journal of Hepatology, 77(2), 410-423. https://doi.org/10.1016/j.jhep.2022.03.015

Background & Aims
Metabolic syndrome can lead to the clinical manifestation of non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) as part of the natural history of NAFLD. Despite a strong causative link, NAFLD-HCC is often... Read More about Unique molecular characteristics of NAFLD-associated liver cancer accentuate ß-catenin/TNFRSF19-mediated immune evasion.

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties..

Behavioural Activation for Social IsoLation (BASIL+) trial (Behavioural activation to mitigate depression and loneliness among older people with long-term conditions): Protocol for a fully-powered pragmatic randomised controlled trial. (2022)
Journal Article
Chew-Graham. (2022). Behavioural Activation for Social IsoLation (BASIL+) trial (Behavioural activation to mitigate depression and loneliness among older people with long-term conditions): Protocol for a fully-powered pragmatic randomised controlled trial. PloS one, e0263856 - ?. https://doi.org/10.1371/journal.pone.0263856

Introduction

Depression is a leading mental health problem worldwide. People with long-term conditions are at increased risk of experiencing depression. The COVID-19 pandemic led to strict social restrictions being imposed across the UK population... Read More about Behavioural Activation for Social IsoLation (BASIL+) trial (Behavioural activation to mitigate depression and loneliness among older people with long-term conditions): Protocol for a fully-powered pragmatic randomised controlled trial..

New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties (2022)
Journal Article
Yang, & Wu. (2022). New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties. Scientific reports, 12, Article 5109. https://doi.org/10.1038/s41598-022-09005-2

Preterm prelabour rupture of membranes is the leading cause of preterm birth and its associated infant mortality and morbidity. However, its underlying mechanism remains unknown. We utilized two novel biomechanical assessment techniques, ball indenta... Read More about New approaches suggest term and preterm human fetal membranes may have distinct biomechanical properties.

Are Corticosteroid Injections Associated With Secondary Adrenal Insufficiency in Adults With Musculoskeletal Pain? A Systematic Review and Meta-analysis of Prospective Studies (2022)
Journal Article
Sim, J., Whelan, G., Smith, B., Moffatt, M., & Littlewood, C. (2022). Are Corticosteroid Injections Associated With Secondary Adrenal Insufficiency in Adults With Musculoskeletal Pain? A Systematic Review and Meta-analysis of Prospective Studies. Clinical Orthopaedics and Related Research, 480(6), 1061-1074. https://doi.org/10.1097/CORR.0000000000002145

Background
Corticosteroid injection is a very common treatment for individuals experiencing musculoskeletal pain, and it is part of the management of numerous orthopaedic conditions. However, there is concern about offering corticosteroid injections... Read More about Are Corticosteroid Injections Associated With Secondary Adrenal Insufficiency in Adults With Musculoskeletal Pain? A Systematic Review and Meta-analysis of Prospective Studies.

Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression (2022)
Journal Article
Mamas. (2022). Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression. American Journal of Cardiology, https://doi.org/10.1016/j.amjcard.2022.01.045

There are limited data on the clinical outcomes of percutaneous coronary intervention (PCI) in patients with acquired immunosuppression who are frequently underrepresented in clinical trials. All PCI procedures between October 2015 and December 2018... Read More about Outcomes of Percutaneous Coronary Intervention in Patients With Acquired Immunosuppression.

Spironolactone effect on the blood pressure of patients at risk of developing heart failure: an analysis from the HOMAGE trial (2022)
Journal Article
Mamas. (2022). Spironolactone effect on the blood pressure of patients at risk of developing heart failure: an analysis from the HOMAGE trial. European Heart Journal - Cardiovascular Pharmacotherapy, 149 - 156. https://doi.org/10.1093/ehjcvp/pvab031

Aims Uncontrolled blood pressure (BP) increases the risk of developing heart failure (HF). The effect of spironolactone on BP of patients at risk of developing HF is yet to be determined. To evaluate the effect of spironolactone on the BP of patients... Read More about Spironolactone effect on the blood pressure of patients at risk of developing heart failure: an analysis from the HOMAGE trial.

A clinical tool to identify older women with back pain at high risk of osteoporotic vertebral fractures (Vfrac): a population-based cohort study with exploratory economic evaluation (2022)
Journal Article
Paskins. (2022). A clinical tool to identify older women with back pain at high risk of osteoporotic vertebral fractures (Vfrac): a population-based cohort study with exploratory economic evaluation. Age and ageing, https://doi.org/10.1093/ageing/afac031

Background: Osteoporotic vertebral fractures (OVFs) identify people at high risk of future fractures, but despite this, less than a third come to clinical attention. The objective of this study was to develop a clinical tool to aid healthcare profess... Read More about A clinical tool to identify older women with back pain at high risk of osteoporotic vertebral fractures (Vfrac): a population-based cohort study with exploratory economic evaluation.

Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency (2022)
Journal Article
Barreto, S., Al-Zubaidi, M., Dale, T., Worrall, A., Kapacee, Z., Kimber, S., …Rutter, A. (2022). Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency. Preprints, https://doi.org/10.20944/preprints202203.0143.v1

<jats:p>Human pluripotent stem cells (hPSCs) have widespread potential biomedical applications. There is a need for large-scale in vitro production of hPSCs, and optimal culture methods are vital in achieving this. Physiological oxygen (2% O2) improv... Read More about Physiological Oxygen Causes the Release of Volatile Organic Compounds from Human Pluripotent Stem Cells with Possible Roles in Maintaining Self-Renewal and Pluripotency.