Is it time for biocatalysis in fragment-based drug discovery? (2020)
Journal Article
Cosgrove. (2020). Is it time for biocatalysis in fragment-based drug discovery?. Chemical Science, 11104 - 11112. https://doi.org/10.1039/D0SC04103C

The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature... Read More about Is it time for biocatalysis in fragment-based drug discovery?.

A single amino acid residue regulates PTEN-binding and stability of the Spinal Muscular Atrophy protein SMN (2020)
Journal Article
Rademacher, S., Detering, N. . T., Schüning, T., Lindner, R., Santonicola, P., Wefel, I., …Claus, P. (2020). A single amino acid residue regulates PTEN-binding and stability of the Spinal Muscular Atrophy protein SMN. Cells, 9(11), Article 2405. https://doi.org/10.3390/cells9112405

Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by decreased levels of the survival of motoneuron (SMN) protein. Post-translational mechanisms for regulation of its stability are still elusive. Thus, we aimed to identify regulatory ph... Read More about A single amino acid residue regulates PTEN-binding and stability of the Spinal Muscular Atrophy protein SMN.

FAST-Forward phase 3 RCT of 1-week hypofractionated breast radiotherapy: 5-year results (2020)
Journal Article
Brunt. (2020). FAST-Forward phase 3 RCT of 1-week hypofractionated breast radiotherapy: 5-year results. Radiotherapy and Oncology, S346 - S347. https://doi.org/10.1016/S0167-8140%2821%2900632-0

Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis. (2020)
Journal Article
Rashid, & Mamas. (2020). Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis. Journal of Cardiovascular Medicine, 897-904. https://doi.org/10.2459/JCM.0000000000001110

BACKGROUND: The management of patients with severe but asymptomatic aortic stenosis is challenging. Evidence on early aortic valve replacement (AVR) versus symptom-driven intervention in these patients is unknown. METHODS: Electronic databases were s... Read More about Early intervention or watchful waiting for asymptomatic severe aortic valve stenosis: a systematic review and meta-analysis..

Prevalence, Characteristics and Clinical Course of Neuropathic Pain in Primary Care Patients Consulting with Low Back-related Leg Pain. (2020)
Journal Article
Dunn. (2020). Prevalence, Characteristics and Clinical Course of Neuropathic Pain in Primary Care Patients Consulting with Low Back-related Leg Pain. Clinical Journal of Pain, https://doi.org/10.1097/AJP.0000000000000879

OBJECTIVES: Little is known about the epidemiology of neuropathic pain in primary care patients consulting with low back-related leg pain. We aimed to describe prevalence, characteristics and clinical course of low back-related leg pain patients with... Read More about Prevalence, Characteristics and Clinical Course of Neuropathic Pain in Primary Care Patients Consulting with Low Back-related Leg Pain..

Scarlett Letter: A study based on experience of stigma by COVID-19 patients in quarantine (2020)
Journal Article
Farooq. (2020). Scarlett Letter: A study based on experience of stigma by COVID-19 patients in quarantine. https://doi.org/10.12669/pjms.36.7.3606

Background and Objectives: Stigma around COVID-19 is a major barrier in global efforts to control the COVID 19 pandemic. Limited data is available regarding stigma faced by COVID-19 patients in low- and middle-income countries (LMIC).... Read More about Scarlett Letter: A study based on experience of stigma by COVID-19 patients in quarantine.

Safety and Efficacy of Coronary Intravascular Lithotripsy for Calcified Coronary Arteries – A Systematic Review and Meta-Analysis (2020)
Journal Article
Mamas. (2020). Safety and Efficacy of Coronary Intravascular Lithotripsy for Calcified Coronary Arteries – A Systematic Review and Meta-Analysis. Expert Review of Cardiovascular Therapy, https://doi.org/10.1080/14779072.2021.1845143

Objectives: Intravascular lithotripsy (IVL) clinical efficacy and safety in the treatment of calcified coronary artery disease (CAC) is not well known. We sought to assess IVL safety and efficacy in CAC.

Methods: A comprehensive online databases s... Read More about Safety and Efficacy of Coronary Intravascular Lithotripsy for Calcified Coronary Arteries – A Systematic Review and Meta-Analysis.

Feasibility study for supporting medication adherence for adults with cystic fibrosis: mixed-methods process evaluation. (2020)
Journal Article
Hind, D., Drabble, S., Arden, M., Mandefield, L., Waterhouse, S., Maguire, C., …O'Cathain, A. (2020). Feasibility study for supporting medication adherence for adults with cystic fibrosis: mixed-methods process evaluation. BMJ Open, e039089 - ?. https://doi.org/10.1136/bmjopen-2020-039089

OBJECTIVES: To undertake a process evaluation of an adherence support intervention for people with cystic fibrosis (PWCF), to assess its feasibility and acceptability. SETTING: Two UK cystic fibrosis (CF) units. PARTICIPANTS: Fourteen adult PWCF; thr... Read More about Feasibility study for supporting medication adherence for adults with cystic fibrosis: mixed-methods process evaluation..

Clinical prediction models to predict the risk of multiple binary outcomes: a comparison of approaches. (2020)
Journal Article
(2020). Clinical prediction models to predict the risk of multiple binary outcomes: a comparison of approaches. Statistics in Medicine, https://doi.org/10.1002/sim.8787

Clinical prediction models (CPMs) can predict clinically relevant outcomes or events. Typically, prognostic CPMs are derived to predict the risk of a single future outcome. However, there are many medical applications where two or more outcomes are o... Read More about Clinical prediction models to predict the risk of multiple binary outcomes: a comparison of approaches..

Measures of Foot Pain, Foot Function, and General Foot Health. (2020)
Journal Article
Roddy. (2020). Measures of Foot Pain, Foot Function, and General Foot Health. Arthritis Care and Research, 294 - 320. https://doi.org/10.1002/acr.24208

'No abstract'

Self-Report Measures of Physical Activity (2020)
Journal Article
Healey, E. L., Allen, K. D., Bennell, K., Bowden, J. L., Quicke, J. G., & Smith, R. (2020). Self-Report Measures of Physical Activity. Arthritis Care & Research, 72(S10), 717 - 730. https://doi.org/10.1002/acr.24211

'No abstract'

The Added Value of Radiographs in Diagnosing Knee Osteoarthritis Is Similar for General Practitioners and Secondary Care Physicians; Data from the CHECK Early Osteoarthritis Cohort. (2020)
Journal Article
(2020). The Added Value of Radiographs in Diagnosing Knee Osteoarthritis Is Similar for General Practitioners and Secondary Care Physicians; Data from the CHECK Early Osteoarthritis Cohort. Journal of Clinical Medicine, https://doi.org/10.3390/jcm9103374

OBJECTIVE: The purpose of this study was to evaluate the added value of radiographs for diagnosing knee osteoarthritis (KOA) by general practitioners (GPs) and secondary care physicians (SPs). METHODS: Seventeen GPs and nineteen SPs were recruited to... Read More about The Added Value of Radiographs in Diagnosing Knee Osteoarthritis Is Similar for General Practitioners and Secondary Care Physicians; Data from the CHECK Early Osteoarthritis Cohort..

Trial characteristics associated with the underrepresentation of women as lead authors in heart failure clinical trials (2020)
Journal Article
Mamas. (2020). Trial characteristics associated with the underrepresentation of women as lead authors in heart failure clinical trials. Journal of the American College of Cardiology, 1919-1930. https://doi.org/10.1016/j.jacc.2020.08.062

Background
Clinical trials change practice in cardiology, and leading them requires research training, mentorship, sponsorship, and networking. Women report challenges in obtaining these opportunities.

Objectives
The purpose of this review was t... Read More about Trial characteristics associated with the underrepresentation of women as lead authors in heart failure clinical trials.

Modelling the impact of the mandatory use of face coverings on public transport and in retail outlets in the UK on COVID-19-related infections, hospital admissions and mortality (2020)
Journal Article
Heald, A. H., Stedman, M., Tian, Z., Wu, P., & Fryer, A. A. (2021). Modelling the impact of the mandatory use of face coverings on public transport and in retail outlets in the UK on COVID-19-related infections, hospital admissions and mortality. International Journal of Clinical Practice, https://doi.org/10.1111/ijcp.13768

Introduction
The rapid spread of the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV26 2/)(COVID-19) virus resulted in governments around the world instigating a range of measures, including mandating the wearing of... Read More about Modelling the impact of the mandatory use of face coverings on public transport and in retail outlets in the UK on COVID-19-related infections, hospital admissions and mortality.

Evidence-based treatment recommendations for neck and low back pain across Europe: A systematic review of guidelines. (2020)
Journal Article
Corp, N., Mansell, G., Stynes, S., Wynne-Jones, G., Morsø, L., Hill, J., & Van Der Windt, D. (2021). Evidence-based treatment recommendations for neck and low back pain across Europe: A systematic review of guidelines. European Journal of Pain, 25(2), https://doi.org/10.1002/ejp.1679

Background and objective: This systematic review synthesised evidence from European neck and low back pain (NLBP) clinical practice guidelines (CPGs) to identify recommended treatment options for use across Europe. Databases and Data Treatment: Compr... Read More about Evidence-based treatment recommendations for neck and low back pain across Europe: A systematic review of guidelines..

Responders to Exercise Therapy in Patients with Osteoarthritis of the Hip: A Systematic Review and Meta-Analysis. (2020)
Journal Article
(2020). Responders to Exercise Therapy in Patients with Osteoarthritis of the Hip: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health, https://doi.org/10.3390/ijerph17207380

The Outcome Measures in Rheumatology workgroup (OMERACT), together with the Osteoarthritis Research Society International (OARSI) developed the OMERACT-OARSI responder criteria. These criteria are used to determine if a patient with osteoarthritis (O... Read More about Responders to Exercise Therapy in Patients with Osteoarthritis of the Hip: A Systematic Review and Meta-Analysis..

Physiotherapists may improve management of knee osteoarthritis through greater psychosocial focus, being proactive with advice, and offering longer-term reviews: a qualitative study. (2020)
Journal Article
Dziedzic. (2020). Physiotherapists may improve management of knee osteoarthritis through greater psychosocial focus, being proactive with advice, and offering longer-term reviews: a qualitative study. Journal of Physiotherapy, https://doi.org/10.1016/j.jphys.2020.09.005

QUESTIONS: What are the experiences of physiotherapists delivering care for people with knee osteoarthritis? How do these experiences align with the national Clinical Care Standard? DESIGN: A qualitative study using individual interviews. PARTICIPANT... Read More about Physiotherapists may improve management of knee osteoarthritis through greater psychosocial focus, being proactive with advice, and offering longer-term reviews: a qualitative study..

Mechanisms of Action of a Web-Based Intervention With Health Professional Support to Increase Adherence to Nebulizer Treatments in Adults With Cystic Fibrosis: Qualitative Interview Study. (2020)
Journal Article
Drabble, S., O'Cathain, A., Arden, M., Keating, S., Hutchings, M., Maguire, C., …Scott, A. (2020). Mechanisms of Action of a Web-Based Intervention With Health Professional Support to Increase Adherence to Nebulizer Treatments in Adults With Cystic Fibrosis: Qualitative Interview Study. Journal of Medical Internet Research, e16782 - ?. https://doi.org/10.2196/16782

BACKGROUND: Adherence to nebulizer treatments in adults with cystic fibrosis (CF) is often low. A new complex intervention to help adults with CF increase their adherence to nebulizer treatments was tested in a pilot randomized controlled trial (RCT)... Read More about Mechanisms of Action of a Web-Based Intervention With Health Professional Support to Increase Adherence to Nebulizer Treatments in Adults With Cystic Fibrosis: Qualitative Interview Study..

Perspectives on public involvement in health research from Singapore: The potential of a supported group model of involvement. (2020)
Journal Article
(2020). Perspectives on public involvement in health research from Singapore: The potential of a supported group model of involvement. Health Expectations, 1074 - 1085. https://doi.org/10.1111/hex.13058

BACKGROUND: Singapore is an international research hub, with an emphasis on translational clinical research. Despite growing evidence of the positive impact of public involvement (PPI) in research, it remains rare in Singapore. AIMS: To investigate S... Read More about Perspectives on public involvement in health research from Singapore: The potential of a supported group model of involvement..

Identification of Patterns of Foot and Ankle Pain in the Community: Cross-sectional Findings from the Clinical Assessment Study of the Foot (2020)
Journal Article
Chean, C. S., Lingham, A., Rathod-Mistry, T., Thomas, M. J., Marshall, M., Menz, H. B., & Roddy, E. (2021). Identification of Patterns of Foot and Ankle Pain in the Community: Cross-sectional Findings from the Clinical Assessment Study of the Foot. Musculoskeletal Care, 19(1), https://doi.org/10.1002/msc.1502

Objectives: To investigate patterns of foot and ankle pain locations and symptoms, socio-demographic and comorbid characteristics to examine whether there are distinct foot and ankle pain phenotypes. Methods: Adults aged =50 years registered with fou... Read More about Identification of Patterns of Foot and Ankle Pain in the Community: Cross-sectional Findings from the Clinical Assessment Study of the Foot.