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Interventions for people with perceptual disorders after stroke: the PIONEER scoping review, Cochrane systematic review and priority setting project (2024)
Journal Article
Hazelton, C., Todhunter-Brown, A., Campbell, P., Thomson, K., Nicolson, D. J., McGill, K., SY Chung, C., Dorris, L., Gillespie, D. C., Hunter, S. M., Williams, L. J., & Brady, M. C. (2024). Interventions for people with perceptual disorders after stroke: the PIONEER scoping review, Cochrane systematic review and priority setting project. Health Technology Assessment, 28(69), 1-141. https://doi.org/10.3310/WGJT3471

Stroke often affects recognition and interpretation of information from our senses, resulting in perceptual disorders. Evidence to inform treatment is unclear. To determine the breadth and effectiveness of interventions for stroke-related perceptual... Read More about Interventions for people with perceptual disorders after stroke: the PIONEER scoping review, Cochrane systematic review and priority setting project.

TCT-59 Optimal Versus Sub-Optimal Intravascular Imaging-guided Percutaneous Coronary Intervention: A Meta-Analysis (2024)
Presentation / Conference Contribution
Hamed, M., Elseidy, S., Ahmed, A., Gabr, E., Kahan, J., & Mamas, M. TCT-59 Optimal Versus Sub-Optimal Intravascular Imaging-guided Percutaneous Coronary Intervention: A Meta-Analysis. Presented at Thirty-Sixth Annual Symposium Transcatheter Cardiovascular Therapeutics (TCT)–Abstracts, Walter E. Washington Convention Center, Washington, DC, USA

Background
Intravascular imaging–guided percutaneous coronary intervention (PCI) has shown promising results. Our study aimed to compare the outcomes of optimal vs suboptimal intravascular imaging–guided PCI.

Ischemic and bleeding risk after ST-segment elevated myocardial infarction in patients with active cancer (2024)
Presentation / Conference Contribution
Dafaalla, M., Costa, F., Jia, H., Wijeysundera, H., Rashid, M., Graham, M., Wojakowski, W., Chieffo, A., Mintz, G., & Mamas, M. Ischemic and bleeding risk after ST-segment elevated myocardial infarction in patients with active cancer. Presented at ESC Congress 2024 30 August – 02 September London, UK Abstract Supplement

Background Treatment of patients with cancer presenting with ST-elevation myocardial infarction (STEMI) is complex given the increased risk of both thrombotic and major bleeding complications. We evaluated the risk of major bleeding and re-infarction... Read More about Ischemic and bleeding risk after ST-segment elevated myocardial infarction in patients with active cancer.

Sex sifferences in lifes essential eight and its association with mortality among adults without known CVD (2024)
Presentation / Conference Contribution
Kobo, O., Kaur, G., Gulati, M., & Mamas, M. Sex sifferences in lifes essential eight and its association with mortality among adults without known CVD. Presented at ESC Congress 2024 30 August – 02 September London, UK Abstract Supplement

Background The American Heart Association’s Life’s Essential 8 (LE8) score is a helpful tool to quantify cardiovascular health (CVH) metrics. Sex differences in relation to LE8 and its association with mortality are not known. Methods The National He... Read More about Sex sifferences in lifes essential eight and its association with mortality among adults without known CVD.

Family-based sexual health intervention for adolescents; A systematic review and meta-analysis (2024)
Presentation / Conference Contribution
Mataraarachchi, D., Shepherd, T., Ariyadasa, G., Bajpai, R., Corp, N., & Paudyal, P. Family-based sexual health intervention for adolescents; A systematic review and meta-analysis. Presented at 17th European Public Health Conference 2024 Sailing the Waves of European Public Health: Exploring a Sea of Innovation Lisbon, Portugal 12–15 November 2024

Background Family-based interventions are important in promoting adolescent sexual health outcomes. However, the effectiveness of these interventions in promoting adolescent sexual and reproductive health (ASRH) in Lower and middle-income countries (... Read More about Family-based sexual health intervention for adolescents; A systematic review and meta-analysis.

Sex differences in secondary prevention and outcomes post-myocardial infarction in Scotland (2024)
Presentation / Conference Contribution
Pana, T., Mamas, M. A., Myint, P. K., & Dawson, D. Sex differences in secondary prevention and outcomes post-myocardial infarction in Scotland. Presented at ESC Congress 2024 30 August – 02 September London, UK Abstract Supplement

Background Sex differences in outcomes after myocardial infarction (MI) are of increasing interest. Differential receipt of evidence-based treatments may contribute to such disparities. Purpose In this study, we investigate sex differences in the bur... Read More about Sex differences in secondary prevention and outcomes post-myocardial infarction in Scotland.

Ethnic disparity in the care and management of non-ST-segment elevation myocardial infarction and its impact on short-term and long-term survival: a long-term study of a national registry (2024)
Presentation / Conference Contribution
Yera, H., Weight, N., Moledina, S. M., & Mamas, M. A. Ethnic disparity in the care and management of non-ST-segment elevation myocardial infarction and its impact on short-term and long-term survival: a long-term study of a national registry. Presented at ESC Congress 2024 30 August – 02 September London, UK Abstract Supplement

Background Previous examination of data from the United Kingdom indicates no apparent ethnic disparity in the treatment of patients hospitalised with non-ST-segment elevation myocardial infarction (NSTEMI). However, it remains uncertain whether this... Read More about Ethnic disparity in the care and management of non-ST-segment elevation myocardial infarction and its impact on short-term and long-term survival: a long-term study of a national registry.

Association of lifes essential 8 and mortality among adults with and without CVD (2024)
Presentation / Conference Contribution
Kobo, O., Kaur, G., Gulati, M., & Mamas, M. Association of lifes essential 8 and mortality among adults with and without CVD. Presented at ESC Congress 2024 30 August – 02 September London, UK Abstract Supplement

Background Differences in the American Heart Association’s Life’s Essential 8 (LE8) score and its association with mortality based on the presence of clinically prevalent cardiovascular disease (CVD) has not been assessed previously. Methods Data fro... Read More about Association of lifes essential 8 and mortality among adults with and without CVD.

Trends and Disparities in Coronary Artery Disease and Obesity‐Related Mortality in the United States From 1999–2022 (2024)
Journal Article
Ahmed, M., Javaid, H., Shafiq, A., Nadeem, Z., Ahsan, A., Nofal, A., Ahmed, R., Alam, M., Fudim, M., Fonarow, G., & Mamas, M. (2024). Trends and Disparities in Coronary Artery Disease and Obesity‐Related Mortality in the United States From 1999–2022. Endocrinology Diabetes & Metabolism, 7(6), 1-7. https://doi.org/10.1002/edm2.70010

Background: Almost half of the US adult population has obesity, which predisposes to atherosclerosis and can lead to poor prognosis in coronary artery disease (CAD). We aim to identify CAD and obesity‐related mortality trends among adults in the Unit... Read More about Trends and Disparities in Coronary Artery Disease and Obesity‐Related Mortality in the United States From 1999–2022.

TCT-5 Safety and Efficacy of Postprocedural Anticoagulation After Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction: A Meta-Analysis of RCTs (2024)
Presentation / Conference Contribution
Elseidy, S., Vorla, M., Hamed, M., Rehan, M., Mohamad, T., Castiello, T., & Mamas, M. TCT-5 Safety and Efficacy of Postprocedural Anticoagulation After Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction: A Meta-Analysis of RCTs. Presented at Thirty-Sixth Annual Symposium Transcatheter Cardiovascular Therapeutics (TCT)–Abstracts, Walter E. Washington Convention Center, Washington, DC, USA

This study provides the first meta-analysis of randomized controlled trials (RCTs) to assess the safety and efficacy of postprocedural anticoagulation in STEMI patients.

TCT-931 Outcomes of Self-Expanding vs Balloon-Expandable Transcatheter Aortic Valves in Patients With Small Aortic Annuli: A Meta-analysis (2024)
Presentation / Conference Contribution
Elseidy, S., Vorla, M., Hamed, M., Rehan, M., Isaac, J., Mohamad, T., Castiello, T., & Mamas, M. TCT-931 Outcomes of Self-Expanding vs Balloon-Expandable Transcatheter Aortic Valves in Patients With Small Aortic Annuli: A Meta-analysis. Presented at Thirty-Sixth Annual Symposium Transcatheter Cardiovascular Therapeutics (TCT)–Abstracts, Walter E. Washington Convention Center, Washington, DC, USA

Background
Despite the benefits of TAVR, there is a lack of head-to-head comparison between different types of transcatheter aortic valves in patients with small aortic annulus essential to guide clinical decisions and improve patient outcomes in th... Read More about TCT-931 Outcomes of Self-Expanding vs Balloon-Expandable Transcatheter Aortic Valves in Patients With Small Aortic Annuli: A Meta-analysis.

Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-2: Specific Entities, Risk Stratification and Challenges After Recovery). (2024)
Journal Article
Yalta, K., Madias, J. E., Kounis, N. G., Y-Hassan, S., Polovina, M., Altay, S., Mebazaa, A., Yilmaz, M. B., Lopatin, Y., Mamas, M. A., Gil, R. J., Thamman, R., Almaghraby, A., Bozkurt, B., Bajraktari, G., Fink, T., Traykov, V., Manzo-Silberman, S., Mirzoyev, U., Sokolovic, S., …Seferovic, P. M. (in press). Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-2: Specific Entities, Risk Stratification and Challenges After Recovery). Balkan Medical Journal, 41(6), 442-457. https://doi.org/10.4274/balkanmedj.galenos.2024.2024-9-99

Takotsubo syndrome (TTS) still remains as an enigmatic phenomenon. In particular, long-term challenges (including clinical recurrence and persistent symptoms) and specific entities in the setting of TTS have been the evolving areas of interest. On th... Read More about Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-2: Specific Entities, Risk Stratification and Challenges After Recovery)..

Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial. (2024)
Journal Article
Worthington, J., Soundy, A., Frost, J., Rooshenas, L., MacNeill, S. J., Realpe Rojas, A., Garfield, K., Liu, Y., Alloway, K., Ben-Shlomo, Y., Burns, A., Chilcot, J., Darling, J., Davies, S., Farrington, K., Gibson, A., Husbands, S., Huxtable, R., McNally, H., Murphy, E., …Caskey, F. J. (2024). Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial. Trials, 25(1), 1-19. https://doi.org/10.1186/s13063-024-08509-8

Background: Chronic kidney disease (CKD) prevalence is steadily increasing, in part due to increased multimorbidity in our aging global population. When progression to kidney failure cannot be avoided, people need unbiased information to inform decis... Read More about Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): Study protocol for a randomised controlled trial..

Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-1: Diagnostic and Therapeutic Challenges). (2024)
Journal Article
Yalta, K., Madias, J. E., Kounis, N. G., Y-Hassan, S., Polovina, M., Altay, S., Mebazaa, A., Yilmaz, M. B., Lopatin, Y., Mamas, M. A., Gil, R. J., Thamman, R., Almaghraby, A., Bozkurt, B., Bajraktari, G., Fink, T., Traykov, V., Manzo-Silberman, S., Mirzoyev, U., Sokolovic, S., …Seferovic, P. M. (in press). Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-1: Diagnostic and Therapeutic Challenges). Balkan Medical Journal, 41(6), 421-441. https://doi.org/10.4274/balkanmedj.galenos.2024.2024-9-98

In the recent years, there has been a burgeoning interest in Takotsubo syndrome (TTS), which is renowned as a specific form of reversible myocardial dysfunction. Despite the extensive literature available on TTS, clinicians still face several practic... Read More about Takotsubo Syndrome: An International Expert Consensus Report on Practical Challenges and Specific Conditions (Part-1: Diagnostic and Therapeutic Challenges)..

Pre‐hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT ‐2 trial (2024)
Journal Article
Appleton, J. P., Dixon, M., Woodhouse, L. J., Anderson, C. S., Ankolekar, S., Cala, L., England, T. J., Godolphin, P. J., Krishnan, K., Mair, G., Muir, K. W., Potter, J., Price, C. I., Randall, M., Robinson, T. G., Roffe, C., Rothwell, P. M., Sandset, E. C., Saver, J. L., Siriwardena, A. N., …Bath, P. M. (in press). Pre‐hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT ‐2 trial. European Journal of Neurology, 31(11), 1-7. https://doi.org/10.1111/ene.16502

Background and purpose: Ambulance trials assessing interventions in suspected stroke patients will recruit patients with currently active symptoms that will resolve into transient ischaemic attack (TIA). The safety and efficacy of glyceryl trinitrate... Read More about Pre‐hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT ‐2 trial.

Flavonoids, gut microbiota and cardiovascular disease: Dynamics and interplay (2024)
Journal Article
Mansour, H., Slika, H., Nasser, S. A., Pintus, G., Khachab, M., Sahebkar, A., & Eid, A. H. (in press). Flavonoids, gut microbiota and cardiovascular disease: Dynamics and interplay. Pharmacological Research, 209(November 2024), 1-13. https://doi.org/10.1016/j.phrs.2024.107452

Cardiovascular disease (CVD) remains the leading cause of global morbidity and mortality. Extensive efforts have been invested to explicate mechanisms implicated in the onset and progression of CVD. Besides the usual suspects as risk factors (obesity... Read More about Flavonoids, gut microbiota and cardiovascular disease: Dynamics and interplay.

Ischemic Heart Disease in the Cancer Population: Trends, Outcomes, Epidemiology, and Challenges in Diagnosis and Treatment. (2024)
Journal Article
Condurache, D.-G., Raisi-Estabragh, Z., Ghosh, A. K., & Mamas, M. A. (in press). Ischemic Heart Disease in the Cancer Population: Trends, Outcomes, Epidemiology, and Challenges in Diagnosis and Treatment. Cardiology Clinics, 43(1), 57-67. https://doi.org/10.1016/j.ccl.2024.08.001

Patients with cancer are at increased risk of ischemic heart disease (IHD). The increased risk of IHD in these patients is due to the interaction of shared risk factors, cancer type and stage, and immuno/chemotherapy and radiotherapy regimens. Manage... Read More about Ischemic Heart Disease in the Cancer Population: Trends, Outcomes, Epidemiology, and Challenges in Diagnosis and Treatment..

Optimising inhaled therapy for patients with asthma. (2024)
Journal Article
Bansal, A., Franklin, L., & Twohig, H. (in press). Optimising inhaled therapy for patients with asthma. BMJ, 386, 1-6. https://doi.org/10.1136/bmj-2024-080353

What you need to know
Sub-optimally controlled asthma is common, in part because of normalisation of symptoms, underuse of preventer therapy, overuse of reliever therapy, and poor inhaler technique. Ensuring patients are using the right inhaled medi... Read More about Optimising inhaled therapy for patients with asthma..

Optical attenuation coefficient-based automatic segmentation of limbal epithelium and age-related differences (2024)
Presentation / Conference Contribution
Zhang, Y., Dimmock, R., Yang, Y., & Huang, Z. (2024, September). Optical attenuation coefficient-based automatic segmentation of limbal epithelium and age-related differences. Presented at 2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium (UFFC-JS), Taipei, Taiwan

The limbus, located at the cornea-conjunctiva junction, houses limbal epithelial stem cells that maintain the corneal epithelium and respond to tissue damage. The limbal epithelial thickness is an indicator of corneal structural or functional alterat... Read More about Optical attenuation coefficient-based automatic segmentation of limbal epithelium and age-related differences.