Silicon in health: A beneficial element in reducing the body burden of aluminium (2018)
Thesis
Jones, K. L. Silicon in health: A beneficial element in reducing the body burden of aluminium. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411347

The essentiality of silicon and the toxicity of aluminium within humans are both topics of much debate; the current conception is that silicon is essential in ameliorating aluminium toxicity, however, the evidence for this remains inconclusive.

T... Read More about Silicon in health: A beneficial element in reducing the body burden of aluminium.

Risk factors for the onset of musculoskeletal pain in children and adolescents (2018)
Thesis
Andreucci, A. Risk factors for the onset of musculoskeletal pain in children and adolescents. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411391

Background

Musculoskeletal pain is a major burden on society. Research in adults has identified risk factors associated with musculoskeletal pain onset, however at present evidence for risk factors in children and adolescents is limited.

Aims... Read More about Risk factors for the onset of musculoskeletal pain in children and adolescents.

Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation (2018)
Thesis
Ali, I. F. Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411432

The emergence and spread of resistance to antimalarial drugs has highlighted the demand to search for new drugs that target novel pathways in the human malaria parasite Plasmodium falciparum. This thesis explores the potential for targeting of the Pf... Read More about Cell death in the human malaria parasite: exploring autophagy as a drug target and early cellular events following drug perturbation.

Primary care decision-making for shoulder pain: identifying treatment effect moderators using clinical expertise (2018)
Thesis
McRobert, C. Primary care decision-making for shoulder pain: identifying treatment effect moderators using clinical expertise. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411441

Background
Shoulder pain is a common, costly condition with variable prognosis. Commonly used treatments for shoulder pain in primary care include: (i) advice & analgesia, (ii) exercise and/or manual therapy, and (iii) corticosteroid injection. Curr... Read More about Primary care decision-making for shoulder pain: identifying treatment effect moderators using clinical expertise.

Action research: towards excellence in teaching, assessment and feedback for clinical consultation skills (2018)
Thesis
Lefroy, J. Action research: towards excellence in teaching, assessment and feedback for clinical consultation skills. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411453

Background
Consultation skills are the core competencies required at graduation of the doctor as a practitioner. Every medical school has its own system of teaching and assessing consultation skills. These are generally amalgams of previous curricu... Read More about Action research: towards excellence in teaching, assessment and feedback for clinical consultation skills.

The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management (2018)
Thesis
Lindsay, C. The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411458

Introduction
Patients surviving a severe stroke are at risk of developing contractures. Evidence suggests that spasticity may be a cause of contractures, particularly in patients who have not recovered functional movement. The relationship and the t... Read More about The early use of botulinum toxin in post stroke spasticity: developing a new approach to contracture management.

Multisite pain and falls in older people (2018)
Thesis
Welsh, V. K. Multisite pain and falls in older people. (Thesis). Keele University. https://keele-repository.worktribe.com/output/410388

Falls are a common occurrence in older people and multisite pain has been identified as a potential falls risk factor in this age group. This thesis aims to describe the relationship between multisite pain and falls in community-dwelling older people... Read More about Multisite pain and falls in older people.

Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression (2018)
Thesis
Merkhan, M. M. Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression. (Thesis). Keele University. https://keele-repository.worktribe.com/output/410396

Human mesenchymal stem cells (hMSCs) have multiple potential roles in regenerative medicine. These roles revolve around the exploitation of their multipotent differentiation potential, their immunogenic privilege, or the broad range of molecules they... Read More about Defining a role for the mesenchymal stem cell secretome in inflammatory response suppression.

Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy (2018)
Thesis
Abo Donia, M. N. A. Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy. (Thesis). Keele University. https://keele-repository.worktribe.com/output/410399

Ovarian cancer is a complex disease characterized by low incidence, accounting for about 4% of cancer diagnoses in women, but with rapid progression and higher mortality rate than any other gynecological malignancy. Approximately 70 % of the cases ar... Read More about Evaluation of drug combinations to sensitize ovarian cancer cells to chemotherapy.

The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair (2018)
Thesis
Bhattacharjee, A. The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair. (Thesis). Keele University. https://keele-repository.worktribe.com/output/410400

Aims
To evaluate the in vitro potential of umbilical cord(UC)-derived cells as an allogeneic cell source that could be used ‘off-the-shelf’ in orthopaedics for bone and cartilage regeneration. The study also assesses the in-vivo efficacy of cell the... Read More about The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair.

Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology (2018)
Thesis
Ahmed, M. A. Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology. (Thesis). Keele University. https://keele-repository.worktribe.com/output/410299

Oxygen is an important molecule in life and is essential for a broad spectrum of physiological reactions that include, but are not restricted to, cell metabolism, respiration and growth. Under physiological conditions, oxygen levels vary from one tis... Read More about Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology.

Development of a clinical care pathway for anaemic patients (2018)
Thesis
Ballal, M. Development of a clinical care pathway for anaemic patients. (Thesis). Keele University. https://keele-repository.worktribe.com/output/418240

Improving cancer survival in the UK is one of the leading items on the agenda of the government. Survival from gastrointestinal cancer is yet to come into line with Europe. In 2000 the department of health (DoH) introduced guidelines for referral of... Read More about Development of a clinical care pathway for anaemic patients.

The unequivocal identification and visualisation of aluminium in human brain tissues using novel techniques. (2017)
Thesis
Mirza, A. The unequivocal identification and visualisation of aluminium in human brain tissues using novel techniques. (Thesis). Keele University. https://keele-repository.worktribe.com/output/409155

The aim of this thesis was to optimise a method for the unequivocal identification of aluminium (Al) in human brain tissue. The second aim was to devise a protocol that was simple to implement and as such could be carried out without the need for sop... Read More about The unequivocal identification and visualisation of aluminium in human brain tissues using novel techniques..

GPs' attitudes, beliefs and behaviours regarding exercise for chronic knee pain: a questionnaire survey (2017)
Journal Article
Roddy, E., Cottrell, E., Foster, N. E., Porcheret, M., & Rathod, T. (2017). GPs' attitudes, beliefs and behaviours regarding exercise for chronic knee pain: a questionnaire survey. BMJ Open, 7(6), e014999 - ?. https://doi.org/10.1136/bmjopen-2016-014999

OBJECTIVES:
The aim of this study was to investigate general practitioners' (GPs) attitudes, beliefs and behaviours regarding the use of exercise for patients with chronic knee pain (CKP) attributable to osteoarthritis.

SETTING: Primary care GPs... Read More about GPs' attitudes, beliefs and behaviours regarding exercise for chronic knee pain: a questionnaire survey.

Interventions to increase adherence to therapeutic exercise in older adults with low back pain and/or hip/knee osteoarthritis: a systematic review and meta-analysis (2017)
Journal Article
Nicolson, P. J. A., Bennell, K. L., Dobson, F. L., Van Ginckel, A., Holden, M. A., & Hinman, R. S. (2017). Interventions to increase adherence to therapeutic exercise in older adults with low back pain and/or hip/knee osteoarthritis: a systematic review and meta-analysis. British Journal of Sports Medicine, 51(10), 791-799. https://doi.org/10.1136/bjsports-2016-096458

Objective To evaluate whether interventions aimed at increasing adherence to therapeutic exercise increase adherence greater than a contextually equivalent control among older adults with chronic low back pain and/or hip/knee osteoarthritis.

Desig... Read More about Interventions to increase adherence to therapeutic exercise in older adults with low back pain and/or hip/knee osteoarthritis: a systematic review and meta-analysis.

Epigenomic changes associated with high-grade non-muscle invasive bladder cancer (2016)
Thesis
Kitchen, M. O. Epigenomic changes associated with high-grade non-muscle invasive bladder cancer. (Thesis). Keele University. https://keele-repository.worktribe.com/output/409152

The development and progression of high-grade non-muscle invasive bladder cancer (NMIBC) results from a complex interplay of environmental and heritable risk factors, including those that impact upon genetic and epigenetic pathways. Recent studies ha... Read More about Epigenomic changes associated with high-grade non-muscle invasive bladder cancer.

Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes
Thesis
Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes. https://keele-repository.worktribe.com/output/423982

Pathological conditions of cartilage resulting from acute injury are a major cause of morbidity. Surgical intervention, in most cases, does not repair cartilage to its native mechanical resilience. The potential benefits of non-invasive approaches fo... Read More about Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes.

Optimising canine olfactory ensheathing cell therapy using tissue engineering tools
Thesis
Delaney, A. M. Optimising canine olfactory ensheathing cell therapy using tissue engineering tools. https://keele-repository.worktribe.com/output/423884

The adult mammalian spinal cord is incapable of significant regeneration following injury. As such, spinal injury is a lifelong debilitating condition which represents a significant burden on healthcare globally. Olfactory ensheathing cells (OECs) ha... Read More about Optimising canine olfactory ensheathing cell therapy using tissue engineering tools.

HIV positive refugees/asylum seekers and clinical trials: some ethical issues
Thesis
HIV positive refugees/asylum seekers and clinical trials: some ethical issues. https://keele-repository.worktribe.com/output/403803

The aim of this thesis was to identify some of the ethical issues of HIV positive asylum seekers and refugees participating in clinical trials in Britain. While all individuals are to some degree vulnerable in clinical trials, I have shown in this th... Read More about HIV positive refugees/asylum seekers and clinical trials: some ethical issues.

Patterns of primary care consultation for physical symptoms in parents and children: an epidemiological study
Thesis
Patterns of primary care consultation for physical symptoms in parents and children: an epidemiological study. https://keele-repository.worktribe.com/output/409099

Non-specific or medically unexplained physical symptoms (MUPS) are common among children, persist in considerable proportions of those affected, and can lead to primary care consultations. A systematic review in this thesis has provided limited evide... Read More about Patterns of primary care consultation for physical symptoms in parents and children: an epidemiological study.