Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer
Thesis
(2018). Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer. Retrieved from https://keele-repository.worktribe.com/output/410307

Several long non-coding RNAs (lncRNAs) have been identified to play key, rate-limiting roles in malignancies, and the mechanisms involved are now being elucidated. This study addressed the roles of NEAT1 and MIAT lncRNAs, in breast cancer.
The short... Read More about Investigation into the role of the long non-coding RNAs NEAT1 and MIAT in breast cancer.

Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes
Thesis
(2012). Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes

Pathological conditions of cartilage resulting from acute injury are a major cause of morbidity. Surgical intervention, in most cases, does not repair cartilage to its native mechanical resilience. The potential benefits of non-invasive approaches fo... Read More about Novel cartilage repair therapy: The effect of low intensity pulsed ultrasound on chondrocytes.

The influence of the microenvironment on vascularisation of osteochondral tissues
Thesis
(2012). The influence of the microenvironment on vascularisation of osteochondral tissues

The regulation of vascularisation is a major challenge facing osteochondral tissue engineering. Articular cartilage is an avascular tissue and the presence of blood vessels is associated with various pathologies of the tissue. Conversely, bone requir... Read More about The influence of the microenvironment on vascularisation of osteochondral tissues.

The cause and effect of mood disturbance in patients with ankylosing spondylitis
Thesis
(2013). The cause and effect of mood disturbance in patients with ankylosing spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory disorder, causing progressive pain and stiffness of the spine and peripheral joints. A systematic review of the literature revealed a high prevalence of possible depression (23-36%) and possible a... Read More about The cause and effect of mood disturbance in patients with ankylosing spondylitis.

Optimising canine olfactory ensheathing cell therapy using tissue engineering tools
Thesis
Delaney, A. M. (2016). Optimising canine olfactory ensheathing cell therapy using tissue engineering tools

The adult mammalian spinal cord is incapable of significant regeneration following injury. As such, spinal injury is a lifelong debilitating condition which represents a significant burden on healthcare globally. Olfactory ensheathing cells (OECs) ha... Read More about Optimising canine olfactory ensheathing cell therapy using tissue engineering tools.

A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands
Thesis
Patterson, K. D. (2016). A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands

INTRODUCTION:
Newborn screening (NBS) for cystic fibrosis (CF) was implemented nationally in July 2007 and has reduced the age of diagnosis and produced better nutritional and survival outcomes.

AIM:
To assess demographic data of a screened coho... Read More about A review of newborn screening results and anthropometric measurements in infants diagnosed with cystic fibrosis in the West Midlands.

Exploitation and clinical trials in developing countries
Thesis
(2015). Exploitation and clinical trials in developing countries

This thesis discusses comprehensively the issue of exploitation from a normative perspective specifically relating to clinical trials within developing countries using a normative definition. Exploitation is defined from an unfairness perspective as... Read More about Exploitation and clinical trials in developing countries.

HIV positive refugees/asylum seekers and clinical trials: some ethical issues
Thesis
(2014). HIV positive refugees/asylum seekers and clinical trials: some ethical issues

The aim of this thesis was to identify some of the ethical issues of HIV positive asylum seekers and refugees participating in clinical trials in Britain. While all individuals are to some degree vulnerable in clinical trials, I have shown in this th... Read More about HIV positive refugees/asylum seekers and clinical trials: some ethical issues.

Investigations into the effects of cholesterol inhibitors on cancer cells in vitro
Thesis
(2014). Investigations into the effects of cholesterol inhibitors on cancer cells in vitro

Cholesterol-rich membrane microdomains have a significant role in cancer progression, particularly in metastasis, and there is evidence that cholesterol inhibitors, most notably statins, can change the behaviour of cancer cells in vitro and in vivo.... Read More about Investigations into the effects of cholesterol inhibitors on cancer cells in vitro.

Biochemical, biophysical, and structural studies of a protein complex implicated in the erythrocyte interaction with the Malaria parasite Plasmodium falciparum
Thesis
(2015). Biochemical, biophysical, and structural studies of a protein complex implicated in the erythrocyte interaction with the Malaria parasite Plasmodium falciparum

This thesis describes biochemical and biophysical studies of two protein domains that are believed to be involved in the interaction between the merozoites of Plasmodium falciparum and human red blood cells. The parasite protein fragment derives from... Read More about Biochemical, biophysical, and structural studies of a protein complex implicated in the erythrocyte interaction with the Malaria parasite Plasmodium falciparum.

Patterns of primary care consultation for physical symptoms in parents and children: an epidemiological study
Thesis
(2013). Patterns of primary care consultation for physical symptoms in parents and children: an epidemiological study

Non-specific or medically unexplained physical symptoms (MUPS) are common among children, persist in considerable proportions of those affected, and can lead to primary care consultations. A systematic review in this thesis has provided limited evide... Read More about Patterns of primary care consultation for physical symptoms in parents and children: an epidemiological study.

The measurement of locomotor disability in epidemiological studies
Thesis
(2010). The measurement of locomotor disability in epidemiological studies

This thesis is concerned with the measurement of locomotor disability (LMD) in epidemiological studies. The central hypothesis was that LMD is a continuous phenomenon and research into this important health indicator, with specific reference to its r... Read More about The measurement of locomotor disability in epidemiological studies.

Assessment of the radial artery access site and its use in invasive cardiac procedures
Thesis
(2013). Assessment of the radial artery access site and its use in invasive cardiac procedures

Vascular access via the radial artery has recently been shown to reduce access site related vascular complications but is associated with a significant learning curve. Radial artery spasm, arterial puncture failure, vascular anomalies, failure to rea... Read More about Assessment of the radial artery access site and its use in invasive cardiac procedures.

Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis.
Thesis
Smith, R. (2017). Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis

Physical activity (PA) is recommended for all adults with osteoarthritis (OA). Adults aged 45 years and over with joint pain, are likely to have already developed OA or are at risk of OA. This thesis examines self-reported PA levels in community dwel... Read More about Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis..

An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint
Thesis
Garcia, J. K. (2017). An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint

Osteoarthritis (OA) is a debilitating joint disease characterised by pain and progressive destruction of elements such as articular cartilage. Autologous chondrocyte implantation is a cellular therapy developed to regenerate damaged cartilage and del... Read More about An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint.

Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering
Thesis
Rotherham, M. (2016). Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering

The Wnt signalling pathways play crucial roles in development, tissue patterning, and stem cell fate determination. These pathways are therefore an attractive therapeutic target in the field of regenerative medicine and tissue engineering. Magnetic n... Read More about Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering.

Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes
Thesis
metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes

Introduction: Pneumonia contributes significantly to the morbidity and mortality in stroke patients, especially those fed via nasogastric tubes.

Methods: This project was conducted in two steps;
1. A randomised controlled trial: The efficacy of p... Read More about Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes.

An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells
Thesis
Al-Mayyahi, R. S. (2017). An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells

Anti-inflammatory drugs such as corticosteroids (CSs) and minocycline (MINO) are widely used in the treatment of a range of clinical conditions and to suppress graft rejection in stem cell transplantation therapy. However, such treatment is associate... Read More about An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells.

Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes
Thesis
Patel, N. (2016). Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes

COPD is a debilitating chronic respiratory disease with a systemic footprint. COPD is a highly heterogeneous disease but invariably its management involves a one-size fits all approach. This fails to address individual variations in disease progressi... Read More about Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes.

Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care
Thesis
Ndlovu, M. (2014). Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care

Musculoskeletal (MSK) pain is a major reason why people consult their general practitioner. Analgesia plays a central role in its treatment but do not always work, resulting in the need to switch amongst analgesia potency levels. Stronger analgesia i... Read More about Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care.