Skip to main content

Research Repository

Advanced Search

Assessment of the radial artery access site and its use in invasive cardiac procedures
Thesis
(2013). Assessment of the radial artery access site and its use in invasive cardiac procedures

Vascular access via the radial artery has recently been shown to reduce access site related vascular complications but is associated with a significant learning curve. Radial artery spasm, arterial puncture failure, vascular anomalies, failure to rea... Read More about Assessment of the radial artery access site and its use in invasive cardiac procedures.

Generation and fitness of transgenic Anopheles gambiae and the impact of multiple feeding on anti-malarial properties of the vida3 transgene
Thesis
(2011). Generation and fitness of transgenic Anopheles gambiae and the impact of multiple feeding on anti-malarial properties of the vida3 transgene

Malaria, the leading cause of death due to vector-borne disease. is responsible for around 250 million cases and 1 million deaths annually, mostly in sub-Saharan Africa where Anopheles gambiae is the major vector.
Novel approaches to malaria control... Read More about Generation and fitness of transgenic Anopheles gambiae and the impact of multiple feeding on anti-malarial properties of the vida3 transgene.

Idiopathic pulmonary fibrosis: exploration of aberrant epithelial wound repair and stem cell-mediated regenerative approaches
Thesis
(2013). Idiopathic pulmonary fibrosis: exploration of aberrant epithelial wound repair and stem cell-mediated regenerative approaches

Idiopathic pulmonary fibrosis (IPF) is a fatal form of fibrotic lung disease. The pathogenesis of IPF is unclear. An aberrant alveolar epithelial wound repair is likely to be involved in the disease process. Alveolar bronchiolisation, a process where... Read More about Idiopathic pulmonary fibrosis: exploration of aberrant epithelial wound repair and stem cell-mediated regenerative approaches.

Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis.
Thesis
Smith, R. (2017). Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis

Physical activity (PA) is recommended for all adults with osteoarthritis (OA). Adults aged 45 years and over with joint pain, are likely to have already developed OA or are at risk of OA. This thesis examines self-reported PA levels in community dwel... Read More about Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis..

An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint
Thesis
Garcia, J. K. (2017). An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint

Osteoarthritis (OA) is a debilitating joint disease characterised by pain and progressive destruction of elements such as articular cartilage. Autologous chondrocyte implantation is a cellular therapy developed to regenerate damaged cartilage and del... Read More about An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint.

Modelling clinical outcomes and cost-effectiveness of primary care interventions for osteoarthritis using prediction and decision models
Thesis
Wulff, J. (2013). Modelling clinical outcomes and cost-effectiveness of primary care interventions for osteoarthritis using prediction and decision models

The overall aim of this thesis is to develop prediction models to identify key predictors of poor outcome in people with osteoarthritis (OA) and examine the cost effectiveness of two approaches to delivering primary care interventions for OA compared... Read More about Modelling clinical outcomes and cost-effectiveness of primary care interventions for osteoarthritis using prediction and decision models.

Human stem cell metabolomics; headspace volatile gas analysis as an indicator of self-renewal and differentiation status
Thesis
Al-Zubaidi, M. A. (2018). Human stem cell metabolomics; headspace volatile gas analysis as an indicator of self-renewal and differentiation status

Self-renewal and an ability to differentiate are key hallmarks of stem cells. Pluripotent stem cells (PSC) have the capacity to differentiate into all cell types found within the three germ layers; ectoderm, endoderm, mesoderm. Multipotent stem cells... Read More about Human stem cell metabolomics; headspace volatile gas analysis as an indicator of self-renewal and differentiation status.

Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering
Thesis
Rotherham, M. (2016). Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering

The Wnt signalling pathways play crucial roles in development, tissue patterning, and stem cell fate determination. These pathways are therefore an attractive therapeutic target in the field of regenerative medicine and tissue engineering. Magnetic n... Read More about Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering.

Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes
Thesis
metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes

Introduction: Pneumonia contributes significantly to the morbidity and mortality in stroke patients, especially those fed via nasogastric tubes.

Methods: This project was conducted in two steps;
1. A randomised controlled trial: The efficacy of p... Read More about Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes.

Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation
Thesis
Baba Ismail, Y. M. (2016). Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation

The most common clinical treatments for large bone deficiencies resulting from trauma, disease or infection are autograft, allograft or bone graft substitutes (BGS). However, these treatments still have limitations for clinical applications. Thus, th... Read More about Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation.

Novel tissue engineering approaches to enhance natural bone formation
Thesis
Deegan, A. J. (2016). Novel tissue engineering approaches to enhance natural bone formation

The bone tissue engineering community has been striving to develop novel approaches that mimic natural bone formation. The rapid generation of mineralised bone tissue with a capacity for vascularisation and the selection of highly osteogenic cell sou... Read More about Novel tissue engineering approaches to enhance natural bone formation.

An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells
Thesis
Al-Mayyahi, R. S. (2017). An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells

Anti-inflammatory drugs such as corticosteroids (CSs) and minocycline (MINO) are widely used in the treatment of a range of clinical conditions and to suppress graft rejection in stem cell transplantation therapy. However, such treatment is associate... Read More about An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells.

Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes
Thesis
Patel, N. (2016). Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes

COPD is a debilitating chronic respiratory disease with a systemic footprint. COPD is a highly heterogeneous disease but invariably its management involves a one-size fits all approach. This fails to address individual variations in disease progressi... Read More about Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes.

Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression
Thesis
Dale, T. P. (2016). Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression

Damaged or diseased mature articular cartilage cannot undergo effective tissue repair and due to its avascular, hypocellular nature defects become widespread and painful. No ‘gold standard’ treatment exists for this indication and the ultimate recour... Read More about Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression.

Explicating and supporting the needs of student nurses during practice placements: a flexible and transferable model developed through action research
Thesis
model developed through action research

This study was designed to identify and address the support needs of pre-registration nursing students during practice placements in the West Midlands region. The study used an action research approach to define student needs and develop a flexible t... Read More about Explicating and supporting the needs of student nurses during practice placements: a flexible and transferable model developed through action research.

Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care
Thesis
Ndlovu, M. (2014). Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care

Musculoskeletal (MSK) pain is a major reason why people consult their general practitioner. Analgesia plays a central role in its treatment but do not always work, resulting in the need to switch amongst analgesia potency levels. Stronger analgesia i... Read More about Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care.

The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale
Thesis
Duncan, K. (2017). The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale

Background: Attitudes and beliefs that healthcare practitioners (HCPs) hold about musculoskeletal (MSK) pain influence their clinical behaviour. The Pain Attitudes and Beliefs Scale (PABS), originally developed for low back pain (LBP), is the most wi... Read More about The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale.

Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index
Thesis
Moody, D. K. (2016). Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index

Frailty measurement in primary care and at transitions of care is needed to enable timely identification of frailty, guide interventions and support proactive, integrated care. However, there is currently no single tool for frailty measurement in the... Read More about Measurement of frailty: development of a primary care framework and validation of an electronic Frailty Index.

Shared decision-making around analgesia for musculoskeletal pain in primary care consultations
Thesis
Hyde, C. (2016). Shared decision-making around analgesia for musculoskeletal pain in primary care consultations

Background
Musculoskeletal (MSK) pain is a major health problem worldwide and in UK primary care. Shared decision-making (SDM) is a process advocated by UK policy directives whereby a general practitioner (GP) and patient share information and the... Read More about Shared decision-making around analgesia for musculoskeletal pain in primary care consultations.