Exploitation and clinical trials in developing countries
Thesis
Exploitation and clinical trials in developing countries. https://keele-repository.worktribe.com/output/405068

This thesis discusses comprehensively the issue of exploitation from a normative perspective specifically relating to clinical trials within developing countries using a normative definition. Exploitation is defined from an unfairness perspective as... Read More about Exploitation and clinical trials in developing countries.

The use of MRI and MNP to image and track cells in vivo for arthritic cell-based therapies
Thesis
The use of MRI and MNP to image and track cells in vivo for arthritic cell-based therapies. https://keele-repository.worktribe.com/output/405328

Cell-based therapies have been proposed as novel approaches to treating Osteoarthritis and Rheumatoid Arthritis. A non-invasive means of monitoring cell populations, post implantation could prove valuable in the clinical translation of such therapies... Read More about The use of MRI and MNP to image and track cells in vivo for arthritic cell-based therapies.

HIV positive refugees/asylum seekers and clinical trials: some ethical issues
Thesis
HIV positive refugees/asylum seekers and clinical trials: some ethical issues. https://keele-repository.worktribe.com/output/403803

The aim of this thesis was to identify some of the ethical issues of HIV positive asylum seekers and refugees participating in clinical trials in Britain. While all individuals are to some degree vulnerable in clinical trials, I have shown in this th... Read More about HIV positive refugees/asylum seekers and clinical trials: some ethical issues.

Investigations into the effects of cholesterol inhibitors on cancer cells in vitro
Thesis
Investigations into the effects of cholesterol inhibitors on cancer cells in vitro. https://keele-repository.worktribe.com/output/403821

Cholesterol-rich membrane microdomains have a significant role in cancer progression, particularly in metastasis, and there is evidence that cholesterol inhibitors, most notably statins, can change the behaviour of cancer cells in vitro and in vivo.... Read More about Investigations into the effects of cholesterol inhibitors on cancer cells in vitro.

Biochemical, biophysical, and structural studies of a protein complex implicated in the erythrocyte interaction with the Malaria parasite Plasmodium falciparum
Thesis
Biochemical, biophysical, and structural studies of a protein complex implicated in the erythrocyte interaction with the Malaria parasite Plasmodium falciparum. https://keele-repository.worktribe.com/output/404128

This thesis describes biochemical and biophysical studies of two protein domains that are believed to be involved in the interaction between the merozoites of Plasmodium falciparum and human red blood cells. The parasite protein fragment derives from... Read More about Biochemical, biophysical, and structural studies of a protein complex implicated in the erythrocyte interaction with the Malaria parasite Plasmodium falciparum.

A mixed methods study of patient centred care in people with chronic venous leg ulceration
Thesis
A mixed methods study of patient centred care in people with chronic venous leg ulceration. https://keele-repository.worktribe.com/output/404170

Aims: To explore the lived experience of patients with chronic venous leg ulceration and to establish whether themes that impact on quality of life are addressed during wound care consultations. To develop a consultation template based on these theme... Read More about A mixed methods study of patient centred care in people with chronic venous leg ulceration.

Patterns of primary care consultation for physical symptoms in parents and children: an epidemiological study
Thesis
Patterns of primary care consultation for physical symptoms in parents and children: an epidemiological study. https://keele-repository.worktribe.com/output/409099

Non-specific or medically unexplained physical symptoms (MUPS) are common among children, persist in considerable proportions of those affected, and can lead to primary care consultations. A systematic review in this thesis has provided limited evide... Read More about Patterns of primary care consultation for physical symptoms in parents and children: an epidemiological study.

The measurement of locomotor disability in epidemiological studies
Thesis
The measurement of locomotor disability in epidemiological studies. https://keele-repository.worktribe.com/output/409101

This thesis is concerned with the measurement of locomotor disability (LMD) in epidemiological studies. The central hypothesis was that LMD is a continuous phenomenon and research into this important health indicator, with specific reference to its r... Read More about The measurement of locomotor disability in epidemiological studies.

Assessment of the radial artery access site and its use in invasive cardiac procedures
Thesis
Assessment of the radial artery access site and its use in invasive cardiac procedures. https://keele-repository.worktribe.com/output/409108

Vascular access via the radial artery has recently been shown to reduce access site related vascular complications but is associated with a significant learning curve. Radial artery spasm, arterial puncture failure, vascular anomalies, failure to rea... Read More about Assessment of the radial artery access site and its use in invasive cardiac procedures.

Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis.
Thesis
Smith, R. Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis. https://keele-repository.worktribe.com/output/408533

Physical activity (PA) is recommended for all adults with osteoarthritis (OA). Adults aged 45 years and over with joint pain, are likely to have already developed OA or are at risk of OA. This thesis examines self-reported PA levels in community dwel... Read More about Self-reported physical activity levels: measurement and assessment in community dwelling adults with or at risk of osteoarthritis..

An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint
Thesis
Garcia, J. K. An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint. https://keele-repository.worktribe.com/output/408535

Osteoarthritis (OA) is a debilitating joint disease characterised by pain and progressive destruction of elements such as articular cartilage. Autologous chondrocyte implantation is a cellular therapy developed to regenerate damaged cartilage and del... Read More about An in vitro study of the chondrogenic and immunomodulatory properties of mesenchymal stem cells from the osteoarthritic joint.

Modelling clinical outcomes and cost-effectiveness of primary care interventions for osteoarthritis using prediction and decision models
Thesis
Wulff, J. Modelling clinical outcomes and cost-effectiveness of primary care interventions for osteoarthritis using prediction and decision models. https://keele-repository.worktribe.com/output/408654

The overall aim of this thesis is to develop prediction models to identify key predictors of poor outcome in people with osteoarthritis (OA) and examine the cost effectiveness of two approaches to delivering primary care interventions for OA compared... Read More about Modelling clinical outcomes and cost-effectiveness of primary care interventions for osteoarthritis using prediction and decision models.

Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering
Thesis
Rotherham, M. Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering. https://keele-repository.worktribe.com/output/408420

The Wnt signalling pathways play crucial roles in development, tissue patterning, and stem cell fate determination. These pathways are therefore an attractive therapeutic target in the field of regenerative medicine and tissue engineering. Magnetic n... Read More about Remote activation of Frizzled receptors using magnetic nanoparticles for bone tissue engineering.

Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes
Thesis
metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes. https://keele-repository.worktribe.com/output/408432

Introduction: Pneumonia contributes significantly to the morbidity and mortality in stroke patients, especially those fed via nasogastric tubes.

Methods: This project was conducted in two steps;
1. A randomised controlled trial: The efficacy of p... Read More about Prevention of pneumonia after stroke: The effect of metoclopramide on aspiration and pneumonia in stroke patients fed via nasogastric tubes.

Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation
Thesis
Baba Ismail, Y. M. Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation. https://keele-repository.worktribe.com/output/408369

The most common clinical treatments for large bone deficiencies resulting from trauma, disease or infection are autograft, allograft or bone graft substitutes (BGS). However, these treatments still have limitations for clinical applications. Thus, th... Read More about Three-Dimensional Structured Hybrid Scaffolds for Enhanced Bone formation.

An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells
Thesis
Al-Mayyahi, R. S. An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells. https://keele-repository.worktribe.com/output/409791

Anti-inflammatory drugs such as corticosteroids (CSs) and minocycline (MINO) are widely used in the treatment of a range of clinical conditions and to suppress graft rejection in stem cell transplantation therapy. However, such treatment is associate... Read More about An investigation of the mechanisms underpinning the effect of anti-inflammatory drugs on neural stem cells.

Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes
Thesis
Patel, N. Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes. https://keele-repository.worktribe.com/output/407259

COPD is a debilitating chronic respiratory disease with a systemic footprint. COPD is a highly heterogeneous disease but invariably its management involves a one-size fits all approach. This fails to address individual variations in disease progressi... Read More about Evaluation of saliva biomarkers in chronic obstructive pulmonary disease: correlation to patient reported outcomes.

Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression
Thesis
Dale, T. P. Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression. https://keele-repository.worktribe.com/output/407215

Damaged or diseased mature articular cartilage cannot undergo effective tissue repair and due to its avascular, hypocellular nature defects become widespread and painful. No ‘gold standard’ treatment exists for this indication and the ultimate recour... Read More about Investigating the chondrogenic phenotype in clinically relevant cells: the effect of hTERT expression.

Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care
Thesis
Ndlovu, M. Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care. https://keele-repository.worktribe.com/output/406911

Musculoskeletal (MSK) pain is a major reason why people consult their general practitioner. Analgesia plays a central role in its treatment but do not always work, resulting in the need to switch amongst analgesia potency levels. Stronger analgesia i... Read More about Modelling factors associated with long-term prescription patterns of analgesia for musculoskeletal conditions in primary care.

The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale
Thesis
Duncan, K. The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale. https://keele-repository.worktribe.com/output/409656

Background: Attitudes and beliefs that healthcare practitioners (HCPs) hold about musculoskeletal (MSK) pain influence their clinical behaviour. The Pain Attitudes and Beliefs Scale (PABS), originally developed for low back pain (LBP), is the most wi... Read More about The development and testing of a generic musculoskeletal version of the Pain Attitudes and Beliefs Scale.