Investigating comorbid mood disorders in people with inflammatory rheumatological conditions: a mixed methods study (2020)
Thesis
Machin, A. R. (2020). Investigating comorbid mood disorders in people with inflammatory rheumatological conditions: a mixed methods study. (Thesis). Keele University

Background
Mood problems in people with rheumatoid arthritis (RA) are under-recognised and treated, contributing to increased mortality. Comorbid depression is associated with increased disease activity and reduced quality of life (QoL), though the... Read More about Investigating comorbid mood disorders in people with inflammatory rheumatological conditions: a mixed methods study.

Understanding self-harm behaviour in older adults: a systematic review and qualitative study (2019)
Thesis
Troya Bermeo, M. I. (2019). Understanding self-harm behaviour in older adults: a systematic review and qualitative study. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/415218

Two worldwide challenges served as a drive for this research: the reality of an ageing population and the identified need of supporting people who self-harm. Addressing self-harm has been increasingly prioritised due to its social, economic and healt... Read More about Understanding self-harm behaviour in older adults: a systematic review and qualitative study.

A urinary proteomics investigation of pregnancy-related complications (2019)
Thesis
Al-Jasim, W. F. (2019). A urinary proteomics investigation of pregnancy-related complications. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414917

Pre-eclampsia (PE) and intrauterine growth restriction (IUGR) are common disorders associated with placental implantation abnormalities in early pregnancy. Both conditions are heterogeneous, having complex and multiple aetiologies. PE complicates 5-8... Read More about A urinary proteomics investigation of pregnancy-related complications.

Use of invasive strategies in the management of non-ST elevation acute myocardial infarction and clinical outcomes (2019)
Thesis
Rashid, M. (2019). Use of invasive strategies in the management of non-ST elevation acute myocardial infarction and clinical outcomes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414984

Non-elevation acute myocardial infarction (NSTEMI) is one of the commonest phenotype of acute coronary syndrome (ACS) and associated with significant morbidity and mortality at the short and long term. An invasive strategy in the form of coronary ang... Read More about Use of invasive strategies in the management of non-ST elevation acute myocardial infarction and clinical outcomes.

Environmental ultraviolet-B exposures and measured health outcomes in English children (2019)
Thesis
Walker, J. (2019). Environmental ultraviolet-B exposures and measured health outcomes in English children. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417800

Purpose
Vitamin D status has been shown to significantly impact extra-skeletal health outcomes. In the UK, the ability of the population to synthesize vitamin D is highly sensitive to environmental factors including ultraviolet-B wavelength light. T... Read More about Environmental ultraviolet-B exposures and measured health outcomes in English children.

Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum (2019)
Thesis
Hmoud, M. K. (2019). Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414945

Despite the efforts in malaria eradication and elimination, malaria still poses a global challenge to health that, through the spread of antimalarial resistance, highlights an urgent need for new approaches for malaria treatment. Heparin and sulphate... Read More about Exploring the erythrocyte invasion–blocking effect of modified heparin and heparin mimetics in the human malaria parasite Plasmodium falciparum.

Applied statistical methods for prediction modelling of upper limb functional recovery after stroke (2019)
Thesis
Al-Shallawi, A. N. S. (2019). Applied statistical methods for prediction modelling of upper limb functional recovery after stroke. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414444

Stroke is the third largest cause of death in the world, with a significant contribution to disability. Motor function impairment, encompassing upper limb impairment, is the most significant post-stroke impairment. Such an impairment contributes to r... Read More about Applied statistical methods for prediction modelling of upper limb functional recovery after stroke.

Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs) (2019)
Thesis
Sykes, J. G. (2019). Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs). (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414327

Autologous chondrocyte implantation (ACI) is the only UK approved cell therapy or knee cartilage defects which might otherwise progress to osteoarthritis. For ACI, chondrocytes isolated from a healthy cartilage biopsy are expanded in number prior to... Read More about Advancing cartilage cell therapy through chondrocyte culture and patient reported outcome measures (PROMs).

A pilot study to identify serum biomarkers for post-stroke spasticity and related skeletal muscle changes (2019)
Thesis
Wasif, A. M. (2019). A pilot study to identify serum biomarkers for post-stroke spasticity and related skeletal muscle changes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414326

Spasticity is a common sensory-motor dysfunction observed following a stroke, and it is one of the signs indicating damage to the upper motor neurone system at the spinal or cerebral level. Stroke survivors often experience Some resistance to passive... Read More about A pilot study to identify serum biomarkers for post-stroke spasticity and related skeletal muscle changes.

Real voices: A participatory action research study to explore the support provided to children visiting adult patients in hospital. (2019)
Thesis
Jervis, J. (2019). Real voices: A participatory action research study to explore the support provided to children visiting adult patients in hospital. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414219

Background: There is evidence that a supportive and open approach to children visiting adult relatives in hospitals has positive benefits for the children, patient, families and healthcare staff. Despite this, many children (<17 years) are still rest...

Engineering and optimising a functional in vitro model of basal ganglia circuitry (2019)
Thesis
Kӧse-Dunn, M. J. (2019). Engineering and optimising a functional in vitro model of basal ganglia circuitry. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413812

The majority of neurological diseases (such as Parkinson’s and Huntington’s diseases) are progressive, debilitating and currently incurable. In an ageing population, the prevalence of such diseases will only increase over time, creating a need for be... Read More about Engineering and optimising a functional in vitro model of basal ganglia circuitry.

Characterising microglial activation: refinement and validation of primary in vitro models (2019)
Thesis
Al-Shaheeb, S. (2019). Characterising microglial activation: refinement and validation of primary in vitro models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413772

Background: Neuroinflammation is common to many neurodegenerative conditions and is principally mediated by microglia. Microglia maintain homeostasis, respond to trauma/infection and can promote repair. This is achieved by switching between surveilla... Read More about Characterising microglial activation: refinement and validation of primary in vitro models.

Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells (2019)
Thesis
Ibrahim, . S. L. (2019). Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413776

Breast cancer is considered the most frequently diagnosed cancer in women and the second most common type of cancer causing deaths among women. It is accounts 25% of all female cancers. It is expected about 1 in 8 women will develop this disease duri... Read More about Exploration of the mechanism of synergy between paclitaxel and BCKDK inhibitors in breast and ovarian cancer cells.

Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders (2019)
Thesis
Hmeidi, H. (2019). Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413771

Current Lung function assessments in children can be clinically challenging and even inapplicable in preschool children, this is due to the test requirements of cooperation and understanding. Hence, there is a need for new techniques that can overcom... Read More about Evaluation of Structured Light Plethysmography for lung function monitoring in pediatric respiratory disorders.

Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis (2019)
Thesis
Moran, J. A. (2019). Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413132

The research described here considers molecular variations of the acute phase response protein, C reactive protein (CRP), and the presence of CRP and anti CRP autoantibodies in rheumatoid arthritis (RA) patient serum.
Monomeric CRP (mCRP) was genera... Read More about Investigation of serum monomeric C-reactive protein and associated auto-antibodies in rheumatoid arthritis.

Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach (2018)
Thesis
AL-Jumaily, R. M. K. (2018). Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412295

Oxygen is an essential factor for life in many organisms. Oxygen concentrations vary widely across different human tissues, but in general, are much lower than the 21% oxygen in atmospheric air. In spite of this, most research continues to be based o... Read More about Molecular cytology of hypoxic cancer and stem cells: an epigenetic approach.

A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials (2018)
Thesis
Potts, J. E. (2018). A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412318

Most analyses in stroke clinical trials assess the primary outcome at a single time point and do not consider conducting a longitudinal analysis, even when the outcome has been recorded at several time points. Efforts to improve the quality of statis... Read More about A comparison of statistical techniques used in the longitudinal analysis of the modified Rankin scale in stroke randomised controlled trials.

An investigation into the role of protein phosphatase 4 in breast cancer (2018)
Thesis
Mohammed, H. N. (2018). An investigation into the role of protein phosphatase 4 in breast cancer. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412025

Breast cancer is the most common malignant tumour among females world-wide. The complexity of the pathogenesis of the disease and its heterogeneous clinical presentation, with an increasing incidence of the development of chemotherapeutic resistant c... Read More about An investigation into the role of protein phosphatase 4 in breast cancer.

Investigation into the role of protein phosphatase 4 catalytic subunit on the survival of leukaemic cell lines (2018)
Thesis
Al-Khazraji, S. K. A. (2018). Investigation into the role of protein phosphatase 4 catalytic subunit on the survival of leukaemic cell lines. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412024

Background: Serine/Threonine protein phosphatase 4 (PP4) plays a crucial role in cell signalling, proliferation and apoptosis, and its catalytic subunit has been reported as an important regulator in many types of cancer, including breast and lung ca... Read More about Investigation into the role of protein phosphatase 4 catalytic subunit on the survival of leukaemic cell lines.

Investigation of cellular and scaffold strategies for engineering articular cartilage (2018)
Thesis
Abu Owida, H. (2018). Investigation of cellular and scaffold strategies for engineering articular cartilage. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/412022

Articular cartilage is a thin hydrated tissue, which covers articulating surfaces. In the native articular cartilage tissue, the extracellular matrix (ECM) is a fibrillar mesh of interacting proteoglycans, collagens, and other non-collagenous protein... Read More about Investigation of cellular and scaffold strategies for engineering articular cartilage.